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| Product | Description | |
|---|---|---|
| GPR30 agonist-1 | GPR30 agonist-1 is an agonist of G protein-coupled receptor 30 (GPR30) with vasorelaxant effects. Synonyms: 3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aS,4R,9bR)-. Grade: ≥98%. CAS No. 415919-74-3. Molecular formula: C19H17BrFNO. Mole weight: 374.25. |  |
| GPR30 agonist-1 | GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 415919-74-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138686. |  |
| GPR34 receptor antagonist | GPR34 receptor antagonist Inhibitor. Uses: Scientific use. Product Category: T8848. CAS No. 907952-06-1. |  |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 is a GPR34 receptor antagonist. Grade: 97%. CAS No. 907952-06-1. Molecular formula: C31H26ClNO4. Mole weight: 512.0. | |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 (Compound D2) is a GPR34 receptor antagonist. GPR34 receptor antagonist 2 can be used for immune diseases, inflammatory diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 907952-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138501. | |
| GPR34 receptor antagonist 3 | GPR34 receptor antagonist 3 (Compound 5e) is a class of GRP34 antagonists, IC50 is 0.680 μM. GPR34 receptor antagonist 3 inhibited ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent way without obvious cytotoxicity. GPR34 receptor antagonist 3 shows antisensory activity in mouse neuropathic pain model [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3049949-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155417. | |
| GPR35 activator-1 | GPR35 activator-1 is a potent GPR35 activator with a Ki of 0.08 nM for human GPR35. CAS No. 2855918-34-0. Molecular formula: C25H18N6O4. Mole weight: 466.45. | |
| GPR35 agonist 1 | GPR35 agonist 1 is a potent and specific GPR35/CXCR8 agonist with an EC50 of 5.8 nM. Synonyms: 6-Bromo-7-hydroxy-8-nitro-3-(1H-tetrazol-5-yl)-2H-chromen-2-one. CAS No. 2079880-92-3. Molecular formula: C10H4BrN5O5. Mole weight: 354.07. | |
| GPR35 agonist 1 | GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good agentgability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2079880-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101033. | |
| GPR35 agonist 4 | GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 871085-49-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107539. | |
| GPR35 agonist 5 | GPR35 agonist 5 is a weak GPR35 agonist. Synonyms: 3,5-dinitro-bisphenol A. CAS No. 2226201-24-5. Molecular formula: C15H14N2O6. Mole weight: 318.28. | |
| Gpr35 modulator 1 | Gpr35 modulator 1 is a potent modulator of Gpr35. CAS No. 2994189-01-2. Molecular formula: C23H14ClF2N5O3. Mole weight: 481.84. | |
| Gpr35 modulator 2 | Gpr35 modulator 2 is a potent modulator of Gpr35. CAS No. 3049339-96-7. Molecular formula: C28H23FN2O4. Mole weight: 470.49. | |
| Gpr35 modulator 3 | Gpr35 modulator 3 is a potent modulator of Gpr35. CAS No. 3055887-18-5. Molecular formula: C25H19FN6O2. Mole weight: 454.46. | |
| GPR3 agonist-2 | GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1983120-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155318A. | |
| GPR40 Activator 1 | GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. Synonyms: GPR40 Activator 1. Grade: >98%. CAS No. 1309435-60-6. Molecular formula: C31H31NO3S. Mole weight: 497.65. | |
| GPR40 Activator 2 | GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1. Synonyms: GPR40 Activator 2. Grade: >98%. CAS No. 1312787-30-6. Molecular formula: C28H29NO6S2. Mole weight: 539.66. | |
| GPR40 agonist 1 | GPR40 agonist 1 is a potent full agonist of GPR40 with EC50s of 2 and 17 nM for hGPR40 and rGPR40, respectively. Synonyms: Benzenepropanoic acid, β-cyclopropyl-3-[[5-(5-fluoro-2-methoxy-4-pyridinyl)-6-(2-methylpropyl)-2-pyrazinyl]methoxy]-, (βS)-; (3S)-3-Cyclopropyl-3-(3-((5-(5-fluoro-2-methoxypyridin-4-yl)-6-isobutylpyrazin-2-yl)methoxy)phenyl)propanoic acid. Grade: ≥95%. CAS No. 1853982-41-8. Molecular formula: C27H30FN3O4. Mole weight: 479.54. | |
