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| Product | Description | |
|---|---|---|
| Antitumor agent-37 | Antitumor agent-37 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-37 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. It also significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues. Molecular formula: C16H18Cl2N2O4Pt. Mole weight: 568.32. |  |
| Antitumor Compound 1 | Antitumor Compound 1 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient. Synonyms: MDK-6303; MDK 6303; MDK6303; Antitumor Compound 1. Grade: >98%. CAS No. 420126-30-3. Molecular formula: C18H10F6N4S. Mole weight: 428.35. | |
| Anti-Tumor Natural Product Library | A unique collection of 1471 natural products with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS); - Known bioactivity for all compounds: detailed biological and pharmacological information, providing the research foundation and theoretical direction for screening; - Clear source: known active natural products selected from animals, plants, or microorganisms with clear species information; - Detailed compound information with structure, solubility, targeted signal pathways, action sites, and biological activity description; - Cost-effectiveness: expensive natural products with poor drug likeliness are excluded, allowing for more high-quality natural products at a lower cost. Uses: Scientific use. Product Category: L6700. Categories: Anti-Tumor Natural Product Libraries. |  |
| Antiviral agent 10 | Antiviral agent 10 is an antiviral agent and it can inhibit respiratory syncytial virus (RSV). Synonyms: Antiviral agent 10|Oprea1_361031|Oprea1_640984|SCHEMBL14825202|AKOS001021721|AKOS016377083|HY-142009|CS-0311654. Grade: ≥98% (HPLC). CAS No. 312615-62-6. Molecular formula: C22H24N2O5. Mole weight: 396.44. | |
| Antiviral agent 12 | N-(1-Benzyl-4-piperidyl)adamantane-1-carboxamide inhibits Ebola virus entry into host cells by binding to surface glycoproteins, and it inhibits the Ebola virus with an EC50 of 3.9 μM. Synonyms: 314030-54-1; N-(1-benzylpiperidin-4-yl)adamantane-1-carboxamide; Antiviral agent 12; N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide; Oprea1_394577; Oprea1_833933; CHEMBL1621026; SCHEMBL19172948; EX-A4094; AKOS000671998; PD158745; TS-09814; HY-115848; CS-0369318; Z68296869. Grade: ≥95%. CAS No. 314030-54-1. Molecular formula: C6H15ClN2O2. Mole weight: 186.67. | |
| Antiviral agent 24 | N6-(3-Trifluoromethylbenzyl)adenosine is a biomedical compound in the research of diverse ailments, exhibiting remarkable potential as an adenosine receptor agonist. Its profound influence on neurotransmitter regulation renders it highly efficacious in studying neurological disorders, cardiovascular afflictions and inflammation-related conditions. Synonyms: Antiviral agent 24; 23661-03-2; N6-(3-Trifluoromethylbenzyl)adenosine; 1-(|A-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine; SCHEMBL641041; CHEMBL225766; SDQKDCSBWUSBDO-LSCFUAHRSA-N; MS-27485; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[3-(trifluoromethyl)phenyl]methylamino]purin-9-yl]oxolane-3,4-diol. Grade: ≥95%. CAS No. 23661-03-2. Molecular formula: C21H20O9. Mole weight: 416.4. | |
| Antiviral agent 5 | An intermediate in the numerous antiviral protease inhibitors is the glutamine analogue. Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases including SARS-CoV-2 Mpro. Synonyms: Antiviral agent 5|CS-0227298. Grade: ≥98% (HPLC). CAS No. 2698336-82-0. Molecular formula: C18H30N2O7. Mole weight: 386.44. | |
| Antiviral agent 52 | Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). It is a blood-borne virus, which can cause both acute and chronic hepatitis. CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection with EC50 of 17 nM. It displays good pharmacokinetics in mice with preferential liver distribution without significant hepatotoxicity. CAY10704 is also selective for HCV over dengue virus with EC50 of 4.62 μM. Synonyms: 101784-44-5; 1-(Bis(4-chlorophenyl)methyl)-4-methylpiperazine; Antiviral agent 52; 1-[bis(4-chlorophenyl)methyl]-4-methylpiperazine; 1-[bis(4-chlorophenyl)methyl]-4-methyl-piperazine; CAY10704; SCHEMBL2056217; CHEMBL3771316; BEA78444; AKOS040755846; HY-113860; CS-0062963. Grade: ≥98%. CAS No. 101784-44-5. Molecular formula: C18H20Cl2N2. Mole weight: 335.27. | |
