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| Product | Description | |
|---|---|---|
| GNE-6468 | GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1677668-27-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19775. |  |
| GNE-6640 | GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2009273-67-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112937. | |
| GNE-6776 | GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2009273-71-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107986. | |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Synonyms: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. Grade: 98%. CAS No. 2009273-71-4. Molecular formula: C20H20N4O2. Mole weight: 348.406. |  |
| GNE684 | GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1). Synonyms: (s)-N-((s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl)-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide. Molecular formula: C23H24N6O3. Mole weight: 432.48. | |
| GNE 6901 | GNE 6901 (compound 40) is a potent GluN2A-selective NMDAR positive allosteric modulator (PAM) with an EC50 of 382 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1698900-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-107423. | |
| GNE-781 | GNE-781 is a potent, selective and orally active bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). GNE-781 exhibits antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner. Synonyms: GNE 781; GNE781. CAS No. 1936422-33-1. Molecular formula: C27H33F2N7O2. Mole weight: 525.59. | |
| GNE-781 | GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1936422-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108696. | |
| GNE-7883 | GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648450-42-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147214. | |
| GNE-7915 | GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. Synonyms: GNE7915; GNE 7915; GNE-7915. CAS No. 1351761-44-8. Molecular formula: C19H21F4N5O3. Mole weight: 443.403. | |
| GNE-7915 tosylate | GNE-7915 tosylate is a potent, selective and brain-penetrant LRRK2 inhibitor with an IC50 of 9 nM. Synonyms: (4-{[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino}-2-fluoro-5-methoxyphenyl)(4-morpholinyl)methanone 4-methylbenzenesulfonate (1:1); Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-, 4-methylbenzenesulfonate (1:1). Grade: ≥95%. CAS No. 2070015-00-6. Molecular formula: C26H29F4N5O6S. Mole weight: 615.60. | |
| GNE-8505 | GNE-8505 is an orally available dual leucine zipper kinase (DLK) inhibitor. Synonyms: example 152 [WO2014111496]. CAS No. 1620573-48-9. Molecular formula: C21H24F3N5O. Mole weight: 419.44. | |
| GNE-8505 | GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 has an IC50 of 0.144 μM for pJNK, and EC50 of 0.457 μM for DRG. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620573-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-114332. | |
| GNE-8525 | This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor efficacy in tumor xenograft model derived from the KM12 cell line. TRKA are believed to be the key oncogenic driver in many tumors including glioblastoma, melanoma and so on. Uses: Antitumor. Synonyms: GNF-8625; GNF 8625; GNF8625. (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol. Grade: 98%. CAS No. 1196546-33-4. Molecular formula: C31H30FN7O. Mole weight: 535.63. | |
| GNE-900 | GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. Synonyms: GNE900; GNE 900; 3-(4-(Piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile; 6-cyano-3-(4-piperidin-1-ylmethyl-phenyl)-9H-dipyrido[2,3-b; 4',3'-d]pyrrole. Grade: 98%. CAS No. 1200126-26-6. Molecular formula: C23H21N5. Mole weight: 367.45. | |
| GNE 9278 | GNE 9278 is a positive allosteric modulator of NMDA receptors. GNE-9278 targets transmembrane domain (TMD) extracellular surface of agonist-bound NMDARs, stabilizing NMDARs in an activated state by slowing L-L-glu & gly off-rate. Synonyms: Benzenesulfonamide, 4-cyclohexyl-N-(1,7-dihydro-5-methyl-7-oxo-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-; GNE-9278; GNE9278; 4-cyclohexyl-N-(5-methyl-7-oxo-2-propyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide. Grade: ≥98% by HPLC. CAS No. 2315311-83-0. Molecular formula: C21H27N5O3S. Mole weight: 429.54. | |
| GNE-955 | GNE-955 is a potent and orally active pan Pim kinase inhibitor, with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. Synonyms: (S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine. CAS No. 1527523-39-2. Molecular formula: C22H24N8O. Mole weight: 416.48. | |
| GNE-9605 | GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. In addition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stability, brain penetration across multiple species, and selectivity of these inhibitors support their use in preclinical efficacy and safety studies. Synonyms: GNE9605; GNE-9605; GNE 9605. Grade: 0.98. CAS No. 1536200-31-3. Molecular formula: C17H20ClF4N7O. Mole weight: 449.839. | |
| GNE-9605 | GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1536200-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12282. | |
