A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC 50 of 19 nM in Caco-2 cell extracts [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0431 phosphate. CAS No. 654671-78-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13749A.
Sitagliptin phosphate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Sitagliptin phosphate
Sitagliptin phosphate is the phosphate salt form of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Uses: Hypoglycemic agents. Synonyms: (2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt; MK-431; ONO-5435. Grade: >98%. CAS No. 654671-78-0. Molecular formula: C16H15F6N5O.H3O4P. Mole weight: 505.31.
Sitagliptin Phosphate
Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. Group: Biochemicals. Alternative Names: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate. Grades: Highly Purified. CAS No. 654671-78-0. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Sitagliptin phosphate monohydrate
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC 50 of 19 nM in Caco-2 cell extracts [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0431 phosphate monohydrate. CAS No. 654671-77-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13749B.
An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release, stimulates the insulin release and lowers blood glucose. Group: Biochemicals. Grades: Highly Purified. CAS No. 654671-77-9. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Sitagliptin Related Compound 1
Sitagliptin Related Compound 1 is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid; Boc-(R)-3-amino-4-(3-fluorophenyl)-butyric acid. Grade: >95%. CAS No. 331763-66-7. Molecular formula: C15H20FNO4. Mole weight: 297.32.
Sitagliptin System Suitability Mixture
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Sitaxsentan sodium. Group: Biochemicals. Alternative Names: N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide. Grades: Highly Purified. CAS No. 210421-74-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C18H14ClN2NaO6S2. US Biological Life Sciences.
Worldwide
Sitaxsentan sodium
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI 1040 sodium; TBC11251 sodium. CAS No. 210421-74-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11103.
site-1 protease
Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys? site, and the envelope glycoprotein of the highly infectious Lassa virus and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys?. Belongs in. No. 167140-48-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4107; site-1 protease; EC 3.4.21.112; 167140-48-9; mammalian subtilisin/kexin isozyme 1; membrane-bound transcription factor site-1 protease; proprotein convertase SKI-1; proprotein convertase SKI-1/S1PPS1; S1P endopeptidase; S1P protease; site-1 peptidase; site-1 protease; SKI-1; SREBP proteinase; SREBP S1 protease; SREBP-1 proteinase; SREBP-2 proteinase; sterol regulatory element-binding protein proteinase; sterol regulatory element-binding protein site 1 protease; sterol-regulated luminal protease; subtilase SKI-1; subtilase SKI-1/S.
This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system. Enzyme Commission Number: EC 2.1.1.72. CAS No. 69553-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1974; site-specific DNA-methyltransferase (adenine-specific); EC 2.1.1.72; 69553-52-2; modification methylase; restriction-modification system. Cat No: EXWM-1974.
This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.113. CAS No. 169592-50-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1712; site-specific DNA-methyltransferase (cytosine-N4-specific); EC 2.1.1.113; 169592-50-1; modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Cat No: EXWM-1712.
Sitoindoside I
Sitoindoside I. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-naphthalen-2-ylamino-1H-pyrimidine-2,4-dione. Appearance: Powder. CAS No. 18749-71-8. Molecular formula: C51H90O7. Mole weight: 815.3. Purity: 0.98. IUPACName: [(2R,3S,4S,5R,6R)-6-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methyl hexadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC1C(C(C(C(O1)OC2CCC3(C4CCC5(C(C4CC=C3C2)CCC5C(C)CCC(CC)C(C)C)C)C)O)O)O. Product ID: ACM18749718. Alfa Chemistry ISO 9001:2015 Certified.
Sitolactone
Sitolactone. Uses: Designed for use in research and industrial production. Product Category: Steroidal Compounds. CAS No. 126784-20-1. Molecular formula: C13H18O3. Mole weight: 222.28. Purity: 95%+. Product ID: ACM126784201. Alfa Chemistry ISO 9001:2015 Certified.