| GPR40 Agonist 2 | GPR40 Agonist 2, an agonist of G-protein coupled receptor 40 (GPR40), can be used in diabetes research. (Extracted from patent WO2009054479A1). Synonyms: Benzenepropanoic acid, β-1-propyn-1-yl-4-(spiro[5.5]undec-2-en-2-ylmethoxy)-, (βS)-; (S)-3-[4-(spiro[5.5]undec-2-en-2-ylmethoxy)-phenyl]-hex-4-ynoic acid; (3S)-3-[4-(Spiro[5.5]undec-2-en-2-ylmethoxy)phenyl]-4-hexynoic acid. CAS No. 1147729-48-3. Molecular formula: C24H30O3. Mole weight: 366.49. | |
| GPR40 agonist 4 | GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54. Uses: Scientific research. Category: Signaling pathways. CAS No. 2102196-57-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103083. | |
| GPR40/FFAR1 modulator 1 | GPR40/FFAR1 modulator 1 is an agonist and allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1). Synonyms: 7-({4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl}methoxy)-4-methyl-2H-chromen-2-one; 2H-1-Benzopyran-2-one, 7-[[4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl]methoxy]-4-methyl-. Grade: ≥95%. CAS No. 874755-26-7. Molecular formula: C21H19N5O3. Mole weight: 389.41. | |
| GPR41 agonist-1 | GPR41 agonist-1 (compound 9) is a potent GPR41 agonist. GPR41 agonist-1 can be used for researching insulin-related disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 506417-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147394. | |
| GPR4 antagonist 1 | GPR4 antagonist 1 is a GPR4 antagonist, with an IC50 of 189 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197879-16-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101536. | |
| GPR4 antagonist 1 | A GPR4 antagonist, with an IC50 of 189 nM. Synonyms: GPR4 receptor modulator 46. CAS No. 1197879-16-5. Molecular formula: C27H37N5. Mole weight: 431.62. | |
| GPR52 agonist-1 | GPR52 agonist-1 is a potent, orally active and blood-brain barrier (BBB) penetrant GPR52 agonist with an pEC50 value of 7.53. GPR52 agonist-1 affects cAMP accumulation through direct interaction with GPR52. GPR52 agonist-1 can significantly suppress Methamphetamine-induced hyperactivity in mice. Antipsychotic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1207965-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-147395. | |
| GPR52 antagonist-1 | GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1239987-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145468. | |
| GPR55 agonist 3 | GPR55 agonist 3 is a GPR55 agonist and it induces β-arrestin recruitment to human GPR55. CAS No. 3006105-44-5. Molecular formula: C19H16F4N4. Mole weight: 376.35. | |
| GPR55 agonist 4 | GPR55 agonist 4 is a GPR55 agonist and it induces β-arrestin recruitment to human GPR55. CAS No. 3006105-55-8. Molecular formula: C19H16FN5O2. Mole weight: 365.36. | |
| GPR81 agonist 1 | GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620992-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135982. | |
| GPR81 Agonist, 3Cl-5OH-BA (3-Chloro-5-hydroxybenzoic Acid, Hydroxycarboxylic Acid Receptor 1 Agonist) | A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~7, 16, 17, 22, and 67uM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100mg/kg, p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 53984-36-4. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| GPR84 antagonist 1 | GPR84 antagonist 1 is a high affinity and highly selective human GPR84 competitive antagonist. Molecular formula: C26H22N4O2. Mole weight: 422.48. | |
| GPR84 antagonist 2 | GPR84 antagonist 2 is a potent, selective and orally active GPR84 antagonist (IC50 = 8.95 nM), which has the potential for the study of ulcerative colitis. It shows improved potency in the calcium mobilization assay and inhibits the chemotaxis of neutrophils and macrophages upon GPR84 activation. Synonyms: Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1). CAS No. 2244269-74-5. Molecular formula: C28H16Cl2NaO4PS2. Mole weight: 605.42. | |