| Antiviral agent 9 | Antiviral agent 9 reaches a single-digit picomolar EC50 value (0.006 nM) against HIV-1 and nearly 300-fold higher selectivity index (SI) compared to tenofovir alafenamide fumarate (TAF). Synonyms: Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(4-((S)-2-(((benzyloxy)carbonyl)amino)-4-cyclopentyl-3-oxobutyl)phenoxy)phosphoryl)-L-alaninate. Molecular formula: C38H50N7O8P. Mole weight: 763.82. | |
| Antiviral protein Y3 | The source of Antiviral protein Y3 is Pleurotus citrinopileatus. It has antiviral activity against Tobacco mosaic virus and antitumor activity against stomach cancer cells in vitro. | |
| Anti-virus agent 1 | Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Remdesivir isopropyl ester analog. CAS No. 1911578-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131233. |  |
| Anti-Virus Compound Library | Quantity: A unique collection of 800 anti-virus compounds effective for new anti-virus drugs high throughput screening and high content screening; - Target viruses include HBV, HCV, HIV, HSV, Influenza Virus, Reverse Transcriptase, etc. covering more than 140 targets; - Structurally diverse and strong bioactivity; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design; - NMR and HPLC/LCMS validated to ensure high purity and quality. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1700. Categories: Anti-Virus Compounds Libraries. | |
| Anti-virus Traditional Chinese Medicine Monomer Library | A collection of 270 TCM monomers with anti-virus activity. An effective tool for drug development and pharmacological studies. Uses: Scientific use. Product Category: L6730. Categories: Anti-virus Traditional Chinese Medicine Monomer Libraries. | |
| Ant-m7GDP | Ant-m7GDP is an exceptional pharmacological compound characterized by its profound capacity to combat viral infections. This awe-inspiring compound exhibits an unparalleled proclivity for selectively targeting and disrupting the intricate guanosine triphosphate cap structures, thereby impeding the vital process of viral mRNA capping. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-diphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H22N6O12P2 (free acid). Mole weight: 576.35 (free acid). | |
| Ant-m7GMP | Ant-m7GMP is a biomedical compound used for the research of RNA-related diseases specifically targeting RNA molecules with the modified nucleotide 7-methylguanosine. By inhibiting the function of these modified RNA molecules, ant-m7GMP offers potential in studying conditions such as cancer, viral infections and neurological disorders. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-monophosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H21N6O9P (free acid). Mole weight: 496.37 (free acid). | |
| Ant-m7GTP | Ant-m7GTP is a crucial tool used to study mRNA splicing and translation. It assists in investigating cellular processes and protein research. By targeting modified nucleotides in the mRNA cap structure is ant-m7GTP aids in understanding diseases like cancer and viral infections, enhancing drug discovery and development efforts. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-triphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H24N6O15P3 (free acid). Mole weight: 656.33 (free acid). | |
| Antofloxacin | Antofloxacin is an orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Uses: Anti-bacterial agents. Synonyms: (S)-Antofloxacin; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 8-amino-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)-. CAS No. 119354-43-7. Molecular formula: C18H21FN4O4. Mole weight: 376.38. | |
| Antofloxacin | Antofloxacin is a well-tolerated, orally active, and broad-spectrum 8-amino-fluoroquinolone compound that exhibits potent antibacterial properties. It demonstrates superior activity against gyrA mutation-positive Helicobacter pylori strains, particularly in strains with mutations in the Asn87 position, when compared to levofloxacin. Additionally, Antofloxacin acts as a weak but reversible inhibitor of CYP1A2 and is clinically used to treat infections caused by various bacterial species. Category: Active pharmaceutical ingredients. CAS No. 119354-43-7. Product ID: API119354437. Molecular formula: C18H21FN4O4. Mole weight: 376.388. |  |
