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| Product | Description | |
|---|---|---|
| APD-III | APD-III is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-48-4. Molecular formula: C53H93N7O13. Mole weight: 1036.34. |  |
| APE1-IN-1 | APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 524708-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136731. |  |
| APE1 Inhibitor III | APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purified APE1 enzyme. Synonyms: N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide. Grade: 99%. CAS No. 524708-03-0. Molecular formula: C19H21N3OS2. Mole weight: 371.52. | |
| APE1 Inhibitor III (Apurinic Endonuclease 1 Inhibitor III) (Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III)(N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide) | A cell-permeable benzothiazolyltetra hydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50=2.0uM in a fluorescence based HTS assay; and 12uM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50=600nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2=80min). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Apecotrep | Apecotrep (TRPC6-IN-3) (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. Apecotrep modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. Apecotrep can be used in research of respiratory system[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TRPC6-IN-3. CAS No. 2311863-36-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148129. | |
| Apelin-12 | Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 229961-08-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2537. | |
| Apelin-12 acetate | Apelin-12 induces calcium mobilization in APJ-Gαq16 cells expressing human APJ and inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells. Apelin-12 inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. Synonyms: Preproapelin (66-77) (human, bovine, mouse, rat) acetate; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat) acetate; Apelin Precursor (66-77) (human, bovine, mouse, rat) acetate. Molecular formula: C66H107N21O16S. Mole weight: 1482.77. | |
| Apelin-12 (human, bovine, mouse, rat) | Apelin-12 (human, bovine, mouse, rat), an endogenous ligand of the human orphan receptor APJ, lowers arterial blood pressure without altering heart rate in anesthetized rats. Its vasoactive effect may be related to the activation of endothelial nitric oxide synthase. Synonyms: Preproapelin (66-77) (human, bovine, mouse, rat); H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat); Apelin Precursor (66-77) (human, bovine, mouse, rat); N5-(Diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grade: ≥95% by HPLC. CAS No. 229961-08-4. Molecular formula: C64H103N21O14S. Mole weight: 1422.72. | |
| Apelin-13 | Apelin-13, an endogenous neuropeptide, is the ligand for the G-protein-coupled receptor APJ, an alternative coreceptor with CD4 for HIV-1 infection. Apelin-13 is generated from apelin-36, which is a putative receptor protein related to the angiotensin receptor (AT1). Apelin-13 exerted an acidification-rate-promoting activity in the CHO cells expressing the APJ receptor with EC50 value of 0.37 nM. Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides. Apelin-13 is also involved in the learning and memory process. Synonyms: Apelin-13 (human, bovine, mouse, rat); H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grade: ≥95%. CAS No. 217082-58-1. Molecular formula: C69H111N23O16S. Mole weight: 1550.85. | |
| Apelin-13 | Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 217082-58-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1944. | |
| Apelin-13 trifluoroacetate salt | Apelin-13 trifluoroacetate salt is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Synonyms: Apelin-13 triTFA. Molecular formula: C75H114F9N23O22S. Mole weight: 1892.89. | |
| Apelin-17 (human, bovine) | Apelin-17 (human, bovine). Group: Biochemicals. Grades: Purified. CAS No. 217082-57-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apelin-17(human, bovine) | Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 217082-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1066. | |
| Apelin-17 (Human, Bovine) | Apelin-17 (human, bovine) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 2.5 nM that is secreted by adipocytes. It potently inhibits forskolin-stimulated cAMP production in vitro. Synonyms: [Phe17]-Apelin 17. Grade: 98.86%. CAS No. 217082-57-0. Molecular formula: C96H156N34O20S. Mole weight: 2138.56. | |
