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| Product | Description | |
|---|---|---|
| Axitinib | Inhibits VEGFR1, VEGFR2, VEGFR3, c-kit and PDGFR tyrosine kinases. Category: Active pharmaceutical ingredients. CAS No. 319460-85-0. Product ID: API319460850. Molecular formula: C22H18N4OS. Mole weight: 386.47. |  |
| Axitinib | Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG-013736. CAS No. 319460-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10065. |  |
| Axitinib | Axitinib. Group: Biochemicals. Alternative Names: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736. Grades: Highly Purified. CAS No. 319460-85-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H18N4OS. US Biological Life Sciences. |  Worldwide |
| Axitinib | Axitinib (AG013736) is a tyrosine kinase inhibitor developed by Pfizer. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Uses: Protein kinase inhibitors. Synonyms: AG 013736; N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide; Inlyta. Grade: ≥98%. CAS No. 319460-85-0. Molecular formula: C22H18N4OS. Mole weight: 386.5. |  |
| Axitinib-[13C,d3] | Axitinib-[13C,d3] is a labelled Axitinib. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Synonyms: [13C,2H3]-N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; (E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide. Grade: > 98%. CAS No. 1261432-00-1. Molecular formula: C21[13C]H15D3N4OS. Mole weight: 390.48. | |
| Axitinib Acid (Axitinib Impurity 37) | Axitinib Acid (Axitinib Impurity 37). Uses: For analytical and research use. CAS No. 319462-34-5. Molecular formula: C21H15N3O2S. Mole weight: 373.43. Catalog: APB319462345. |  |
| Axitinib (AG-013736) | Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. Group: Inhibitors. Alternative Names: AG 013736. CAS No. 319460-85-0. Pack Sizes: 50mg. Product ID: S1005. Formula: C22H18N4OS. Smiles: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Axitinib-d3 | Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG-013736-d3. CAS No. 1126623-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-10065S1. | |
| Axitinib-d3 | Labeled analogue of Axitinib, a tyrosine kinase inhibitor. Axitinib is used in cancer therapy. Group: Biochemicals. Alternative Names: N-(Methyl-d3)-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736-d3. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Axitinib-[d3] | Axitinib-[d3] is the labelled analogue of Axitinib. Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models. Synonyms: Axitinib D3; N-(Methyl-d3)-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; AG 013736-d3; Axitinib-d3 (N-methyl-d3). Grade: 95% by HPLC; 98% atom D. CAS No. 1126623-89-9. Molecular formula: C22H15D3N4OS. Mole weight: 389.49. | |
| Axitinib-D3 (Axitinib Impurity 36) | Axitinib-D3 (Axitinib Impurity 36). Uses: For analytical and research use. CAS No. 1126623-89-9. Molecular formula: C22H15D3N4OS. Mole weight: 389.49. Catalog: APB1126623899. | |
| Axitinib Impurity 1 | Axitinib Impurity 1 is an impurity of Axitinib, a drug primarily used in the treatment of advanced renal cell carcinoma and metastatic thyroid cancer. Synonyms: Axitinib Impurity c. Grade: > 95%. CAS No. 885126-40-9. Molecular formula: C22H18N4OS. Mole weight: 386.48. | |
| Axitinib Impurity 10 | Axitinib Impurity 10. Uses: For analytical and research use. Alternative Names: (E)-N-methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.61. Catalog: APB1443118726. | |
| Axitinib Impurity 11 | Axitinib Impurity 11. Uses: For analytical and research use. Alternative Names: 2-((1-acetyl-3-iodo-1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 1639138-00-3. Molecular formula: C17H14IN3O2S. Mole weight: 451.28. Catalog: APB1639138003. | |
| Axitinib Impurity 12 | Axitinib Impurity 12. Uses: For analytical and research use. Alternative Names: 2-((1H-indazol-6-yl)sulfinyl)-N-methylbenzamide. CAS No. 1959572-97-4. Molecular formula: C15H13N3O2S. Mole weight: 299.35. Catalog: APB1959572974. | |
| Axitinib Impurity 13 | Axitinib Impurity 13. Uses: For analytical and research use. Alternative Names: 2-((3-iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide. CAS No. 1443118-71-5. Molecular formula: C15H12IN3O2S. Mole weight: 425.24. Catalog: APB1443118715. | |
