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| Product | Description | |
|---|---|---|
| Fusidic acid | Fusidic acid is a bacteriostatic steroid antibiotic which targets protein synthesis in gram-positive bacteria. Alternative Names: (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid; 29-Nor-8α,9β,13α,14β-dammara-17(20),24-dien-21-oic acid, 3α,11α,16β-trihydroxy-, 16-acetate, (Z)-; Flucidin; Foban; Fucithalmic; Fugen; Fusidinic acid; NSC 56192; Optifucin; Phudicin; Ramycin; SQ 16603; Usidin; (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoic acid. Grades: 98%. CAS No. 6990-6-3. Molecular formula: C31H48O6. Mole weight: 516.72. |  |
| Fusidic acid | Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. Fusidic acid holds promise for research in anticancer and anti-infective applications.[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Fusidate; SQ-16603. CAS No. 6990-6-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1350. |  |
| Fusidic Acid | Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Group: Biochemicals. Alternative Names: (3α, 4α, 8α, 9 β, 11α, 13α, 147 β,167 β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid; Flucidin; Fucithalmic; Fusidinic Acid; NSC 56192; Ramycin; SQ 16603. Grades: Highly Purified. CAS No. 6990-6-3. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| FUSIDIC ACID | Fusidic acid is a steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. It has a role as a protein synthesis inhibitor, an EC 2.7.1.33 (pantothenate kinase) inhibitor and an Escherichia coli metabolite. It is a 3alpha-hydroxy steroid, an 11alpha-hydroxy steroid, a sterol ester, a steroid acid, an alpha,beta-unsaturated monocarboxylic acid and a steroid antibiotic. It is a conjugate acid of a fusidate. It derives from a hydride of a 5alpha-cholestane. CAS No. 6990-6-3. Product ID: PAP-0038. Molecular formula: C31H48O6. Category: Antibacterial, anti-inflammatory and antiviral. Product Keywords: Antibacterial, Anti-inflammatory and Antiviral Series; FUSIDIC ACID; PAP-0038; Antibacterial, anti-inflammatory and antiviral; C31H48O6; 6990-06-3. Standard: EP/ BP. Color: White to Off-White. EC Number: 230-256-0. Physical State: neat. Solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent). Storage: Sealed in dry,2-8°C. Applications: Fusidic acid is an antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections. Boiling Point: 521.49°C (rough estimate). Melting Point: 190-192°C. Density: 1.0389 (rough estimate). Product Description: Fusidic acid is an antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections. |  |
| Fusidic acid acyl glucuronide | Fusidic acid acyl glucuronide is a metabolite originating from fusidic acid, acting as an efficacious antimicrobial compound employed for studying diverse bacterial ailments. It manifestly demonstrates amplified pharmacokinetic attributes encompassing heightened bioavailability and metabolic steadfastness. Alternative Names: Fusidic acid, β-D-glucopyranuronosyl ester; 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, β-D-glucopyranuronosyl ester, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-; Fusidic Acid Acyl β-D-Glucuronide; (2S,3S,4S,5R,6S)-6-(((Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Grades: ≥95%. CAS No. 13013-66-6. Molecular formula: C37H56O12. Mole weight: 692.83. | |
| Fusidic Acid-d6 | Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Group: Biochemicals. Alternative Names: (3α, 4α, 8α, 9 β, 11α, 13α, 147 β,167 β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid-d6; Flucidin-d6; Fucithalmic-d6; Fusidinic Acid-d6; NSC 56192-d6; Ramycin-d6; SQ 16603-d6. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Fusidic acid EP Impurity A | Fusidic acid EP Impurity A. Uses: For analytical and research use. Alternative Names: (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-5,6-dihydroxy-6-methylheptanoic acid. CAS No. 80445-74-5. Molecular formula: C31H50O8. Mole weight: 550.72. Catalog: APB80445745. |  |
| Fusidic acid EP Impurity B | Fusidic acid EP Impurity B. Uses: For analytical and research use. Alternative Names: (3R,4S,5S,8S,9S,10S,11R,13R,14S,16S,Z)-3,11-dihydroxy-17-(6-hydroxy-7,7-dimethyl-2-oxooxepan-3-ylidene)-4,8,10,14-tetramethylhexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate. Molecular formula: C31H48O7. Mole weight: 532.71. Catalog: APB02072. | |
| Fusidic acid EP Impurity C | Fusidic acid EP Impurity C. Uses: For analytical and research use. Alternative Names: (3R,4S,5S,8S,9S,10S,11R,13R,14S,16S,Z)-3,11-dihydroxy-17-((R)-6-(2-hydroxypropan-2-yl)-2-oxodihydro-2H-pyran-3(4H)-ylidene)-4,8,10,14-tetramethylhexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate. Molecular formula: C31H48O7. Mole weight: 532.71. Catalog: APB06363. | |
