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| Product | Description | |
|---|---|---|
| AZD4573 | AZD4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2057509-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112088. |  |
| AZD-4635 | AZD-4635 is an orally available adenosine 2A receptor (A2AR) inhibitor. Synonyms: AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071; 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine. CAS No. 1321514-06-0. Molecular formula: C15H11ClFN5. Mole weight: 315.736. |  |
| AZD-4694 | AZD-4694 is a bio-active chemical compound and is used as a diagnostic imaging agent. It was developed by AstraZeneca. Synonyms: AZD 4694; AZD-4694; AZD4694; NAV4694; NAV 4694; NAV-4694; Flutafuranol; 2-(2-Fluoro-6-methylaminopyridin-3-yl)benzofuran-5-ol. Grade: >98%. CAS No. 1054629-49-0. Molecular formula: C14H11FN2O2. Mole weight: 258.25. | |
| AZD4721 | AZD4721, a potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2), has the potential to study inflammatory diseases. Synonyms: RIST4721; N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide; 1-Azetidinesulfonamide, N-[6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-2-[[(4-fluorophenyl)methyl]thio]-4-pyrimidinyl]-3-methyl-. Grade: ≥95%. CAS No. 1418112-77-2. Molecular formula: C19H25FN4O5S2. Mole weight: 472.55. | |
| AZD4747 | AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2489226-14-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154959. | |
| AZD-4818 | AZD-4818 is a potent, orally active antagonist of chemokine CCR1. AZD-4818 can be used for researching chronic obstructive pulmonary disease (COPD) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1003566-93-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15545. | |
| AZD4877 | AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly. Synonyms: AZD-4877; AZD 4877; (+)-N-(3-Aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide. CAS No. 1176760-49-8. Molecular formula: C28H33N5O2S. Mole weight: 503.66. | |
| AZD-5069 | AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Synonyms: AZD-5069; AZD 5069; AZD5069. Grade: 98%. CAS No. 878385-84-3. Molecular formula: C18H22F2N4O5S2. Mole weight: 476.51. | |
| AZD-5069 | AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment. Uses: Scientific research. Category: Signaling pathways. CAS No. 878385-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19855. | |
| AZD5153 | AZD5153 is a bivalent, selective, and orally active BET/BRD4 bromodomain inhibitor with an IC50 of value of 5 nM for full-length BRD4 (FL-BRD4). AZD5153 ligates two bromodomains in BRD4 simultaneously. AZD5153 can be used for the study of cancer, such as acute myeloid leukemia, multiple myeloma, and diffuse large B-cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1869912-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100653. | |
| AZD 5153 | AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET). It can simultaneously bind two bromodomains in BRD4 with the IC50 value of 5 nM, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. AZD5153 also shows enhanced potency as a result of bivalent binding and a clear correlation between BRD4 activity and cellular potency. Synonyms: AZD-5153; AZD5153; (R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one. Grade: 98%. CAS No. 1869912-39-9. Molecular formula: C25H33N7O3. Mole weight: 479.57. | |
| AZD5153 6-Hydroxy-2-naphthoic acid | AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1869912-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100653A. | |
| AZD5153 6-Hydroxy-2-naphthoic acid | AZD5153 6-Hydroxy-2-naphthoic acid, a 6-hydroxy-2-naphthoic acid salt of AZD-5153, is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor possessing a bivalent binding mode (pKi = 8.3 for BRD4). Synonyms: AZD5153 6-Hydroxy-2-naphthoic acid; AZD 5153 6-Hydroxy-2-naphthoic acid; AZD-5153 6-Hydroxy-2-naphthoic acid; 6-hydroxynaphthalene-2-carboxylic acid; 4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one. CAS No. 1869912-40-2. Molecular formula: C36H41N7O6. Mole weight: 667.75. | |
| AZD5248 | AZD5248 is a dipeptidyl peptidase 1 (DPP1) inhibitor that can be used for the research of chronic obstructive lung disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254318-44-9. Pack Sizes: 1 mg. Product ID: HY-12733. | |
| AZD5305 | AZD5305 is a potent, selective and orally active inhibitor of PARP1 with IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 is under clinical trials for advanced solid tumor treatment. Synonyms: Saruparib; AZD 5305; AZD-5305. CAS No. 2589531-76-8. Molecular formula: C22H26N6O2. Mole weight: 406.48. | |
| AZD5305 (Saruparib) | Saruparib (AZD5305) is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM). Group: Inhibitors. CAS No. 2589531-76-8. Pack Sizes: 5mg. Product ID: S9875. Formula: C22H26N6O2. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| AZD 5363 | AZD5363 is used in inhibiting the proliferation of certain tumor cell lines. Inhibits AKT1, AKT2, AKT3, P70S6K and PKA. Group: Biochemicals. Grades: Highly Purified. CAS No. 1143532-39-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H25ClN6O2, Molecular Weight: 428.95. US Biological Life Sciences. |  Worldwide |
