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| Product | Description | |
|---|---|---|
| juvenile-hormone esterase | Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters. Group: Enzymes. Synonyms: JH-esterase; juvenile hormone analog esterase; juvenile hormone carboxyesterase; methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase. Enzyme Commission Number: EC 3.1.1.59. CAS No. 50812-15-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3487; juvenile-hormone esterase; EC 3.1.1.59; 50812-15-2; JH-esterase; juvenile hormone analog esterase; juvenile hormone carboxyesterase; methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase. Cat No: EXWM-3487. |  |
| Juvenile hormone iii | Juvenile hormone iii. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TRANS,TRANS-10,11-EPOXY-3,7,11-TRIMETHYL-2,6-DODECADIENIC ACID METHYL ESTER;10-EPOXY-3,7,11-TRIMETHYL-TRANS,TRANS-2,6-DODECADIENOIC ACID METHYL ESTER;MANDUCA HORMONE;JH-III;JH II;JUVENILE HORMONE 11;JUVENILE HORMONE III;[+/-]-CIS-10,11-EPOXY-3,7,11-TRIME. Product Category: Heterocyclic Organic Compound. CAS No. 22963-93-5. Molecular formula: C16H26O3. Mole weight: 266.38. Product ID: ACM22963935. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Juvenile hormone III | Juvenile hormone III. CAS No: 24198-95-6 |  Sarchem Laboratories New Jersey NJ |
| juvenile hormone-III synthase | The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species. Group: Enzymes. Synonyms: farnesoic acid methyltransferase; juvenile hormone acid methyltransferase; JHAMT. Enzyme Commission Number: EC 2.1.1.325. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1933; juvenile hormone-III synthase; EC 2.1.1.325; farnesoic acid methyltransferase; juvenile hormone acid methyltransferase; JHAMT. Cat No: EXWM-1933. | |
| Juvenimicin A2 | It is produced by the strain of Micromono spora chalcea var. izumensis. Juvenimicin A2 can resist gram-positive bacteria and individual gram-negative bacteria. Synonyms: BRN 1413776; 6-De(2-oxoethyl)-4'-deoxy-6-methylcirramycin A1. CAS No. 61417-47-8. Molecular formula: C30H51NO8. Mole weight: 553.73. |  |
| Juvenimicin A3 | It is produced by the strain of Micromono spora chalcea var. izumensis. Juvenimicin A3 can resist gram-positive bacteria and individual gram-negative bacteria. Synonyms: Rosaramicin; Rosaramicina; Rosaramicine; Rosaramicinum; Antibiotic 67-694; NSC 175150; 3-Ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-9-((3,4,6-tridesoxy-3-dimethylamino-beta-O-xylo-hexopyranosyl)oxy)-4,17-dioxabicyclo(14.1.0)heptadec-14-en-10-acetaldehyd. CAS No. 35834-26-5. Molecular formula: C31H51NO9. Mole weight: 581.74. | |
| JW 133 (10mg/mL in Methyl Acetate) | JW 133 is an intermediate used to synthesize potent CB2-Selective Cannabinoid Receptor Ligands such as 4-oxo-1,4-dihydroquinoline-3-carboxamides and 3-(1',1'-Dimethylbutyl)-1-deoxy-Δ8-THC analogs. Group: Biochemicals. Grades: Highly Purified. CAS No. 259869-55-1. Pack Sizes: 100ul, 1mL. Molecular Formula: C22H32O. US Biological Life Sciences. |  Worldwide |
| JW480 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| JW 480 | JW 480 has been found to be a potent and selective inhibitor of KIAA1363 (AADACL1), which is a kind of serine hydrolase enzyme. Synonyms: JW 480; JW480; JW-480; 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate. Grades: ≥98% by HPLC. CAS No. 1354359-53-7. Molecular formula: C22H23NO2. Mole weight: 333.42. | |
| JW55 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JW55 | JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively. Synonyms: JW55; JW-55; JW 55. CAS No. 664993-53-7. Molecular formula: C25H26N2O5. Mole weight: 434.492. | |
| JW 55 | JW 55. Group: Biochemicals. Grades: Purified. CAS No. 664993-53-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JW 618 | JW 618 is an inhibitor of monoacylglycerol lipase (MAGL), displaying IC50 values of 123, 385, and 6.9 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. MAGL is a 33 kDa serine hydrolase that catalyses the hydrolysis of monoacylglycerols to their corresponding fatty acids. Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate. Grades: ≥98%. CAS No. 1416133-88-4. Molecular formula: C17H14F6N2O2. Mole weight: 392.3. | |
| JW 642 | Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively). Synonyms: JW642; JW-642; JW 642. Grades: >98%. CAS No. 1416133-89-5. Molecular formula: C21H20F6N2O3. Mole weight: 462.39. | |
