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H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 is a highly potent human somatostatin subtype 2 receptor (hsst2) antagonist with Kis of >1000, 12, 100±57, 895 and 520 nM for hsst1, hsst2, hsst3, hsst4 and hsst5, respectively. Synonyms: PRL-2915; 4-chloro-L-phenylalanyl-D-cysteinyl-3-(3-pyridyl)-L-alanyl-D-tryptophyl-L-lysyl-2-tert-butyl-L-glycyl-L-cysteinyl-3-(2-naphthyl)-L-alaninamide (2->7)-disulfide; H-Phe(4-Cl)-D-Cys-3Pal-D-Trp-Lys-Gly(tBu)-Cys-2Nal-NH2 (Disulfide bridge: Cys2-Cys7); Cpa-D-Cys-Pal-D-Trp-Lys-Tle-Cys-Nal-amide. Grade: 95%. CAS No. 209006-18-8. Molecular formula: C59H71ClN12O8S2. Mole weight: 1175.87.
H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 is the somatostatin-14 analog, with a high affinity of 5.98 nM for somatostatin receptor subtype 5 (SST5) (1.4 nM for somatostatin-14). It is the first antagonist with high affinity for SST5. Synonyms: H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 (Disulfide bridge: Cys2-Cys7); 4-chloro-L-phenylalanyl-D-cysteinyl-3-(3-pyridyl)-L-alanyl-D-tryptophyl-N-methyl-L-lysyl-L-threonyl-L-cysteinyl-3-(2-naphthyl)-L-alaninamide (2->7)-disulfide; H-Phe(4-Cl)-D-Cys(1)-3Pal-D-Trp-N(Me)Lys-Thr-Cys(1)-2Nal-NH2; PRL-3195; 4-Cpa-cyclo(D-Cys-3-Pal-D-Trp-MeLys-Thr-Cys)-2-Nal-NH2. Grade: ≥90%. CAS No. 341519-04-8. Molecular formula: C58H69ClN12O9S2. Mole weight: 1177.83.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis. Synonyms: H-Pen(Acm)-Trt(2-Cl)-Resin; H-Pen(Acm)-Barlos Resin; S-Acetamidomethyl-L-penicillamine 2-chlorotrityl resin.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis. Synonyms: H-Pen(Trt)-Trt(2-Cl)-Resin; H-Pen(Trt)-Barlos Resin; S-Trityl-L-penicillamine 2-chlorotrityl resin.
HPGDS-inhibitor-1
HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM. Synonyms: MDK36122; MDK36122; MDK-36122; H-PGDS Inhibitor I; Prostaglandin D Synthase (hematopoietic-type) Inhibitor I. CAS No. 1033836-12-2. Molecular formula: C19H19F4N3O. Mole weight: 381.3746.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
H-Phe-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-phenylalanine 2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Phe(2-Me)-OH
H-Phe(2-Me)-OH is a phenylalanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 80126-53-0. Pack Sizes: 10 g; 25 g. Product ID: HY-W016555.
H-Phe(4-Ac)-OH. Group: Biochemicals. Alternative Names: H-Phe(4-Ac)-OH. Grades: Highly Purified. CAS No. 122555-04-8. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
H-Phe(4-Ac)-OH ≥97% (HPLC)
H-Phe(4-Ac)-OH ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
H-Phe(4-Ac)-OH HCl
H-Phe(4-Ac)-OH HCl, an essential chemical for a wide range of pharmaceutical and peptide synthesis, boasts exceptional adequacy as a constituent for drug production. This product serves as a key reagent as well as a fundamental building block in the synthesis of peptide-based medications. Medical professionals and researchers commonly employ H-Phe(4-Ac)-OH HCl as an effective measure in the treatment of chronic pain and inflammation arising due to a multitude of conditions, including but not limited to osteoarthritis and rheumatoid arthritis. Synonyms: 4-Acetyl-L-phenylalanine Hydrochloride; 4-Acetylphenylalanine hydrochloride; (S)-3-(4-Acetylphenyl)-2-aminopropanoic acid HCl; p-Acetylphenylalanine hydrochloride. CAS No. 20299-31-4. Molecular formula: C11H14ClNO3. Mole weight: 243.68.
H-Phe-cyclohexylamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-Phenylalanine-cyclohexylamide, N-Cyclohexyl-L-phenylalaninamide, AC1LEMHZ, SureCN353959, Phenylalanine Cyclohexylamide, 78082_ALDRICH, 78082_FLUKA, AKOS010391288, AG-B-72934, L-|A-amino-N-cyclohexylhydrocinnamamide, (S)-|A-Amino-N-cyclohexylbenzenepropanamide, FT-0665362, (2S)-2-amino-N-cyclohexyl-3-phenylpropanamide, 17186-53-7. Product Category: Heterocyclic Organic Compound. CAS No. 17186-53-7. Molecular formula: C15H22N2O. Mole weight: 246.36. Purity: 0.96. IUPACName: (2S)-2-amino-N-cyclohexyl-3-phenylpropanamide. Canonical SMILES: C1CCC(CC1)NC(=O)C(CC2=CC=CC=C2)N. Product ID: ACM17186537. Alfa Chemistry ISO 9001:2015 Certified.