| Axitinib Impurity 14 | Axitinib Impurity 14. Uses: For analytical and research use. Alternative Names: 2-((3-iodo-1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 885126-34-1. Molecular formula: C15H12IN3OS. Mole weight: 409.24. Catalog: APB885126341. | |
| Axitinib Impurity 15 | Axitinib Impurity 15. Uses: For analytical and research use. Alternative Names: (Z)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide. CAS No. 885126-40-9. Molecular formula: C22H18N4OS. Mole weight: 386.47. Catalog: APB885126409. | |
| Axitinib Impurity 15 | Axitinib Impurity 15. Uses: For analytical and research use. CAS No. 1428728-84-0. Molecular formula: C44H36N8O2S2. Mole weight: 772.94. Catalog: APB1428728840. | |
| Axitinib Impurity 16 | Axitinib Impurity 16. Uses: For analytical and research use. Alternative Names: 2-((1-acetyl-1H-indazol-6-yl)thio)-N-methylbenzamide. Molecular formula: C17H15N3O2S. Mole weight: 325.38. Catalog: APB01212. | |
| Axitinib Impurity 17 | Axitinib Impurity 17. Uses: For analytical and research use. Alternative Names: N-methyl-2-((1-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide. CAS No. 2749797-54-2. Molecular formula: C22H20N4OS. Mole weight: 388.49. Catalog: APB2749797542. | |
| Axitinib Impurity 18 | Axitinib Impurity 18. Uses: For analytical and research use. Alternative Names: 2,2'-(1H,1'H-[3,3'-biindazole]-6,6'-diylbis(sulfanediyl))bis(N-methylbenzamide). Molecular formula: C30H24N6O2S2. Mole weight: 564.68. Catalog: APB02755. | |
| Axitinib Impurity 19 | Axitinib Impurity 19. Uses: For analytical and research use. CAS No. 319462-41-4. Molecular formula: C21H16N4OS. Mole weight: 372.48. Catalog: APB319462414. | |
| Axitinib Impurity 19 | Axitinib Impurity 19. Uses: For analytical and research use. Alternative Names: 1H-indazole-4,6-diamine. CAS No. 885518-52-5. Molecular formula: C7H8N4. Mole weight: 148.17. Catalog: APB885518525. | |
| Axitinib Impurity 2 | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide). Grade: > 95%. CAS No. 1428728-83-9. Molecular formula: C44H36N8O2S2. Mole weight: 772.96. | |
| Axitinib Impurity 2 | Axitinib Impurity 2. Uses: For analytical and research use. Alternative Names: 2,2'-((3,3'-(2,4-di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide). CAS No. 1428728-83-9. Molecular formula: C44H36N8O2S2. Mole weight: 772.94. Catalog: APB1428728839. | |
| Axitinib Impurity 20 | Axitinib Impurity 20. Uses: For analytical and research use. Alternative Names: 6-nitro-1-nitroso-1H-indazole. Molecular formula: C7H4N4O3. Mole weight: 192.13. Catalog: APB02754. | |
| Axitinib Impurity 20 | Axitinib Impurity 20. Uses: For analytical and research use. CAS No. 850568-25-1. Molecular formula: C12H11BN2O3. Mole weight: 242.04. Catalog: APB850568251. | |
| Axitinib Impurity 21 | Axitinib Impurity 21. Uses: For analytical and research use. Alternative Names: 2,2'-disulfanediylbis(N-methylbenzamide). CAS No. 2527-58-4. Molecular formula: C16H16N2O2S2. Mole weight: 332.44. Catalog: APB2527584. | |
| Axitinib Impurity 21 | Axitinib Impurity 21. Uses: For analytical and research use. CAS No. 6515-13-5. Molecular formula: C8H9N. Mole weight: 119.17. Catalog: APB6515135. | |
| Axitinib Impurity 22 | Axitinib Impurity 22. Uses: For analytical and research use. Alternative Names: 2-((2-(methylcarbamoyl)phenyl)disulfanyl)benzoic acid. Molecular formula: C15H13NO3S2. Mole weight: 319.40. Catalog: APB02753. | |
| Axitinib Impurity 23 | Axitinib Impurity 23. Uses: For analytical and research use. Alternative Names: (E)-1-(6-iodo-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-1-yl)ethanone. Molecular formula: C16H12IN3O. Mole weight: 389.19. Catalog: APB02751. | |
| Axitinib Impurity 23 | Axitinib Impurity 23. Uses: For analytical and research use. CAS No. 1443118-75-9. Molecular formula: C23H20N4O2S2. Mole weight: 448.56. Catalog: APB1443118759. | |
| Axitinib Impurity 24 | Axitinib Impurity 24. Uses: For analytical and research use. Alternative Names: (E)-2-(2-(6-((2-(methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)vinyl)pyridine 1-oxide. Molecular formula: C22H18N4O2S. Mole weight: 402.47. Catalog: APB02752. | |
