A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
LEAP2 is a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. It has activity against gram-positive bacteria and yeasts. Synonyms: Liver-expressed antimicrobial peptide 2; LEAP-2. Molecular formula: C192H319N64O57S4. Mole weight: 4563.40.
LEAP-2
LEAP-2 is an antibacterial peptide isolated from Homo sapiens. Synonyms: Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu.
LEAP-2
LEAP-2 is an antimicrobial peptide derived from human blood [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human liver expressed antimicrobial peptide-2. CAS No. 1683582-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5645.
LEAP-2-RA1 peptide precursor, partial
LEAP-2-RA1 peptide precursor, partial is an antibacterial peptide isolated from Odorrana andersonii (golden crossband frog). Synonyms: Gln-Val-Ser-Gln-Arg-Arg-Gly-Pro-Arg-Met-Thr-Pro-Phe-Trp-Arg-Ala-Val-Gly-Asn-Lys-Pro-Val-Gly-Ala-Phe-Cys-Gln-Gln-Gly-Leu-Glu-Cys-Thr-Thr-Lys-Val-Cys-Arg-Arg-Gly-His-Cys-Thr.
Acid Dyes. CAS No. 12269-81-7. Catalog: ACM12269817.
Lebocin
Lebocin is an antibacterial peptide isolated from Pseudoplusia includens. Synonyms: Pro-Asp-Phe-Lys-Leu-Pro-Gly-Met-Lys-Tyr-Pro-Ile-Pro-Ala-Thr-Thr-Pro-Pro-Phe-Val-Pro-Lys-Arg-Ser-Arg-Phe-Pro-Ile-Tyr-Ala. Grades: 97.5%. Molecular formula: C166H251N39O38S. Mole weight: 3433.
Lebocin-1/2 precursor
Lebocin-1/2 precursor is an antibacterial peptide isolated from Bombyx mori. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Asp-Leu-Arg-Phe-Leu-Tyr-Pro-Arg-Gly-Lys-Leu-Pro-Val-Pro-Thr-Pro-Pro-Pro-Phe-Asn-Pro-Lys-Pro-Ile-Tyr-Ile-Asp-Met-Gly-Asn-Arg-Tyr. Grades: 98.2%. Molecular formula: C179H271N45O43S. Mole weight: 3773.46.
Lebocin-3 precursor
Lebocin-3 precursor is an antibacterial peptide isolated from Bombyx mori. Synonyms: Asp-Leu-Arg-Phe-Leu-Tyr-Pro-Arg-Gly-Lys-Leu-Pro-Val-Pro-Thr-Leu-Pro-Pro-Phe-Asn-Pro-Lys-Pro-Ile-Tyr-Ile-Asp-Met-Gly-Asn-Arg-Tyr. Grades: 96.3%. Molecular formula: C180H275N45O43S. Mole weight: 3789.5.
Lebocin-4 precursor
Lebocin-4 precursor is an antibacterial peptide isolated from Bombyx mori. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Asp-Leu-Arg-Phe-Trp-Asn-Pro-Arg-Glu-Lys-Leu-Pro-Leu-Pro-Thr-Leu-Pro-Pro-Phe-Asn-Pro-Lys-Pro-Ile-Tyr-Ile-Asp-Met-Gly-Asn-Arg-Tyr. Grades: 97.3%. Molecular formula: C184H277N47O45S. Mole weight: 3899.57.
Lebocin-like anionic peptide 1
Lebocin-like anionic peptide 1 is an antibacterial peptide isolated from Galleria mellonella. It has activity against gram-positive bacteria and fungi. Synonyms: Glu-Ala-Asp-Glu-Pro-Leu-Trp-Leu-Tyr-Lys-Gly-Asp-Asn-Ile-Glu-Arg-Ala-Pro-Thr-Thr-Ala-Asp-His-Pro-Ile-Leu-Pro-Ser-Ile-Ile-Asp-Asp-Val-Lys-Leu-Asp-Pro-Asn-Arg-Arg-Tyr-Ala. Molecular formula: C215H334N58O68. Mole weight: 4819.36.
