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| Product | Description | |
|---|---|---|
| AZ084 | AZ084 is a potent, selective, allosteric and orally active CCR8 antagonist with a Ki of 0.9 nM. It has the potential to treat asthma. Synonyms: Methanone, (5-amino-2-pyridinyl)[9-[(2,3-dihydro-2,2-dimethyl-4-benzofuranyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl]-; (5-Amino-2-pyridinyl){9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methanone. Grade: ≥97%. CAS No. 929300-19-6. Molecular formula: C26H34N4O2. Mole weight: 434.57. |  |
| AZ084 | AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. Has potential to treat asthma[1]. AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 929300-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119217. |  |
| AZ 10397767 | AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grade: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. | |
| AZ 10417808 | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grade: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
| AZ 10606120 dihydrochloride | AZ 10606120 dihydrochloride is the dihydrochloride salt of AZ 10606120, which is a potent and negative allosteric modulator of the human P2X7 receptor. Its KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively. It binds in a positive cooperative manner to sites and acts as a negative allosteric modulator. It is a key modulator of the PI3K/GSK3β/VEGF signaling network. It inhibits tumor growth and shows antiangiogenic effects in mice. Synonyms: AZ10606120; AZ 10606120; AZ-10606120; N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide Dihydrochloride; 2-(1-Adamantyl)-N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]quinolin-5-yl]acetamide Dihydrochloride. Grade: ≥98% by HPLC. CAS No. 607378-18-7. Molecular formula: C25H36N4O2Cl2. Mole weight: 495.48. | |
| AZ10606120 dihydrochloride | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10?nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 607378-18-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108669. | |
| AZ11645373 | AZ11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Uses: Purinergic p2x receptor antagonists. Synonyms: 2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-; 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione; AZ 11645373; AZ-11645373; 3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione. Grade: >98%. CAS No. 227088-94-0. Molecular formula: C24H21N3O5S. Mole weight: 463.51. | |
| AZ11665362 | AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Uses: Az11665362 might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grade: 98%. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. | |
| AZ 12080282 dihydrochloride | AZ 12080282 dihydrochloride is a potent Hh inhibitor with IC50 value <0.012 μM. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency. Synonyms: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride. Grade: ≥98%. Molecular formula: C23H20N4O2ยท2HCl. Mole weight: 457.35. | |
| AZ 12216052 | AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grade: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. | |
| AZ 12216052 | AZ 12216052. Group: Biochemicals. Grades: Purified. CAS No. 1290628-31-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| AZ12601011 | AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2748337-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122856. | |
| AZ12601011 | AZ12601011 is one of inhibitors of Transforming Growth Factor β Superfamily Type 1 receptors. Synonyms: AZ12601011; AKOS040732507; MS-24586; HY-122856; CS-0090034. Grade: 98%. Molecular formula: C19H15N5. Mole weight: 313.36. | |
| AZ12672857 | AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945396-55-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136895. | |
| AZ12672857 | AZ12672857 is an orally active inhibitor of EphB4 and Src kinases. It shows potent inhibition of proliferation of c-Src transfected 3T3 cells (IC50 = 2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50 = 9 nM). Grade: 98%. CAS No. 945396-55-4. Molecular formula: C26H38N8O2. Mole weight: 486.57. | |
| AZ12799734 | AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1117684-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123900. | |
| AZ-1355 | AZ-1355 is an effective lipid-lowering agent. It inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro. Synonyms: 11,12-Dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate; AZ 1355; NSC 364889. CAS No. 75451-07-9. Molecular formula: C17H17NO4. Mole weight: 299.32. | |
| AZ13705339 | AZ13705339 is a potent and selective PAK1 inhibitor (IC50 = 0.33 nM). PAK1 is commonly overexpressed in breast tumors. Synonyms: AZ13705339; AZ 13705339; AZ-13705339; 2-[[N-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile. Grade: 99%. CAS No. 2016806-57-6. Molecular formula: C33H36FN7O3S. Mole weight: 629.75. | |
| AZ13824374 | AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3040082-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-136521. | |
| AZ14170133 | AZ14170133 (SG 3932; AZ-0133) is a Drug-Linker Conjugates for ADC. AZ14170133 consists of the ADC cytotoxic payload topoisomerase 1 inhibitor and a linker. AZ14170133 can be used for synthesis of ADC AZD9592 (HY-171124) and AZD 8205 (HY-171689). AZ14170133 can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SG 3932; AZ-0133. CAS No. 2495742-34-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145399. | |
| AZ1495 | AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2196204-23-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111101. | |
| AZ191 | AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grade: >98%. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| AZ191 | AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1594092-37-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12277. | |