| Antofloxacin hydrochloride | Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone antibiotic with potent antibacterial activities. Anthofloxacin hydrochloride is a weak, reversible CYP1A2 inhibitor for the treatment of various bacterial infections. It is also used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis (AP), acute cystitis and multiple folliculitis. Uses: Anti-bacterial agents. Synonyms: (S)-Antofloxacin hydrochloride; (S)-8-amino-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 8-amino-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride (1:1), (3S)-. Grade: ≥95%. CAS No. 873888-67-6. Molecular formula: C18H22ClFN4O4. Mole weight: 412.84. | |
| Antofloxacin Hydrochloride | Antofloxacin Hydrochloride, a fluoroquinolone antimicrobial, is used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis. Category: Active pharmaceutical ingredients. CAS No. 873888-67-6. Product ID: API873888676. Molecular formula: C18H22ClFN4O4. Mole weight: 412.84. | |
| Antrafenine | Antrafenine (Stakane) is a non-narcotic analgesic. Antrafenine demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine significantly alleviates the pain of osteoarthritis. Antrafenine exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine can be used in pain and anti-inflammatory research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stakane. CAS No. 55300-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0235. | |
| Antrafenine dihydrochloride | Antrafenine dihydrochloride. Group: Biochemicals. Alternative Names: 2- [ [7- (Trifluoromethyl) -4-quinolinyl] amino] benzoic acid [4-[3- (trifluoromethyl) phenyl]-1-piperazinyl]ethyl ester hydrochloride. Grades: Highly Purified. CAS No. 55300-30-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C30H28Cl2F6N4O2. US Biological Life Sciences. |  Worldwide |
| Antrafenine Dihydrochloride | Antrafenine Dihydrochloride is the dihydrochloride form of Antrafenine, which is a piperazine derivative drug. It acts as an analgesic and anti-inflammatory drug, but is not widely used. Uses: Antrafenine dihydrochloride acts as an analgesic and anti-inflammatory drug. Synonyms: 2-[[7-(TrifluoroMethyl)-4-quinolinyl]amino]benzoic Acid [4-[3-(TrifluoroMethyl)phenyl]-1-piperazinyl]ethyl Ester dihydrochloride; Benzoic acid, 2-((7-(trifluoromethyl)-4-quinolinyl)amino)-, 2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl ester, dihydrochloride. Grade: 98%. CAS No. 55300-30-6. Molecular formula: C30H28Cl2F6N4O2. Mole weight: 661.47. | |
| Antrimycin A | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. Antrimycin A has anti-Mycobamrimn smegmatis (Mycobamrimn smegmatis) and human Mycobacterium tuberculosis H37 Rv activity, and also has an effect on rifampicin and capreomycin-resistant bacteria. Synonyms: Antrimycin; Cirratiomycin B; L-Serine, 2-(hydroxymethyl)seryl-L-alanyl-L-erythro-alpha,beta-diaminobutyryl-L-2,3,4,5-tetrahydro-3-pyridazinecarbonyl-L-alanyl-(E)-2,3-didehydroisoleucyl-. Grade: >98%. CAS No. 80801-26-9. Molecular formula: C28H47N9O11. Mole weight: 685.72. | |
| Antrimycin B | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. Synonyms: 2-(Hydroxymethyl)-Ser-L-Ala-[(3S)-3-amino-L-Abu-]-1,6-didehydro-L-Pyz-L-Abu-2,3-didehydro-L-Ile-L-Ser-OH. CAS No. 82518-60-3. Molecular formula: C29H49N9O11. Mole weight: 699.75. | |
| Antrimycin C | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. CAS No. 82534-66-5. Molecular formula: C30H51N9O11. Mole weight: 713.78. | |
| Antroquinonol | Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects[1]. Antroquinonol can be used for the research of colon cancer[2]. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Antroquinonol. CAS No. 1010081-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19893. | |
| Anwuligan | Anwuligan. Group: Biochemicals. Alternative Names: Macelignan; Calophyn. Grades: Plant Grade. CAS No. 107534-93-0. Pack Sizes: 20mg. Molecular Formula: C20H24O4, Molecular Weight: 328.402. US Biological Life Sciences. | Worldwide |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| Anziaic acid | It is produced by the strain of Stereocaulon ramulosum. Synonyms: NSC 766393; 6-Hydroxy-4-[(2,4-dihydroxy-6-pentylbenzoyl)oxy]-2-pentylbenzoic acid; 2,4-Dihydroxy-6-pentylbenzoic acid 4-carboxy-3-hydroxy-5-pentylphenyl ester; 4-(2,4-Dihydroxy-6-pentylbenzoyloxy)-6-pentylsalicylic acid; Benzoic acid, 2,4-dihydroxy-6-pentyl-, 4-carboxy-3-hydroxy-5-pentylphenyl ester; 4-Carboxy-3-hydroxy-5-pentylphenyl 2,4-dihydroxy-6-pentylbenzoate; Anzic acid. Grade: ≥98% by HPLC. CAS No. 641-68-9. Molecular formula: C24H30O7. Mole weight: 430.49. | |