| JW651 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JW67 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JW 67 | JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human colorectal cancer cells. Synonyms: JW 67; JW 67; JW 67; Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione. Grades: ≥97% by HPLC. CAS No. 442644-28-2. Molecular formula: C21H18N2O6. Mole weight: 394.38. | |
| JW 67 | JW 67. Group: Biochemicals. Grades: Purified. CAS No. 442644-28-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3, 2'-[1, 3]dioxane--2'', 3'''-[3H]indole]-2, 2'''(1H, 1'''H)-dione) | Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Group: Biochemicals. Grades: Highly Purified. CAS No. 442644-28-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JW74 | JW74 is a tankyrase-specific inhibitor. JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. At the molecular level, JW74 induces stabilization of AXIN2, a key component of the β-catenin destruction complex, resulting in reduced levels of nuclear β-catenin. At the functional level, JW74 induces reduced cell growth in all three tested cell lines, in part due to a delay in cell cycle progression and in part due to an induction of caspase-3-mediated apoptosis. Furthermore, JW74 induces differentiation in U2OS cells, which under standard conditions are resistant to osteogenic differentiation. JW74 also enhances differentiation of OS cell lines, which do not harbor a differentiation block. Synonyms: JW74; JW-74; JW 74. Grades: 0.98. CAS No. 863405-60-1. Molecular formula: C24H20N6O2S. Mole weight: 456.5196. | |
| JW74 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JWH-007-d9 Hydrochloride | JWH-007-d9 Hydrochloride. Group: Biochemicals. Alternative Names: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3. 2. 1]octane-d9 Hydrochloride; endo-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-Azabicyclo[3. 2. 1]octane-d9 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C24H21D9ClF2NO , Molecular Weight: 431.01. US Biological Life Sciences. | Worldwide |
| JWH-018 4-Hydroxypentyl metabolite-D5 (indole-D5) solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-018 4-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-018 5-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-018 5-Pentanoic acid metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-018 6-Hydroxyindole | JWH-018 6-Hydroxyindole is a metabolite of JWH 018 (P283650) which acts as a cannabinoid receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307803-44-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C24H23NO2, Molecular Weight: 357.44. US Biological Life Sciences. | Worldwide |
| JWH-018 Adamantyl Analog | JWH 018 adamantyl analog is a mildly selective agonist of the peripheral cannabinoid receptor, where the naphthalene ring is substituted with an adamantyl group. Adamantyl substitutions provide structural rigidity and bulk. Though no biological activity has been reported for JWH 018 adamantyl analog, Δ8-THC analogs with adamantyl substituted for the carbon side chain demonstrate improved affinity and selectivity of central cannabinoid and peripheral cannabinoid receptor binding. This synthetic cannabinoid has been identified in a herbal product. Group: Biochemicals. Alternative Names: (1s,?3s)-adamantan-1-yl(1-pentyl-1H-?indol-3-yl)methanone. Grades: Highly Purified. CAS No. 1345973-49-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H31NO, &lambda:max: 214, 247, 305nm. US Biological Life Sciences. | Worldwide |
| JWH-019 5-Hydroxyhexyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-019 6-Hydroxyhexyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-073 3-Hydroxybutyl metabolite-D5 (indole-D5) solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-073 3-Hydroxybutyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-073 4-Butanoic acid metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-073 4-Hydroxybutyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH 073 6-Methoxyindole | JWH 073 6-Methoxyindole. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C24H23NO2, Molecular Weight: 357.5. US Biological Life Sciences. | Worldwide |
