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| Product | Description | |
|---|---|---|
| Auristatin F | Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N,N-Dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-; N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide. Grade: ≥97% by HPLC. CAS No. 163768-50-1. Molecular formula: C40H67N5O8. Mole weight: 745.99. |  |
| Auristatin F | Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163768-50-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15583. |  |
| Aurkin A | Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1534060-58-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125956. | |
| Aurodox | It is produced by the strain of Streptomyces goldiniensis var. goldiniensis. Aurodox is a polyketide antibiotic originally isolated from S. goldiniensis, which inhibits bacterial protein biosynthesis by interrupting the functional cycle of Elongation Factor-Tu (EF-Tu). Aurodox is a type 3 secretion system (T3SS) inhibitor and growth promotor in poultry. It is active against Gram-positive bacteria, including B. megaterium, B. anthracis, and M. hominis (MICs = 0.06, 0.6, and 3-10 μg/ml, respectively). Synonyms: Antibiotic X 5108; Goldinodox; Goldinomycin; 1-methyl-Mocimycin; Benzamide; CYT11387. Grade: ≥95%. CAS No. 12704-90-4. Molecular formula: C44H62N2O12. Mole weight: 810.97. | |
| Aurodox (1-Methylmocimycin, Antibiotic X 5108, Goldinodox, Goldinomycin, NSC 233989) | Antibiotic. Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu). Type 3 secretion system (T3SS) inhibitor. Growth promotor in poultry. Group: Biochemicals. Grades: Highly Purified. CAS No. 12704-90-4. Pack Sizes: 1mg, 2.5mg. US Biological Life Sciences. |  Worldwide |
| Aurodox (1-Methylmocimycin, Antibiotic X 5108, Goldinodox, Goldinomycin, NSC 233989, Benzamide, CYT11387) | Isolated from Streptomyces sp. K06-0806. Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu). Effective against streptococcus pyogenes infections. It may promote growth in poultry. Group: Biochemicals. Grades: Highly Purified. CAS No. 12704-90-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Aurofusarin | Dimeric naphthoquinone. Antibiotic activity. Mycotoxin. Toxic against mammalians and avian species. Analytical standard in food industry. Group: Biochemicals. Alternative Names: 4H-Naphtho[2,3-b]pyran, bimol. deriv.; 5,5-Dihydroxy-8,8-dimethoxy-2,2-dimethyl[7,7-bi-4H-naphtho[2,3-b]pyran]-4,4,6,6,9,9-hexone; Aurofusarin; NSC 244432. Grades: Highly Purified. CAS No. 13191-64-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Auroglaucin | It is produced by the strain of Aspergillus spp. Synonyms: 2-[(1E,3E,5E)-1,3,5-Heptatrienyl]-3,6-dihydroxy-5-(3-methyl-2-butenyl)benzaldehyde; Auroglaucine; 2-((1E,3E,5E)-hepta-1,3,5-trien-1-yl)-3,6-dihydroxy-5-(3-methylbut-2-en-1-yl)benzaldehyde. CAS No. 41451-81-4. Molecular formula: C19H22O3. Mole weight: 298.38. | |
| Aurora 3, Control peptide (STK13, Serine Threonine Kinase 13, Aurora C, AIE2, AIK3, Aurora Related Kinase 3, Aurora/IPL1-like) | A synthetic peptide derived from the N-terminus of the human Aurora-3 protein. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Aurora A Inhibitor I | Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM. It is 1000-fold more selective for Aurora A than Aurora B. Synonyms: TC-S 7010; TC S 7010; TCS7010. Grade: >98%. CAS No. 1158838-45-9. Molecular formula: C31H31ClFN7O2. Mole weight: 588.07. | |
| Aurora A inhibitor II | Aurora A inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA; IC50 = 4.3 nM). Synonyms: 4-[[2-[[4-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)-Benzamide. Grade: 99%. CAS No. 1158838-43-7. Molecular formula: C31H29ClFN7O3. Mole weight: 602.06. | |
| Aurora B inhibitor 1 | Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor. It also inhibits JAK3 and JAK2. Synonyms: Methanone, (5-chloro-2-fluorophenyl)?[(3S)?-3-[[4-(3-cyclopropyl-3-fluoro-1-azetidinyl)?-6-[(5-methyl-1H-pyrazol-3-yl)?amino]?-2-pyrimidinyl]?oxy]?-1-pyrrolidinyl]?-. CAS No. 937276-52-3. Molecular formula: C25H26ClF2N7O2. Mole weight: 529.97. | |
| Aurora inhibitor 1 | Aurora inhibitor 1 is a potent Aurora inhibitor (IC50 = 4 nM and 13 nM for Aurora A and Aurora B kinase). CAS No. 2227019-45-4. Molecular formula: C23H25N9S. Mole weight: 459.57. | |