| Anzurstobart | Anzurstobart is a CD47/SIRPα inhibitor with human SIRPα Kd of 0.0541 nM and human SIRPα IC50 of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-95251; BMS-986351. CAS No. 2543693-10-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990033. | |
| AO-365/43472821 | AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 μM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 μM). AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA)-induced injury. AO-365/43472821 decreased tau (pSer396)/tau and Aβ1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1081122-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-179177. | |
| AOA (Aminooxyacetic acid) hemihydrochloride | AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor. AOA hemihydrochloride inhibits the malate-aspartate shuttle (MAS). Group: Inhibitors. Alternative Names: Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, Aminooxyacetate hemihydrochloride. CAS No. 2921-14-4. Pack Sizes: 25mg. Product ID: S4989. Formula: C2H5NO3.1/2HCl. Smiles: C(C(=O)O)ON.C(C(=O)O)ON.Cl. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| AOH1160 | AOH1160 is a first-in-class, potent and orally available inhibitor of PCNA, which plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. AOH1160 selectively kills many types of cancer cells at below micromolar concentrations without causing significant toxicity to a broad range of nonmalignant cells. Synonyms: N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide. Grade: 99%. CAS No. 2089314-57-6. Molecular formula: C25H20N2O3. Mole weight: 396.44. | |
| AOH1160-1LE | AOH1160-1LE is a derivative of AOH1160, a small-molecule PCNA inhibitor. AOH1160-1LE was shown to bind into the PCNA-interacting protein-box (PIP-box). Molecular formula: C28H24N2O5. Mole weight: 468.50. | |
| AOH1996 | AOH1996 is a small-molecule PCNA inhibitor that enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner. AOH1996 was identified as a selective chemotherapeutic. Synonyms: AOH 1996; AOH-1996; NSC789796; NSC-789796. Grade: 98%. CAS No. 2089314-64-5. Molecular formula: C26H22N2O4. Mole weight: 426.46. | |
| AOH1996-1LE | AOH1996-1LE is a derivative of AOH1160, a small-molecule PCNA inhibitor. AOH1996-1LE was shown to bind into the PCNA-interacting protein-box (PIP-box). | |
| AOP | AOP. Group: Biochemicals. Alternative Names: 7-(Azabenzotriazol-1-yl)oxy tris (dimethylamino) phosphonium hexafluorophosphate. Grades: Highly Purified. CAS No. 156311-85-2. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C11H21F6N7OP2. US Biological Life Sciences. | Worldwide |
| Aorta, Bovine | Aorta, Bovine. Group: Biologicals. Grades: Tissue. Pack Sizes: 10Ea. US Biological Life Sciences. | Worldwide |
| Aorta, Rabbit | Aorta, Rabbit. Group: Biologicals. Grades: Tissue. Pack Sizes: 50Ea. US Biological Life Sciences. | Worldwide |
| Aortic Artery Endothelial Cells, Human (Frozen) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement, is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Aortic Artery Endothelial Cells, Human (T-25 flask) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement, is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| AOZ-[d4] | AOZ-[d4] is the labelled analogue of AOZ, which is a metabolite of Furazolidone. Synonyms: AOZ-d4; 3-Amino-2-oxazolidinone-d4; 3-Amino-1,3-oxazolidin-2-one-d4; NSC 111187-d4; NSC 196570-d4; NSC 38250-d4; Vetranal-d4. Grade: ≥97%; ≥97% atom D. CAS No. 1188331-23-8. Molecular formula: C3H2D4N2O2. Mole weight: 106.12. | |
| AP 1189 | AP 1189 exhibits biased agonistic activity towards the melanocortin 1 and melanocortin 3 receptors. Synonyms: Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, acetate (1:1), (2E)-; AP1189; AP-1189; Resomelagon acetate; (E)-2-((E)-3-(1-(2-nitrophenyl)-1H-pyrrol-2-yl)allylidene)hydrazine-1-carboximidamide acetate. Grade: ≥95%. CAS No. 1809420-72-1. Molecular formula: C14H14N6O2.C2H4O2. Mole weight: 358.35. | |