| JWH 073 N-(4-Hydroxybutyl) β-D-Glucuronide | JWH 073 N-(4-Hydroxybutyl) β-D-Glucuronide. Group: Biochemicals. Alternative Names: 4-[3-(1-Naphthalenylcarbonyl)-1H-indol-1-yl]butyl β-D-Glucopyranosiduronic Acid. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C29H31NO7, Molecular Weight: 505.56. US Biological Life Sciences. | Worldwide |
| JWH-122 4-Hydroxypentyl metabolite-D5 solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-122 4-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-122 5-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-122 (Indole-d5) 5-Hydroxypentyl | JWH-122 (Indole-d5) 5-Hydroxypentyl is labelled JWH-122 5-Hydroxypentyl (J211465) which is a urinary metabolite of JWH-122. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H20D5NO2, Molecular Weight: 376.5. US Biological Life Sciences. | Worldwide |
| JWH 122 N-(4-pentenyl) Analog-d4 | JWH 122 N-(4-pentenyl) Analog-d4. Group: Biochemicals. Alternative Names: MAM2201 N-(4-pentenyl) Analog-d4; JWH 022 4-methylnaphthyl Analog-d4;(4-Methylnaphthalen-1-?yl)(1-(pent-?4-?en-1-yl)-1H-indol-3-yl)methanone-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H19D4NO, Molecular Weight: 357.48. US Biological Life Sciences. | Worldwide |
| JWH-122 N-Pentanoic Acid-d4 | JWH-122 N-Pentanoic Acid-d4. Group: Biochemicals. Alternative Names: 5-Carboxy-JWH-122; 5-(3-(4-methyl-1-naphthoyl)-1H-indol-1-yl)pentanoic Acid-d4; MAM-2201 5-Pentanoic Acid-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H19D4NO3, Molecular Weight: 389.48. US Biological Life Sciences. | Worldwide |
| JWH 176 | JWH 176. Group: Biochemicals. Alternative Names: 1-[(E)-(3-Pentyl-1H-inden-1-ylidene)methyl]-naphthalene. Grades: Highly Purified. CAS No. 619294-62-1. Pack Sizes: 1mg. Molecular Formula: C25H24, Molecular Weight: 324.459999999999. US Biological Life Sciences. | Worldwide |
| JWH-203 | A cannabimimetic indole derivative that acts as both a cannabinoid receptor CB1 and CB2 agonist. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone; JWH 203. Grades: Highly Purified. CAS No. 864445-54-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| JWH-203-d11 | Labeled analogue of a cannabimimetic indole derivative that acts as both a cannabinoid receptor CB1 and CB2 agonist. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-1-[1-(pentyl-d11)-1H-indol-3-yl]ethanone; JWH 203-d11. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| JWH-210 4-Hydroxypentyl metabolite-D5 solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-210 4-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-210 5-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH 250 | A new class of cannabimimetic indoles. Group: Biochemicals. Alternative Names: 2-(2-Methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone. Grades: Highly Purified. CAS No. 864445-43-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JWH-250 4-Hydroxypentyl metabolite | ampule of 1 mL, certified reference material, 100 ?g/mL in methanol. Group: Certified reference materials (crms). | |
| JWH-250 4-Hydroxypentyl metabolite-D5 solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH-250 5-Hydroxypentyl metabolite solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| JWH 250-d11 | Labeled JWH 250. A new class of cannabimimetic indoles. Group: Biochemicals. Alternative Names: 2-(2-Methoxyphenyl)-1-(1-(pentyl-d11)-1H-indol-3-yl)ethanone. Grades: Highly Purified. CAS No. 1346598-78-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JWH 252 | JWH 252. Group: Biochemicals. Alternative Names: 1-(2-Methyl-1-pentyl-1H-indol-3-yl)-2-(2-methylphenyl)ethanone. Grades: Highly Purified. CAS No. 864445-40-9. Pack Sizes: 10mg. Molecular Formula: C23H27NO, Molecular Weight: 333.47. US Biological Life Sciences. | Worldwide |
| JWH 252-d11 | JWH 252-d11. Group: Biochemicals. Alternative Names: 1-(2-Methyl-1-pentyl-1H-indol-3-yl)-2-(2-methylphenyl)ethanone-d11. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H16D11NO, Molecular Weight: 344.53. US Biological Life Sciences. | Worldwide |
| JWH 387 | JWH 387. Group: Biochemicals. Alternative Names: (4-Bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone. Grades: Highly Purified. CAS No. 1366067-59-5. Pack Sizes: 10mg. Molecular Formula: C24H22BrNO, Molecular Weight: 420.34. US Biological Life Sciences. | Worldwide |
