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Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. Molecular Formula: C11H6F3NO2S, Method for Determining. US Biological Life Sciences.
Worldwide
SMI-4a
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 ?M and a Ki of 0.6 ?M. SMI-4a also inhibits Pim-2 (IC50 of 100 ?M), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TCS-PIM-1-4a. CAS No. 438190-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16576A.
A selective, ATP-competitive inhibitor Pim-1 (IC50=21nm) and Pim-2 (IC50=100nm) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
SMIFH2
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton. Uses: Designed for use in research and industrial production. Additional or Alternative Names: STK197413, ZINC01203437, SMIFH2, AC1M4GYW, MolPort-002-178-894, (5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, AKOS001651888, BIM-0040107.P001, (5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione, 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, 340316-62-3. Product Category: Inhibitors. Appearance: Solid. CAS No. 340316-62-3. Molecular formula: C15H9BrN2O3S. Mole weight: 377.21. Purity: 0.96. IUPACName: (5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione. Canonical SMILES: C1=CC(=CC(=C1)Br)N2C(=O)C(=CC3=CC=CO3)C(=O)NC2=S. Product ID: ACM340316623. Alfa Chemistry ISO 9001:2015 Certified.
SMIFH2
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 340316-62-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16931.
SMIFH2. Group: Biochemicals. Grades: Purified. CAS No. 340316-62-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Smi I
One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA (SspI-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme >95% of the dna fragments can be ligated and recut. ligation >95% in presence of 10% peg. Group: Restriction Enzymes. Purity: 1000U; 5000U. ATTT↑AAAT TAAA↓TTTA. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer O, BSA. Storage: -20°C. Form: Liquid. Source: Streptococcus milleri S. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 100 μg/ml BSA; 50% glycerol. Cat No: ET-1177RE.
Smilagenin
Smilagenin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (25R)-SPIROSTAN-3BETA-OL; 25R,5BETA-SPIROSTAN-3BETA-OL; ISOSARSAPOGENIN; (25R)-Spirostan-3.β.-ol; (25R)-5beta-spirostan-3beta-ol; ISOSARSAPOGENINE; ESMILAGENIN; SMILAGENIN; ISOSARSASAPOGENIN. Product Category: Steroidal Compounds. CAS No. 126-18-1. Molecular formula: C27H44O3. Mole weight: 416.64. Purity: 0.98. IUPACName: (25R)-5β-spirostan-3β-ol. Canonical SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)OC1. Density: 1.11g/cm³. ECNumber: 204-775-8. Product ID: ACM126181. Alfa Chemistry ISO 9001:2015 Certified.
Smilagenin
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases [1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density [2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD [3]. Uses: Scientific research. Group: Natural products. CAS No. 126-18-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106353.
Smilagenin acetate
Smilagenin acetate is a sapogenin derivative extracted from patent US20030004147A1. Smilagenin acetate increases the expression of acetylcholine m2 receptors and can be used for the research of dementia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4947-75-5. Pack Sizes: 5 mg. Product ID: HY-N7421.
Smilax sarsaparilla, ext.
Smilax sarsaparilla, ext. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Smilax sarsaparilla, ext.;SARSAPARILLA ROOT EXTRACT. Product Category: Heterocyclic Organic Compound. CAS No. 91770-66-0. Purity: 0.96. Product ID: ACM91770660. Alfa Chemistry ISO 9001:2015 Certified.
SmiM I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CAYNN↑NNRTG GTRNN↓NNYAC. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer W. Storage: -20°C. Form: Liquid. Source: Sphingobacterium mizutae M. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; and 50% glycerol. Cat No: ET-1178RE.
SMN-C3
SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA). Uses: Scientific research. Group: Signaling pathways. CAS No. 1449597-34-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112633.
SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 5uM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the beta-galactosidase activity (IC50 = 11.0uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences.
Worldwide
Smo Antagonist, SA1 (3-(3-(4-Fluorophenyl)-2, 5, 7-trimethylpyrazolo[1, 5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide)
A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1uM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the b-galactosidase activity (IC50 = 3.8uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences.
SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 =19um). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the b-galactosidase activity (IC50 =1.0um) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences.
Worldwide
SMO-IN-2
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC 50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1822355-27-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-150564.
Smoke Point Standard
ASTM D 1322 / IP 57, 24.25 mm. Group: Cloud point standards.
