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| Product | Description | |
|---|---|---|
| Apalutamide Impurity 37 | Apalutamide Impurity 37. Uses: For analytical and research use. Alternative Names: ethyl 1-aminocyclobutanecarboxylate. CAS No. 285570-26-5. Molecular formula: C7H13NO2. Mole weight: 143.18. Catalog: APB285570265. |  |
| Apalutamide Impurity 38 | Apalutamide Impurity 38. Uses: For analytical and research use. Alternative Names: ethyl 1-((tert-butoxycarbonyl)amino)cyclobutanecarboxylate. CAS No. 163554-54-9. Molecular formula: C12H21NO4. Mole weight: 243.3. Catalog: APB163554549. | |
| Apalutamide impurity 3 (apalutamide impurity 3) | Apalutamide impurity 3 (apalutamide impurity 3). Uses: For analytical and research use. CAS No. 1805396-62-6. Molecular formula: C7H4F3N3. Mole weight: 187.13. Catalog: APB1805396626. | |
| Apalutamide Impurity 4 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide Di-(2-fluoro-N-methylbenzamide); 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Grade: 95%. CAS No. 2894796-76-8. Molecular formula: C29H21F5N6O3S. Mole weight: 628.58. |  |
| Apalutamide Impurity 4 | Apalutamide Impurity 4. Uses: For analytical and research use. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Molecular formula: C29H21F5N6O3S. Mole weight: 628.57. Catalog: APB02990. | |
| Apalutamide Impurity 40 | Apalutamide Impurity 40. Uses: For analytical and research use. Alternative Names: 2-bromo-5-nitro-3-(trifluoromethyl)pyridine. CAS No. 956104-42-0. Molecular formula: C6H2BrF3N2O2. Mole weight: 270.99. Catalog: APB956104420. | |
| Apalutamide Impurity 41 | Apalutamide Impurity 41. Uses: For analytical and research use. Alternative Names: 5-nitro-3-(trifluoromethyl)picolinonitrile. CAS No. 573762-57-9. Molecular formula: C7H2F3N3O2. Mole weight: 217.1. Catalog: APB573762579. | |
| Apalutamide Impurity 42 | Apalutamide Impurity 42. Uses: For analytical and research use. Alternative Names: 5-amino-3-(trifluoromethyl)picolinamide. Molecular formula: C7H6F3N3O. Mole weight: 205.14. Catalog: APB02971. | |
| Apalutamide impurity 4 (apalutamide impurity 4) | Apalutamide impurity 4 (apalutamide impurity 4). Uses: For analytical and research use. CAS No. 1805601-57-3. Molecular formula: C7H4F3N3. Mole weight: 187.13. Catalog: APB1805601573. | |
| Apalutamide Impurity 5 | Apalutamide Impurity 5. Uses: For analytical and research use. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide. Molecular formula: C40H27F8N9O4S. Mole weight: 881.75. Catalog: APB02989. | |
| Apalutamide Impurity 6 | Apalutamide Impurity 6. Uses: For analytical and research use. Alternative Names: O-phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate. Molecular formula: C28H19F4N5O3S2. Mole weight: 613.61. Catalog: APB01817. | |
| Apalutamide Impurity 7 | Apalutamide Impurity 7. Uses: For analytical and research use. Alternative Names: 4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide. CAS No. 915087-26-2. Molecular formula: C13H14FN3O. Mole weight: 247.27. Catalog: APB915087262. | |
| Apalutamide Impurity 8 | Apalutamide Impurity 8. Uses: For analytical and research use. Alternative Names: 5-amino-3-(trifluoromethyl)picolinonitrile. CAS No. 573762-62-6. Molecular formula: C7H4F3N3. Mole weight: 187.12. Catalog: APB573762626. | |
| Apalutamide Impurity 9 | Apalutamide Impurity 9. Uses: For analytical and research use. Alternative Names: 1-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea. CAS No. 2422147-84-8. Molecular formula: C8H5F3N4S. Mole weight: 246.21. Catalog: APB2422147848. | |
| Apalutamide metabolite M4 | Apalutamide metabolite M4 is a metabolite of Apalutamide, which is an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide-COOH; Apalutamide Acid Impurity; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid. CAS No. 1332391-04-4. Molecular formula: C20H12F4N4O3S. Mole weight: 464.39. | |
| Apamin | Apamin. Group: Biochemicals. Grades: Purified. CAS No. 24345-16-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Apamin | Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Apamine. CAS No. 24345-16-2. Pack Sizes: 500 μg; 1 mg. Product ID: HY-P0256. |  |
| APAO | Liquid; OtherSolid. CAS No. 9010-79-1. Molecular formula: C5H10. Mole weight: 70.13g/mol. IUPAC Name: ethene;prop-1-ene. SMILES: CC=C.C=C. InChI: InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H,1H2,2H3;1-2H2. |  |