| JWH 387-d11 | JWH 387-d11. Group: Biochemicals. Alternative Names: (4-Bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone-d11. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C24H11D11BrNO, Molecular Weight: 431.41. US Biological Life Sciences. | Worldwide |
| JWH-398-d5 | JWH-398-d5. Group: Biochemicals. Alternative Names: (4-Chloronaphthalen-1-yl)(1-(5-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5)methanone; (4-Chloro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone-d5. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C24H17D5ClNO, Molecular Weight: 380.92. US Biological Life Sciences. | Worldwide |
| JWH 398 N-(4-Hydroxypentyl) Metabolite-d5 | JWH 398 N-(4-Hydroxypentyl) Metabolite-d5. Group: Biochemicals. Alternative Names: (4-Chloronaphthalen-1-yl)(1-(4-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5)methanone. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C24H17D5ClNO2, Molecular Weight: 396.92. US Biological Life Sciences. | Worldwide |
| JWH 412 | JWH 412. Group: Biochemicals. Alternative Names: (4-Fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone. Grades: Highly Purified. CAS No. 1364933-59-4. Pack Sizes: 1mg. Molecular Formula: C24H22FNO, Molecular Weight: 359.44. US Biological Life Sciences. | Worldwide |
| JX 06 | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
| JX-06 | JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JX-06; JX 06; JX06. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.49. Purity: >98%. IUPACName: Bis(morpholinothiocarbonyl) disulfide. Canonical SMILES: S=C(SSC(N1CCOCC1)=S)N2CCOCC2. Product ID: ACM729464. Alfa Chemistry ISO 9001:2015 Certified. Categories: JP-06. | |
| JX 401 | JX 401. Group: Biochemicals. Grades: Purified. CAS No. 349087-34-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JX 401 | JX 401, cell-permeable piperidinamide compound, is a reversible and highly potent inhibitor of p38α isoform MAP kinase containing a 4-benzylpiperidine motif. Its IC50 value is 32 nM and displays no activity on the p38γ isoform. It effectively blocks the differentiation of L8 myoblasts to myotubes in a reversible manner and blocks the differentiation of myoblasts and myotubes in mammalian cells in culture. It is not a competitive inhibitor with respect to either ATP or substrate. It is hyperactive in inflammatory diseases and may reverse inflammation. Synonyms: JX-401; JX 401; JX401; 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine; [2-Methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-methanone; N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine. Grades: ≥98% by HPLC. CAS No. 349087-34-9. Molecular formula: C21H25NO2S. Mole weight: 355.49. | |
| JYL1421 | JYL1421 is a TRPV1 receptor antagonist. JYL1421 concentration-dependently (0.1-2 mM) inhibited capsaicin-evoked substance P, calcitonin gene-related peptide and somatostatin release from isolated tracheae. It also concentration-dependently decreased capsaicin-induced Ca(2+) accumulation in cultured trigeminal ganglion cells. Synonyms: 3-[ (4-Tert-butylphenyl) methyl]-1-[ (3-fluoro-4-methanesulfonamidophenyl) methyl]thiourea. Grades: ≥95%. CAS No. 401907-26-4. Molecular formula: C20H26FN3O2S2. Mole weight: 423.6. | |
| JYN42346 | JYN42346, also known as Complement factor D-IN-2, is an inhibitor of complement factor D. JYN42346 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. JYN42346 can be used for the research of autoimmune diseases. JYN42346 was first reported in patent WO2015130838A1 (compound 190). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Complement factor D-IN-2; JYN42346; JYN 42346; JYN-42346. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1903742-34-6. Molecular formula: C27H24BrN7O3. Mole weight: 574.44. Purity: >98%. IUPACName: (1R,3S,5R)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide. Canonical SMILES: O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)[C@]5([H])C[C@]5([H])C1)NC6=NC(Br)=CC=C6. Product ID: ACM1903742346. Alfa Chemistry ISO 9001:2015 Certified. | |
| JZL184 | JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. Synonyms: JZL184; JZL 184; JZL-184. Grades: >98%. CAS No. 1101854-58-3. Molecular formula: C27H24N2O9. Mole weight: 520.49. | |
| JZL 184 hydrate | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JZL195 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JZL195 | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250. |  |
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