| Fusidic acid EP Impurity D | Fusidic acid EP Impurity D. Uses: For analytical and research use. Alternative Names: (3R,4S,5S,8S,9S,10S,11R,13R,14S,16S,Z)-3,11-dihydroxy-17-((S)-6-(2-hydroxypropan-2-yl)-2-oxodihydro-2H-pyran-3(4H)-ylidene)-4,8,10,14-tetramethylhexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate. Molecular formula: C31H48O7. Mole weight: 532.71. Catalog: APB06362. | |
| Fusidic acid EP Impurity E | Fusidic acid EP Impurity E. Uses: For analytical and research use. Alternative Names: (2Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-7-hydroxy-6-methylhept-5-enoic acid. Molecular formula: C31H48O7. Mole weight: 532.71. Catalog: APB06361. | |
| Fusidic acid EP Impurity F | Fusidic acid EP Impurity F. Uses: For analytical and research use. Alternative Names: (2Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methyl-7-oxohept-5-enoic acid. CAS No. 1415035-94-7. Molecular formula: C31H46O7. Mole weight: 530.69. Catalog: APB1415035947. | |
| Fusidic acid EP Impurity G | Fusidic acid EP Impurity G. Uses: For analytical and research use. Alternative Names: (Z)-2-((4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-11-hydroxy-4,8,10,14-tetramethyl-3-oxododecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid. CAS No. 4680-37-9. Molecular formula: C31H46O6. Mole weight: 514.69. Catalog: APB4680379. | |
| Fusidic acid EP Impurity H | Fusidic acid EP Impurity H. Uses: For analytical and research use. Alternative Names: (Z)-2-((3R,4S,5S,8S,9S,10S,13R,14S,16S)-16-acetoxy-3-hydroxy-4,8,10,14-tetramethyl-11-oxododecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid. CAS No. 16711-91-4. Molecular formula: C31H46O6. Mole weight: 514.69. Catalog: APB16711914. | |
| Fusidic acid EP Impurity I | Fusidic acid EP Impurity I. Uses: For analytical and research use. Alternative Names: (Z)-6-methyl-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16R)-3,11,16-trihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)hept-5-enoic acid. CAS No. 5951-83-7. Molecular formula: C29H46O5. Mole weight: 474.67. Catalog: APB5951837. | |
| Fusidic acid EP Impurity J | Fusidic acid EP Impurity J. Uses: For analytical and research use. Alternative Names: (2aS,3S,4R,6aS,6bS,7R,8aR,11aR,12aS,12bS)-4,7-dihydroxy-3,6a,12a,12b-tetramethyl-9-(4-methylpent-3-en-1-yl)-2a,3,4,5,6,6a,6b,7,8,8a,11a,12,12a,12b-tetradecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-10(2H)-one. CAS No. 13011-12-6. Molecular formula: C29H44O4. Mole weight: 456.66. Catalog: APB13011126. | |
| Fusidic acid EP Impurity K | Fusidic acid EP Impurity K. Uses: For analytical and research use. Alternative Names: (2aS,3S,4R,6aS,6bS,7R,8aR,11aS,12aS,12bS)-4,7-dihydroxy-3,6a,12a,12b-tetramethyl-9-(4-methylpent-3-en-1-yl)-2a,3,4,5,6,6a,6b,7,8,8a,11a,12,12a,12b-tetradecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-10(2H)-one. CAS No. 4701-54-6. Molecular formula: C29H44O4. Mole weight: 456.66. Catalog: APB4701546. | |
| Fusidic acid EP Impurity L | Fusidic acid EP Impurity L. Uses: For analytical and research use. Alternative Names: (Z)-2-((3R,4S,5S,8R,10S,13R,14S,16S)-16-acetoxy-3-hydroxy-4,8,10,14-tetramethyl-3,4,5,6,7,8,12,13,15,16-decahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid. CAS No. 74048-41-2. Molecular formula: C31H46O5. Mole weight: 498.69. Catalog: APB74048412. | |
| Fusidic acid EP Impurity M | Fusidic acid EP Impurity M. Uses: For analytical and research use. Alternative Names: (Z)-2-((3R,4S,5S,8S,9S,10S,13R,14S,16S)-16-acetoxy-3-hydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid. CAS No. 1013937-16-0. Molecular formula: C31H48O5. Mole weight: 500.71. Catalog: APB1013937160. | |
| Fusidic Acid EP Impurity O | Fusidic Acid EP Impurity O. Uses: For analytical and research use. CAS No. 13090-91-0. Molecular formula: C29H46O5. Mole weight: 474.68. Catalog: APB13090910. | |
| Fusidic acid EP Impurity O Sodium Salt | Fusidic acid EP Impurity O Sodium Salt. Uses: For analytical and research use. Alternative Names: (Z)-6-methyl-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-3,11,16-trihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)hept-5-enoate, sodium salt (1:1). CAS No. 55601-53-1. Molecular formula: C29H45O5·Na. Mole weight: 496.68. Catalog: APB55601531. | |
| Fusidic acid impurity1 | Fusidic acid impurity1. Uses: For analytical and research use. Molecular formula: C7H7N3O3. Mole weight: 181.15. Catalog: APB07898. | |
| Fusidic acid impurity2 | Fusidic acid impurity2. Uses: For analytical and research use. Molecular formula: C32H50O7. Mole weight: 546.75. Catalog: APB07899. | |
| Fusidic acid impurity 5 | Fusidic acid impurity 5. Uses: For analytical and research use. CAS No. 16391-75-6. Molecular formula: C35H59NO8. Mole weight: 621.86. Catalog: APB16391756. | |
| Fusidic acid impurity 6 | Fusidic acid impurity 6. Uses: For analytical and research use. Molecular formula: C31H46O7. Mole weight: 530.7. Catalog: APB07900. | |
