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| Product | Description | |
|---|---|---|
| Sitostenone | Sitostenone is isolated from the roots of Xanthium sibiricum. Sitostenone has antioxidant activity and can be used in the treatment of androgen-dependent diseases, especially benign prostatic hyperplasia. Alternative Names: Stigmast-4-en-3-one; (24R)-24-Ethylcholest-4-en-3-one; (24R)-Stigmast-4-en-3-one; 4-En-3-stigmastone; NSC 49082; β-Rosasterol oxide; β-Sitost-4-en-3-one; β-Sitostenone; Δ4-Sitosterol-3-one; beta-sitostenone. Grades: >98%. CAS No. 1058-61-3. Molecular formula: C29H48O. Mole weight: 412.69. |  |
| Sitosterol | Sitosterol Inhibitor. Uses: Scientific use. Product Category: T2966. CAS No. 83-46-5. |  |
| Sitosterol-d7 | Sitosterol-d7. Group: Others. Purity: >99%. Mole weight: 421.75. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; Sitosterol-d7; (24-Ethyl)-heptadeuteriostigmast-5-en-3ss-ol. Cat No: FLBZ-078. |  |
| Sitosterol-[d7] | Sitosterol-[d7] is the labelled analogue of Sitosterol, a common sterol in plants isolated from wheat germ oil, corn oil. Sitosterol is an antilipemic drug and is used in the treatment of prostatic adenoma. Alternative Names: (24-ethyl)-heptadeuteriostigmast-5-en-3β-ol; Sitosterol-25,26,26,26,27,27,27-D7; 24(R,S)-Stigmast-5-en-3β-ol-d7; Sitosterol-d7; 5-Cholesten-24(RS)-ethyl-3β-ol-25,26,26,26,27,27,27-d7; Cupreol-d7; Azuprostat-d7; 22,23-Dihydrostigmasterol-d7; Quebrachol-d7; Triastonal-d7; β-Sitosterol-d7 (mixture of diasteromers); beta-Sitosterin-d7. Grades: 98%; ≥98% atom D. CAS No. 2260669-28-9. Molecular formula: C29H43D7O. Mole weight: 421.75. | |
| Sitravatinib | Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGCD516; MG-516. CAS No. 1123837-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16961. |  |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Alternative Names: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat | Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546; LY544349; ONO5046. CAS No. 127373-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443. | |
| Sivelestat sodium | Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium. CAS No. 150374-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443A. | |
| Sivelestat sodium salt | Sivelestat sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 150374-95-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Sivelestat sodium tetrahydrate | Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate. CAS No. 201677-61-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17443B. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Alternative Names: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| Sivopixant | Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-600918. CAS No. 2414285-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-137451. | |
| Siyry | A Kb-restricted epitope peptide. CAS No. 178561-37-0. Molecular formula: C50H71N11O13. Mole weight: 1034.1600000000001. | |
| SIYRY acetate | A Kb-restricted epitope peptide. Molecular formula: C52H75N11O15. Mole weight: 1094.25. | |
| SJ000063181 | SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8). SJ000063181 induces ventralization in zebrafish embryos[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945189-68-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147372. | |
| SJ000291942 | SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. Uses: Scientific research. Category: Signaling pathways. CAS No. 425613-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112331. | |
| SJ 172550 | SJ 172550. Group: Biochemicals. Grades: Purified. CAS No. 431979-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SJ-172550 | SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 431979-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16664. | |
| SJ3149 | SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026986-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160444. | |
| SJ572403 | SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SJ403. CAS No. 19970-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114712. | |
| SJ6986 | SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765625-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132199. | |
| SJB2-043 | SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 63388-44-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15757. | |
| SJB3-019A | SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-80012. | |
| SJF-0628 | SJF-0628 is a RAF PROTAC degrader. SJF-0628 induces targeted degradation of BRAF in various cancer cell lines (colorectal cancer cell lines (Colo-205, LS-411N, HT-29, RKO) and triple-negative breast cancer cell line DU-4475). SJF-0628 decreases pMEK and pErk levels in DU-4475 cells. SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of colorectal cancer and triple-negative breast cancer. (Pink: RAF ligand (HY-12057), Blue: VHL Ligand ( HY-125845), Black: Linker (HY-B0912))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413035-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-136420. | |
