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| Product | Description | |
|---|---|---|
| Grosvenorine | Grosvenorine. Group: Biochemicals. Grades: Plant Grade. CAS No. 156980-60-8. Pack Sizes: 10mg. Molecular Formula: C33H40O19, Molecular Weight: 740.66. US Biological Life Sciences. |  Worldwide |
| Grosvenorine | Grosvenorine is extracted from roots of the fruits of Siraitia grosuenorii. It has free radical scavenging activity. Alternative Names: Grosvenorin. Grades: >98%. CAS No. 156980-60-8. Molecular formula: C33H40O19. Mole weight: 740.7. |  |
| Growth arrest-specific protein 7 (281-290) | Growth arrest-specific protein 7 (281-290) is a peptide derived from Growth arrest-specific protein 7. Growth arrest-specific protein 7 plays a role in promoting maturation and morphological differentiation of cerebellar neurons. Alternative Names: GAS-7 (281-290). | |
| Growth Hormone | Growth hormone (GH, somatotropin) is a peptide hormone produced by the anterior pituitary gland. It is a single-chain polypeptide which consists of 191 amino acids. It is crucial in the regulation of growth, metabolism, and cell repair in humans. The secretion of growth hormone is stimulated by growth hormone-releasing hormone (GHRH) and inhibited by somatostatin. Growth hormone is released in a pulsatile manner with highest secretory peaks occurring during sleep and exercise. Applications: Gh is indicated for the treatment of gh deficiency in children and adults, to increase height, muscle mass and bone density. it is also indicated for treatment of turner syndrome, growth failure due to chronic kidney disease and prader-willi syndrome. gh is also used to treat muscle wasting that can follow severe burns and hiv infection. Category: Hormones. Synonyms: GH1; GH; GHN; GH-N; hGH-N; Pituitary Growth Hormone; Growth Hormone 1; Somatotropin. Product ID: 92801ES. Mole weight: Approximately 22 kDa. InChIKey: LEHSKCILCGLHIK-DLRMDCPISA-N. Appearance: Sterile filtered white lyophilized (freeze-dried) powder. |  |
| GRP (14-27) (human, porcine, canine) | GRP (14-27) (human, porcine, canine). Alternative Names: C-Terminal peptide bombesin; Gastrin releasing peptide (14-27); H-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. CAS No. 81608-29-9. Molecular formula: C75H110N24O16S2. Mole weight: 1667.98. | |
| Grp75 Antibody [N3C14] | GRP 75,Grp75,Grp75/MOT. Group: Antibodies. Alternative Names: GRP 75,MOT, HSPA9. Pack Sizes: 20ul. Product ID: F0782. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| GRP78/BIP Antibody [J10G21] | BiP,BiP/GRP78,GRP78 BiP,GRP78/HSPA5,HSPA5,HSPA5/BiP/GRP78. Group: Antibodies. Alternative Names: BiP,BiP/GRP78,GRP78/HSPA5,HSPA5. Pack Sizes: 20ul. Product ID: F0221. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GRP78/BIP Antibody [N15D19] | BiP,BiP/GRP78,GRP78 BiP,GRP78/HSPA5,HSPA5,HSPA5/BiP/GRP78. Group: Antibodies. Alternative Names: BiP,BiP/GRP78,GRP78/HSPA5,HSPA5. Pack Sizes: 20uL. Product ID: F2702. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Grp94 Inhibitor-1 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2234897-35-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112910. |  |
| GRPP (human) | GRPP (human) is a synthetic analogue of a cleavage product resulting from proglucagon processing in pancreatic α- and intestinal L-cells. Alternative Names: Preproglucagon (21-50) (human); H-Arg-Ser-Leu-Gln-Asp-Thr-Glu-Glu-Lys-Ser-Arg-Ser-Phe-Ser-Ala-Ser-Gln-Ala-Asp-Pro-Leu-Ser-Asp-Pro-Asp-Gln-Met-Asn-Glu-Asp-OH; glicentin-related polypeptide (human); L-arginyl-L-seryl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-threonyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-seryl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-alanyl-L-seryl-L-glutaminyl-L-alanyl-L-alpha-aspartyl-L-prolyl-L-leucyl-L-seryl-L-alpha-aspartyl-L-prolyl-L-alpha-aspartyl-L-glutaminyl-L-methionyl-L-asparagyl-L-alpha-glutamyl-L-aspartic acid. Grades: ≥95%. CAS No. 1132745-52-8. Molecular formula: C136H215N41O58S. Mole weight: 3384.47. | |
| GRP (porcine) | GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that acts as an agonist for the gastrin-releasing peptide receptor (GRPR). It was shown to activate GABAergic interneurons in the amygdala resulting in an increase in GABA release and fear suppression in mice in vivo. Alternative Names: Gastrin Releasing Peptide porcine. CAS No. 74815-57-9. Molecular formula: C126H198N38O31S2. Mole weight: 2805.31. | |
| GRPSp | GRPSp was found in the mud crab Scylla paramamosain. It is active against Gram-positive A. viridans, M. Luteus, (MIC=6-25 μg/ml). Grades: >97% by HPLC. | |
| Grubbs Catalyst, 2nd gen | 100mg Pack Size. Group: Catalysts. Formula: C46H65Cl2N2PRu. CAS No. 246047-72-3. Prepack ID 60505776-100mg. Molecular Weight 848.97. See USA prepack pricing. |  |
| Grubbs Catalyst, 2nd Generation | Grubbs Catalyst, 2nd Generation is a ruthenium-based olefin metathesis catalyst. Group: Biochemicals. Grades: Highly Purified. CAS No. 246047-72-3. Pack Sizes: 250mg, 500 mg. Molecular Formula: C46H65Cl2N2PRu. US Biological Life Sciences. | Worldwide |
