A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery. Uses: Adjuvants, anesthesia. Synonyms: Atropine sulfate monohydrate; Atropini sulfas; Isopto Atropine; Atropinum sulphuricum; Atropine sulfate. Grade: >98%. CAS No. 5908-99-6. Molecular formula: 2C17H23NO3.H2O4S.H2O. Mole weight: 694.837.
Atropine sulfate hydrate (2:1:2)
Atropine sulfate hydrate (2:1:2) is a pharmaceutically significant compound extensively utilized in the biomedical domain, serving as an efficacious muscarinic antagonist for the research of diverse medical ailments encompassing hypersecretion of saliva, bradycardia and specific gastrointestinal disorders. Uses: Adjuvants, anesthesia. Synonyms: endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate sulfate dihydrate(2:1:2). CAS No. 73791-47-6. Molecular formula: 2C17H23NO3.H2O4S.2H2O. Mole weight: 712.852.
Atropine sulfate Impurity 11
Atropine sulfate Impurity 11. Uses: For analytical and research use. Alternative Names: (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-oxo-2-phenylpropanoate. CAS No. 22226-37-5. Molecular formula: C17H21NO3. Mole weight: 287.35. Catalog: APB22226375.
Atropine sulfate Impurity 13
Atropine sulfate Impurity 13. Uses: For analytical and research use. Alternative Names: (1R,3r,5S)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane 8-oxide. CAS No. 4438-22-6. Molecular formula: C17H23NO4. Mole weight: 305.37. Catalog: APB4438226.
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1365659-05-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990008.
Atrovastatin-PEG3-FITC
Atrovastatin-PEG3-FITC (compound S31) is a KRAS-PDEδ interaction inhibitor. Atrovastatin-PEG3-FITC acts as a ligand in fluorescence anisotropy assay[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1440755-31-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134977.
Atrovastatin-PEG3-FITC
Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor and it acts as a ligand in fluorescence anisotropy assay. CAS No. 1440755-31-6. Molecular formula: C64H68FN5O12S. Mole weight: 1150.31.
Atrovenetin
Atrovenetin is an antibiotic produced by Penicillum herquei PRL 1838 and Pen. atrovenetum SM 683. Molecular formula: C19H18O6. Mole weight: 342.34.
atroxase
A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen. In peptidase family M12 (astacin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.24.43. CAS No. 181186-94-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4325; atroxase; EC 3.4.24.43; 181186-94-7. Cat No: EXWM-4325.
Attacin-C
Attacin-C is an antimicrobial peptide produced by Drosophila melanogaster (Fruit fly). It has antibacterial and antifungal activity. Synonyms: AttC; Gln-Arg-Pro-Tyr-Thr-Gln-Pro-Leu-Ile-Tyr-Tyr-Pro-Pro-Pro-Pro-Thr-Pro-Pro-Arg-Ile-Tyr-Arg-Ala. Grade: >98%. Molecular formula: C133H198N34O32. Mole weight: 2785.24.
ATTO 390 NHS ester
ATTO 390 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 390 NHS ester is an NHS ester derivative of ATTO 390 that can be used to label proteins or antibodies. Uses: Scientific research. Category: Signaling pathways. CAS No. 914203-48-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-D1917.
ATTO 425-Biotin
ATTO 425 is a new label with high quantum yield (0.90) as well as sufficient stokes shift (excitation maximum 436 nm, emission maximum 484 nm). It is optimized for excitation with argon laser, and is characterized by high photostability. It does nearly not show cis-trans-isomerization, which limits brightness and reproducibility for many other dyes. Uses: Atto fluorescent labels are designed for high sensitivity applications, including single molecule detection. atto labels have rigid structures that do not show any cis-trans-isomerization. thus these labels display exceptional intensity with minimal spectral shift on conjugation. atto 425 biotin is suitable for fluorescence labeling of avidin/streptavidin conjugated molecules. Grade: ≥95.0% (HPCE). Molecular formula: C37H53N5O7S. Mole weight: 711.91.
ATTO 488
ATTO 488 is a hydrophilic rhodamine-based fluorescent dye with strong absorption and high fluorescence quantum yield. ATTO 488 is suitable for flow cytometry (FACS), fluorescence in situ hybridization (FISH) and most other labeling uses (Ex/Em: 500/520 nm)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 923585-42-6. Pack Sizes: 1 mg. Product ID: HY-D2000.
ATTO 488 carboxylic acid
ATTO 488 carboxylic acid is a new fluorescent label based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies. Uses: Scientific research. Category: Signaling pathways. CAS No. 1443553-08-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-D1305.