H-Phe-Glu-OH
It is a taste modulating peptide extracted from Cocoa Beans. Synonyms: Phenylalanylglutamate; Phe-glu; L-phenylalanyl-L-glutamic acid; FE dipeptide; L-Phe-L-Glu; L-Phenylalanyl-L-Glutamate; Phenylalanine Glutamate dipeptide. Grade: >99%. CAS No. 3617-45-6. Molecular formula: C14H18N2O5. Mole weight: 294.30.
H-Phe-Gly-His-p-nitro-Phe-Phe-Ala-Phe-OMe
A good substrate for pepsin which is also cleaved by cathepsin D. Synonyms: Phe-Gly-His-Phe(NO2)-Phe-Ala-Phe-OMe; Methyl L-phenylalanylglycyl-L-histidyl-4-nitro-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-phenylalaninate. CAS No. 50572-79-7. Molecular formula: C48H54N10O10. Mole weight: 931.00.
H-Phe-Met-Arg-Phe-NH2 is a molluscan neuropeptide isolated from the ganglia of Macrocallista nimbosa. Synonyms: Fmrfamide; FMRF amide; (S)-N-((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-4-(methylthio)butanamido)-5-guanidinopentanamide; Molluscan Cardioexcitatory Neuropeptide. CAS No. 152165-14-5. Molecular formula: C29H42N8O4S. Mole weight: 598.76.
H-Phe-Phe-Phe-OH is a bitter-tasting peptide due to its hydrophobicity. Synonyms: Phe-phe-phe; Phenylalanyl-phenylalanyl-phenylalanine; l-phenylalanyl-l-phenylalanyl-l-phenylalanine. Grade: 95%. CAS No. 2578-81-6. Molecular formula: C27H29N3O4. Mole weight: 459.54.
H-PHE-TRP-OH. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-Phe-L-Trp-OH. Appearance: White solid. CAS No. 24587-41-5. Molecular formula: C20H21N3O3. Mole weight: 351.4. Purity: 0.98. Product ID: ACM24587415. Alfa Chemistry ISO 9001:2015 Certified.
H-Phg-2-chlorotrityl resin
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis. Synonyms: H-Phg-Trt(2-Cl)-Resin; H-Phg-Barlos Resin; L-Phenylglycine 2-chlorotrityl resin.
A carnitine palmitoyltransferase-1 inhibitor. It has been shown to improve whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance. Uses: Enzyme inhibitors. Synonyms: Oxfenicine; 4-Hydroxy-L-phenylglycine; L-4-Hydroxyphenylglycine; (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid. Grade: ≥98%. CAS No. 32462-30-9. Molecular formula: C8H9NO3. Mole weight: 167.16.
HPHI
HPHI. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HPHI;Restriction endonuclease Hph I. Product Category: Heterocyclic Organic Compound. CAS No. 81295-26-3. Product ID: ACM81295263. Alfa Chemistry ISO 9001:2015 Certified. Categories: HP: To the Highest Level Na!
HPi1
HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC 50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei , Lactobacillus reuteri , and Bifidobacterium longum [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 13080-21-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-120536.
HPI 1
HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation) with no effect on Wnt signaling. HPI 1 also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM), and prevents the proliferation of cerebellar granule neuron precursors expressing SmoM2. Synonyms: HPI 1; HPI1; HPI-1; 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester. Grade: ≥95% by HPLC. CAS No. 599150-20-6. Molecular formula: C27H29NO6. Mole weight: 463.52.
Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6um for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5um); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling. Group: Biochemicals. Grades: Highly Purified. CAS No. 599150-20-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
HPI-1 hydrate
HPI-1 hydrate. Group: Biochemicals. Alternative Names: 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester hydrate. Grades: Highly Purified. CAS No. 1262770-72-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C27H31NO7. US Biological Life Sciences.
HPK1-IN-10 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 103. HPK1-IN-10 has the potential for the research of HPK1 related diseases. CAS No. 2734168-69-3. Molecular formula: C31H34N6O2. Mole weight: 522.64.
HPK1-IN-11
HPK1-IN-11 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 2. HPK1-IN-11 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2734167-68-9. Molecular formula: C27H25N5O2. Mole weight: 451.52.
HPK1-IN-12
HPK1-IN-12 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 85. HPK1-IN-12 has the potential for the research of HPK1 related diseases. Uses: Hpk1-in-12 is a potent inhibitor of hpk1, a serine/threonine protein kinase that is involved in the regulation of cell growth and differentiation. it is being investigated for its potential use in the treatment of cancer and other diseases. Synonyms: N-(4-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-2-methyl-4-pyrimidinamine. CAS No. 2734168-51-3. Molecular formula: C25H24FN5O2. Mole weight: 445.49.