| AZD-5363 | AZD-5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD-5363 binds to and inhibits all AKT isoforms. This agent may be used as monotherapy or combination therapy for a variety of human cancers. Synonyms: AZD5363; AZD 5363; Capivasertib. Grade: 98%. CAS No. 1143532-39-1. Molecular formula: C21H25ClN6O2. Mole weight: 428.9152. | |
| AZD5363 (Capivasertib) | Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2. Group: Inhibitors. CAS No. 1143532-39-1. Pack Sizes: 5mg. Product ID: S8019. Formula: C21H25ClN6O2. Smiles: C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AZD 5363 dihydrochloride | AZD5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD5363 binds to and inhibits all AKT isoforms.This agent may be used as monotherapy or combination therapy for a variety of human cancers. Synonyms: (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide dihydrochloride. Grade: 99%. CAS No. 2108875-84-7. Molecular formula: C21H25ClN6O2.2HCl. Mole weight: 501.84. | |
| AZD5423 | AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1034148-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108243. | |
| AZD-5423 | AZD-5423 is a nonsteroidal glucocorticoid. It is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. It was developed by AstraZeneca. Uses: Azd-5423 is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. Synonyms: AZD-5423; AZD 5423; AZD5423; UNII-641H0Q518W; 2,2,2-Trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)-2-propanyl)acetamide. Grade: >98 %. CAS No. 1034148-04-3. Molecular formula: C25H21F4N3O3. Mole weight: 487.45. | |
| AZD5438 | AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively). Broad cdk inhibition may provide an effective method to impair the dysregulated cell cycle that drives tumorigenesis and AZD5438 has the pharmacologic profile that provides an ideal probe to test this premise. Synonyms: AZD5438; AZD-5438; AZD 5438. Grade: 0.98. CAS No. 602306-29-6. Molecular formula: C18H21N5O2S. Mole weight: 371.45664. | |
| AZD-5438 | AZD-5438 is a potent CDK1, CDK2, and CDK9 inhibitor, with IC50s of 16 nM, 6 nM, and 20 nM in cell-free assays, respectively. AZD-5438 shows less inhibition activity against GSK3β, CDK5 and CDK6[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 602306-29-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10012. | |
| AZD5462 | AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2787501-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148087. | |
| AZD5582 | AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1258392-53-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12600. | |
| AZD5582 | AZD5582 is a potent IAP inhibitor, which is a dimeric compound based on the AVPI motif of Smac. AZD5582 binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). AZD5582 causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro. AZD5582 was nominated as a candidate for clinical development. Synonyms: AZD5582; AZD-5582; AZD 5582. Grade: ≥98% by HPLC. CAS No. 1258392-53-8. Molecular formula: C58H78N8O8. Mole weight: 1015.31. | |
| AZD5582 acetate | AZD5582 acetate is a potent IAP inhibitor that binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). It causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro. Synonyms: AZD 5582 acetate; AZD-5582 acetate; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide] acetate. Grade: ≥95%. Molecular formula: C60H82N8O10. Mole weight: 1075.36. | |
| AZD 5582 dihydrochloride | AZD 5582 dihydrochloride is a potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein. It can bind to the BIR3 domain of XIAP to prevent interaction with caspase-9. Synonyms: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide. Grade: ≥97%. CAS No. 1883545-51-4. Molecular formula: C58H78N8O8·2HCl. Mole weight: 1088.21. | |
| AZD5582 dihydrochloride | AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883545-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110346. | |
| AZD5597 | AZD5597 is an inhibitor of CDK with IC50 values of both 2 nM for CDK1 and CDK2. AZD5597 can inhibit the proliferation of tumor cells and has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924641-59-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-50914. | |
| AZD-5597 | AZD-5597 is a potent CDK inhibitor with in vitro anti-proliferative effects against a range of cancer cell lines. AZD-5597 has excellent physiochemical properties and large margins against inhibition of CYP isoforms and the hERG ion channel. Synonyms: AZD 5597; AZD5597; Methanone, [4-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]-; [4-[[5-Fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]methanone; (S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone. Grade: >98%. CAS No. 924641-59-8. Molecular formula: C23H28FN7O. Mole weight: 437.52. | |