Lebrikizumab
Lebrikizumab is a humanized monoclonal antibody that binds to IL-13. Lebrikizumab has the potential for the treatment of atopic dermatitis (AD). CAS No. 953400-68-5.
Lebrikizumab
Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 ( IL-13 ) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TNX-650. CAS No. 953400-68-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99025.
Lecideoidin
It is the depsidone isolated from a Lecidea sp. Synonyms: 11H-Dibenzo[b,e][1,4]dioxepin-7-carboxylic acid, 2,9-dichloro-3,8-dihydroxy-1,6-dimethyl-11-oxo-, methyl ester; 2,9-Dichloro-3,8-dihydroxy-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid methyl ester. CAS No. 72458-10-7. Molecular formula: C17H12Cl2O7. Mole weight: 399.18.
Lecirelin
Lecirelin is a synthetic gonadotropin releasing hormone (GnRH) analogue. It is a medication commonly used in veterinary medicine. Synonyms: (D-Tle6)-Leuprolide; (D-Tle6)-Leuprorelin; Dalmarelin. CAS No. 61012-19-9. Molecular formula: C59H84N16O12. Mole weight: 1209.42.
Lecirelin acetate
Lecirelin acetate, a synthetic gonadotropin-releasing hormone (GnRH) analogue, has a good effect in the treatment of bovine ovarian follicular cysts. It is a medication commonly used in veterinary. Synonyms: Luteinizing hormone-releasing factor (pig), 6-(3-methyl-D-valine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, acetate; Dalmarelin acetate; Gestran acetate; Gestran Plus acetate; Supergestran acetate; H-Pyr-His-Trp-Ser-Tyr-D-Gly(tBu)-Leu-Arg-Pro-NHEt.CH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-2-tert-butyl-D-glycyl-L-leucyl-L-arginyl-L-proline ethylamide acetic acid. Grades: ≥95%. Molecular formula: C61H88N16O14. Mole weight: 1269.45.
Lecithin
Lecithin has emulsification and lubricant properties, and is a surfactant. Group: Biochemicals. Grades: Highly Purified. CAS No. 8002-43-5. Pack Sizes: 250mg, 1g. Molecular Formula: N/A. US Biological Life Sciences.
Worldwide
Lecithin
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells. Uses: Scientific research. Group: Natural products. Alternative Names: Polyene phosphatidylcholine. CAS No. 8002-43-5. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B2235.
Lecithin
Lecithin is a naturally occurring fatty substance that is essential for many biological processes in the body. It is a type of phospholipid that is found in high concentrations in the brain, liver, and other tissues. Lecithin is commonly used as an emulsifier in food products to help blend ingredients and prevent separation. It is also used in the production of pharmaceuticals and dietary supplements due to its potential health benefits. Uses: 1. food industry: lecithin is widely used as a food additive in emulsifiers, stabilizers, and preservatives to improve texture, increase shelf life, and enhance flavor. 2. health supplements: lecithin is added to dietary supplements as a source of choline, which is important for brain function and liver function, as well as for maintaining healthy cholesterol levels. 3. pharmaceuticals: lecithin i. Group: Emollients/oils/wax. Alternative Names: Lecithine; Phosphatidylcholine; Lecithins. CAS No. 8002-43-5. Appearance: yellow to brownish colored oily substance, often with a viscous or syrupy texture. IUPACName: [(2R)-3-hexadecanoyloxy-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: CCCCCCCCCCCCCCCC (=O)OC[C@H] (COP (=O) ([O-])OCC[N+] (C) (C)C)OC (=O)CCCCCCC/C=C\C/C=C\CCCCC. Catalog: CI-SC-0361.