HPK1-IN-13
HPK1-IN-13 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 64. HPK1-IN-13 has the potential for the research of HPK1 related diseases. Uses: It is being investigated for its potential use in the treatment of cancer and other diseases. CAS No. 2734168-30-8. Molecular formula: C25H24FN5O2. Mole weight: 445.49.
HPK1-IN-14
HPK1-IN-14 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 79. HPK1-IN-14 has the potential for the research of HPK1 related diseases. Synonyms: N-(2-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-4-pyrimidinamine. CAS No. 2734168-45-5. Molecular formula: C24H23FN6O2. Mole weight: 446.48.
HPK1-IN-15
HPK1-IN-15 is a potent and selective inhibitor of HPK1 extracted from patent WO2018049200A1, compound 50. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. Synonyms: N-(3-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-4-pyrimidinamine. CAS No. 2201098-03-3. Molecular formula: C24H21ClF3N5. Mole weight: 471.91.
HPK1-IN-16
HPK1-IN-16 is a potent and selective inhibitor of HPK1 extracted from patent WO2019051199A1, compound 39. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2294965-95-8. Molecular formula: C28H27FN4O. Mole weight: 454.54.
HPK1-IN-17
HPK1-IN-17 is a potent and selective inhibitor of HPK1 extracted from patent WO2019238067A1, compound 73. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2403600-07-5. Molecular formula: C26H28N6O. Mole weight: 440.54.
HPK1-IN-18
HPK1-IN-18 is a potent and selective inhibitor of HPK1 extracted from patent WO2019238067A1, compound 1. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2403598-42-3. Molecular formula: C24H24N4. Mole weight: 368.47.
HPK1-IN-19
HPK1-IN-19 is a potent and selective inhibitor of HPK1 extracted from patent WO2018102366A1 compound I-47. CAS No. 2227609-33-6. Molecular formula: C27H32N7O2P. Mole weight: 517.56.
HPK1-IN-2
HPK1-IN-2 is an orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1), Lck and Flt3 with IC50 of <0.05 μM, <0.5 μM and <0.05 μM, respectively. CAS No. 2056122-11-1. Molecular formula: C19H20N6OS. Mole weight: 380.47.
HPK1-IN-20
HPK1-IN-20 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2020235902A1 compound 106. CAS No. 2561490-78-4. Molecular formula: C26H28N6O2. Mole weight: 456.54.
HPK1-IN-3
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. Synonyms: HPK1-IN-3; 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; CHEMBL4878586; BDBM552521; WO2022098809, Example 4-8; MS-29115; HY-138568; CS-0159070; 4-((2-fluoro-6-(trifluoromethyl)phenyl)amino)-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidine-5-carboxamide; YK1. Grade: 98%. Molecular formula: C23H22F4N6O2. Mole weight: 490.45.
HPK1-IN-4
HPK1-IN-4 is a HPK1 (MAPK41) inhibitor with an IC50 of 0.061 nM. Synonyms: HPK1-IN-4; 2739844-28-9; CHEMBL4865305; EX-A5129; BDBM50569672; AKOS040758005; MS-27782; HY-138569; CS-0159071. Grade: 99%. CAS No. 2739844-28-9. Molecular formula: C23H26N6O3. Mole weight: 434.49.
HPK1-IN-7
HPK1-IN-7 is a potent, orally active HPK1 inhibitor with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). Synonyms: (S)-5-((4-((2-Hydroxy-1-phenylethyl)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one. Grade: 99%. CAS No. 2320462-65-3. Molecular formula: C24H22N6O4. Mole weight: 458.48.
HPK1-IN-8
HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1. CAS No. 1214561-09-7. Molecular formula: C19H17FN6O2S. Mole weight: 412.44.
HPMC (Hypromellose) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Hypromellose; (Hydroxypropyl)methyl cellulose; Celacol HPM 5000. CAS No. 9004-65-3. Pack Sizes: 500 mg; 1 g. Product ID: HY-A0104.
HPN-01
HPN-01 is a potent and selective inhibitor of IKK, with pIC50s of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. It shows greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src and VEGFR-2. Synonyms: [1,1':3',1''-Terphenyl]-5'-carboxamide, 4'-amino-4''-(aminosulfonyl)-4-chloro-; 4'-Amino-4-chloro-4''-sulfamoyl-1,1':3',1''-terphenyl-5'-carboxamide; 2-Amino-3-(4-sulfamoylphenyl)-5-(4-chlorophenyl)benzamide; 4'-amino-4-chloro-4''-sulfamoyl-[1,1'; 3',1'']terphenyl-5'-carboxylic acid amide. Grade: ≥98%. CAS No. 928655-63-4. Molecular formula: C19H16ClN3O3S. Mole weight: 401.87.