Sitostenone
Sitostenone is isolated from the roots of Xanthium sibiricum. Sitostenone has antioxidant activity and can be used in the treatment of androgen-dependent diseases, especially benign prostatic hyperplasia. Synonyms: Stigmast-4-en-3-one; (24R)-24-Ethylcholest-4-en-3-one; (24R)-Stigmast-4-en-3-one; 4-En-3-stigmastone; NSC 49082; β-Rosasterol oxide; β-Sitost-4-en-3-one; β-Sitostenone; Δ4-Sitosterol-3-one; beta-sitostenone. Grade: >98%. CAS No. 1058-61-3. Molecular formula: C29H48O. Mole weight: 412.69.
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC 50 s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively [1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MGCD516; MG-516. CAS No. 1123837-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16961.
SiTrzCz2
SiTrzCz2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(6-(3-(Triphenylsilyl)phenyl)-1,3,5-triazine-2,4-diyl)bis(9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 2422045-58-5. Molecular formula: C51H35N5Si. Mole weight: 745.94 g/mol. Product ID: ACM2422045585. Alfa Chemistry ISO 9001:2015 Certified.
Sivelestat
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EI546; LY544349; ONO5046. CAS No. 127373-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17443.
Sivelestat sodium
Sivelestat sodium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150374-95-1. Molecular formula: C20H21N2NaO7S. Mole weight: 456.45. Catalog: APB150374951.
Sivelestat sodium salt
Sivelestat sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 150374-95-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SJ3149 is a selective and potent molecular glue degrader of CK1? protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026986-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-160444.
SJ6986
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765625-93-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132199.
SJ6986
SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SJ6986; SJ-6986; SJ 6986. Product Category: Others. Appearance: Solid powder. CAS No. 2765625-93-0. Molecular formula: C20H14F3N3O7S. Mole weight: 497.4. Purity: >98%. IUPACName: N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O. Product ID: ACM2765625930. Alfa Chemistry ISO 9001:2015 Certified.
SJ988497
SJ988497 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2595365-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151902.
SJF-0628
SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants ( DC 50 : 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413035-41-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136420.
SJF-1521
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865.
SJF-8240
SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230821-68-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123961.
SK-216
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 654080-03-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122714.
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2523016-96-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139156.
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC 50 of 1109 nM. SK609 hydrochloride has the potential for parkinson research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092797-77-7. Pack Sizes: 5 mg. Product ID: HY-117059.
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors ( AhR ) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Methylindole; 3-Methyl-1H-indole. CAS No. 83-34-1. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W007355.
Skeletal Nickel Catalyst slurry in Water
Skeletal Nickel Catalyst slurry in Water. Group: Biochemicals. Alternative Names: Raney Nickel slurry in Water. Grades: Highly Purified. CAS No. 7440-02-0. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences.
Worldwide
Skepinone-L
Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CBS3830. CAS No. 1221485-83-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15300.
SKF 38393 hydrobromide
SKF 38393 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 20012-10-6. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
SKF 38393 hydrochloride
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-SKF-38393 hydrochloride; SKF-38393A. CAS No. 62717-42-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12520A.
SKF-525A, Hydrochloride - CAS 62-68-0
Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Group: Fluorescence/luminescence spectroscopy.
SKF 81297 is a potent and selective dopamine D1 receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71636-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12236A.
SKF 81297 hydrobromide
SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67287-39-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12236.
SKF 81297 hydrobromide
SKF 81297 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SKF 83822 hydrobromide
SKF 83822 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 74115-10-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SKF 83959
SKF83959 is a potent and selective dopamine D 1 -like receptor partial agonist. SKF83959 K i values for rat D 1 , D 5 , D 2 and D 3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80751-85-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-130344.
SKF 83959 hydrobromide
SKF83959 hydrobromide is a potent and selective dopamine D 1 -like receptor partial agonist. SKF83959 hydrobromide K i values for rat D 1 , D 5 , D 2 and D 3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67287-95-0. Pack Sizes: 5 mg. Product ID: HY-103412.
SKF 83959 hydrobromide
SKF 83959 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-95-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.