| Apelin-17 (human, bovine) acetate | Apelin-17 (human, bovine) acetate, secreted by adipocytes, is an endogenous ligand of the G protein-coupled APJ receptor with an EC50 of 2.5 nM. It is an endogenous apelin receptor agonist that potently inhibits forskolin-stimulated cAMP production in vitro. Synonyms: H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH.CH3CO2H; L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine acetic acid. Grade: ≥95%. Molecular formula: C98H160N34O22S. Mole weight: 2198.63. | |
| Apelin-36 (human) | Apelin-36 (human) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 20 nM that is secreted by adipocytes. It is the full-length mature peptide produced from the translated 77 amino acid prepropeptide. It acts primarily in the central nervous and peripheral system. It is important in regulating fluid homeostasis, cardiovascular function, insulin and hypertension sensitivity. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. It endogenously binds with high affinity to human APJ receptors expressed in HEK 293 cells. Synonyms: H-Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-leucyl-L-valyl-L-glutaminyl-L-prolyl-L-arginyl-glycyl-L-seryl-L-arginyl-L-asparagyl-glycyl-L-prolyl-glycyl-L-prolyl-L-tryptophyl-L-glutaminyl-glycyl-glycyl-L-arginyl-L-arginyl-L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grade: ≥95% by HPLC. CAS No. 252642-12-9. Molecular formula: C184H297N69O43S. Mole weight: 4195.87. | |
| Apelin-36 (human) | Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. Group: Biochemicals. Grades: Highly Purified. CAS No. 252642-12-9. Pack Sizes: 1mg. Molecular Formula: C184H297N69O43S, Mass Spectrum: Consistent with structure. US Biological Life Sciences. | Worldwide |
| Apelin-36(human) | Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC50=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 252642-12-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1064. | |
| Apelin-36 (rat, mouse) | Apelin-36 (rat, mouse) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 5.4 nM that is secreted by adipocytes. It potently inhibits cAMP production in vitro. It is important in regulating fluid homeostasis, cardiovascular function and feeding. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. Synonyms: Apelin-36 (rat, mouse); Apelin 36 (rat, mouse); Apelin36 (rat, mouse). Grade: 95%. CAS No. 230299-95-3. Molecular formula: C185H304N68O43S. Mole weight: 4200.93. | |
| Apelin-36 (rat, mouse) | Apelin-36 (rat, mouse). Group: Biochemicals. Grades: Purified. CAS No. 230299-95-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apelin-36(rat, mouse) | Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 230299-95-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1065. | |
| a-Pentylcinnamaldehyde diethyl acetal | a-Pentylcinnamaldehyde diethyl acetal. Group: Biochemicals. Grades: Highly Purified. CAS No. 60763-41-9. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C18H28O2. US Biological Life Sciences. | Worldwide |
| APETx2 | APETx2. Group: Biochemicals. Grades: Purified. CAS No. 713544-47-9. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| APETx2 | APETx2, an ion channel 3 (ASIC3) channel blocker, has been found to exhibit analgesic properties against acid-induced and inflammatory pain. Synonyms: APETx2; 713544-47-9; AKOS024458355; H-Gly-DL-xiThr-DL-Ala-DL-Cys(1)-DL-Ser-DL-Cys(2)-Gly-DL-Asn-DL-Ser-DL-Lys-Gly-DL-xiIle-DL-Tyr-DL-Trp-DL-Phe-DL-Tyr-DL-Arg-DL-Pro-DL-Ser-DL-Cys(3)-DL-Pro-DL-xiThr-DL-Asp-DL-Arg-Gly-DL-Tyr-DL-xiThr-Gly-DL-Ser-DL-Cys(2)-DL-Arg-DL-Tyr-DL-Phe-DL-Leu-Gly-DL-xiThr-DL-Cys(1)-DL-Cys(3)-DL-xiThr-DL-Pro-DL-Ala-DL-Asp-OH. Grade: >98%. CAS No. 713544-47-9. Molecular formula: C196H280N54O61S6. Mole weight: 4561.06. | |
| APF Sialoglycopeptide ammonium salt | APF Sialoglycopeptide ammonium salt is a cutting-edge biomedical compound, demonstrating remarkable capabilities in research of dental caries. Proven to possess potent antimicrobial properties against the notorious Streptococcus mutans, this compound also exhibits an extraordinary affinity for hydroxyapatite, amplifying the process of tooth remineralization. Synonyms: O-(Acetamido-3,5-dideoxy-D-glycero-a-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-b-D- galactopyranosyl-(1→3)-O-a-2-acetamido-2-deoxy-D-galactopyranosyl-(1 →O)- Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala; NeuNAc-a(2→3)-Gal-b(1→3)-GalNAc-a-Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala. Molecular formula: C63H107N11O29. Mole weight: 1482.58. | |