| Axitinib Impurity 25 | Axitinib Impurity 25. Uses: For analytical and research use. Alternative Names: (E)-6-nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole. CAS No. 886230-75-7. Molecular formula: C19H18N4O3. Mole weight: 350.14. Catalog: APB886230757. | |
| Axitinib Impurity 26 | Axitinib Impurity 26. Uses: For analytical and research use. Alternative Names: (E)-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole. Molecular formula: C19H19N3O. Mole weight: 305.37. Catalog: APB02750. | |
| Axitinib Impurity 27 | Axitinib Impurity 27. Uses: For analytical and research use. Alternative Names: 2-((1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. Catalog: APB944835852. | |
| Axitinib Impurity 28 | Axitinib Impurity 28. Uses: For analytical and research use. CAS No. 886230-74-6. Molecular formula: C12H12IN3O3. Mole weight: 373.15. Catalog: APB886230746. | |
| Axitinib Impurity 28 | Axitinib Impurity 28. Uses: For analytical and research use. Alternative Names: 2,2'-((1H-indazole-3,6-diyl)bis(sulfanediyl))bis(N-methylbenzamide). Molecular formula: C23H20N4O2S2. Mole weight: 448.56. Catalog: APB02749. | |
| Axitinib Impurity 29 | Axitinib Impurity 29. Uses: For analytical and research use. CAS No. 319472-78-1. Molecular formula: C7H4I2N2. Mole weight: 369.93. Catalog: APB319472781. | |
| Axitinib Impurity 29 | Axitinib Impurity 29. Uses: For analytical and research use. Alternative Names: 2-((3-acetyl-1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 1443118-74-8. Molecular formula: C17H15N3O2S. Mole weight: 325.38. Catalog: APB1443118748. | |
| Axitinib Impurity 3 | Axitinib Impurity 3. Uses: For analytical and research use. Alternative Names: (E)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfinyl)benzamide. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.47. Catalog: APB1347304180. | |
| Axitinib Impurity 3 | Axitinib Impurity 3. Uses: For analytical and research use. Molecular formula: C30H24N6O2S2. Mole weight: 564.68. Catalog: APB06659. | |
| Axitinib Impurity 31 | Axitinib Impurity 31. Uses: For analytical and research use. CAS No. 886230-77-9. Molecular formula: C19H18IN3O. Mole weight: 431.28. Catalog: APB886230779. | |
| Axitinib Impurity 32 | Axitinib Impurity 32. Uses: For analytical and research use. CAS No. 2242852-05-5. Molecular formula: C19H19N3O. Mole weight: 305.38. Catalog: APB2242852055. | |
| Axitinib Impurity 33 | Axitinib Impurity 33. Uses: For analytical and research use. CAS No. 2527-66-4. Molecular formula: C8H7NOS. Mole weight: 165.21. Catalog: APB2527664. | |
| Axitinib Impurity 34 | Axitinib Impurity 34. Uses: For analytical and research use. CAS No. 319463-51-9. Molecular formula: C22H19ClN4OS. Mole weight: 422.93. Catalog: APB319463519. | |
| Axitinib Impurity 4 | Axitinib Impurity 4. Uses: For analytical and research use. Alternative Names: (E)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfonyl)benzamide. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. Catalog: APB1348536593. | |
| Axitinib Impurity 5 | Axitinib Impurity 5. Uses: For analytical and research use. Alternative Names: (Z)-2-(2-(6-((2-(methylcarbamoyl)phenyl)sulfinyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide. Molecular formula: C22H18N4O3S. Mole weight: 418.47. Catalog: APB02757. | |
| Axitinib Impurity 6 | Axitinib Impurity 6. Uses: For analytical and research use. Alternative Names: (Z)-2-(2-(6-((2-(methylcarbamoyl)phenyl)sulfonyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide. Molecular formula: C22H18N4O4S. Mole weight: 434.47. Catalog: APB02758. | |
| Axitinib Impurity 6 | Axitinib Impurity 6 is an impurity arising from the depths of Axitinib - an oral tyrosine kinase inhibitor profoundly employed in the therapy against advanced renal carcinoma. Synonyms: Axitinib Impurity d. Grade: > 95%. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.62. | |
| Axitinib Impurity 7 | Axitinib Impurity 7. Uses: For analytical and research use. Alternative Names: (E)-2-((1-acetyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 1639137-80-6. Molecular formula: C24H20N4O2S. Mole weight: 428.51. Catalog: APB1639137806. | |
| Axitinib Impurity 8 | Axitinib Impurity 8. Uses: For analytical and research use. Alternative Names: (Z)-6-nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole. Molecular formula: C19H18N4O3. Mole weight: 350.37. Catalog: APB02756. | |