| Fusidic acid sodium salt | Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium fusidate; SQ-16360. CAS No. 751-94-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1350A. | |
| Fusidic acid sodium salt | 1g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C31H47NaO6. CAS No. 751-94-0. Prepack ID 71875523-1g. Molecular Weight 538.69. See USA prepack pricing. |  |
| Fusidienol A | Fusidienol A is produced by the strain of Phoma spp. and Fusidium griseum. It is a Ras Farnesyl protein transferase inhibitor. Molecular formula: C16H12O6. Mole weight: 300.26. | |
| Fusion Inhibitory Peptide | Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide. CAS No. 75539-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-114437. | |
| Fusion PLA 3D Printing Filament | Fusion PLA 3D Printing Filament. |  |
| Fustin | Fustin is a natural compound isolated from the peel of Toxicodendron vernicifluum F. Barkley. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. Alternative Names: Dihydrofisetin. Grades: 98.0%. CAS No. 20725-03-5. Molecular formula: C15H12O6. Mole weight: 288.26. | |
| Futalosine | A new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. An antibiotic cancer inhibitor. Alternative Names: 3-[1,5,6-Trideoxy-1-(1,6-dihydro-6-oxo-9H-purin-9-yl)-β-D-ribo-heptofuranuronoyl]benzoic Acid. CAS No. 210644-32-9. Molecular formula: C19H18N4O7. Mole weight: 414.37. | |
| Futalosine | A new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Group: Biochemicals. Alternative Names: 3-[1,5,6-Trideoxy-1-(1,6-dihydro-6-oxo-9H-purin-9-yl)- β -D-ribo-heptofuranuronoyl] benzoic Acid. Grades: Highly Purified. CAS No. 210644-32-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| futalosine hydrolase | This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes. Group: Enzymes. Synonyms: futalosine nucleosidase; MqnB. Enzyme Commission Number: EC 3.2.2.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3980; futalosine hydrolase; EC 3.2.2.26; futalosine nucleosidase; MqnB. Cat No: EXWM-3980. |  |
| Futibatinib | Futibatinib is an orally bioavailable, selective and irreversible inhibitor of fibroblast growth factor receptors (FGFRs), displaying antineoplastic activity. It inhibits FGFR-mediated signal transduction and tumor cell proliferation. Alternative Names: 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1-pyrazolo[3,4-d]pyrimidinyl]-1-pyrrolidinyl]-2-propen-1-one; 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one. Grades: ≥ 98 %. CAS No. 1448169-71-8. Molecular formula: C22H22N6O3. Mole weight: 418.45. | |
| Futibatinib | Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3.9, 1.3, 1.6, and 8.3 nM for FGFR 1-4, respectively. Futibatinib inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0.9?nM; V5651=1-3?nM; N550H=3.6?nM; E566G=2.4?nM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-120. CAS No. 1448169-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100818. | |
| Futuximab | Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1310460-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99628. | |
| Fuziline | Fuziline. Group: Biochemicals. Alternative Names: 15-Hydroxyneoline; 15-Epinagarine; Senbusine C. Grades: Plant Grade. CAS No. 80665-72-1. Pack Sizes: 20mg. Molecular Formula: C24H39NO7, Molecular Weight: 453.569. US Biological Life Sciences. | Worldwide |
| Fuziline | Fuziline is extracted from the roots of Aconitum carmichaeli Debx. Alternative Names: Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-; 15-Epinagarine; 15-Hydroxyneoline; Senbusine C. Grades: >98%. CAS No. 80665-72-1. Molecular formula: C24H39NO7. Mole weight: 453.6. | |
| FW1256 | FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117089-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121955. | |
| FX-11 | FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LDHA Inhibitor FX11. CAS No. 213971-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16214. | |
| FX-909 | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924573-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153344. | |
| Fz7-21 | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ac-LPSDDLEFWCHVMY-NH2. CAS No. 2247635-23-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1454. | |
| Fz7-21 | Fz7-21, a peptide antagonist of Frizzled 7 receptor, selectively binds to Frizzled 7 CRD subclass. Alternative Names: FZD7 binding peptide; Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2. Grades: ≥97% by HPLC. CAS No. 2247635-23-8. Molecular formula: C83H114N18O23S2. Mole weight: 1796.05. | |
| FzM1 | FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1680196-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116553. | |
| FzM1.8 | FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2204290-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117163. | |
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