| Aurora Kinase A active human, Recombinant | Aurora A kinase also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. Human aurora kinase a (genbank accession no. nm_003600), amino acids 2-403 with n-terminal his6-tag, mw=50 kda, expressed in a baculovirus infected sf9 cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7. Purity: > 90% (SDS-PAGE). ARK1. Mole weight: mol wt 50 kDa. Activity: ~17,000 units/mg protein. Form: aqueous solution. Source: baculovirus infected Sf9 cells. Species: Human. Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7. Pack: Minimum 50 ng protein/vial by Bradford. Cat No: NATE-0087. |  |
| Aurora kinase inhibitor-2 | Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 331770-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112355. | |
| Aurora Kinase Inhibitor II | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 μM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Synonyms: 4-(4?-Benzamidoanilino)-6,7-dimethoxyquinazoline. Grade: ≥98%. CAS No. 331770-21-9. Molecular formula: C23H20N4O3. Mole weight: 400.4. | |
| Aurora Kinase Inhibitor III | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grade: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| Aurora Kinase Inhibitor VI, ZM447439 (4-(4-(N-Benzoylamino)anilino)-6- methoxy-7- (3- (1-morpholino) propoxy) quinazoline) | A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50=110 and 130nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50=0.88, 1.03 and 1.79uM for Lck, Src and MEK1, respectively, and IC50>10uM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20uM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aurothioglucose | Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: AUROTHIOGLUCOSE; Solganal; 12192-57-3; Gold thioglucose; Aurothioglucose 80%; Aurothioglucose hydrate; Solganol; Gold(1+); 3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-thiolate; gold(1+); (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-thiolate; DTXSID5046013; NCGC00096015-01; Spectrum_001866; NSC-759601; KBioSS_002383; SPECTRUM1500132; DTXCID3026013; KBio2_002379; KBio2_004947; KBio2_007515; HMS2091K17; Pharmakon1600-01500132; Tox21_111549; NSC759601; CCG-213700; PD057378; SBI-0206666.P002; CAS-12192-57-3; AB00053375_02; SR-05000001568; SR-05000001568-1; BRD-A89825407-001-01-8. Grade: >98%. CAS No. 12192-57-3. Molecular formula: C6H11AuO5S. Mole weight: 392.18. | |
| Aurothioglucose | Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gold thioglucose. CAS No. 12192-57-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-A0068. | |
| Aurothioglucose-13C6 | Aurothioglucose-13C6 is a labelled analogue of Aurothioglucose, which is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: [1-(thio-κS)-D-Glucopyranosato-κO2]-gold-13C6; 1-thio-D-Glucose S-gold Derivative-13C6; (1-thio-D-Glucopyranosato)-Gold-13C6; (1-thio-D-Glucopyranosato-O2,S1)gold-13C6; 1-thio-D-Glucopyranose Gold Complex-13C6; (D-Glucopyranosylthio)gold-13C6; Aureotan-13C6; Auromyose-13C6; Aurothioglucose-13C6; Aurumine-13C6; Authron-13C6; Brenol-13C6; 1-thio-Glucose Gold Salt (1:1)-13C6; Glysanol B-13C6; Gold Thioglucose-13C6; (D-Glucopyranosylthio)gold-13C6; Oronol-13C6; Solganal-13C6; Solganal B-13C6. Grade: 70% by HPLC; 98.7% atom 13C. Molecular formula: [13C]6H11AuO5S. Mole weight: 398.14. | |
| Australian Chemical Suppliers | Australian Chemical Suppliers Database | Australian Chemical Suppliers Australia |
| Australifungin | Australifungin is produced by the strain of Sporormiella australis. As an inhibitor of Shinganine n-acyl-transferase, it has strong antifungal activity, with MIC of 0.015-0.5 μg/mL for candida, cryptococcus neoforme, saccharomyces cerescens and other fungi, and 0.125 ~ 1μg/ mL for aspergillus. Australian fennetol has a low antifungal effect. Molecular formula: C23H36O6. Mole weight: 408.53. | |
| Australine hydrochloride | Australine hydrochloride. Alternative Names: AUSTRALINE HCL;AUSTRALINE HYDROCHLORIDE;AUSTRALINE, HYDROCHLORIDE, CASTANOSPERMUM AUSTRALE;(1R,2R,3R,7S,7AR)-3-HYDROXYMETHYL-1,2,7-TRIHYDROXYPYRROLIZIDINE HCL;(1R,2R,3R,7S,7AR)-3-HYDROXYMETHYL-1,2,7-TRIHYDROXYPYRROLIZIDINE, HYDROCHLORIDE;1H-Pyrrolizine-1. CAS No. 118396-02-4. Product ID: ACM118396024. Molecular formula: C8H16ClNO4. Mole weight: 225.67. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Australine,hydrochloride,castanospermum australe | Australine,hydrochloride,castanospermum australe. Alternative Names: AUSTRALINE HCL;AUSTRALINE HYDROCHLORIDE;AUSTRALINE, HYDROCHLORIDE, CASTANOSPERMUM AUSTRALE;(1R,2R,3R,7S,7AR)-3-HYDROXYMETHYL-1,2,7-TRIHYDROXYPYRROLIZIDINE HCL;(1R,2R,3R,7S,7AR)-3-HYDROXYMETHYL-1,2,7-TRIHYDROXYPYRROLIZIDINE, HYDROCHLORIDE. CAS No. 186766-07-4. Purity: ≥95%. Product ID: ACM186766074. Molecular formula: C8H15NO4.HCl. Mole weight: 225.67. Alfa Chemistry - ISO 9001:32057 Certified. | |