| AZ194 | AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241651-99-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145169. | |
| AZ2 | AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). Grade: 99%. CAS No. 2231760-33-9. Molecular formula: C20H23N3O2S. Mole weight: 369.48. | |
| AZ20 | AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1233339-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15557. | |
| AZ20 | In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Synonyms: AZ20; AZ-20; AZ 20. Grade: >98%. CAS No. 1233339-22-4. Molecular formula: C21H24N4O3S. Mole weight: 412.51. | |
| AZ-2088 | AZ-2088 is a powerful and discriminating inhibitor exhibiting its prowess by selectively antagonizing the Akt pathway. Synonyms: AZ 2088; AZ2088; Dimethylheptyl(1-hydroxy-p-menth-2-yl)ammonium bromide; N-Heptyl-2-hydroxy-N,N,2-trimethyl-5-(propan-2-yl)cyclohexan-1-aminium bromide. Grade: >98%. CAS No. 20091-61-6. Molecular formula: C19H40BrNO. Mole weight: 378.44. | |
| AZ 23 | AZ 23 is a potent and selective tyrosine kinase (Trk) inhibitor with the potential for therapeutic utility in neuroblastoma and multiple other cancer indications. Uses: Multiple cancer therapy. Synonyms: AZ-23; AZ 23; AZ23; UNII-009OMI967N; 5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine. Grade: 99%. CAS No. 915720-21-7. Molecular formula: C17H19ClFN7O. Mole weight: 391.83. | |
| AZ-3 | AZ-3 is a potent and selective inhibitor of JAK1 with an IC50 of 34 nM. Synonyms: 2,4-Pyrimidinediamine, N2-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-3-pyridinyl]-5-methyl-N4-[(1R)-1-methylpropyl]-; N4-[(2R)-2-Butanyl]-N2-{2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-3-pyridinyl}-5-methyl-2,4-pyrimidinediamine. Grade: ≥95%. CAS No. 2228908-91-4. Molecular formula: C20H28FN7. Mole weight: 385.48. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grade: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31; (S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grade: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. | |
| AZ31 | AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of <1.2 nM for ATM enzyme, and an IC50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2088113-98-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-112198. | |
| AZ'3137 | AZย3137 is an orally active PROTAC-type androgen receptor (AR) degrader with a DC50 value of 22 nM. AZย3137 can degrade L702H mutant AR (DC50 of 92 nM). AZ'3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Pink: AR Ligand (HY-172954); Blue: CRBN ligand (HY-172955); Black: linker (HY-W262798); E3 Ligand+Linker: HY-172956)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2960179-55-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-162702. | |
| AZ3146 | AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat. Uses: Scientific research. Category: Signaling pathways. CAS No. 1124329-14-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14710. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grade: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grade: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. Uses: Scientific research. Category: Signaling pathways. CAS No. 2288709-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112305. | |
| AZ3246 | AZ3246 is an orally active and selective inhibitor of HPK1 with an IC50 of < 3 nM. AZ3246 induces IL-2 secretion in T cells with an EC50 of 90 nM. AZ3246 is a low-clearance antitumor compound that can be used for the study of breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2893978-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173006. | |
| Az-33 | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grade: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
| AZ3451 | AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2100284-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112558. | |
| AZ 3451 | AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grade: ≥98%. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. | |
| AZ3976 | AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with IC50 of 26 μM in an enzymatic chromogenic assay. AZ3976 inhibited PAI-1 by enhancing the latency transition of active PAI-1. Synonyms: AZ 3976; AZ-3976. Grade: >98%. CAS No. 1418747-15-5. Molecular formula: C15H19N5O3. Mole weight: 317.34. | |
| AZ505 | AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ 505; AZ-505; N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide. Grade: 98%. CAS No. 1035227-43-0. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. | |
| AZ505 | AZ505 is a potent and selective SMYD2 inhibitor with an IC50 of 0.12 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1035227-43-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15226. | |
| AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505 ditrifluoroacetate; AZ 505 ditrifluoroacetate; AZ-505 ditrifluoroacetate. Grade: >98%. CAS No. 1035227-44-1. Molecular formula: C33H40Cl2F6N4O8. Mole weight: 805.59. | |
| AZ506 | AZ506 is a potent SMYD2 inhibitor (IC50 = 17 nM) that inhibits SMYD2 methyltransferase activity in cells, resulting in a decrease in the SMYD2-mediated methylation signal. Synonyms: 3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-; 5-(2-{4-[2-(1H-Indol-3-yl)ethyl]-1-piperazinyl}phenyl)-N-[3-(1-pyrrolidinyl)propyl]nicotinamide. Grade: ≥95%. CAS No. 2043321-54-4. Molecular formula: C33H40N6O. Mole weight: 536.71. | |
| AZ506 | AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2043321-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134828. | |
| AZ5104 | AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592. | |