| Axitinib Impurity 8 | Axitinib Impurity 8 is an impurity of axitinib fortifying the therapy against the perilous adversity known as advanced renal carcinoma. Synonyms: 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide; BenzaMide, 2-(1H-indazol-6-ylthio)-N-Methyl-; Axitinib Impurity e. Grade: > 95%. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. | |
| Axitinib Impurity 9 | Axitinib Impurity 9. Uses: For analytical and research use. Alternative Names: N-methyl-2-((3-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide. CAS No. 1443118-73-7. Molecular formula: C22H20N4OS. Mole weight: 388.49. Catalog: APB1443118737. | |
| Axitinib Impurity C | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide; Axitinib EP Impurity C; Axitinib Impurity 56. Grade: ≥95%. CAS No. 1959572-97-4. Molecular formula: C15H13N3O2S. Mole weight: 299.35. | |
| Axitinib Impurity D | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2-[(1-Acetyl-1H-indazol-6-yl)sulfinyl]-N-methylbenzamide; Axitinib EP Impurity D. Grade: ≥95%. CAS No. 1959572-98-5. Molecular formula: C17H15N3O3S. Mole weight: 341.38. | |
| Axitinib N-oxide | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: (E)-N-Methyl-2-[[3-[2-(1-oxido-2-pyridinyl)ethenyl]-2H-indazol-6-yl]thio]benzamide. Grade: ≥95%. Molecular formula: C22H18N4O2S. Mole weight: 402.47. | |
| Axitinib sulfone | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Sulfonyl axitinib; (E)-N-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylsulfonyl)benzamide; N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Grade: ≥95%. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. | |
| Axitinib sulfoxide | A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide; Axitinib Impurity A. Grade: > 95%. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.48. | |
| AXKO-0046 | AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC50 value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3103525-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147216. | |
| Axltide | Axltide is based on mouse insulin receptor substrate 1 (amino acids 979-989). It is also a substrate for the kinases AXL, DDR2, MST1 and JAK2. Synonyms: Axl/Insulin Receptor Substrate Peptide; H-Lys-Lys-Ser-Arg-Gly-Asp-Tyr-Met-Thr-Met-Gln-Ile-Gly-OH; L-lysyl-L-lysyl-L-seryl-L-arginyl-glycyl-L-alpha-aspartyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-glutaminyl-L-isoleucyl-glycine. Grade: ≥98%. CAS No. 143364-95-8. Molecular formula: C63H107N19O20S2. Mole weight: 1514.77. | |
| AY 9944 | Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol ?7-reductase and ?8,7-sterol isomerase. A sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: trans-N1, N4-Bis [ (2-chlorophenyl) methyl ] -1, 4-cyclohexane dimethanamine Hydrochloride; N, N'-Bis (o-chlorobenzyl)-trans-1, 4-cyclohexanebis (methylamine) Dihydrochloride. Grades: Highly Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 | AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 366-93-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107420. | |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. | |
| Ayanin | Ayanin isolated from the rhizomes of Curcuma aromatica. Synonyms: QUERCETIN 3,7,4'-TRIMETHYL ETHER; AYANIN; 2-(3-Hydroxy-4-methoxyphenyl)-3,7-dimethoxy-5-hydroxy-4H-1-benzopyran-4-one; 3',5-Dihydroxy-3,4',7-trimethoxyflavone; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxychromen-4-one. Grade: 0.985. CAS No. 572-32-7. Molecular formula: C18H16O7. Mole weight: 344.3. | |
| AY-NH2 | AY-NH2. Group: Biochemicals. Grades: Purified. CAS No. 352017-71-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AY-NH2 | AY-NH is a selective proteinase-activated receptor 4 (PAR4) receptor agonist peptide. It stimulates aggregation of rat and human platelets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. Synonyms: PAR-4 Agonist Peptide, amide; L-Alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide; PAR-4-AP; Proteinase-activated Receptor 4 Activating Peptide. Grade: 98%. CAS No. 352017-71-1. Molecular formula: C34H48N8O7. Mole weight: 680.79. | |
| AZ0108 | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one; AZ0108; AZ-0108; AZ 0108. Grade: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
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