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Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131uM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells. Group: Biochemicals. Alternative Names: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide. Grades: Highly Purified. CAS No. 410536-97-9. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Sirtinol (Sir Two Inhibitor Naphthol, 2-N-(1-phenethyl)benzamide)
Specific cell permeable SIRT1 (sirtuin-1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer. Group: Biochemicals. Alternative Names: Sir Two Inhibitor Naphthol, 2--N-(1-phenethyl)benzamide. Grades: Highly Purified. CAS No. 410536-97-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
Worldwide
Sirtratumab vedotin
Sirtratumab vedotin is an antibody-drug conjugate consisting of a SLITRK6-specific human antibody conjugated to MMAE via a protease-cleavable linker. Sirtratumab vedotin has the potential for the treatment of advanced urothelial cancer. Alternative Names: ASG-15ME; AGS15E. CAS No. 1824663-83-3.
Sirukumab
Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO-136. CAS No. 1194585-53-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99316.
SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374313-54-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128918.
SIS3
SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521984-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13013.
SIS3
SIS3. Group: Biochemicals. Grades: Purified. CAS No. 521984-48-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SIS3 free base
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521985-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100444.
SIS3 HCl
SIS3 is a potent and specific inhibitor of Smad3 via inhibiting the effects of TGF-β1. SIS3 inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation with no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. It inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Alternative Names: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride. Grades: >98%. CAS No. 521984-48-5. Molecular formula: C28H27N3O3.HCl. Mole weight: 489.99.
SIS3 Hydrochloride
SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. Group: Inhibitors. CAS No. 521984-48-5. Pack Sizes: 2mg. Product ID: S7959. Formula: C28H27N3O3.HCl. Smiles: CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Sisomicin
Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity. Group: Biochemicals. Alternative Names: O-3-Deoxy-4-C-methyl-3-(methylamino)- β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy- D-Streptamine; Antibiotic 66-40; Antibiotic 6640; Rickamicin; Sch 13475; Siseptin. Grades: Highly Purified. CAS No. 32385-11-8. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Sisomicin
It is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis NRRL 3292. It has a broad-spectrum antibacterial effects against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa. It has no cross-resistance to kanamycin, but has cross-resistance to gentamycin. 50 mg/kg of Sisomicin has protective effect on mice infected with Rickettsia spinosa. Uses: Protein synthesis inhibitors. Alternative Names: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-; Antibiotic 6640; SCH 13475; Rickamicin; Sisomycin; Sissomicin; O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine; Antibiotic 66-40; BactoCeaze; Ensamycin; Sch 13475; Siseptin. Grades: ≥98%. CAS No. 32385-11-8. Molecular formula: C19H37N5O7. Mole weight: 447.53.
Sisomicin B
It is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis. It has broad-spectrum antimicrobial activity. Alternative Names: Sisomicin B; 6-O-[3-Deoxy-3-(methylamino)-α-D-xylopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hexa-4-enopyranosyl)-2-deoxy-D-streptamine; Antibiotic 66-40B; 6640B; D-Streptamine, O-3-deoxy-3-(methylamino)-alpha-D-xylopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-. CAS No. 53797-16-3. Molecular formula: C18H35N5O7. Mole weight: 433.50.
Sisomicin D
It is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis. It has broad-spectrum antimicrobial activity. Alternative Names: 6-O-[3-Deoxy-3-(methylamino)-β-L-arabinopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hexa-4-enopyranosyl)-2-deoxy-D-streptamine; Antibiotic 66-40D; 66-40D. CAS No. 53759-50-5. Molecular formula: C18H35N5O7. Mole weight: 433.50.
Sisomicin impurity 1
Sisomicin impurity 1. Uses: For analytical and research use. Molecular formula: C12H24N4O4. Mole weight: 288.35. Catalog: APB11397.
Sisomicin impurity 2
Sisomicin impurity 2. Uses: For analytical and research use. Molecular formula: C18H35N5O7. Mole weight: 433.51. Catalog: APB11396.