| GNE-9815 | GNE-9815 is one of the most highly kinase-selective RAF inhibitors targeting KRAS mutant cancers via combination treatment. Synonyms: GNE9815; GNE 9815. CAS No. 2729996-45-4. Molecular formula: C26H22FN5O2. Mole weight: 455.48. | |
| GNE-9822 | GNE-9822, a pyrazole derivative, has been found to be a ITK inhibitor that could probably be effective in studies of some inflammatory disorders. Synonyms: GNE-9822; GNE 9822; GNE9822; (S)-N-[1-[3-(Dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide. Grade: 98%. CAS No. 1557232-32-2. Molecular formula: C24H32N6O. Mole weight: 420.56. | |
| GNE-9822 | GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM, and an EC50 value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1557232-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12410. | |
| GNE-987 | GNE-987 is a VHL-dependent BRD4 PROTAC degrader. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417371-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-129937A. | |
| GNE-987 | GNE-987, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, is used in PROTAC-Antibody Conjugate (PAC). GNE-987 shows picomolar activity of cell BRD4 degradation (DC50 = 0.03 nM for EOL-1 AML cell line), and binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50s = 4.7 and 4.4 nM, respectively). It combines a potent BET binder/inhibitor, a VHL binding fragment and a 10 methylene spacer moiety. Synonyms: 7-(3,5-Difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide; N-[11-({7-(3,5-Difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide. Grade: ≥98%. CAS No. 2417371-71-0. Molecular formula: C56H67F2N9O8S2. Mole weight: 1096.31. | |
| GNE-987 GSH linker-1 | GNE-987 GSH linker-1, a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 (HY-129937A) and disulfide-containing linker. GNE-987 GSH linker-1 remains inactive as a degrader until intracellular release of GNE-987 via disulfide reduction and linker self-immolation. GNE-987 GSH linker-1 can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417370-39-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129938. | |
| Gnetol | Gnetol is a phenolic compound isolated from the root of Gnetum montanum. Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86361-55-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-126052. | |
| GNF1331 | GNF1331 is a potent, selective and orally bioavailable porcupine (PORCN) inhibitor with IC50 value of 12 nM. It plays a critical role in multiple cancers, such as cutaneous squamous cell carcinoma (SCC), colorectal cancer and breast cancer. Uses: Gnf1331 plays a critical role in multiple cancers, such as cutaneous squamous cell carcinoma (scc), colorectal cancer and breast cancer. Synonyms: N-(6-methoxy-1,3-benzothiazol-2-yl)-2-[(4-propyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide; GNF-1331; GNF 1331; GNF1331. Grade: 98%. CAS No. 603101-22-0. Molecular formula: C20H20N6O2S2. Mole weight: 440.54. | |
| GNF179 | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179; GNF-179. Grade: >98%. CAS No. 1261114-01-5. Molecular formula: C22H23ClFN5O. Mole weight: 427.9. | |
| GNF179 | GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1261114-01-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15975. | |
| GNF179 Metabolite | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179 Metabolite; GNF-179 Metabolite. Grade: >98%. CAS No. 1310455-86-7. Molecular formula: C14H16FN3. Mole weight: 245.3. | |
| GNF179 Metabolite-13C2 | GNF179 Metabolite-13C2. Grade: > 95%. Molecular formula: C12H16FN3[13C]2. Mole weight: 247.28. | |
| GNF 2 | GNF 2. Group: Biochemicals. Grades: Purified. CAS No. 778270-11-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| GNF-2 | GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. Synonyms: GNF2; GNF-2; GNF 2. Grade: 98.73%. CAS No. 778270-11-4. Molecular formula: C18H13F3N4O2. Mole weight: 374.32. | |
| GNF2133 | GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 μM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2561414-56-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142295. | |
| GNF351 | GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1227634-69-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-102023. | |
| GNF351 | GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). GNF351 is capable of competing with the photoaffinity ligand for binding to the human AHR and has a relative affinity for the AHR similar to that of SR1. CAS No. 1227634-69-6. Molecular formula: C24H25N7. Mole weight: 411.50. | |
| GNF362 | GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3 kinase B (Itpkb) with an IC50 of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3 kinase B (Itpkb) is a Ca2+-dependent kinase, which phosphorylates the 3 position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4][1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1003019-41-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126750. | |
| GNF4877 | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2041073-22-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129492. | |