| AZ-5104 | AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1421373-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0793. | |
| AZ5576 | AZ5576 is a potent and highly selective CDK9 inhibitor (IC50: <5 nM). AZ5576 inhibits the phosphorylation of RNA polymerase II at Ser2, thereby inhibiting transcriptional elongation. AZ5576 can be used for hematological Malignancy research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2751721-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143584. | |
| AZ 5704 | AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM in an enzyme inhibition assay. It exhibits 600-fold selectivity for ATM over other kinases. AZ 5704 is also orally bioavailable. Synonyms: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide; AZ-5704; AZ5704. Grade: ≥98%. CAS No. 1941214-06-7. Molecular formula: C23H23FN6O2. Mole weight: 434.47. | |
| AZ6102 | AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-6. It also inhibits Wnt signaling in DLD-1 cells. IC50: TNKS2= 1 nM; TNKS1= 3 nM; Wnt signaling. Synonyms: 2-[4-[6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-oneAZ6102; AZ-6102; AZ 6102.AZ 6102|rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidi. CAS No. 1645286-75-4. Molecular formula: C25H28N6O. Mole weight: 428.53. | |
| AZ6102 | AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1645286-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12975. | |
| AZ617 | AZ617 is a human-specific, TLR4-dependent agonist that activates NFκB. Synonyms: AZ-617; AZ 617. Grade: 98% by HPLC. CAS No. 2247439-36-5. Molecular formula: C40H38N4O4. Mole weight: 638.8. | |
| AZ 628 | AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 878739-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11004. | |
| AZ 628 | AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grade: >98%. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ'6421 | AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361115-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-135312. | |
| AZ7371 | AZ7371 is a novel non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with IC50 of 10 nM. Synonyms: AZ-7371; AZ 7371; TBA-7371; DprE1-IN-1. Grade: 98%. CAS No. 1494675-86-3. Molecular formula: C18H21N5O3. Mole weight: 355.40. | |
| AZ7550 | AZ7550, an active metabolite of AZD9291, inhibits IGF1R activity with an IC50 of 1.6 μM in a cell-free assay. Synonyms: Osimertinib metabolite M3; 2-Propenamide, N-(4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-; N-(4-Methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-2-propenamide; N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide. Grade: ≥95%. CAS No. 1421373-99-0. Molecular formula: C27H31N7O2. Mole weight: 485.58. | |
| AZ7550 | AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1421373-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0794. | |
| AZ7550 hydrochloride | AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits IGF1R activity with an IC50 of 1.6 μM in a cell-free assay. Synonyms: N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide hydrochloride (1:1); 2-Propenamide, N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 2309762-40-9. Molecular formula: C27H32ClN7O2. Mole weight: 522.04. | |
| AZ7550 Mesylate | AZ7550 Mesylate, an active metabolite of AZD9291, inhibits the activity of IGF1R with an IC50 of 1.6 μM. Synonyms: AZ7550 trimesylate salt; N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide methanesulfonate (1:3); 2-Propenamide, N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-, methanesulfonate (1:3). Grade: ≥98%. CAS No. 2319837-99-3. Molecular formula: C30H43N7O11S3. Mole weight: 773.90. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grade: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZ82 | AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449578-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12241. | |
| AZ876 | AZ876 is a novel high-affinity LXR agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively, it was previously shown to inhibit progression of atherosclerosis in mice without incurring the aforementioned adverse effects. Whether AZ876 exerts additional protection in the heart remains to be explored. LXR activation with AZ876 attenuated this increase, and significantly reduced TAC-induced increases in heart weight, myocardial fibrosis, and cardiac dysfunction without affecting blood pressure. AZ876 was also 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human. Synonyms: AZ 876; AZ-876; AZ12260493; AZ 12260493; AZ-12260493. Grade: ≥98%. CAS No. 898800-26-5. Molecular formula: C24H29N3O3S. Mole weight: 439.57. | |
| AZ8838 | AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2100285-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123617. | |
| AZ9482 | AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1825345-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-119653. | |
| AZ'9567 | AZ'9567 is an orally active MAT2a inhibitor with a pIC50 of 9.1. AZ'9567 binds to MAT2a allosterically, reduces the synthesis of SAM, decreases SDMA levels, and exerts antiproliferative effects on MTAP-knockout cells. AZ'9567 depletes SAM, causes methionine accumulation in plasma and tissues, triggers adaptive disorders in one-carbon metabolism, transsulfuration metabolism and lipid metabolism, and induces oxidative stress, hepatic steatosis and lipid homeostasis imbalance. AZ'9567 can be used in studies related to MTAP-deficient/deleted cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3056570-19-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162353. | |
| AZ960 | AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 905586-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10411. | |
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