| AP14145 hydrochloride | AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. CAS No. 2387505-59-9. Molecular formula: C18H18ClF3N4O. Mole weight: 398.81. | |
| AP18 | AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 μM at human and mouse respectively. It has been used to study TRPA1 signaling in mice and rats as well as in vitro. It blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. It also blocks cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. It reverses CFA-induced mechanical hyperalgesia in mice. Uses: Ap18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. Synonyms: AP-18; AP 18; AP18. 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime; AP-18; 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime; (NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine; (2E,3E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime. Grade: 98%. CAS No. 55224-94-7. Molecular formula: C11H12ClNO. Mole weight: 209.67. | |
| AP 18 | AP 18. Group: Biochemicals. Grades: Purified. CAS No. 55224-94-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AP-18 | AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55224-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W014421. | |
| AP-18 | AP-18. Group: Biochemicals. Alternative Names: 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one Oxime. Grades: Highly Purified. CAS No. 55224-94-7. Pack Sizes: 5mg. Molecular Formula: C11H12ClNO, Molecular Weight: 209.67. US Biological Life Sciences. | Worldwide |
| AP1867 | AP1867 is a synthetic FKBP12F36V-directed ligand[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 195514-23-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114434. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grade: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC FKBP12-binding moiety 2. CAS No. 2230613-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-114420. | |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grade: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
| AP-1/NF-κB activation inhibitor 1 | AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor with an IC50 of 1 μM. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells. Synonyms: AP-1/NF-kappaB activation inhibitor 1; 2-(Trifluoromethyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl ester. Grade: 99%. CAS No. 188936-12-1. Molecular formula: C13H11F3N4O4. Mole weight: 344.25. | |
| AP20187 | Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice. AP20187 stimulation significantly increases hepatic glycogen content and muscular glucose uptake similarly to insulin. The homodimerizer has been widely used to study signal transduction pathways (by inducing oligomerization of cell surface receptor proteins), but it can be used to induce the activity/re-localization of any protein that is affected by oligomerization. To test the role of homodimerization in kinase activation, we constructed a fusion protein consisting of the SLK catalytic domain (amino acids 1-373) and a modified FK506 binding protein, Fv (Fv-SLK 1-373). Addition of AP20187 (an analog of FK506) enhanced the homodimerization of Fv-SLK 1-373. Synonyms: AP 20187; AP-20187. Grade: >98%. CAS No. 195514-80-8. Molecular formula: C82H107N5O20. Mole weight: 1482.75. | |
| AP20187 | AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. Uses: Scientific research. Category: Signaling pathways. Alternative Names: B/B Homodimerizer. CAS No. 195514-80-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13992. | |
| AP219 | AP219 is a control compound for AP39, which contains the triphenylphosphonium scaffold but lacking the H2 S-releasing portion. AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. Synonyms: (9-Carboxynonyl)triphenylphosphonium; 779282-36-9; AP219; 9-carboxynonyl(triphenyl)phosphanium; (9-Carboxynonyl)triphenyl-phosphonium; CHEMBL3582497; SCHEMBL20859564; AKOS040755143; (9-Carboxynonyl)triphenyl-phosphonium Bromide (>90%). Grade: ≥98%. CAS No. 779282-36-9. Molecular formula: C28H34O2P. Mole weight: 433.6. | |
| AP-22161 | AP-2216, designed to bind selectively to the Src SH2 domain by targeting a cysteine residue, has the potential to be further developed for treating osteoporosis. Synonyms: 4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-formylbenzoic acid; AP-22161; AP 22161; AP22161; SCHEMBL7243003; G7VE62573J; UNII-G7VE62573J. Grade: >98%. CAS No. 268741-42-0. Molecular formula: C32H39N3O7. Mole weight: 577.67. | |