| GNF 5 | GNF 5. Group: Biochemicals. Grades: Purified. CAS No. 778277-15-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GNF-5 | GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 μM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 778277-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15738. | |
| GNF-5 | GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2, a selective allosteric inhibitor of Bcr-Abl. GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 μM against Bcr-Abl mutants G250E, E255V, and M351T, respectively. Synonyms: GNF-5; GNF 5; GNF5. CAS No. 778277-15-9. Molecular formula: C20H17F3N4O3. Mole weight: 418.38. | |
| GNF 5837 | GNF 5837 is a potent and selective pan-Trk inhibitor that blocks tumor gowth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. GNF 5837 displays antiproliferative effects in cellular Ba/F3 assays with IC50 values of 7, 9 and 11 nM for cells expressing Tel-TrkC, Tel-TrkB and Tel-TrkA respectively. Synonyms: GNF5837; GNF-5837; GNF 5837. 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea. CAS No. 1033769-28-6. Molecular formula: C28H21F4N5O2. Mole weight: 535.503. | |
| GNF 5837 | GNF 5837. Group: Biochemicals. Grades: Purified. CAS No. 1033769-28-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GNF-5837 | GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1033769-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13491. | |
| GNF-6231 | GNF-6231 is a potent porcupine inhibitor that blocks Wnt signaling. GNF-6231 exhibits potential antitumor properties via inhibition of aberrant Wnt signaling. Synonyms: [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl-; N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl[2,4'-bipyridine]-5-acetamide; GNF 6231; GNF6231; N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-fluoro-3-methyl-[2,4'-bipyridin]-5-yl)acetamide. Grade: >98%. CAS No. 1243245-18-2. Molecular formula: C24H25FN6O2. Mole weight: 448.49. | |
| GNF-6231 | GNF-6231 is a porcupine (IC50= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1243245-18-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100408. | |
| GNF-7 | GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 839706-07-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10943. | |
| GNF-7 | GNF-7 is a type-II T315I inhibitor. GNF-7 inhibits Ack1 and germinal center kinase (GCK). GNF-7 is among the first type-II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design the third generation Bcr-Abl kinase inhibitors. Uses: Protein kinase inhibitors. Synonyms: GNF7; GNF 7; N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide. Grade: 98%. CAS No. 839706-07-9. Molecular formula: C28H24F3N7O2. Mole weight: 547.54. | |
| GNF-8625 monopyridin-N-piperazine hydrochloride | GNF-8625 monopyridin-N-piperazine hydrochloride is a TRK inhibitor. (Extracted from the patent WO 2020038415 A1). Synonyms: TRKi-2; (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine hydrochloride. CAS No. 2412055-62-8. Molecular formula: C25H27ClFN7. Mole weight: 479.98. | |
| G-NGA2 N-Glycan | G-NGA2 N-Glycanthe transformative compound engaging in protein modifications. It finds applications in studying glycosylation-related disorders and diseases. Synonyms: Monogalactosylated asialo, biantennary (G-NGA2); Monogalactosylated, asialo, bi-antennary N-linked glycan; Monogalactosylated, asialo, biantennary N-glycan (G-NGA2); O-2-(Acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-2)-O-alpha-D-mannopyranosyl-(1-6)-O-[O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-2)-alpha-D-mannopyranosyl-(1-3)]-O-beta-D-mannopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-D-glucose. Grade: ≥90%. CAS No. 103584-68-5. Molecular formula: C56H94N4O41. Mole weight: 1479.35. | |
| GNQWFI | GNQWFI, an anti-Flt1 peptide, is a VEGFR1-specific antagonist. GNQWFI blocks the interaction of VEGFR1 with various VEGFR1 ligands, such as VEGFA, VEGFB, and placental growth factor (PIGF) and inhibits VEGF-induced endothelial cell migration and tube formation. GNQWFI is promising for research of cancer, asthma, and other ocular diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 853995-60-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P10831. | |
| GnRH antagonist 2 | GnRH antagonist 2, a GnRH receptor antagonist, can be used in the study of endometriosis. Synonyms: Urea, N-[4-[7-[(2,6-difluorophenyl)methyl]-3-[(dimethylamino)methyl]-4,5,6,7-tetrahydro-5-(6-methoxy-3-pyridazinyl)-4,6-dioxo-2H-pyrazolo[3,4-d]pyrimidin-2-yl]phenyl]-N'-methoxy-. Grade: ≥98%. CAS No. 1709823-61-9. Molecular formula: C28H27F2N9O5. Mole weight: 607.57. | |
| GnRH Associated Peptide (GAP) (1-13), human | GnRH Associated Peptide (GAP) (1-13), human is a potent inhibitor of prolactin secretion and stimulates the release of gonadotropins. Active immunization with peptides corresponding to the GAP sequences can significantly increase prolactin secretion. Synonyms: L-Valine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-α-glutamyl-L-isoleucyl-; L-α-Aspartyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-α-glutamyl-L-isoleucyl-L-valine; H-Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val-OH. Grade: 95%. CAS No. 100111-07-7. Molecular formula: C65H101N15O25. Mole weight: 1492.58. | |