| ApG | ApG is a scientifically advanced compound, specifically designed to study inflammatory skin disorders as well as combat skin infections. It comprises a potent blend of bioactive drugs exhibiting exceptional antimicrobial and anti-inflammatory attributes. Grade: ≥ 95% by HPLC. Molecular formula: C20H25N10O11P (free acid). Mole weight: 612.14 (free acid). | |
| APG-1387 | APG-1387 is an inhibitor of IAPs. Study shows that APG-1387 could induce apoptosis of PLC/PRF/5 which was HBV positive both in vitro and in vivo. Synonyms: APG 1387; APG1387. Grade: 98% by HPLC. CAS No. 1570231-89-8. Molecular formula: C60H72N10O10S2. Mole weight: 1157.4. | |
| APG-2449 | APG-2449 is an orally active inhibitor for BCL-2 and multikinase (ALK/FAK/ROS1) with potent antitumor activities. APG-2449 reduces cell viability and enhances apoptosis in acute myeloid leukemia cells in vitro. APG-2449 decreases activation of FAK and its downstream effectors. APG-2449 can be studied in research for mesothelioma tumor, non-small cell lung cancer, ovarian cancer, hematologic and solid malignancies[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2196186-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155163. | |
| APHA Compound 8 | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grade: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
| APHE-2 | APHE-2 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. Synonyms: 1H-Indole, 3-(2-propyl-5-oxazolyl)-; WS-30581A. CAS No. 93773-64-9. Molecular formula: C14H14N2O. Mole weight: 226.27. | |
| APHE-3 | APHE-3 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. APHE-3 can also inhibit lymphocyte proliferation in the presence of Phytohemagglutinin, with IC50 of about 0.1 mmol/L. Synonyms: Pimprinine; WS 30581C. Grade: >95% by HPLC. CAS No. 13640-26-1. Molecular formula: C12H10N2O. Mole weight: 198.22. | |
| APHE-4 | APHE-4 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. Synonyms: WS 30581B. CAS No. 93773-63-8. Molecular formula: C15H16N2O. Mole weight: 240.30. | |
| a-Phenyl-a-(2-pyridyl)acetonitrile | a-Phenyl-a-(2-pyridyl)acetonitrile. Group: Biochemicals. Alternative Names: a-Phenyl-2-pyridineacetonitrile; 2-Pyridyl phenyl acetonitri le; NSC 16276. Grades: Highly Purified. CAS No. 5005-36-7. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C13H10N2. US Biological Life Sciences. | Worldwide |
| a-Phenyllactic acid 99+% | a-Phenyllactic acid 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 515-30-0. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| a-Phenylpiperidine-2-acetamide ≥97% (HPLC) | a-Phenylpiperidine-2-acetamide ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| a-Phenyl-trans-cinnamamide | Crystalline. CAS No. 20432-29-5. Pack Sizes: Typically in stock: 1g. Mole weight: 223.28. MP/BP: M.P. 127. Order No: FR-0594. |  Frinton Laboratories |
| a-Phenyl-trans-cinnamic acid | White powder, 98%. Synonym: trans-2,3-Diphenylpropionic acid. CAS No. 91-48-5. Pack Sizes: Typically in stock: 25g, 100g. Mole weight: 224.26. MP/BP: M.P. 170-171. Order No: FR-0253. | Frinton Laboratories |
| aphidicolan-16β-ol synthase | This is a bifunctional enzyme which also has EC 5.5.1.14 syn-copalyl diphosphate synthase activity. Aphidicolan-16β-ol is a precursor of aphidicolin, a specific inhibitor of DNA polymerase α (EC 2.7.7.7). Group: Enzymes. Synonyms: PbACS. Enzyme Commission Number: EC 4.2.3.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5201; aphidicolan-16β-ol synthase; EC 4.2.3.42; PbACS. Cat No: EXWM-5201. |  |
| Aphidicolin | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38966-21-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6733. | |
| Aphidicolin | Aphidicolin is an antibiotic produced by Cephalosporium aphidicola and Nigrospora sphaerica, which has the effect of inhibiting mitosis and anti-DNA virus. Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line. Uses: A reversible inhibitor of eukaryotic nuclear dna replication. Synonyms: (+)-Aphidicolin; (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol. Grade: >98%. CAS No. 38966-21-1. Molecular formula: C20H34O4. Mole weight: 338.48. | |