| GPR84 antagonist 8 | GPR84 antagonist 8 is a selective antagonist of GPR84. Synonyms: 4H-Pyrimido[6,1-a]isoquinolin-4-one, 2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydro-9-(2-pyridinylmethoxy)-; 2-(1,4-Dioxan-2-ylmethoxy)-9-(2-pyridinylmethoxy)-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one. Grade: ≥95%. CAS No. 1445846-30-9. Molecular formula: C23H23N3O5. Mole weight: 421.45. | |
| gpr endopeptidase | Initiates the degradation of small, acid-soluble proteins during spore germination in Bacillus megaterium. Type example of peptidase family M63. Group: Enzymes. Synonyms: germination proteinase. Enzyme Commission Number: EC 3.4.24.78. CAS No. 75718-32-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4362; gpr endopeptidase; EC 3.4.24.78; 75718-32-0; germination proteinase. Cat No: EXWM-4362. |  |
| G Protein Antagonist | G Protein Antagonist. Uses: For analytical and research use. CAS No. 143675-79-0. Mole weight: 1093.26. Catalog: AP143675790. |  |
| G-Protein antagonist peptide | G-Protein antagonist peptide is a competitive and reversible inhibitor of M2 muscarinic cholinergic receptors. G-Protein antagonist peptide inhibits M2 muscarinic receptor activation of Gi or Go and suppresses Gs activation by β-adrenoceptors. Synonyms: GPAnt-2; G Protein Antagonist. Grade: >98%. CAS No. 143675-79-0. Molecular formula: C57H64N12O9S. Mole weight: 1093.27. | |
| G-Protein antagonist peptide acetate | G-Protein antagonist peptide is a competitive and reversible inhibitor of M2 muscarinic cholinergic receptors. G-Protein antagonist peptide inhibits M2 muscarinic receptor activation of Gi or Go and suppresses Gs activation by β-adrenoceptors. Synonyms: GPAnt-2 acetate; G Protein Antagonist acetate. Molecular formula: C59H68N12O11S. Mole weight: 1153.33. | |
| G-protein coupled receptor 143 (126-134) | G-protein coupled receptor 143 (126-134) is a 9-aa peptide. G-protein coupled receptor 143 is a receptor for tyrosine, L-DOPA and dopamine. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Synonyms: Ocular albinism type 1 protein (126-134). | |
| G-protein-coupled receptor kinase | Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, β-adrenergic-receptor kinase). Group: Enzymes. Synonyms: G protein-coupled receptor kinase; GPCR kinase; GPCRK; GRK4; GRK5; GRK6; STK16. Enzyme Commission Number: EC 2.7.11.16. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3135; G-protein-coupled receptor kinase; EC 2.7.11.16; G protein-coupled receptor kinase; GPCR kinase; GPCRK; GRK4; GRK5; GRK6; STK16. Cat No: EXWM-3135. | |
| GPRP | GPRP is an inhibitor of fibrin polymerization. It binds to fibrinogen (Ki = 400 mM). Synonyms: Gly-pro-arg-pro; L-Proline,glycyl-L-prolyl-L-arginyl-; (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid. CAS No. 67869-62-9. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| GPRP | GPRP (Gly-Pro-Arg-Pro; Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction between fibrinogen and the platelet membrane glycoprotein ?b/IIIa complex (glycoprotein IIb/IIIa receptor). GPRP increases the level of free thrombin in activated platelet-rich plasma by reducing the adsorption of thrombin onto fibrin. GPRP inhibits platelet aggregation and prolongs the thrombin-initiated clotting time in plasma. GPRP is applicable for research related to thrombosis and thrombotic diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gly-Pro-Arg-Pro; Pefa 6003. CAS No. 67869-62-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074. | |
| GPRP acetate | GPRP acetate, a fibrinogen-related peptide, inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). Synonyms: Pefa 6003; Pefabloc FG; GPRP.CH3CO2H; glycyl-L-prolyl-L-arginyl-L-proline acetic acid; (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate; H-Gly-Pro-Arg-Pro-OH acetate. Grade: ≥95%. CAS No. 157009-81-9. Molecular formula: C18H31N7O5.C2H4O2. Mole weight: 485.53. | |
| GPRP acetate | GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate. CAS No. 157009-81-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074A. | |
| GPS1573 | GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2445822-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10571. | |