| SJF 1521 | It is an EGFR-targeting PROTAC small molecule that can induce EGFR degradation. Epidermal growth factor receptor (EGFR), also known as ErbB1/HER1, is a proto-oncogene associated with a variety of cancers, including glioblastoma multiforme, head and neck cancer, and non-small cell lung cancer. Alternative Names: N-({2-[2-(2-{4-[4-({3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-6-quinazolinyl]phenoxy}ethoxy)ethoxy]ethoxy}acetyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide; (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; L-Prolinamide, N-[2-[2-[2-[2-[4-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-; EGFR PROTAC. Grades: ≥95%. CAS No. 2230821-40-4. Molecular formula: C57H61ClFN7O9S. Mole weight: 1074.65. | |
| SJF-1521 | SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research. (Pink: EGFR ligand (HY-177379); Black: Linker (HY-128804); Blue: VHL Ligand (HY-125845))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865. | |
| SJF 1528 | Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells). Category: Active pharmaceutical ingredients. CAS No. 2230821-38-0. Product ID: API2230821380. Molecular formula: C55H57ClFN7O8S. Mole weight: 1030.61. |  |
| SJF-1528 | SJF-1528 (PROTAC 1) is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-38-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131864. | |
| SJF-1528 | It is an EGFR-targeting PROTAC small molecule that can induce EGFR degradation. Epidermal growth factor receptor (EGFR), also known as ErbB1/HER1, is a proto-oncogene associated with a variety of cancers, including glioblastoma multiforme, head and neck cancer, and non-small cell lung cancer. Alternative Names: (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; N-{[2-(2-{4-[4-({3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-6-quinazolinyl]phenoxy}ethoxy)ethoxy]acetyl}-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide; L-Prolinamide, N-[2-[2-[2-[4-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]phenoxy]ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-; SJF 1528; SJF1528. Grades: ≥95%. CAS No. 2230821-38-0. Molecular formula: C55H57ClFN7O8S. Mole weight: 1030.60. | |
| SJF-8240 | It is an isoform-selective PROTAC generated by the p38 MAPK family using a single warhead (foretinib) and recruited E3 ligase (von Hippel-Lindau). It can recruit VHL and cause the degradation of p38α, p38δ, c-Met and RIPK2. Alternative Names: N-[3-(3-{3-[(4-{2-Fluoro-4-[({1-[(4-fluorophenyl)carbamoyl]cyclopropyl}carbonyl)amino]phenoxy}-6-methoxy-7-quinolinyl)oxy]propoxy}propoxy)propanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide; L-Prolinamide, N-[3-[3-[3-[[4-[2-fluoro-4-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]phenoxy]-6-methoxy-7-quinolinyl]oxy]propoxy]propoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-. Grades: ≥95%. CAS No. 2230821-68-6. Molecular formula: C58H65F2N7O11S. Mole weight: 1106.24. | |
| SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. Alternative Names: SJG 136; SJG136; SJG-136; SP-2001; SP2001; SP 2001; BN 2629; BN2629; BN-2629; SG2000; SG 2000; SG-2000; NSC 694501; NSC694501; NSC-694501. Grades: >98.0%. CAS No. 232931-57-6. Molecular formula: C31H32N4O6. Mole weight: 556.61. | |
| SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC-694501. CAS No. 232931-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14573. | |
| SJPYT-195 | SJPYT-195 is a cytotoxic GSPT1 degrader and can be used for PROTAC synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2973762-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150616. | |
| SJPYT-310 | SJPYT-310 is a selective PXR antagonist. SJPYT-310 shows no significant cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883814-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-173072. | |
| SK1-I | SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM[1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BML-258. CAS No. 1072443-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119016. | |
| SK1-IN-1 | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1218816-71-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101805. | |
| SK-216 | SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 654080-03-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122714. | |
| SK2187 | SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JB301. CAS No. 3038446-91-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171768. | |
| SK2188 | SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: Thalidomide (HY-14658); Black: Linker: Amino-PEG4-alcohol (HY-W008005))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JB325. CAS No. 3038446-94-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171767. | |
| SK33 | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1928724-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135732. | |
| SK-3-91 | SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397))[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2769753-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137341. | |
| SK-575 | SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2523016-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139156. | |
| SKA 31 | SKA 31. Group: Biochemicals. Grades: Purified. CAS No. 40172-65-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Skeletal muscle-targeted peptide MSP | Skeletal muscle-targeted peptide MSP is a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP). Skeletal muscle-targeted peptide MSP can target the virus through a different binding ligand to the muscle. Skeletal muscle-targeted peptide MSP can be used for the research of diseases of the heart and skeletal muscles[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 216763-24-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10643. | |