Sisomicin impurity 3
Sisomicin impurity 3. Uses: For analytical and research use. Molecular formula: C18H35N5O7. Mole weight: 433.51. Catalog: APB11399.
Sisomicin impurity 4
Sisomicin impurity 4. Uses: For analytical and research use. CAS No. 53759-50-5. Molecular formula: C18H35N5O7. Mole weight: 433.51. Catalog: APB53759505.
Sisomicin impurity 5
Sisomicin impurity 5. Uses: For analytical and research use. Molecular formula: C19H35N5O8. Mole weight: 461.52. Catalog: APB11401.
Sisomicin impurity 6
Sisomicin impurity 6. Uses: For analytical and research use. CAS No. 53797-16-3. Molecular formula: C18H35N5O7. Mole weight: 433.51. Catalog: APB53797163.
Sisomicin impurity 7
Sisomicin impurity 7. Uses: For analytical and research use. Molecular formula: C12H24N4O4. Mole weight: 288.35. Catalog: APB11400.
Sisomicin impurity 8
Sisomicin impurity 8. Uses: For analytical and research use. Molecular formula: C18H35N5O7. Mole weight: 433.51. Catalog: APB11402.
Sisomicin impurity 9
Sisomicin impurity 9. Uses: For analytical and research use. CAS No. 1154757-24-0. Molecular formula: C25H48N6O10. Mole weight: 592.69. Catalog: APB1154757240.
Sisomicin sulfate
Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria. Uses: Scientific research. Category: Signaling pathways. CAS No. 53179-09-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 500 mg. Product ID: HY-B1222.
Sisomicin sulfate
Sisomicin sulfate. Group: Biochemicals. Grades: Highly Purified. CAS No. 53179-09-2. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: 2C19H37N5O7·5H2SO4. US Biological Life Sciences.
Worldwide
Sisomicin sulfate (2:5)
Sisomicin Sulfate is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis NRRL 3292. It has a broad-spectrum antibacterial effects against Gram-positive and Gram-negative bacteria. Uses: Anti-bacterial agents. Alternative Names: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5); D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5) (salt); Antibiotic 66-40 sulfate; Baymicin; Extramycin; Mensiso; Sisobiotic; Sisolline; Sisomicin sulfate; Sisomin; Sisomycin sulfate; Sissomicin sulfate. Grades: ≥95%. CAS No. 53179-09-2. Molecular formula: C19H37N5O7.5/2H2O4S. Mole weight: 1385.44.
S-Isopropylisothiourea hydrobromide
S-Isopropylisothiourea hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 4269-97-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Sissotrin
Sissotrin (Biochanin A 7-glucoside) has potent antimicrobial and antioxidant activities. Sissotrin is active against the yeasts and Gram-positive and Gram-negative bacteria with MICs of 32-256 μg/mL[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Biochanin A 7-glucoside; Sissonin. CAS No. 5928-26-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1240.
Sissotrin
Sissotrin is a natural flavonoid isolated from the herbs of Trifolium pratense L. It can impair glucose tolerance. Alternative Names: Biochanin A-beta-D-glucoside. Grades: >98%. CAS No. 5928-26-7. Molecular formula: C22H22O10. Mole weight: 446.4.
Sisunatovir
Sisunatovir is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. Sisunatovir exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Alternative Names: RV-521; RV 521; RV521. Grades: 99.08%. CAS No. 1903763-82-5. Molecular formula: C23H22F4N4O. Mole weight: 446.44.
Sisunatovir
Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RV521. CAS No. 1903763-82-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123475.
Sisunatovir hydrochloride
Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RV521 hydrochloride. CAS No. 1903763-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123475A.
Sitafloxacin
Sitafloxacin (Sitafloxacin anhydrous) is an orally active fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.Sitafloxacin has been used in the study of respiratory tract infections and urinary tract infections. Category: Active pharmaceutical ingredients. CAS No. 127254-12-0. Product ID: API127254120. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.81.
Sitafloxacin hydrate
Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DU6859a hydrate. CAS No. 163253-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0395C.