ATTO 488 maleimide
ATTO 488 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 maleimide is a maleimide derivative of ATTO 488, which can be used to label proteins or antibodies. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219127-42-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D2002.
ATTO 488 NHS ester
ATTO 488 NHS ester is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 488 NHS ester is an NHS ester derivative of ATTO 488 that can be used to label proteins or antibodies. Uses: Scientific research. Category: Signaling pathways. CAS No. 863772-22-9. Pack Sizes: 1 mg. Product ID: HY-D2001.
ATTO 514-Biotin
ATTO 514 is a new hydrophilic fluorescent label with excellent water solubility. The dye exhibits strong absorption, high fluorescence quantum yield and exceptional thermal and photo-stability. Thus ATTO 514 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. The fluorescence is excited most efficiently in the range 510-535 nm. A suitable source of excitation is the 514 nm line of the Argon-Ion laser.Biotin conjugates can be used in applications like ELISA or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates.find more information here.
ATTO 520-Biotin
ATTO 520-Biotin. Uses: Atto 520 is a fluorescent label with high molecular absorption (110.000) and quantum yield (0.90) as well as sufficient stokes shift (excitation maximum 520 nm, emission maximum 542 nm). it does nearly not show cis-trans-isomerisation, which limits brightness and reproducibility for many other dyes. due to an insignificant triplet formation rate it is well suited for single molecule detection applications. can be utilized in applications such as elisa or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates. atto-520 fluorescent-labeled biotin can be loaded onto magnetic beads coated with streptavidin through specific ligand-receptor interactions. Grade: ≥95.0% (HPCE). Molecular formula: C37H53ClN6O8S. Mole weight: 777.37.
ATTO 594-Biotin
ATTO 594 is a novel fluorescent label belonging to the class of Rhodamine dyes. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, excellent water solubility, and very little triplet formation. After coupling to a substrate ATTO 594 carries a net electrical charge of -1.find more information here. Grade: ≥90% (HPCE).
ATTO 610-Biotin
ATTO 610-Biotin. Uses: Atto 610 belongs to a new generation of fluorescent labels invented by atto-tec. the dye is designed for application in the area of life science, e.g. labeling of dna, rna or proteins. characteristic features of the label are strong absorption, high fluorescence quantum yield, high photostability, good water solubility, and very little triplet formation. atto 610 is a ph sensitive product. while practically stable up to ph 8.5, it slowly degrades at higher ph. biotin conjugates can be used in applications like elisa or immunohistochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates. Grade: ≥85% (HPCE). Molecular formula: C40H57ClN6O7S. Mole weight: 801.43.
ATTO 655-Biotin
ATTO 655-Biotin. Uses: Atto 655 conjugated to biotin is useful for binding to proteins (i.e., avidin and streptavidin). the fluorescent properties include excellent thermal and photo-stability, high quantum yield, strong absorption (663 nm) and fluorescence (684 nm), and low triplet formation. it is a zwitterionic dye, carrying a net electrical charge of zero. electron donors such as guanine and tryptophan can easily quench the fluorescence of this fluorophore. biotin conjugated with atto 655 was applied to assess efficiency of bsa/avidin structures bound to a surface. Grade: ≥95.0% (HPCE).
ATTO 665 Biotin
ATTO 665 is a new fluorescent label closely related to ATTO 647N. It shows extraordinary high fluorescence quantum yield, excellent thermal and photo-stability, outstanding ozone resistance, and very little triplet formation. ATTO 665 is a cationic (charge +1). The dye is moderately hydrophilic. Biotin conjugates can be used in applications like ELISA or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-onjugates.find more information here. Grade: ≥95.0% (HPCE).
ATTO 740-Biotin
ATTO 740 belongs to a new generation of fluorescent labels for the near infrared spectral region. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the dye are strong absorption and good fluorescence as well as excellent thermal and photo-stability. ATTO 740 is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1.ATTO 740 is a pH sensitive product. While practically stable up to pH 7.4 (PBS-buffer), it slowly degrades at higher pH. If exposed to higher pH for coupling purposes, we recommend reducing the pH immediately after completion of the reaction.Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates.find more information here. Grade: ≥90.0% (HPCE).
ATTO MB2-Biotin
ATTO MB2-Biotin is a derivative of the well-known redox dye Methylene Blue. The dye can be reversibly reduced to the Colorless leuko form. Upon oxidation (e.g. with oxygen) the dye recovers, and the absorption is fully restored.The dye is suitable for labeling of DNA, RNA, proteins etc. In common with most ATTO-labels the dye shows a high extinction coefficient.ATTO MB2-Biotin ester is moderately hydrophilic.find more information here.