Smoke Tree Extract (Ratio)
Smoke Tree Extract (Ratio). Group: Others. Purity: 4:1~20:1. Smoke Tree Extract (Ratio). Cat No: EXTW-051.
Smoothened Agonist, SAG - CAS 364590-63-6
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Group: Fluorescence/luminescence spectroscopy.
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ?3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Group: Biochemicals. Grades: Highly Purified. CAS No. 364590-63-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
SMPT
SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 112241-19-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-126405.
SMS121
SMS121 is a CD36 inhibitor with a KD values of about 5 μM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163541.
SMS2-IN-1
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2098890-15-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102041.
S-MTC
S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor. Uses: Enzyme inhibitors. Synonyms: L-Ornithine, N5-[imino(methylthio)methyl]-; N5-[Imino(methylthio)methyl]-L-ornithine; (S)-2-Amino-5-((imino(methylthio)methyl)amino)pentanoic acid; S-Methyl-L-thiocitrulline; S-Methylthiocitrulline; L-S-Methylthiocitrulline; N(delta)-(S-Methylisothioureido)norvaline. Grade: ≥95%. CAS No. 156719-41-4. Molecular formula: C7H15N3O2S. Mole weight: 205.28.
SMTP-1
SMTP-1 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C25H35NO5. Mole weight: 429.5.
SMTP-2
SMTP-2 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. The activity of SMTP-2 is weaker than SMTP-1. Molecular formula: C25H37NO7. Mole weight: 463.6.
SMTP-3
SMTP-3 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C26H35NO7. Mole weight: 473.6.
SMTP-4
SMTP-4 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C32H39NO6. Mole weight: 533.7.
SMTP-5
SMTP-5 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C29H41NO6. Mole weight: 499.6.
SMTP-6
SMTP-6 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C34H40N2O6. Mole weight: 572.7.
Smyrindioloside. Group: Biochemicals. Grades: Plant Grade. CAS No. 87592-77-6. Pack Sizes: 5mg. Molecular Formula: C20H24O10, Molecular Weight: 424.4. US Biological Life Sciences.
Worldwide
SN 003
SN 003. Group: Biochemicals. Grades: Purified. CAS No. 197801-88-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SN-008
SN-008, a less active SN-011 analog, can be used as a negative control [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2249106-01-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145009.
SN-011
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC 50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2249435-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145010.
sn-1,2-Dioctanoylglycerol (DOG)
Cell permeable lipid shown to mimic the effect of tumor-promoting phorbol diesters on mitogenesis and EGF binding and action in intact cells. Group: Biochemicals. Alternative Names: DOG. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 15 of linoleoyl and γ-linolenoyl groups attached to the sn-1 position of glycerolipids. The enzyme is an ω desaturase, and determines the location of the double bond by counting three carbons from the methyl end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. cf. EC 1.14.19.35, sn-2 acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: desB (gene name). Enzyme Commission Number: EC 1.14.19.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1000; sn-1 acyl-lipid ω-3 desaturase (ferredoxin); EC 1.14.19.36; desB (gene name). Cat No: EXWM-1000.
sn-1 linoleoyl-lipid 6-desaturase
The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 6 of linoleoyl groups (18:2) attached to the sn-1 position of glycerolipids. The enzyme is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desD (gene name). Enzyme Commission Number: EC 1.14.19.46. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1011; sn-1 linoleoyl-lipid 6-desaturase; EC 1.14.19.46; desD (gene name). Cat No: EXWM-1011.
sn-1 oleoyl-lipid 12-desaturase
The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 12 of oleoyl groups (18:1) attached to the sn-1 position of glycerolipids. The enzyme is a methyl-end desaturase, introducing the new double bond between a pre-existing double bond and the methyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desA (gene name). Enzyme Commission Number: EC 1.14.19.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1010; sn-1 oleoyl-lipid 12-desaturase; EC 1.14.19.45; desA (gene name). Cat No: EXWM-1010.
sn-1 stearoyl-lipid 9-desaturase
The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 9 of stearoyl groups (18:0) attached to the sn-1 position of glycerolipids. The enzyme is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desC (gene name). Enzyme Commission Number: EC 1.14.19.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0991; sn-1 stearoyl-lipid 9-desaturase; EC 1.14.19.28; desC (gene name). Cat No: EXWM-0991.