| APAO for bitumen modification | Liquid; OtherSolid. CAS No. 9010-79-1. Molecular formula: C5H10. Mole weight: 70.13g/mol. IUPAC Name: ethene;prop-1-ene. SMILES: CC=C.C=C. InChI: InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H,1H2,2H3;1-2H2. | |
| APAO for plastic modification | Liquid; OtherSolid. CAS No. 9010-79-1. Molecular formula: C5H10. Mole weight: 70.13g/mol. IUPAC Name: ethene;prop-1-ene. SMILES: CC=C.C=C. InChI: InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H,1H2,2H3;1-2H2. | |
| Apatamide impurity 1 | Apatamide impurity 1. Uses: For analytical and research use. Molecular formula: C28H19F4N5O3S2. Mole weight: 613.61. Catalog: APB11869. | |
| Apatamide impurity 10 | Apatamide impurity 10. Uses: For analytical and research use. CAS No. 199330-60-4. Molecular formula: C10H14N2O2. Mole weight: 194.23. Catalog: APB199330604. | |
| Apatamide impurity 11 | Apatamide impurity 11. Uses: For analytical and research use. Molecular formula: C11H14N2O4. Mole weight: 238.24. Catalog: APB11879. | |
| Apatamide impurity 12 | Apatamide impurity 12. Uses: For analytical and research use. Molecular formula: C7H6F3N3O. Mole weight: 205.14. Catalog: APB11871. | |
| Apatamide impurity 13 | Apatamide impurity 13. Uses: For analytical and research use. Molecular formula: C8H5F3N4O. Mole weight: 230.15. Catalog: APB11873. | |
| Apatamide impurity 14 | Apatamide impurity 14. Uses: For analytical and research use. Molecular formula: C8H3F3N4. Mole weight: 212.14. Catalog: APB11872. | |
| Apatamide impurity 15 | Apatamide impurity 15. Uses: For analytical and research use. Molecular formula: C14H6F6N6. Mole weight: 372.23. Catalog: APB11874. | |
| Apatamide impurity 16 | Apatamide impurity 16. Uses: For analytical and research use. CAS No. 406933-21-9. Molecular formula: C7H3F3N2. Mole weight: 172.11. Catalog: APB406933219. | |
| Apatamide impurity 17 | Apatamide impurity 17. Uses: For analytical and research use. Molecular formula: C7H4F3N3O. Mole weight: 203.12. Catalog: APB11875. | |
| Apatamide impurity 18 | Apatamide impurity 18. Uses: For analytical and research use. Molecular formula: C16H4F6N6S2. Mole weight: 458.36. Catalog: APB11876. | |
| Apatamide impurity 19 | Apatamide impurity 19. Uses: For analytical and research use. Molecular formula: C16H8F6N6O. Mole weight: 414.27. Catalog: APB11877. | |
| Apatamide impurity 2 | Apatamide impurity 2. Uses: For analytical and research use. Molecular formula: C27H18F4N6O3S2. Mole weight: 614.59. Catalog: APB11870. | |
| Apatamide Impurity 21 | Apatamide Impurity 21. Uses: For analytical and research use. CAS No. 2894796-76-8. Molecular formula: C29H21F5N6O3S. Mole weight: 628.57. Catalog: APB2894796768. | |
| Apatamide impurity 36 | Apatamide impurity 36. Uses: For analytical and research use. Alternative Names: 2-fluoro-4-hydroxy-N-methylbenzamide. CAS No. 1243392-80-4. Molecular formula: C8H8FNO2. Mole weight: 169.15. Catalog: APB1243392804. | |
| Apatamide impurity 6 | Apatamide impurity 6. Uses: For analytical and research use. CAS No. 2894796-77-9. Molecular formula: C40H27F8N9O4S. Mole weight: 881.76. Catalog: APB2894796779. | |
| Apatamide impurity 7 | Apatamide impurity 7. Uses: For analytical and research use. Molecular formula: C8H5F3N4S. Mole weight: 246.21. Catalog: APB11878. | |
| Apatamide impurity 8 | Apatamide impurity 8. Uses: For analytical and research use. CAS No. 1415552-04-3. Molecular formula: C9H6F3N3S. Mole weight: 245.22. Catalog: APB1415552043. | |
| Apatamide impurity 9 | Apatamide impurity 9. Uses: For analytical and research use. CAS No. 1513077-71-8. Molecular formula: C10H16N2O3. Mole weight: 212.25. Catalog: APB1513077718. | |
| Apatinib | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Synonyms: Rivoceranib; YN968D1. Grade: 98%. CAS No. 811803-05-1. Molecular formula: C24H23N5O. Mole weight: 397.48. | |
| Apatinib impurity 1 | Apatinib impurity 1. Uses: For analytical and research use. Molecular formula: C24H22N6O2. Mole weight: 426.48. Catalog: APB12230. | |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Synonyms: YN968D1. Grade: >98%. CAS No. 1218779-75-9. Molecular formula: C25H27N5O4S. Mole weight: 493.58. | |