| Grubbs catalyst I | Grubbs catalyst I. Group: Biochemicals. Alternative Names: Bis- (tri cyclohexylphosphino) -benzylide ne ruthenium dichloride. Grades: Highly Purified. CAS No. 172222-30-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C44H74Cl2P2Ru. US Biological Life Sciences. | Worldwide |
| Grubbs catalyst II | Grubbs catalyst II. Group: Biochemicals. Alternative Names: [1, 3-Bis- (2, 4, 6-tri methyl phenyl) -2-imidazolidinylide ne ] -dichloro- (phenyl methyl ene ) (tri cyclohexylphosphine) -ruthenium. Grades: Highly Purified. CAS No. 246047-72-3. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C46H65Cl2N2PRu. US Biological Life Sciences. | Worldwide |
| Grundmann's ketone | Grundmann's Ketone is an intermediate in synthesizing (7Z)-Calcipotriene, which is an isomeric impurity of Calcipotriene, a vitamin D3 analogue with low calcemic activity. Alternative Names: 1-((1R)-1,5-Dimethylhexyl)octahydro-7a-methyl-4H-inden-4-one, (1R,3aR,7aR)-. CAS No. 66251-18-1. Molecular formula: C18H32O. Mole weight: 264.45. | |
| Gruticibart | Gruticibart is an anti-F11 human IgG4 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: AB023; Xisomab 3G3; MAB 14E11. CAS No. 2704554-77-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990743. | |
| GS143 | GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 916232-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110261. | |
| GS-2278 | GS-2278 is an LPAR1 (lysophosphatidic acid receptor 1) antagonist with potential for research in idiopathic pulmonary fibrosis (IPF)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2750508-72-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159983. | |
| GS 39783 | GS 39783. Group: Biochemicals. Alternative Names: N4,N6-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine; N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine. Grades: Highly Purified. CAS No. 39069-52-8. Pack Sizes: 10mg. Molecular Formula: C15H23N5O2S, Molecular Weight: 337.44. US Biological Life Sciences. | Worldwide |
| GS-441524 | GS-441524 is a pyrrolotriazine, a nitrile, a C-nucleoside, and an aromatic amine. It is a (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile which is 2-substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group. It is an active metabolite of remdesivir. It is a broad-spectrum inhibitor of replication of RNA viruses, with inhibitory activity being confirmed for HCV, parainfluenza and SARS-CoV. It has the drug targets of a drug metabolite, an antiviral agent and an anticoronaviral agent. Applications: Gs-441524 is a potent antiviral nucleoside analogue that has transformed the treatment of previously fatal viral diseases, most notably in feline medicine. it is the parent molecule and primary metabolite of the well-known human antiviral remdesivir. Category: Intermediates. CAS No. 1191237-69-0. Product ID: INT1191237690. Molecular formula: C12H13N5O4. Mole weight: 291.26. EINECS: 857-885-9. InChIKey: BRDWIEOJOWJCLU-LTGWCKQJSA-N. Appearance: White to off-white solid. | |
| GS-441524 | GS-441524 is an analog nucleotide inhibitor against feline infectious peritonitis virus (FIPV). EC50 is 0.78?uM. GS-441524 is also a metabolite and intermediate of Remdesivir. Alternative Names: 2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivir metabolite GS-441524; GS 441524; GS441524; (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. Grades: 97%. CAS No. 1191237-69-0. Molecular formula: C12H13N5O4. Mole weight: 291.26. | |
| GS-441524 | GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1191237-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-103586. | |
| GS-443902 | GS-443902 is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. Uses: Antiviral agents. Alternative Names: GS-441524 triphosphate; Remdesivir metabolite; RDV-TP. Grades: 99.87%. CAS No. 1355149-45-9. Molecular formula: C12H16N5O13P3. Mole weight: 531.20. | |
| GS-443902 trisodium | GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium. CAS No. 1355050-21-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126303C. | |
| GS-444217 | GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262041-49-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100844. | |
| GS-566500 | GS-566500 is a compound of Sofosbuvir metabolite. Category: Active pharmaceutical ingredients. CAS No. 1233335-78-8. Product ID: API1233335788. Molecular formula: C13H19FN3O9P. Mole weight: 411.27. | |
| GS 6201 | GS 6201. Group: Biochemicals. Grades: Purified. CAS No. 752222-83-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GS-621763 | GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2647442-13-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145119. | |