| AZD-5672 | AZD5672 is CCR5 receptor antagonist originated by AstraZeneca. In Jul 2009, Phase-II for Rheumatoid arthritis in USA was discontinued. Uses: Rheumatoid arthritis. Synonyms: AZD-5672; AZD 5672; AZD5672; UNII-61XQN688TW; (R)-N-(1-(3-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-(methylsulfonyl)phenyl)acetamide. Grade: 98%. CAS No. 780750-65-4. Molecular formula: C32H38F2N2O5S2. Mole weight: 632.79. | |
| AZD5904 | AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. Uses: Scientific research. Category: Signaling pathways. CAS No. 618913-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111341. | |
| AZD-5904 | AZD-5904 is a potent orally bioavailable MPO inhibitor. It inhibited the isolated MPO enzyme with an IC50 value of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity. It was used for multiple sclerosis and COPD and has been evaluated in single and multiple dose studies in healthy volunteers. Uses: Azd-5904 was used for multiple sclerosis and copd. Synonyms: AZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904. (S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one. Grade: 98%. CAS No. 618913-30-7. Molecular formula: C10H12N4O2S. Mole weight: 252.29. | |
| AZD5991 | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grade: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
| AZD-5991 | AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143061-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101533. | |
| AZD-5991 (S-enantiomer) | AZD-5991 (S-enantiomer), the less active enantiomer of AZD-5991, is an McL-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay. Uses: Antineoplastic agents. Synonyms: 22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-, (3aS)-. Grade: ≥95%. CAS No. 2143061-82-7. Molecular formula: C35H36ClN5O3S3. Mole weight: 672.26. | |
| AZD-6126 | AZD6126 is a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. Synonyms: AZD6126; AZD 6126; N-Acetylcochinol-O-phosphate; (5S)-5-acetamido-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-3-yl dihydrogen phosphate; N-[9,10,11-Trimethoxy-3-(phosphonooxy)-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl]ethanimidic acid. CAS No. 219923-05-4. Molecular formula: C20H24NO8P. Mole weight: 437.38. | |
| AZD6244 (Selumetinib) | Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3. Group: Inhibitors. Alternative Names: ARRY-142886. CAS No. 606143-52-6. Pack Sizes: 200mg. Product ID: S1008. Formula: C17H15BrClFN4O3. Smiles: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AZD6280 | AZD6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder. Uses: Scientific research. Category: Signaling pathways. CAS No. 942436-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19872. | |
| AZD-6280 | AZD-6280 is a selective GABAA(α2/3) receptor modulator for the treatment of generalized anxiety disorder. Synonyms: AZD6280; UNII-B9Z1OEH19D; AZD 6280; B9Z1OEH19D; CHEMBL1783256. Grade: 98%. CAS No. 942436-93-3. Molecular formula: C20H22N4O3. Mole weight: 366.4. | |
| AZD6482 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. Phase 1. Synonyms: KIN193; AZD6482; KIN 193; AZD 6482; KIN-193; AZD-6482. Grade: >98%. CAS No. 1173900-33-8. Molecular formula: C22H24N4O4. Mole weight: 408.45. | |
| AZD 6482 | AZD 6482 (KIN-193) is a potent and selective p110β inhibitor with an IC50 of 0.69 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KIN-193. CAS No. 1173900-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10344. | |
| AZD6482 (S-isomer) | This active molecular is the S-configuration isomer of AZD6482. AZD6482 is a selective, ATP competitive PI3Kβ inhibitor and IC50 value is 0.01 μm. Meanwhile, AZD6482 also inhibited insulin-induced human adipocyte glucose uptake in vitro and IC50 value is 4.4 μm. In May 2008, AstraZeneca completed a phase I trial in Thrombosis in Sweden. In Jul 2010, Phase-I for Thrombosis in Sweden was discontinued. Uses: Thrombosis. Synonyms: AZD6482 (S-isomer); AZD 6482 (S-isomer); AZD-6482 (S-isomer); (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid,1173900-33-8 (AZD6482). Grade: 98%. CAS No. 1173900-37-2. Molecular formula: C22H24N4O4. Mole weight: 408.46. | |
| AZD6738 | AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2. Synonyms: AZD-6738; AZD 6738. Grade: 98%. CAS No. 1352226-88-0. Molecular formula: C20H24N6O2S. Mole weight: 412.51. | |
| AZD7325 | AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes[1][4]. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro[2]. AZD7325 has the potential for the investigation of anxiety and dravet syndrome[3]. PAM: positive allosteric modulator. Uses: Scientific research. Category: Signaling pathways. CAS No. 942437-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-111052. | |
| AZD7507 | AZD7507 is a CSF-1R inhibitor with anti-tumor activity. Synonyms: AZD-7507; AZD 7507. Grade: >98%. CAS No. 1041852-85-0. Molecular formula: C23H27FN6O3. Mole weight: 454.5. | |
| AZD7507 | AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1041852-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117244. | |
| AZD7545 | AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. Synonyms: AZD7545; AZD-7545; AZD 7545. Grade: >98%. CAS No. 252017-04-2. Molecular formula: C19H18ClF3N2O5S. Mole weight: 478.87. | |