| Apatinib (YN968D1) | Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis. Group: Inhibitors. Alternative Names: Rivoceranib, YN968D1. CAS No. 811803-05-1. Pack Sizes: 5mg. Product ID: S5248. Formula: C24H23N5O. Smiles: O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=C(NCC4=CC=NC=C4)N=CC=C3. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| Apaziquone | Apaziquone. Group: Biochemicals. Alternative Names: 5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione; Apaziquone; EO 9; EO 9 (pharmaceutical); NSC 382456; NSC 382459; (E)-5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-Indole-4,7-dione. Grades: Highly Purified. CAS No. 114560-48-4. Pack Sizes: 2.5mg. Molecular Formula: C15H16N2O4, Molecular Weight: 288.3. US Biological Life Sciences. | Worldwide |
| Apaziquone | Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. Synonyms: 1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)-; APAZIQUONE. CAS No. 141304-51-0. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| APC-100 | APC-100 is an orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells. Uses: Antioxidants. Synonyms: 2,2,5,7,8-Pentamethyl-6-chromanol; Chromanol; 6-Hydroxy-2,2,5,7,8-pentamethylchroman; APC100; 3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-Benzopyran-6-ol. Grade: 98%. CAS No. 950-99-2. Molecular formula: C14H20O2. Mole weight: 220.312. | |
| APC 366 | APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 158921-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-105999. | |
| APC 366 | APC 366, an inhibitor of tryptase, has been found to reduce airway inflammation and block postchallenge airway hyperresponsiveness in vivo. Synonyms: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide. Grade: >98%. CAS No. 158921-85-8. Molecular formula: C22H28N6O4. Mole weight: 440.5. | |
| APC 366 | APC 366. Group: Biochemicals. Grades: Purified. CAS No. 158921-85-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| APC-366 hydrochloride | APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM. Synonyms: APC 366; APC 366; APC 366; AC1L42OR; N-(1-Hydroxy-2-naphthoyl)-L-arginine-L-prolinamide; 158921-85-8. Grade: 98%. CAS No. 178925-65-0. Molecular formula: C22H29ClN6O4. Mole weight: 477. | |
| APC 366 trifluoroacetate salt | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grade: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
| AP C5 | AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor with pIC50 of 7.2, which displays >20-fold selectivity for PKG2 over PKG1 and PKA. Synonyms: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine; AP-C5; APC5. Grade: ≥98%. CAS No. 2234272-10-5. Molecular formula: C16H13N5. Mole weight: 275.31. | |
| APC-6336 | APC-6336 is a Hepatitis C virus NS3 protein inhibitor. Synonyms: (2R)-2-[[2-[(6-carbamoyl-1H-benzimidazol-2-yl)methyl]-3-methylbenzimidazole-5-carbonyl]amino]-3-phosphonopropanoic acid; APC-6336; APC 6336; APC6336; UNII-4124YUO44Z; CRA-6336; 4124YUO44Z. Grade: >98%. CAS No. 263870-19-5. Molecular formula: C21H21N6O7P. Mole weight: 500.4. | |
| a-(p-Chlorophenyl)cinnamonitrile | White crystals. CAS No. 3695-93-0. Pack Sizes: Typically in stock: 10g, 50g. Mole weight: 239.7. MP/BP: M.P. 114-116. Order No: FR-0877. |  Frinton Laboratories |
| Apcin | Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 300815-04-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110287. | |
| Apcin | Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grade: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65. | |
| Apcin-A | Apcin-A is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Synonyms: Apcin-A; 1683617-62-0; 3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate; starbld0000888; SCHEMBL22567019; EX-A5236; AKOS030257613; MS-25252; HY-130841; CS-0114386. CAS No. 1683617-62-0. Molecular formula: C10H14Cl3N5O2. Mole weight: 342.61. | |
| APcK110 | KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer. Synonyms: APcK 110; APcK-110; 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine. Grade: >98%. CAS No. 1001083-74-4. Molecular formula: C34H49N5O6. Mole weight: 349.36. | |
| APcK 110 | APcK 110. Group: Biochemicals. Grades: Purified. CAS No. 1001083-74-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ApCp | ApCp, an avant-garde and unprecedented compound, used for studying an array of ailments, encompassing malignant neoplasms and immune-mediated disorders. Uses: Enzyme inhibitors. Synonyms: Adenosine, 5'-[hydrogen P-(phosphonomethyl)phosphonate]; Adenosine, 5'-(trihydrogen methylenediphosphonate); Adenosine, 5'-[hydrogen (phosphonomethyl)phosphonate]; Adenosine, 5'-methylenediphosphonate; α,β-Methylene adenosine 5'-diphosphate; α,β-Methylene-ADP; α,β-Methylene adenosine diphosphate; Adenosine α,β-methylenediphosphate; α,β-Methylene-5'-ADP; Adenosine 5'-(α,β-methylene)diphosphate; MethADP; AMPCP; 5'-Adenylyl methylenephosphonate. Grade: ≥ 95% by HPLC. CAS No. 3768-14-7. Molecular formula: C11H17N5O9P2. Mole weight: 425.23. | |