| GnRH Associated Peptide (GAP) (1-13), human acetate | GnRH Associated Peptide (GAP) (1-13), human acetate is a potent inhibitor of prolactin secretion and stimulates the release of gonadotropins. Active immunization with peptides corresponding to the GAP sequences can significantly increase prolactin secretion. Synonyms: H-Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val-OH.CH3CO2H; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-asparagyl-L-leucyl-L-isoleucyl-L-alpha-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-alpha-glutamyl-L-isoleucyl-L-valine acetic acid. Grade: ≥95%. Molecular formula: C67H105N15O27. Mole weight: 1552.63. | |
| GnRH II trifluoroacetate salt | GnRH II is a peptide that is encoded by the GNRH2 gene in humans. It acts as an agonist of the GnRH receptor (GnRHR). Synonyms: Gonadotropin-releasing Hormone II; ?LHRH II; 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidylglycyl-L-tryptophyl-L-tyrosyl-L-prolyl-glycinamide, trifluoroacetate salt. Grade: ≥95%. Molecular formula: C60H69N17O13·xCF3COOH. Mole weight: 1236.30. | |
| GNX-865 | GNX-865 is a mitochondrial permeability transition pore (mPTP) inhibitor that protects against ischemia-reperfusion injury in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223568-82-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119909. | |
| GO-203 TFA | GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222186-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1925A. | |
| GO-203 TFA | GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. Group: Inhibitors. CAS No. 1222186-26-6. Pack Sizes: 2mg. Product ID: S8674. Formula: C87H170N52O19S2.C2HF3O2. Smiles: C(CCN)CC(C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CCC(=O)N)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)N.C(=O)(C(F)(F)F)O. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Go6976 | Go6976 is a Protein Kinase C (PKC) inhibitor, with an IC50 of 20 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 136194-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10183. | |
| Go 6976 | Go 6976. Group: Biochemicals. Grades: Purified. CAS No. 136194-77-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| GO-6976 | Go6976 is a potent PKC inhibitor with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively). Synonyms: GO-6976; GO 6976; PD-406976; PD 406976; PD406976. Grade: >98%. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.435. | |
| Go6983 | GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Synonyms: Go6983, Go-6983; Go 6983; GO6983. Grade: >98%. CAS No. 133053-19-7. Molecular formula: C26H26N4O3. Mole weight: 442.519. | |
| Go 6983 | Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gö 6983; Goe 6983. CAS No. 133053-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13689. | |
| Go 6983 | Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. Group: Inhibitors. Alternative Names: GOE 6983, Gö 6983. CAS No. 133053-19-7. Pack Sizes: 10mg. Product ID: S2911. Formula: C26H26N4O3. Smiles: CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Goadsporin | It is produced by the strain of Streptomyces sp. TP-A0584. It can promote the secondary metabolism and morphogenesis of Streptomyces, and it is a tool to analyze the regulatory mechanism of Streptomyces. CAS No. 883434-90-0. Molecular formula: C72H97N19O20S2. Mole weight: 1612.78. | |
| Goat's Rue Herb Powder | Goat's Rue Herb Powder. |  CA, FL & NJ |
| GoatThroat Pump EPDM Seal GT200 | The GoatThroat GT200 is a pump for liquid transferring that has a EPDM (Ethylene Propylene Diene Monomer) seal. Pumps help workers stay safe by reducing or completely eliminating spills. GoatThroat pumps are compatible with many different chemicals and viscosities. This durable pump will last you a long time if properly used. Uses: Transfer of liquids. Grades: Food Grade. Pack Sizes: 1. Categories: Goat Throat pumps. |  USA |
| GoatThroat Pump Nitrile Seal GT100 | The GoatThroat GT100 is a pump for transferring liquids that has a nitrile seal. Depending on the viscosity of the liquid, this pump can dispense 4 gallons every minute. Just like gloves or goggles, an effective pump can be one of the best pieces of PPE in the workplace. GoatThroat pumps are known for their durability over time and consistent safe usage. Uses: Transfer of liquids. Grades: Food Grade. Pack Sizes: 1. Categories: Goat Throat pumps. | USA |
| GoatThroat Pump Viton Seal GT300 | The GoatThroat GT300 is a pump for transferring different kinds of liquids that has a viton seal. It can fit almost any container from a 2-gallon jug to a 55-gallon drum. Dispensing is as easy as turning on a faucet! GoatThroat pumps are some of the best, safest, most efficient, and affordable pumps out there. Uses: Transfer of liquids. Grades: Food Grade. Pack Sizes: 1. Categories: Goat Throat pumps. | USA |
| Gocatamig | HY-P990920 is an CD3E/ALB/DLL3-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-6070; HPN328. CAS No. 2851862-91-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990920. | |
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