| GPS491 | GPS491 (EC50 = 0.47 μM) inhibits the expression of HIV-1 structural protein Gag, changes the accumulation of HIV-1 RNA, reduces the abundance of RNAs encoding the structural proteins, and increases the level of viral RNAs encoding the regulatory proteins. Synonyms: 2-(trifluoromethyl)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)thiazole-5-carboxamide. Grade: ≥98%. CAS No. 2655502-29-5. Molecular formula: C13H5F6N3OS2. Mole weight: 397.32. | |
| GPTA | GPTA. Mole weight: 428. |  |
| GPTA-TF | GPTA-TF. Mole weight: 428. | |
| GPV0057 | GPV0057 (Compound 5d) is a selective and potent P-glycoprotein (P-gp) inhibitor. GPV0057 is also a selective potassium channel Kir2.1 activator. GPV0057 competitively binds to the substrate-binding site of P-gp, inhibiting ATP-dependent drug efflux to reverse multidrug resistance in tumor cells. GPV0057 can also stabilizes the open state of Kir2.1 and promotes potassium ion influx. GPV0057 is promising for research of tumors with high P-gp expression, Kir2.1-deficient diseases such as heart failure and Andersen-Tawil Syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86383-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173162. | |
| GPX100 | GPX-100 is an analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Synonyms: Epirubicin Impurity 1; 13-Deoxyepirubicin; GPX 100; GPX-100; 13-deoxy-doxorubicin; (1S,3R)-3,5,12-Trihydroxy-3-(2-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-1-methoxy-, (8R,10S)-. Grade: ≥95%. CAS No. 952648-77-0. Molecular formula: C27H31NO10. Mole weight: 529.54. | |
| GPX150 | GPX-150 is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Synonyms: GPX 150; GPX-150; 5(8H)-Naphthacenone, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-, (8R,10S)-. CAS No. 236095-29-7. Molecular formula: C27H32N2O9. Mole weight: 528.56. | |
| GPX4 activator 1 | GPX4 activator 1 (Compound A9) is a allosteric activator of GPX4 (Kd = 5.86 μM, EC50 = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030098-18-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161928. | |
| GPX4 activator 2 | GPX4 activator 2 is a GPX4 activator with a Ka value of 0.426 μM for human GPX4. GPX4 activator 2 reduces lipid hydroperoxide levels, prevents lipid peroxide accumulation, and inhibits ferroptosis. GPX4 activator 2 rescues cell death induced by Erastin (HY-15763). GPX4 activator 2 exerts cardioprotective effects in a mouse model of doxorubicin (HY-15142A)-induced myocardial injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 950365-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161929. | |
| GPX4-IN-19 | GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe2+ accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3102894-57-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-178364. | |
| GPX4-IN-3 | GPX4-IN-3 is an effective inhibitor of glutathione peroxidase 4 (GPX4) and can be used as a selective ferroptosis inducer. It shows 71.7% inhibition for GPX4 with 1 μM. Synonyms: NSC-835419; 2-(benzo[b]thiophen-3-yl)-2-(2-chloro-N-(4-(oxazol-5-yl)phenyl)acetamido)-N-phenethylacetamide. Grade: ≥95%. Molecular formula: C29H24ClN3O3S. Mole weight: 530.04. | |
| GPX4-IN-3 | GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2761004-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141809. | |
| GPX4-IN-4 | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2920221-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149923. | |
| GPX4-IN-5 | GPX4-IN-5 is a covalent inhibitor of GPX4 (IC50: 0.12 μM). GPX4-IN-5 can induce ferroptosis and has anti-tumor effects. GPX4-IN-5 can be used in the study of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922824-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-155663. | |
| GQ-16 | GQ-16 is an effective and partial agonist for peroxisome proliferator-activated receptor γ (PPARγ) (Ki = 160 nM). It does not activate PPARα, PPARβ/δ, or RXRα. Synonyms: 5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione. Grade: ≥98%. CAS No. 870554-67-9. Molecular formula: C19H16BrNO3S. Mole weight: 418.3. | |