| GS-704277 | GS-704277 is an alanine metabolite of Remdesivir (HY-104077). GS-704277 is further hydrolyzed to GA-441524 (HY-103586) with antiviral activity. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1911579-04-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-136303. | |
| GS967 | GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Alternative Names: GS967; GS-967; GS 967; GS458967; GS 458967; GS-458967. Grades: 95%. CAS No. 1262618-39-2. Molecular formula: C14H7F6N3O. Mole weight: 347.22. | |
| GS967 | GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late INa ) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262618-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg. Product ID: HY-12593. | |
| GSA 10 | GSA 10. Group: Biochemicals. Grades: Purified. CAS No. 300833-95-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GSA-10 | GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 300833-95-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12317. | |
| Gsa I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 70°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme about 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CCCAG↑C G↓GGTCG. Activity: 10000-20000u.a./ml. Appearance: 10 X SE-buffer W, BSA. Storage: -20°C. Form: Liquid. Source: Geobacillus stearothermophilus Y. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1115RE. |  |
| GSDMD Antibody [B5P20] | Gasdermin D,GSDMD,GSDMDC1. Group: Antibodies. Alternative Names: DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; GSDMDC1; GSDMD. Pack Sizes: 20uL. Product ID: F1568. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GSH-CdTe, | GSH-CdTe. |  |
| GSH (Glutathione) | GSH (Glutathione). CAS No. 70-18-8. Product ID: CI-HC-0352. Molecular formula: C10H17N3O6S. Mole weight: 307.33 g/mol. ECNumber: 200-725-4. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| GSH (L-Glutathione reduced) | GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Group: Inhibitors. Alternative Names: Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine. CAS No. 70-18-8. Pack Sizes: 100mg. Product ID: S4606. Formula: C10H17N3O6S. Smiles: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSHtracer | GSHtracer is a ratiometric probe for measuring of GSH levels. GSHtracer exhibits Ex/Em from 520/580 nm to 430/510 nm (upon GSH binding) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1479071-34-5. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131013. | |
| GSK046 | GSK046 (iBET-BD2), a chemical probe, is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: iBET-BD2. CAS No. 2474876-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136571. | |
| GSK0660 | GSK0660 is a selective PPARδ antagonist. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10, and it may block TNFα-induced retinal leukostasis. Alternative Names: GSK0660; GSK-0660; GSK 0660. Grades: 96%. CAS No. 1014691-61-2. Molecular formula: C19H18N2O5S2. Mole weight: 418.48. | |
| GSK0660 | GSK0660 is a potent PPARβ antagonist with an IC50 of 155 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1014691-61-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12377. | |
| GSK 0660 | GSK 0660. Group: Biochemicals. Grades: Purified. CAS No. 1014691-61-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GSK1016790A | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone. It elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells with EC50 values of 18 and 2.1 nM, respectively. It also evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM, which is 300 fold more potent than 4a-PDD. It was developed by GlaxoSmithKline. Uses: Gsk1016790a regulats urinary bladder activity and endothelial control of vascular tone. Alternative Names: GSK1016790A; GSK-1016790A; GSK 1016790A. N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide. Grades: >98 %. CAS No. 942206-85-1. Molecular formula: C28H32Cl2N4O6S2. Mole weight: 655.61. | |
| GSK1016790A | GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 942206-85-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19608. | |
| GSK1016790A | GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD. Applications: A novel and potent trpv4 channel agonist. Group: Coenzymes. Synonyms: (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide. CAS No. 942206-85-1. Purity: ≥98%. Mole weight: 655.61. Form: Solid. (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide; GSK1016790A; 942206-85-1. Cat No: COEC-115. | |
| GSK1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Alternative Names: GSK-1059615; GSK 1059615; GSK1059615. Grades: >98%. CAS No. 958852-01-2. Molecular formula: C18H11N3O2S. Mole weight: 333.36. | |
| GSK1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 958852-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12036. | |
| GSK1059865 | GSK1059865 is a potent orexin 1 receptor antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 1191044-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101534. | |
| GSK-1070916 | GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-1070916A. CAS No. 942918-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70044. | |