| AUT1 | AUT1 is a modulator of recombinant human Kv3 channel. Synonyms: AUT-1; AUT 1. Grade: 98% by HPLC. CAS No. 1311136-84-1. Molecular formula: C18H19N3O4. Mole weight: 341.4. | |
| AUTAC1 | AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC), which contains a degradation tag and a warhead to provide target specificity. It is composed of an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety, with the Fumagillol binding covalently to MetAP2. AUTAC1 has potential anticancer activity as it can degrade MetAP2 and FKBP12 proteins and is used in the synthesis of PROTACs. This compound represents a novel targeted-clearance strategy that harnesses the autophagy-lysosome pathway for the degradation of specific proteins, expanding the scope of targeted protein degradation beyond the limitations of proteasomal clearance. Synonyms: (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl ((R)-4-(((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)methyl)-2,5-dioxo-10,13,16-trioxa-3,6-diazanonadecan-19-yl)carbamate; 6,9,12-Trioxa-2,16,19-triazaheneicosanoic acid, 18-[[[2-amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-17,20-dioxo-. Grade: ≥95%. CAS No. 2241669-09-8. Molecular formula: C44H63FN8O11S. Mole weight: 931.08. | |
| AUTAC4 | AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2267315-04-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-134640. | |
| Au TiO2 Core Shell Nanoparticles | Au TiO2 Core Shell Nanoparticles. Purity: 99.9%. |  |
| Au TiO2 Core-Shell Nanoparticles | Au TiO2 Core-Shell Nanoparticles. Purity: 99.9%. | |
| Autocamtide 2 | Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Autocamtide II; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine. Grade: ≥95%. CAS No. 129198-88-5. Molecular formula: C65H118N22O20. Mole weight: 1527.77. | |
| Autocamtide 2, amide | Autocamtide 2, amide is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-NH2. Grade: ≥95%. Molecular formula: C65H119N23O19. Mole weight: 1526.79. | |
| Autocamtide 2-related inhibitory peptide | Autocamtide 2-related inhibitory peptide. Uses: For analytical and research use. CAS No. 167114-91-2. Mole weight: 1497.74. Catalog: AP167114912. |  |
| Autocamtide-2-related inhibitory peptide | Autocamtide-2-related inhibitory peptide. Group: Biochemicals. Grades: Purified. CAS No. 167114-91-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Autocamtide-2-Related Inhibitory Peptide | Autocamtide-2-related inhibitory peptide is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II) with I50 value of 40 nM. It is selective over PKC, PKA and CaM kinase IV. Synonyms: AIP; [Ala9]-Autocamtide 2. Grade: ≥97% by HPLC. CAS No. 167114-91-2. Molecular formula: C64H116N22O19. Mole weight: 1497.74. | |
| Autocamtide-2-related inhibitory peptide, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. It blocks reinstatement of morphine-seeking behavior in vivo by pretreatment. Synonyms: AIP Myristoylated; Myr-AIP. Grade: >98%. CAS No. 201422-04-0. Molecular formula: C78H142N22O20. Mole weight: 1708.12. | |
| Autocamtide-2-related inhibitory peptide, myristoylated acetate | Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor that blocks the reinstatement of morphine-seeking behavior in vivo by pretreatment. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. Synonyms: AIP Myristoylated acetate; Myr-AIP acetate; N2-(1-Oxotetradecyl)-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine acetate; m-AIP acetate; Myristoylated autocamtide-2-related inhibitory peptide acetate; H-Lys(myristoyl)-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.CH3CO2H. Grade: ≥95%. Molecular formula: C80H146N22O22. Mole weight: 1768.15. | |
| Autocamtide-2-related inhibitory peptide TFA | Autocamtide-2-related inhibitory peptide TFA is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II). Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide-2-Related Inhibitory Peptide Trifluoroacetate; CaM kinase II inhibitor TFA salt. Grade: ≥98%. Molecular formula: C64H116N22O19.C2HF3O2. Mole weight: 1611.76. | |
| Autocamtide 2 TFA | Autocamtide 2 TFA is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide 2 trifluoroacetate salt. Grade: ≥95%. Molecular formula: C67H119F3N22O22. Mole weight: 1641.79. | |