| GQ1b-Ganglioside | GQ1b-Ganglioside is a vital biomedical product utilized for its neuroprotective properties. This compound acts as a crucial element in the treatment of various neurological disorders, including Guillain-Barré syndrome and Miller Fisher syndrome. Synonyms: Tetrasialoganglioside 1b; Ganglioside GQ1b; GQ1b. CAS No. 68652-37-9. | |
| GQ3-Oligosaccharide | GQ3-Oligosaccharide is an extraordinary bioactive compound employed in the research of neurodegenerative ailments, showcasing remarkable neuroprotective attributes. GQ3-Oligosaccharide actively contributes to the diminution of oxidative stress and inflammation, thereby facilitating the augmentation of neuronal viability and efficacious functioning. Synonyms: Neu5Aca2-8Neu5Aca2-8Neu5Acb2-8Neu5Aca2-3Galb1-4Glc. Molecular formula: C56H86N4O43Na4. Mole weight: 1595.24. | |
| GR103545 | GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). Synonyms: GR-103545 fumarate; (R)-Methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate; (R)-(-)-GR103545 fumarate. CAS No. 126766-43-6. Molecular formula: C23H29Cl2N3O7. Mole weight: 530.40. | |
| GR103545 fumarate | GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). 11GR103545 is a radiotracer for imaging κ-OR in vivo[1] | |
| GR 103691 | GR 103691 is a potent dopamine D3 receptor antagonist. Uses: Dopamine antagonists. Synonyms: GR 103691; GR103691; GR-103691; 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide. Grade: 99%. CAS No. 162408-66-4. Molecular formula: C30H35N3O3. Mole weight: 485.62. | |
| GR 113808 | GR 113808 is a potent and selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, Kd=0.15 nM for binding to cloned human 5-HT4 receptors). GR 113808 displays > 300-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Uses: Serotonin antagonists. Synonyms: GR 113808; GR113808; GR-113808. 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester. Grade: ≥98% by HPLC. CAS No. 144625-51-4. Molecular formula: C19H27N3O4S. Mole weight: 393.5. | |
| GR 113808 | GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144625-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103152. | |
| GR 125487-d3 sulfamate | GR 125487-d3 sulfamate is a deuterated salt form of GR 125487, which is a potent 5-HT4 receptor antagonist used for the treatment of gastrointestinal motility. Synonyms: 5-Fluoro-2-methoxy-d3-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate. Grade: 96% by HPLC; 99% atom D. Molecular formula: C19H23D3FN3O5S.H2NSO3H. Mole weight: 527.6. | |
| GR 125487 sulfamate | GR 125487, a potent and selective 5-HT4 antagonist, is used in many biological assays to cross confirm the 5-HT4R agonist's activity. Synonyms: GR 125487 sulfamate; GR 125487; GR125487; GR-125487. 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate. Grade: ≥97% by HPLC. CAS No. 859502-43-5. Molecular formula: C19H26FN3O5S.H2NSO3H. Mole weight: 524.58. | |
| GR-125743 | GR-125743 is a novel 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. It is used for the research of Parkinson's disease and cardiovascular diseases. Synonyms: N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(pyridin-4-yl)benzamide; GR 125743. Grade: >99%. CAS No. 148547-33-5. Molecular formula: C25H28N4O2. Mole weight: 416.52. | |
| GR 127935 | GR 127935 is a potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors), exhibiting >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Uses: Serotonin antagonists. Synonyms: [1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-; N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-carboxamide; GR127935; GR-127935. Grade: ≥95%. CAS No. 148672-13-3. Molecular formula: C29H31N5O3. Mole weight: 497.59. | |
| Gr 127935 hydrochloride | Gr 127935 hydrochloride. CAS No. 148672-13-3. Purity: >99 %. Product ID: ACM148672133. Molecular formula: C29H31N5O3. Mole weight: 497.59. Alfa Chemistry - ISO 9001:32057 Certified. |  |
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