ATTO Rho101 Biotin
ATTO Rho101 is a new rhodamine dye, based on the well-known laser dye Rhodamine 101. The new label is functionalized for coupling to bio-molecules such as DNA, RNA or proteins. ATTO Rho101 shows extraordinary brightness and photostability.After coupling to a substrate ATTO Rho101 carries a net electrical charge of +1. The dye is moderately hydrophilic.find more information here.
ATTO Rho11 Biotin
ATTO Rho11 Biotin. Uses: Atto rho11 biotin is a new rhodamine dye for coupling to bio-molecules such as dna, rna, proteins etc. the label shows very high fluorescence efficiency and exceptionally high photostability. the dye is moderately hydrophilic. atto rho11 is a cationic dye. after coupling to a substrate the label carries a net electrical charge of +1. biotin conjugates can be used in applications like elisa or immunohistochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates.
ATTO Rho12 Biotin
ATTO Rho12 is a rhodamine dye for application in life sciences, e.g. labeling of DNA, RNA or proteins. The label shows strong absorption, high fluorescence quantum yield, and high photostability.After coupling to a substrate ATTO Rho12 carries a net electrical charge of +1.The dye is moderately hydrophilic. ATTO Rho12 consists of a mixture of three isomers with practically identical absorption and fluorescence properties.find more information here.
ATTO Rho13 Biotin
ATTO Rho13 Biotin is a new rhodamine dye for application in life sciences, e.g. labeling of DNA, RNA or proteins. The label shows strong absorption, high fluorescence quantum yield, and high photostability. After coupling to a substrate ATTO Rho13 Biotin carries a net electrical charge of +1.The dye is moderately hydrophilic. Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates.
ATTO Rho14 Biotin
ATTO Rho14 is a rhodamine featuring a functionality for coupling to biomolecules such as DNA, RNA or proteins. The label shows strong absorption, and extraordinarily high fluorescence quantum yield. In fact ATTO Rho14 is thebrightest label available in this wavelength range. In addition the dye exhibits an exceptionally high photostability.After coupling to a substrate ATTO Rho14 carries a net electrical charge of +1.Absorption and fluorescence are pH-independent in the range of pH 2 to 11, used in typical applications. The dye is moderately hydrophilic.find more information here.
ATTO Rho6G-Biotin
ATTO Rho6G-Biotin is a new rhodamine dye, based on the well-known laser dye Rhodamine 6G. The new label is functionalized for coupling to biomolecules such as DNA, RNA or proteins. ATTO Rho6G-Biotin shows strong absorption, extraordinary high fluorescence quantum yield, high thermal and photo-stability, and very little triplet formation.After coupling to a substrate ATTO Rho6G-Biotin carries a net electric charge of +1.The label is moderately hydrophilic.find more information here.
ATTO Thio12 Biotin
ATTO Thio12 Biotin is a new label closely related to the well-known rhodamines. The dye can be used for labeling of DNA, RNA or proteins. The characteristic feature of the label is high yield of triplet formation.The dye is moderately hydrophilic. ATTO Thio12 Biotin is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1.Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates.
AtuFECT01
AtuFect01 is part of the lipid system AtuPLEX and shows more effective siRNA binding activity and delivery to vascular endothelial cells. Synonyms: β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecenyl-, trihydrochloride, (2S)-; β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecen-1-yl-, hydrochloride (1:3), (2S)-; (S)-2-amino-N-((S)-2-amino-3-(hexadecyl((Z)-octadec-9-en-1-yl)amino)-3-oxopropyl)-5-guanidinopentanamide trihydrochloride. Grade: ≥95%. CAS No. 869094-19-9. Molecular formula: C43H87N7O2.3HCl. Mole weight: 843.58.
Atuliflapon
Atuliflapon is a novel 5-lipoxygenase activating protein (FLAP) inhibitor for the treatment of coronary artery disease. Synonyms: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide; AZD5718; Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-; AZD-5718; AZD 5718. Grade: ≥98% by HPLC. CAS No. 2041075-86-7. Molecular formula: C24H26N6O3. Mole weight: 446.50.
Atuliflapon
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5?Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD5718. CAS No. 2041075-86-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122908.
Atuveciclib
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb/CDK9 inhibitor. Atuveciclib (BAY-1143572) inhibits CDK9/CycT1 with an IC50 of 13 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-1143572. CAS No. 2923012-24-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12871B.
Atuveciclib S-Enantiomer
Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor with an IC50 of 16 nM for CDK9/CycT1. Synonyms: BAY-1143572 S-Enantiomer; (S)-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine; 4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine. Grade: ≥95%. CAS No. 250279-81-1. Molecular formula: C18H18FN5O2S. Mole weight: 387.43.