| AP2238 | AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Uses: Cholinesterase inhibitors. Synonyms: AP-2238; AP 2238; AP2238; CHEMBL75121; UNII-545225E0BC; BDBM10949; DNC007569; 2H-1-Benzopyran-2-one, 6,7-dimethoxy-3-(4-((methyl(phenylmethyl)amino)methyl)phenyl)-; 3-[4-(N-Benzyl-N-methylaminomethyl)phenyl]-6,7-dimethoxy-2H-1-benzopyran-2-one. Grade: 98%. CAS No. 553681-56-4. Molecular formula: C26H25NO4. Mole weight: 415.48. | |
| AP-22408 | AP-22408, a Src tyrosine kinase inhibitor, is an orally bioavailable phosphotyrosine mimic resulting from a structurebased design. Synonyms: [4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-phosphonophenyl]phosphonic acid; AP-22408; AP 22408; AP22408; UNII-3U3L5QR4KV; CC1; AC1L9I7C; 3U3L5QR4KV; SCHEMBL7245569. Grade: >98%. CAS No. 268741-43-1. Molecular formula: C30H41N3O10P2. Mole weight: 665.61. | |
| AP23464 | AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases. It displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells with an IC50=14 nM. Synonyms: AP-23464; AP 23464; (4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dimethylphosphine oxide. Grade: >98%. CAS No. 845895-51-4. Molecular formula: C30H38N5O2P. Mole weight: 475.53. | |
| AP23846 | AP23846 is a potent c-Src kinase inhibitor (IC50 approximately 0.5 nmol/L in vitro, approximately 10-fold more potent than PP2, the most widely used commercially available Src family kinase inhibitor). Synonyms: AP-23846; (4-((2-cyclopentyl-9-ethyl-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 878654-51-4. Molecular formula: C20H16FN3O2. Mole weight: 439.53. | |
| AP23848 | AP23848 is a potent Bcr-Abl inhibitor. Synonyms: AP-23848; AP 23848; PF-562771; (4-((2-Cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 834894-21-2. Molecular formula: C13H15N5O6. Mole weight: 531.63. | |
| AP 24534 | AP 24534. Group: Biochemicals. Grades: Purified. CAS No. 943319-70-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AP-24600 | AP-24600 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AP-24600; AP 24600; AP24600; DA-12847; KB-310048; DA 12847; KB 310048; DA12847; KB310048; UNII-OZ477A282R; OZ477A282R; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid. Grade: 98%. CAS No. 1300690-48-5. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| AP 26113 | AP 26113. Group: Biochemicals. Grades: Highly Purified. CAS No. 1350848-43-9. Pack Sizes: 1mg. Molecular Formula: C26H34ClN6O2P, Molecular Weight: 529.01. US Biological Life Sciences. | Worldwide |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grade: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
| AP2A | AP2A, a prized medication within the biomedical industry, has transcended the boundaries of healing, showcasing its versatility in treating numerous afflictions, including but not limited to, managing pain, alleviating inflammatory disorders, and thwarting cancer. Prized for its utmost efficacy, AP2A efficaciously binds and regulates the activity of specific enzymatic and protein molecules that initiate the cascade of these aforementioned conditions. With its potential for therapeutic use being exhaustively studied and researched, it stands as an invaluable asset in the biomedicine realm. Synonyms: P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 85065-24-3. Molecular formula: C20H26N10O13P2 (free acid). Mole weight: 676.43 (free acid). | |
| AP2Ribavirin | AP2Ribavirin, an antiviral drug, exerts its efficacy against the Hepatitis C virus (HCV) by curbing the replication of viral RNA through interference with RNA-dependent RNA polymerase. Coupled with other HCV drugs, AP2Ribavirin enhances therapeutic outcomes - serving as a frontline defense against this viral infection. Synonyms: 1,2,4-Triazole-3-carboxamide adenine dinucleotide, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H25N9O14P2 (free acid). Mole weight: 653.39 (free acid). | |
| AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429061-80-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126124. | |
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