| Aphidicolin-17-monoacetate | Aphidicolin-17-monoacetate is an antibiotic produced by Phoma betae PS-13, which inhibits DNA polymerase and interferes with root growth. Molecular formula: C22H36O5. Mole weight: 380.52. | |
| Aphidicolin-3,18-orthoacetate | Aphidicolin-3,18-orthoacetate is an antibiotic produced by Phoma betae. It is a kind of phytotoxin, which can inhibit the growth of the roots of rice and mango. Molecular formula: C22H36O5. Mole weight: 380.52. | |
| APHS | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 209125-28-0. Pack Sizes: 1 mg (38.11 mM * 100 μL in Methyl acetate); 5 mg (38.11 mM * 500 μL in Methyl acetate); 10 mg (38.11 mM * 1 mL in Methyl acetate). Product ID: HY-129284. | |
| Aphthosin | Aphthosin is a tetrapeptide glycoside isolated from Peltigera aphthosa (L.) Willd. Synonyms: 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-β-resorcylic acid, 4-ester with 6-methyl-β-resorcylic acid, 4-ester with methyl 6-methyl-β-resorcylate (8CI). CAS No. 31449-13-5. Molecular formula: C34H30O13. Mole weight: 646.59. | |
| API-1 | Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growt h arrest and apoptosis in human cancer cells expressing constitutively active Akt. Synonyms: API 1; API1; NSC177233; NSC 177233; NSC-177233; 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(beta-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide. Grade: >98%. CAS No. 36707-00-3. Molecular formula: C28H30FN5O2. Mole weight: 337.29. | |
| API-1 | API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36707-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110077. | |
| API-1 | API-1. Group: Biochemicals. Grades: Purified. CAS No. 36707-00-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| API-2 | API-2. Group: Biochemicals. Grades: Purified. CAS No. 35943-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Apicidin | Apicidin is a cyclic peptide antibiotic with broad-spectrum antiproliferative, antiparasitic and antiprotozoan activity. It is a histone deacetylase (HDAC) inhibitor with anti-angiogenesis and apoptosis-inducing effects. Synonyms: OSI 2040; Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl); Apicidin Ia; 2H-Pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone, octahydro-6-[(1-methoxy-1H-indol-3-yl)methyl]-9-[(1S)-1-methylpropyl]-3-(6-oxooctyl)-, (3S,6S,9S,15aR)-. Grade: >98%. CAS No. 183506-66-3. Molecular formula: C34H49N5O6. Mole weight: 623.78. | |
| Apicidin | Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OSI 2040. CAS No. 183506-66-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N6735. | |
| Apicidin | Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 - 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin. Group: Biochemicals. Alternative Names: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040. Grades: Highly Purified. CAS No. 183506-66-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| Apicidin, HDAC Inhibitor (Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl) | Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-. Group: Biochemicals. Alternative Names: Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl. Grades: Highly Purified. CAS No. 183506-66-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Apicularen A | Apicularen A is a macrolide antibiotic produced by Chondromyces robustus Cma 13. Apicularen A has no antibacterial activity, but for human and animal tumor cells such as KB-3-1, KB-V1, K-562, HL-60, U-937, A-498, A-549, PC-3 and SK-OV -3 grade has strong cytotoxicity. CAS No. 220757-04-0. Molecular formula: C25H31NO6. Mole weight: 441.52. | |
| Apicularen B | Apicularen B is a macrolide antibiotic produced by Chondromyces robustus Cma 13. Apicularen B has low cytotoxicity and weak anti-Gram-positive bacteria activity. CAS No. 220757-06-2. Molecular formula: C33H44N2O11. Mole weight: 644.71. | |
| Apidaecin IB acetate | Apidaecin IB acetate is an insect antimicrobial peptide with a minimum concentration of 8 μM against Escherichia coli (E. coli ML35, o18k1h7 and ATCC 25922). Synonyms: H-Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-OH.CH3CO2H; glycyl-L-asparagyl-L-asparagyl-L-arginyl-L-prolyl-L-valyl-L-tyrosyl-L-isoleucyl-L-prolyl-L-glutaminyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-histidyl-L-prolyl-L-arginyl-L-leucine acetic acid; 18-L-leucine-Apidaecin Ia acetate; Apidaecin Ib acetate. Grade: ≥95%. Molecular formula: C97H154N32O25. Mole weight: 2168.46. | |