ATUX-1215
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in Bleomycin hydrochloride (HY-17565A)-treated animals. ATUX-1215 can slow the progression of lung fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2910929-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156420.
Atuzabrutinib
Atuzabrutinib is a Bruton's tyrosine kinase inhibitor. Synonyms: (2E)-2-{(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4,4-dimethylpent-2-enenitrile; 1-Piperidinepropanenitrile, 3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-α-(2,2-dimethylpropylidene)-β-oxo-, (αE,3R)-; (R,E)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile. CAS No. 1581714-49-9. Molecular formula: C30H30FN7O2. Mole weight: 539.61.
ATWLPPR Peptide
ATWLPPR Peptide is a biological active peptide. (This peptide is a specific VEGFR2/KDR heptapeptide antagonist, it binds VEGFR2 (KDR/flk), completely inhibiting VEGF binding to KDR and preventing VEGF-induced angiogenesis in-vivo. It specifically inhibits human endothelial cell proliferation in-vitro and totally abolishes VEGF-induced angiogenesis in-vivo.). Uses: Scientific research. Category: Signaling pathways. CAS No. 272121-15-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1663.
ATX-II
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome[1][2][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60748-45-0. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P1604.
AU-12122
AU-12122 is a novel-developed CDK7 inhibitor, which is potent and orally bioactive. It induces apoptosis of acute monocytic leukemia THP-1. Uses: The potential treatment of acute monocytic leukemia. Synonyms: AU-12122; AU 12122; AU12122.
AU1235
AU1235, an adamantyl urea derivative, is an inhibitor of Mycobacterium tuberculosis that was active on MDR strains and had a bactericidal effect on replicating bacteria. Synonyms: AU1235; AU 1235; AU-1235; 1-(1-adamantyl)-3-(2,3,4-trifluorophenyl)urea; 1-(2-adamantyl)-3-(2,3,4-trifluorophenyl)urea. CAS No. 1338780-86-1. Molecular formula: C17H19F3N2O. Mole weight: 324.34.
AU1235
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338780-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101867.
AU-15330
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380274-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145388.
AU-15330
AU-15330 is highly specific and VHL-dependent PROTAC degrader of the SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1). It induces effective inhibition of tumour growth in xenograft models of prostate cancer and acts synergistically with enzalutamide, an AR antagonist. It induces disease remission in castration-resistant prostate cancer (CRPC) models and is nontoxic. Synonyms: AU 15330; AU15330; (2S,4R)-1-((S)-2-(2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide. Grade: ≥95%. CAS No. 2380274-50-8. Molecular formula: C39H49N9O5S. Mole weight: 755.93.
AU-16235
AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380275-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145388B.
AU-24118
AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4 ligand (HY-171774); Blue: CRBN ligand (HY-171775))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3084244-26-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163410.
AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grade: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6.
Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VU0424238. CAS No. 1396337-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16617.
Au Nanoparticles(D: 100 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 12 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 140 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 15 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 160 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 180 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 200 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
Au Nanoparticles(D: 80 nm )
Gold-coloured powder or tiny sheets;Soft yellow metal; gold-colored powder or tiny sheets. CAS No. 7440-57-5. Molecular formula: Au;Au. Mole weight: 196.96657g/mol. IUPAC Name: gold. SMILES: [Au]. InChI: InChI=1S/Au.
AUNP-12
AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grade: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55.
Au-PEG-Biotin, MW 550-5k
The functionalized and PEGylated highly concentrated gold nanoparticles have the same narrow size distribution as our non-functionalized particles but carry groups on the surface. Au multiple size options range from 5 nm to 100 nm. PEG molecular weight varies from 550 MW to 5000 MW. Synonyms: Gold Nanoparticles, Au-PEG-Biotin; Spherical Gold Nanoparticle-polyethylene glycol-biotin. Grade: ≥90%. Mole weight: Customizable.
AUR1545
AUR1545 is a selective KAT2A/KAT2B ((GCN5/PCAF)) PROTAC degrader that induces monocyte differentiation and inhibits the growth of acute myeloid leukemia cells. AUR1545 inhibits cell growth, induces epithelial differentiation and suppresses tumor growth in small cell lung cancer models. AUR1545 inhibits cell growth and induces differentiation in neuroendocrine prostate cancer cells and primary patient-derived organoids. AUR1545 is applicable to research related to acute myeloid leukemia, small cell lung cancer and neuroendocrine prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031593-79-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-173158.