| Skepinone-L | Skepinone-L (CBS3830), a chemical probe, is a selective p38 mitogen-activated protein kinase inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBS3830. CAS No. 1221485-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15300. | |
| SKF-34288 hydrochloride | SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride. CAS No. 320386-54-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128923. | |
| SKF 38393 hydrobromide | SKF 38393 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 20012-10-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| SKF 38393 hydrochloride | SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-SKF-38393 hydrochloride; SKF-38393A. CAS No. 62717-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12520A. | |
| SKF 81297 | SKF 81297 is a potent and selective dopamine D1 receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71636-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12236A. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67287-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12236. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-82958 hydrobromide | SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide. CAS No. 74115-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10435A. | |
| SKF-83566 | SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM)[1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinsons disease and nicotine craving alleviation[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 99295-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-103430A. | |
| SKF 83822 hydrobromide | SKF 83822 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 74115-10-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 83959 | SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80751-85-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130344. | |
| SKF 83959 hydrobromide | SKF 83959 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-95-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Alternative Names: SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene. Grades: >98%. CAS No. 72873-74-6. Molecular formula: C16H12FN3S. Mole weight: 297.36. | |
| SKF 86002 dihydrochloride | SKF 86002 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 116339-68-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 86466 hydrochloride | SKF 86466 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 86129-54-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 89976A | SKF 89976A hydrochloride is a potent GABA transporter inhibitor with selectivity for GAT-1 (IC50 = 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). SKF 89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). SKF 89976A can pass the blood-brain barrier following systemic administration. Alternative Names: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride; 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1); 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-butenyl)-, monohydrochloride; 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride; SKF89976A; SKF-89976A; SKF 89976 hydrochloride; SKF89976 hydrochloride; SKF-89976 hydrochloride. Grades: ≥99% by HPLC. CAS No. 85375-15-1. Molecular formula: C22H25NO2.HCl. Mole weight: 371.91. | |
| SKF 91488 dihydrochloride | SKF 91488 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 68941-21-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-96365 | SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 162849-90-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-125942. | |
| Skf 96365 hydrochloride | Skf 96365 hydrochloride. CAS No. 130495-35-1. Purity: >99 %. Product ID: ACM130495351. Molecular formula: C22H27ClN2O3. Mole weight: 402.91. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| SKF 96365 hydrochloride | SKF 96365 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 130495-35-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-96365 (hydrochloride) | SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130495-35-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100001. | |
| SKF 97541 | SKF 97541. Group: Biochemicals. Grades: Purified. CAS No. 127729-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKI2852 | SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346554-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-19325. | |
| SKI-606 (Bosutinib) | Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT / mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. Group: Inhibitors. Alternative Names: SKI-606. CAS No. 380843-75-4. Pack Sizes: 1g. Product ID: S1014. Formula: C26H29Cl2N5O3. Smiles: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| SKI II | SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC50 values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 312636-16-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13822. | |
| SKI II | SKI II. Group: Biochemicals. Grades: Purified. CAS No. 312636-16-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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