| Apigenin | Apigenin is an antioxidant plant flavanoid which contains anti-inflammatory and anticancer properties. Apigenin may induce apoptosis and may inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Apigenin is also known to be a MAP kinase inhibitor and a selective inhibitor of Protein Kinase 2 (CK2). Category: Active pharmaceutical ingredients. CAS No. 520-36-5. Product ID: API520365. Molecular formula: C15H10O5. Mole weight: 270.24. Appearance: Powder. |  |
| Apigenin | Apigenin. CAS No. 520-36-5. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications. |  |
| Apigenin | Apigenin. Group: Biochemicals. Grades: Purified. CAS No. 520-36-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Apigenin | 1g Pack Size. Group: Aroma Chemicals, Building Blocks, Organics. Formula: C15H10O5. CAS No. 520-36-5. Prepack ID 22930039-1g. Molecular Weight 270.24. See USA prepack pricing. |  |
| Apigenin | Apigenin. CAS No. 520-36-5. Product ID: PE-0323. Category: Active Pharmaceutical Ingredient. Product Keywords: Pharmaceutical Excipients; Other Materials; Active Pharmaceutical Ingredient; /; Apigenin; PE-0323; 520-36-5; 520-36-5. Grade: Pharmaceutical Grade. |  |
| Apigenin | Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1. CAS No. 520-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-N1201. | |
| Apigenin (4',5,7-Trihydroxyflavone) | Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignan. Group: Biochemicals. Alternative Names: 4',5,7-Trihydroxyflavone. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Apigenin 4'-β-D-glucuronide Triacetate Methyl Ester | Apigenin 4'-β-D-glucuronide Triacetate Methyl Ester is an intermediate in synthesizing Isorhoifolin, a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects. Synonyms: Apigenin 4'-β-D-Gucopyranoside Triacetate Methyl Ester. Molecular formula: C28H28O14. Mole weight: 588.51. | |
| Apigenin 4'-O- β-D-Glucuronide | Flavone component of the aerial parts of alfalfa (Medicago sativa L.) and pyrethrum flowers (Chrysanthemum cinerarifolium). Apigenin 4'-O- β-D-Glucuronide can be utilized for food or feed use and biological study of chemical composition of protein-xanthophyll concentrate dietary supplement made from alfalfa. Group: Biochemicals. Grades: Highly Purified. CAS No. 51771-57-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H18O11, Molecular Weight: 446.36. US Biological Life Sciences. | Worldwide |
| apigenin 4'-O-methyltransferase | Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly. Group: Enzymes. Synonyms: flavonoid O-methyltransferase; flavonoid methyltransferase; S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase. Enzyme Commission Number: EC 2.1.1.75. CAS No. 118251-36-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1976; apigenin 4'-O-methyltransferase; EC 2.1.1.75; 118251-36-8; flavonoid O-methyltransferase; flavonoid methyltransferase; S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase. Cat No: EXWM-1976. | |
| Apigenin-4'-O-sulfate Potassium Salt | Apigenin-4'-O-sulfate Potassium Salt is a sulfated form of Apigenin (A726500) flavone, present in numerous plant species. Group: Biochemicals. Grades: Highly Purified. CAS No. 120537-28-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H9KO8S, Molecular Weight: 388.39. US Biological Life Sciences. | Worldwide |
| Apigenin 6,8-di-C-glucoside | Vicenin -2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Synonyms: Vicenin II; Vicenin 2; Violantin. Grade: >98%. CAS No. 23666-13-9. Molecular formula: C27H30O15. Mole weight: 594.5. | |
| Apigenin 6-C-α-L-arabinopyranosyl-8-C- β-D-xylopyranoside | Apigenin 6-C-α-L-arabinopyranosyl-8-C- β-D-xylopyranoside. Group: Biochemicals. CAS No. 677021-30-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Apigenin 7-β-D-glucuronide Triacetate Methyl Ester | Apigenin 7-β-D-glucuronide Triacetate Methyl Ester is an intermediate in synthesizing Isorhoifolin, a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects. Synonyms: Apigenin 7-β-D-Gucopyranoside Triacetate Methyl Ester. Molecular formula: C28H28O14. Mole weight: 588.51. | |
| Apigenin 7- β-D-Gucopyranoside Triacetate Methyl Ester | Apigenin 7- β-D-Gucopyranoside Triacetate Methyl Ester is an intermediate in synthesizing Isorhoifolin (I819700), a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C28H28O14, Molecular Weight: 588.51. US Biological Life Sciences. | Worldwide |
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