Sitafloxacin Hydrate
Sitafloxacin Hydrate (DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. Category: Active pharmaceutical ingredients. CAS No. 163253-35-8. Product ID: API163253358. Molecular formula: C19H18ClF2N3O3·3/2H2O. Mole weight: 436.84.
Sitafloxacin hydrochloride
Sitafloxacin hydrochloride (DU6859a), a potent fluoroquinolone antibiotic with oral activity, demonstrates antichlamydial activity and a broad antibacterial spectrum against gram-positive, gram-negative, and anaerobic bacteria, in addition to atypical pathogens. It is utilized in researching respiratory tract and urinary tract infections. Category: Active pharmaceutical ingredients. CAS No. 346607-37-2. Product ID: API346607372. Molecular formula: C19H19Cl2F2N3O3. Mole weight: 446.28.
Sitafloxacin Impurity 10
Sitafloxacin Impurity 10. Uses: For analytical and research use. Molecular formula: C16H13F3N2O. Mole weight: 338.29. Catalog: APB09790.
Sitafloxacin Impurity 14
Sitafloxacin Impurity 14. Uses: For analytical and research use. Molecular formula: C19H18F3N3O3. Mole weight: 393.37. Catalog: APB09792.
Sitafloxacin Impurity 15
Sitafloxacin Impurity 15. Uses: For analytical and research use. Molecular formula: C16H13F3N2O3. Mole weight: 338.29. Catalog: APB09791.
Sitafloxacin Impurity 16
Sitafloxacin Impurity 16. Uses: For analytical and research use. CAS No. 148693-51-0. Molecular formula: C16H15ClFN3O3. Mole weight: 351.76. Catalog: APB148693510.
Sitafloxacin Impurity 17
Sitafloxacin Impurity 17. Uses: For analytical and research use. Molecular formula: C19H19ClF2N4O2. Mole weight: 408.83. Catalog: APB09793.
Sitafloxacin Impurity 18
Sitafloxacin Impurity 18. Uses: For analytical and research use. CAS No. 127199-14-8. Molecular formula: C4H5FO2. Mole weight: 104.08. Catalog: APB127199148.
Sitafloxacin Impurity 19
Sitafloxacin Impurity 19. Uses: For analytical and research use. CAS No. 127199-16-0. Molecular formula: C8H14FNO2. Mole weight: 175.2. Catalog: APB127199160.
Sitafloxacin Impurity 20
Sitafloxacin Impurity 20. Uses: For analytical and research use. CAS No. 149404-98-8. Molecular formula: C3H6FN. Mole weight: 75.09. Catalog: APB149404988.
Sitafloxacin Impurity 21
Sitafloxacin Impurity 21. Uses: For analytical and research use. CAS No. 114152-96-4. Molecular formula: C3H7ClFN. Mole weight: 111.54. Catalog: APB114152964.
Sitafloxacin Impurity 22
Sitafloxacin Impurity 22. Uses: For analytical and research use. CAS No. 1638744-20-3. Molecular formula: C3H7ClFN. Mole weight: 111.54. Catalog: APB1638744203.
Sitafloxacin Impurity 23
Sitafloxacin Impurity 23. Uses: For analytical and research use. CAS No. 129306-06-5. Molecular formula: C13H14N2O2. Mole weight: 230.27. Catalog: APB129306065.
Sitafloxacin Impurity 24
Sitafloxacin Impurity 24. Uses: For analytical and research use. CAS No. 129306-07-6. Molecular formula: C13H18N2. Mole weight: 202.3. Catalog: APB129306076.
Sitafloxacin Impurity 25
Sitafloxacin Impurity 25. Uses: For analytical and research use. CAS No. 144282-35-9. Molecular formula: C13H18N2. Mole weight: 202.3. Catalog: APB144282359.
Sitafloxacin Impurity 26
Sitafloxacin Impurity 26. Uses: For analytical and research use. CAS No. 1432056-70-6. Molecular formula: C18H26N2O2. Mole weight: 302.42. Catalog: APB1432056706.
Sitafloxacin Impurity 27
Sitafloxacin Impurity 27. Uses: For analytical and research use. CAS No. 101513-77-3. Molecular formula: C7H2ClF3O2. Mole weight: 210.54. Catalog: APB101513773.