| Autogramin-1 | Autogramin-1 is a novel autophagy inhibitor that selectively targets the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A), and directly competes with cholesterol binding to the GRAMD1A StART domain. Synonyms: Autogramin 1; Autogramin1. Grade: >98%. CAS No. 2375541-73-2. Molecular formula: C23H27N5O5S. Mole weight: 485.56. | |
| autoinducer-2 kinase | The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. Group: Enzymes. Synonyms: lsrK (gene name). Enzyme Commission Number: EC 2.7.1.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3021; autoinducer-2 kinase; EC 2.7.1.189; lsrK (gene name). Cat No: EXWM-3021. | |
| Autoinducing Peptide I | Autoinducing Peptide I is a cyclic octapeptide secreted by Staphylococcus aureus and can be used in vaccine research[1]. Uses: Scientific research. Category: Peptides. Alternative Names: AIP-I. CAS No. 200010-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4909. | |
| Autoinducing Peptide I | Autoinducing Peptide I is an autoinducing peptide (AIP) that activates the agr (accessory gene regulator) site to control the expression of extracellular proteins in S. aureus. Synonyms: AIP1; H-Tyr-Ser-Thr-cyclo(-Cys-Asp-Phe-Ile-Met); L-Methionine, L-tyrosyl-L-seryl-L-threonyl-L-cysteinyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-, (8→4)-thiolactone; L-Tyrosyl-L-seryl-N-{(3S,6S,9S,12S,15R)-9-benzyl-6-[(2S)-2-butanyl]-12-(carboxymethyl)-3-[2-(methylsulfanyl)ethyl]-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetraazacyclohexadecan-15-yl}-L-threoninamide. Grade: ≥95%. CAS No. 200010-29-3. Molecular formula: C43H60N8O13S2. Mole weight: 961.11. | |
| Autophagy Compound Library | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. |  |
| Autophagy-IN-5 | Autophagy-IN-5 (Compound A9) is an inhibitor for autophagy with an EC50 of 0.736 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262888-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160896. | |
| Autophagy-IN-C1 | Autophagy-IN-C1 can induce apoptosis and block autophagy in hepatocellular carcinoma (HCC) cells. Synonyms: Autophagy-IN-C1; CHEMBL5082200; HY-141813; CS-0226365; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)urea. Molecular formula: C29H28F6N4O2. Mole weight: 578.55. | |
| Autophagy inducer 3 | Autophagy inducer 3 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2691054-63-2. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146052. | |
| Autophagy Inhibitor IV, Cpd18 (3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18) | A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10mM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Autophinib | Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644443-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101920. | |
| Autophinib | Autophinib is a novel potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin with IC50 values of 0.04 μM and 0.09 μM, respectively. Synonyms: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine. CAS No. 1644443-47-9. Molecular formula: C14H11ClN6O3. Mole weight: 346.73. | |
| Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one) | An orally bioavailable piperazinyl benzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidyl choline) as substrates, respectively; 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.).CAS No:1144035-53-9. Group: Biochemicals. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| Auxinole | Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression. Uses: Scientific research. Category: Signaling pathways. CAS No. 86445-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111444. | |
| Auxinole | Auxinole is a potent TIR1 antagonist. Auxinole binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex, suppressing auxin-responsive gene expression. Synonyms: BS-45814; HY-111444. Grade: 99%. CAS No. 86445-22-9. Molecular formula: C20H19NO3. Mole weight: 321.37. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grade: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| AUZ 454 | AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. Uses: Scientific research. Category: Signaling pathways. Alternative Names: K03861. CAS No. 853299-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15004. | |
| AV-153 | AV-153, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 3,5-Diethyl 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-3,4,5-pyridinetricarboxylate monosodium salt; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-, 3,5-diethyl ester, monosodium salt; 2,6-Dimethyl-1,4-dihydro-3,5-bis(ethoxycarbonyl)pyridine-4-carboxylic acid sodium salt; Sodium 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylate. CAS No. 27296-05-5. Molecular formula: C14H18NNaO6. Mole weight: 319.29. | |