SN 2
SN 2 is a potent activator of TRPML3 ion channel with an EC 50 of 1.8 μM [1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 823218-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16696.
SN 2
SN 2. Group: Biochemicals. Grades: Purified. CAS No. 823218-99-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride is an impurity from Clopidogrel (C587250) which acts as an anti-platelet agent. Group: Biochemicals. Alternative Names: (α S) -2-Chloro-α - [ [2- (2-thienyl) ethyl] amino] benzeneacetic Acid Methyl Ester Hydrochloride; (S) -2-chloro-α - [ [2- (2-thienyl) ethyl] amino] benzeneacetic Acid Methyl Ester Hydrochloride; (α S) -2-Chloro-α - [ [2- (2-thienyl) ethyl] amino] benzeneacetic Acid Methyl Ester Hydrochloride; (+)-(S)-Methyl α-[[2-(2-Thienyl)ethyl]amino]-α-(2-chlorophenyl)acetate Hydrochloride; (S)-(+)-Methyl α-[[2-(Thien-2-yl)ethyl]amino]-α-(2-chlorophenyl)acetate Hydrochloride. Grades: Highly Purified. CAS No. 141109-19-5. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
This plastidial enzyme desaturates 16:2 fatty acids attached to the sn-2 position of glycerolipids to 16:3 fatty acids, and converts18:2 to 18:3 in both the sn-1 and sn-2 positions. It acts on all 16:2- or 18:2-containing chloroplast membrane lipids, including phosphatidylglycerol, monogalactosyldiacylglycerol, digalactosyldiaclyglycerol, and sulfoquinovosyldiacylglycerol. The enzyme introduces a cis double bond at a location 3 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. cf. EC 1.14.19.25, acyl-lipid ω-3 desaturase (cytochrome b5) and EC 1.14.19.36, sn-1 acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: FAD7; FAD8. Enzyme Commission Number: EC 1.14.19.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0999; sn-2 acyl-lipid ω-3 desaturase (ferredoxin); EC 1.14.19.35; FAD7; FAD8. Cat No: EXWM-0999.
sn-2 palmitoyl-lipid 9-desaturase
The enzyme, characterized from the cyanobacterium Nostoc sp. 36, introduces a cis double bond at carbon 9 of palmitoyl groups (16:0) attached to the sn-2 position of glycerolipids. Group: Enzymes. Synonyms: DesC2. Enzyme Commission Number: EC 1.14.19.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0990; sn-2 palmitoyl-lipid 9-desaturase; EC 1.14.19.27; DesC2. Cat No: EXWM-0990.
SN 38
SN 38. Group: Biochemicals. Grades: Purified. CAS No. 86639-52-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SN-38
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704.
SN-38. (7-Ethyl-10-hydroxycamptothecin)
A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
SN-38 Carboxylate Disodium Salt.
The active metabolite of. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
SN-38-d3
SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 ?M, respectively[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: NK012-d3. CAS No. 718612-49-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-13704S.
SN-38-[d3]
SN-38-[d3] is a labelled analogue of SN-38. SN-38 is the active metabolite of irinotecan. Uses: Labelled sn-38, a metabolite of irinotecan, a dna topoisomerase inhibitor. Synonyms: SN-38 D3. Grade: 95% atom D. CAS No. 718612-49-8. Molecular formula: C22H17D3N2O5. Mole weight: 395.42.
SN-38 glucuronide
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SN-38G. CAS No. 121080-63-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126373.
Induction of Glutath. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 200mg. US Biological Life Sciences.
Worldwide
SN40
SN40 is a potent amino acid transport (AAT) inhibitor with K i s of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768663-14-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146241.
SN40 hydrochloride
SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with K i s of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768663-15-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-146241B.
SN50
SN50 is a cell permeable inhibitor of NF-?B translocation. Uses: Scientific research. Group: Peptides. CAS No. 213546-53-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0151.
SN50
SN50, a cell-permeable peptide inhibitor of NF-Κb, prevents tissue destruction (epithelial defects/ulceration) in a mouse cornea after a central alkali burn. Synonyms: Nuclear Factor NF-KB Inhibitor SN50; NFkappaB Inhibitor. Grade: ≥97% by HPLC. CAS No. 213546-53-3. Molecular formula: C129H230N36O29S. Mole weight: 2781.5.