Sitafloxacin Impurity 28
Sitafloxacin Impurity 28. Uses: For analytical and research use. Molecular formula: C9H4ClF3O3. Mole weight: 252.57. Catalog: APB09795.
Sitafloxacin Impurity 29
Sitafloxacin Impurity 29. Uses: For analytical and research use. Molecular formula: C11H9F3O4. Mole weight: 262.18. Catalog: APB09794.
Sitafloxacin Impurity 30
Sitafloxacin Impurity 30. Uses: For analytical and research use. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.82. Catalog: APB09797.
Sitafloxacin Impurity 31
Sitafloxacin Impurity 31. Uses: For analytical and research use. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.82. Catalog: APB09796.
Sitafloxacin Impurity 32
Sitafloxacin Impurity 32. Uses: For analytical and research use. CAS No. 127254-10-8. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.82. Catalog: APB127254108.
Sitafloxacin Impurity 33
Sitafloxacin Impurity 33. Uses: For analytical and research use. CAS No. 127199-06-8. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.82. Catalog: APB127199068.
Sitafloxacin Impurity 34
Sitafloxacin Impurity 34. Uses: For analytical and research use. Molecular formula: C12H8ClF2NO2. Mole weight: 271.65. Catalog: APB09798.
Sitafloxacin Impurity 35
Sitafloxacin Impurity 35. Uses: For analytical and research use. CAS No. 500569-52-8. Molecular formula: C19H19F2N3O3. Mole weight: 375.38. Catalog: APB500569528.
Sitafloxacin Impurity 36
Sitafloxacin Impurity 36. Uses: For analytical and research use. CAS No. 2365490-44-2. Molecular formula: C13H8ClF2NO4. Mole weight: 315.66. Catalog: APB2365490442.
Sitafloxacin Impurity 37
Sitafloxacin Impurity 37. Uses: For analytical and research use. Molecular formula: C13H9ClF2N2O3. Mole weight: 314.67. Catalog: APB09799.
Sitafloxacin Impurity 38
Sitafloxacin Impurity 38. Uses: For analytical and research use. Molecular formula: C16H16FN3O3. Mole weight: 317.32. Catalog: APB09800.
Sitafloxacin Impurity 40
Sitafloxacin Impurity 40. Uses: For analytical and research use. Molecular formula: C19H19F2N3O4. Mole weight: 391.37. Catalog: APB09801.
Sitafloxacin Impurity 41
Sitafloxacin Impurity 41. Uses: For analytical and research use. CAS No. 500295-84-1. Molecular formula: C19H19F2N3O4. Mole weight: 391.37. Catalog: APB500295841.
Sitafloxacin Impurity 42
Sitafloxacin Impurity 42. Uses: For analytical and research use. Molecular formula: C18H18ClF2N3O2. Mole weight: 381.81. Catalog: APB09802.
Sitafloxacin Impurity 7
Sitafloxacin Impurity 7. Uses: For analytical and research use. Molecular formula: C5H8FNO. Mole weight: 117.12. Catalog: APB09788.
Sitafloxacin Impurity 8
Sitafloxacin Impurity 8. Uses: For analytical and research use. CAS No. 129306-12-3. Molecular formula: C6H12N2. Mole weight: 112.18. Catalog: APB129306123.
Sitafloxacin Impurity 9
Sitafloxacin Impurity 9. Uses: For analytical and research use. CAS No. 144216-11-5. Molecular formula: C10H5F2NO3. Mole weight: 225.15. Catalog: APB144216115.
Sitafloxacin Impurity A
Sitafloxacin Impurity A. Uses: For analytical and research use. CAS No. 500295-83-0. Molecular formula: C16H16FN3O3. Mole weight: 317.32. Catalog: APB500295830.
Sitafloxacin Impurity P-1
Sitafloxacin Impurity P-1. Uses: For analytical and research use. CAS No. 2044706-49-0. Molecular formula: C16H17ClFN3O3. Mole weight: 353.78. Catalog: APB2044706490.