| APCP-363 | APCP-363 a bio-active chemical. Uses: Apcp-363 a bio-active chemical. Synonyms: CP-363; CP 363; CP363; APCP-363; APO-363; APCP 363; APO 363; APCP363; APO363; UNII-N1969I6FAP. 3-hydroxy-2-(1-methoxyethyl)-1,6-dimethylpyridin-4-one. Grade: ≥98%. CAS No. 340023-40-7. Molecular formula: C10H15NO3. Mole weight: 197.23. | |
| ApCpp | ApCpp is a highly intriguing and intricate biochemical compound with multifaceted role as a substrate for diverse enzymes. It has promising applications in research of ailments such as cancer, neurodegenerative disorders and metabolic syndromes of varied etiologies. Synonyms: (AMPCPP); Adenosine-5'-[(α,β)-methyleno]triphosphate, Sodium salt; α,β-Methyleneadenosine-5'-triphosphate. Grade: ≥ 98% by HPLC. CAS No. 7292-42-4. Molecular formula: C11H18N5O12P3 (free acid). Mole weight: 505.21 (free acid). | |
| ApCpp (Nic) | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920; 2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grade: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
| APD597 (JNJ-38431055) | APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo. Synonyms: APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055. Grade: 98%. CAS No. 897732-93-3. Molecular formula: C21H29N5O6S. Mole weight: 479.55. | |
| APD668 | APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki=0.1 μM). APD668 can be used for the research of steatohepatitis and diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 832714-46-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15565. | |
| APD668 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Synonyms: APD668; APD-668; APD 668; JNJ28630368; JNJ-28630368; JNJ 28630368. Grade: 0.99. CAS No. 832714-46-2. Molecular formula: C21H24FN5O5S. Mole weight: 477.511. | |
| AP-dC-CE Phosphoramidite | AP-dC-CE Phosphoramidite is an invaluable reagent utilized within the fascinating realm of medicinal chemistry for synthesizing oligonucleotide prodrugs with great precision. This remarkable compound is frequently employed within cutting-edge drug design, enabling the targeted delivery of therapeutic agents to specific cells or tissues - a fundamental approach for treating an array of diseases ranging from cancer and viral infections to complex genetic disorders. Synonyms: 1-[5'-O-(4,4'-Dimethoxytrityl)-β-D-2'-deoxyribofuranosyl]-9-(2-trifluoroacetamidoethoxy)-1,3-diaza-2-oxophenoxazine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite. Molecular formula: C49H54F3N6O10P. Mole weight: 974.97. | |
| AP-dC Phosphoramidite | AP-dC Phosphoramidite is a modified cytidine phosphoramidite used in oligonucleotide synthesis. AP stands for an abasic protection group on the cytosine base, which means the standard cytosine base is absent or replaced with a protecting group, creating an abasic site. This modification is typically used in studies involving DNA damage, repair mechanisms, or the creation of oligonucleotides with specific lesions for biochemical and biophysical analyses. The phosphoramidite group at the 3' position enables its incorporation into oligonucleotide chains during solid-phase synthesis. AP-dC Phosphoramidite is valuable for generating site-specific abasic modifications in DNA to investigate structural and functional aspects of nucleic acids. Synonyms: N-[2-[[3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-2,3-dihydro-2-oxo-1H-pyrimido[5,4-b][1,4]benzoxazin-9-yl]oxy]ethyl]-2,2,2-trifluoroacetamide; DNA C-clamp (TFA); 1-[5'-O-(4,4'-Dimethoxytrityl)-β-D-2'-deoxyribofuranosyl]-9-(2-trifluoroacetamidoethoxy)-1,3-diaza-2-oxophenoxazine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; AP-dC-CE Phosphoramidite. Grade: ≥97%. CAS No. 1360536-91-9. Molecular formula: C49H54F3N6O10P. Mole weight: 974.96. | |
| APD-I | APD-I is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-49-5. Molecular formula: C51H89N7O13. Mole weight: 1008.29. | |
| APD-II | APD-II is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87099-78-3. Molecular formula: C52H91N7O13. Mole weight: 1022.32. | |
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