| GSK-1070916A | GSK-1070916A is an ATP-competitive inhibitor of the serine / threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types. Alternative Names: GSK 1070916; GSK-1070916; GSK 1070916; GSK1070916A; GSK 1070916A; NMI-900; NMI 900; NMI900; N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea. Grades: 98%. CAS No. 942918-07-2. Molecular formula: C30H33N7O. Mole weight: 507.63. | |
| GSK126 | GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases. Group: Inhibitors. Alternative Names: GSK2816126A, GSK2816126. CAS No. 1346574-57-9. Pack Sizes: 5mg. Product ID: S7061. Formula: C31H38N6O2. Smiles: CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK126 | GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK2816126A. CAS No. 1346574-57-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13470. | |
| GSK126 | GSK126 Inhibitor. Uses: Scientific use. Product Category: T2079. CAS No. 1346574-57-9. |  |
| GSK126 | GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Alternative Names: GSK2816126; GSK-2816126; GSK 2816126; GSK-126; GSK 126; (S)-1-(sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide. Grades: 98%. CAS No. 1346574-57-9. Molecular formula: C31H38N6O2. Mole weight: 526.69. | |
| GSK126 | GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Group: Biochemicals. Alternative Names: N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-Indole-4-carboxamide; N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide. Grades: Highly Purified. CAS No. 1346574-57-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GSK1324726A | GSK1324726A Inhibitor. Uses: Scientific use. Product Category: T6021. CAS No. 1300031-52-0. | |
| GSK1324726A | GSK1324726A is a novel, potent and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50 = 41 nM), BRD3 (IC50 = 31 nM), and BRD4 (IC50 = 22 nM). Alternative Names: I-BET-726; I-BET 726; I-BET726; GSK-1324726A; GSK 1324726A. Grades: >98%. CAS No. 1300031-52-0. Molecular formula: C25H23ClN2O3. Mole weight: 434.91. | |
| GSK1324726A | GSK1324726A is a novel, potent, and selective inhibitor of BET proteins with high affinity to BRD2 (IC50=41 nM), BRD3 (IC50=31 nM), and BRD4 (IC50=22 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: I-BET726. CAS No. 1300031-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13960. | |
| GSK1379725A | GSK1379725A is a selective BPTF ligand with a Kd of 2.8 uM, showing no binding activity for Brd4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802251-00-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112398. | |
| GSK143 dihydrochloride | GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC50=7.1)[1]. GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2341796-81-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12736A. | |
| GSK-1482160 | GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1001389-72-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19888. | |
| GSK-1520489A | GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1042433-41-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147312. | |
| GSK1521498 | GSK-1521498 is a novel μ-Opioid receptor antagonist. It shows to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating in animals and humans. It is mainly used for the treatment of obesity and alcohol dependence. It was developed by GlaxoSmithKline and in clinic phase 2. Uses: Gsk-1521498 is mainly used for the treatment of obesity and alcohol dependence. Alternative Names: GSK-1521498; GSK1521498; GSK 1521498; GSK-1521498B;N-[[2,6-difluoro-4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1H-inden-2-amine;N-((3,5-difluoro-3'-(1H-1,2,4-triazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-inden-2-amine. Grades: >98 %. CAS No. 1007573-18-3. Molecular formula: C24H20F2N4. Mole weight: 402.44. | |
| GSK1521498 free base | GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and agents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1007573-18-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115066. | |
| GSK1702934A | GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924377-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111098. | |
| GSK1795091 | GSK1795091 (CRX-601), an immunologic stimulator, is a synthetic TLR4 agonist. Antitumor activity. GSK1795091 can be used as a vaccine adjuvant to enhance both mucosal and systemic immunity to influenza virus vaccines. Not only, GSK1795091 inhibits tumor growth and increases the survival in mice model, but results in long term survival in influenza challenge model in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CRX-601. CAS No. 1233589-81-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111792. | |
| GSK180 | GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799725-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112179. | |
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