| AV-153 free base | AV-153 free base, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; 3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylic acid; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester; 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid. Grade: ≥95%. CAS No. 19350-66-4. Molecular formula: C14H19NO6. Mole weight: 297.30. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| AV-412 Tosylate | AV-412 is a dual EGFR/ErbB2 kinase inhibitor. It completely inhibits the tumor growth of both H1650 and H1975 xenografts in nude mice. It is proved that AV-412 suppresses tumor growth via the inhibition of EGFR. Besides that, AV-412 also shows antitumor effects against various tumor models expressing EGFR, ErbB2 or both receptors, such as breast cancer KPL-4, prostate cancer DU145 and lung cancer LC-376. Uses: Antineoplastic agents. Synonyms: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate); MP-412; MP 412; MP412; AV-412; AV 412; AV412; AV-412 tosylate. Grade: >98%. CAS No. 451493-31-5. Molecular formula: C41H44ClFN6O7S2. Mole weight: 851.41. | |
| Ava10-Terlipressin | An impurity of Terlipressin. Terlipressin is a synthetic vasopressin analogue primarily used to improve kidney function in adults with hepatorenal syndrome (HRS), a condition that causes kidney problems in individuals with severe liver disease. It acts as a vasoconstrictor, predominantly in the splanchnic circulation, which helps increase arterial pressure and reduce portal venous pressure. Synonyms: Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2(Cys4&Cys9 bridge); [Ava10]-Terlipressin; GGGCYFQNC-Ava-KG-NH2(Cys4&Cys9 bridge); Ava(10)-Terlipressin; [5-Aminovaleric acid]10-Terlipressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9); Glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-5-aminopentanoate-L-lysyl-glycinamide (4->9)-disulfide. Grade: ≥95%. Molecular formula: C52H76N16O15S2. Mole weight: 1229.39. | |
| Ava23-Calcitonin (salmon) | An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Ava-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); Ava Calcitonin; [Ava23]-Calcitonin (salmon); CSNLSTCVLGKLSQELHKLQTY-Ava-RTNTGSGTP-NH2(Cys1&Cys7 bridge); L-Cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-5-aminopentanoate-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide; Proline ring opening calcitonin (salmon); Calcitonin (salmon) (Proline ring opening); [5-Aminovaleric acid]23-calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H242N44O48S2. Mole weight: 3433.91. | |
| Avacincaptad pegol | To treat geographic atrophy secondary to age-related macular degeneration. Category: Active pharmaceutical ingredients. Synonyms: ARC1905. CAS No. 1491144-00-3. Product ID: API1491144003. Molecular formula: C395H492N142O262P39F21((CH2)2O)n. Mole weight: 56 kDa. |  |
| Avacincaptad pegol | Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Izervay. CAS No. 1613641-69-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148457. | |
| Avacincaptad pegol sodium | Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARC1905. CAS No. 1491144-00-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147080. | |
| Avacopan | Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC50 of 0.1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCX168. CAS No. 1346623-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17627. | |
| Avadomide | Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC 122. CAS No. 1015474-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100507. | |
| Avadomide hydrochloride | Avadomide hydrochloride. Alternative Names: CC 122 hydrochloride. CAS No. 1398053-45-6. Product ID: ACM-MG-1398053456. Molecular formula: C14H15ClN4O3. Mole weight: 322.75. IUPAC Name: 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione;hydrochloride. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grade: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. | |
| Avagacestat | Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-708163. CAS No. 1146699-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50845. | |
| Avanafil | Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TA1790. CAS No. 330784-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18252. | |
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