| AZD7545 | AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 252017-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16082. | |
| AZD-7594 | AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator. Synonyms: AZD-7594; AZD 7594; AZD7594; AZ13189620; AZ-13189620; AZ 13189620; 3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-[(3R)-oxolan-3-yl]benzamide. CAS No. 1196509-60-0. Molecular formula: C32H32F2N4O6. Mole weight: 606.627. | |
| AZD7648 | AZD7648 is a potent and selective DNA-PK inhibitor with anti-tumor activity. Synonyms: AZD-7648; AZD 7648. Grade: 98%. CAS No. 2230820-11-6. Molecular formula: C18H20N8O2. Mole weight: 380.4. | |
| AZD7648 | AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. Group: Inhibitors. CAS No. 2230820-11-6. Pack Sizes: 5mg. Product ID: S8843. Formula: C18H20N8O2. Smiles: CC1=CC2=NC=NN2C=C1NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCOCC5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AZD-7648 | AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230820-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-111783. | |
| AZD7687 | AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). Synonyms: AZD7687; AZD 7687; AZD-7687. Grade: >98%. CAS No. 1166827-44-6. Molecular formula: C21H25N3O3. Mole weight: 367.44. | |
| AZD7687 | AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1166827-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15497. | |
| AZD-7762 | AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. Synonyms: AZD 7762; AZD7762. Grade: 0.98. CAS No. 860352-01-8. Molecular formula: C17H19FN4O2S. Mole weight: 362.423. | |
| AZD-7762 | AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1. Uses: Scientific research. Category: Signaling pathways. CAS No. 860352-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10992. | |
| AZD 7762 hydrochloride | AZD 7762 hydrochloride is the hydrochloride salt of AZD 7762, which is a selective and potent ATP-competitive inhibitor of Chk1 and Chk2 with IC50 values of 5 nM for both kinases. It shows at least >10 fold selectivity over a panel of 164 kinases. It is used as a potentiation cytotoxicity DNA-damaging agent. It is active in vivo. Synonyms: AZD 7762 hydrochloride; AZD7762 hydrochloride; AZD-7762 hydrochloride; 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride; 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1246094-78-9. Molecular formula: C17H20FN4O2SCl. Mole weight: 398.88. | |
| AZD 7986 | AZD 7986 is a potent and selective inhibitor of Dipeptidyl Peptidase 1 (DPP1) with pIC50 of 8.4. It is in phase I clinical trials by AstraZeneca for the treatment of chronic obstructive pulmonary disease (COPD). Synonyms: brensocatib; INS1007; (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide. Grade: 98%. CAS No. 1802148-05-5. Molecular formula: C23H24N4O4. Mole weight: 420.46. | |
| AZD8055 | AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (?1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1. Group: Inhibitors. CAS No. 1009298-09-2. Pack Sizes: 1g. Product ID: S1555. Formula: C25H31N5O4. Smiles: CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AZD8055 | A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Group: Biochemicals. Alternative Names: 5- [2, 4-Bis [ (3S) -3-methyl-4-morpholinyl] pyrido [2, 3-d] pyrimidin-7-yl] -2-methoxy Benzene methanol; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]- 2-methoxyphenyl] methanol; AZD 8055; [5- [2, 4-Bis ( (3S) -3-methylmorpholin-4-yl) pyrido [5, 6-e] pyrimidin-7-yl] -2-methoxyphenyl] methanol. Grades: Purified. CAS No. 1009298-09-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AZD8055 | AZD8055 Inhibitor. Uses: Scientific use. Product Category: T1859. CAS No. 1009298-09-2. |  |
| AZD-8055 | AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1009298-09-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10422. | |
| AZD-8055 | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. Synonyms: AZD8055; AZD-8055; AZD 8055. Grade: 0.98. CAS No. 1009298-09-2. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| AZD8154 | AZD8154 is a novel inhaled selective inhibitor of PI3Kγδ targeting airway inflammatory disease. Synonyms: AZD-8154. CAS No. 2215022-45-8. Molecular formula: C27H29N5O4S2. Mole weight: 551.68. | |
| AZD8154 | AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2215022-45-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115870. | |
| AZD8186 | AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC5050=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1627494-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12330. | |
| AZD8186 | AZD 8186 is a selective PI3Kβ/δ inhibitor (IC50= 0.003 μM for PI3Kβ, and 0.017 μM for PI3Kδ) with potential antineoplastic activity. It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 μM and exhibits high oral efficacy in mouse cancer models. Synonyms: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide; AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. | |
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