Lecithin
Lecithins vary greatly in their physical form, from viscous semiliquids to powders, depending upon the free fatty acid content. They may also vary in color from brown to light yellow, depending upon whether they are bleached or unbleached or on the degree of purity. When they are exposed to air, rapid oxidation occurs, also resulting in a dark yellow or brown color. Lecithins have practically no odor. Those derived from vegetable sources have a bland or nutlike taste, similar to that of soybean oil. Synonyms: E322; egg lecithin; LSC 5050; LSC 6040; mixed soybean phosphatides; ovolecithin; Phosal 53 MCT; Phospholipon 101 H; ProKote LSC; soybean lecithin; soybean phospholipids; Sternpur; vegetable lecithin. CAS No. 8002-43-5. Product ID: PE-0430. Category: Dispersant; Wetting Agents; Emulsifier; Stabilizer; Transdermal accelerator; Precursor drug carrier. Product Keywords: Dispersion Excipients; Emulsifier Excipients; Carrier Excipients; Stabilizers; PE-0430; Lecithin; Dispersant; Wetting Agents; Emulsifier; Stabilizer; Transdermal accelerator; Precursor drug carrier; ; 8002-43-5. UNII: NA. Chemical Name: Lecithin. Grade: Pharmceutical Excipients. Administration route: Inhalation; injection; otic preparations; oral ; rectal, topical, and vaginal. Dosage Form: Inhalations; IM and IV injections; otic preparations; oral capsules, suspensions and tablets; rectal, topical, and vaginal preparations. Stability and Storage Conditio
Lecithin
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Lecithin Hydrogenated. Group: Biochemicals. Grades: Highly Purified. CAS No. 92128-87-5. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. US Biological Life Sciences.
Worldwide
Lecithin Hydrogenated
Lecithin Hydrogenated is a phosphocholine with palmitic acid at the sn-1 position and stearic acid at the sn-2 position. It can be used in formulation of micelles, liposomes, and other types of artificial membranes. Lecithin Hydrogenated is an emulsifier used in cosmetics and also acts as a penetration enhancer. Synonyms: PSPC; 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphatidylcholine; Epikuron 100H; Epikuron 200H; Epikuron 200SH; Hydrogenated lecithins; Kryosome 1703H; Lecinol S-GF; Lipoid P 75-3; Lipoid S 75S; Magic50-BW0105; Nikkol Resinol S 10. CAS No. 92128-87-5. Molecular formula: C42H84NO8P. Mole weight: 762.11.
Lecithin liquid from Soy bean
500g Pack Size. Group: Analytical Reagents, Biochemicals, Organics. CAS No. 8002-43-5. Prepack ID 90029399-500g. See USA prepack pricing.
Lecithin liquid from Soy bean
250g Pack Size. Group: Analytical Reagents, Biochemicals, Organics. CAS No. 8002-43-5. Prepack ID 90029399-250g. See USA prepack pricing.
LED209
LED209 is a highly selective for histidine sensor kinase QseC that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro. Synonyms: 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thioureaLED 209; LED-209; LED209245342-14-7HNDRSTUKPCLQLT-UHFFFAOYSA-NN-Phenyl-4- (3-phenylthioureido) Benzene sulfonamide N-phenyl-4- [ [ (phenylamino) thioxo methyl ] amino] Benzene sulfonamide AC1MQ46PCHEMBL516533SCHEMBL3396831. CAS No. 245342-14-7. Molecular formula: C19H17N3O2S2. Mole weight: 383.48.
Ledaborbactam
Iedaborbactam (VNRX-5236), as a β-lactamase inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VNRX-5236. CAS No. 1842397-36-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132823.
Ledaborbactam
Ledaborbactam is a beta-lactamase inhibitor. Synonyms: (3R)-2-hydroxy-3-(propanamido)-3,4-dihydro-2H-1,2-benzoxaborinine-8-carboxylic acid; VNRX-7145 acid; VNRX-7145 active metabolite; (3R)-3,4-Dihydro-2-hydroxy-3-((1-oxopropyl)amino)-2H-1,2-benzoxaborin-8-carboxylic acid; 2H-1,2-Benzoxaborin-8-carboxylic acid, 3,4-dihydro-2-hydroxy-3-[(1-oxopropyl)amino]-, (3R)-. CAS No. 1842397-36-7. Molecular formula: C12H14BNO5. Mole weight: 263.06.
Ledaborbactam Etzadroxil
Ledaborbactam Etzadroxil is a beta-lactamase inhibitor. Synonyms: [(2-ethylbutanoyl)oxy]methyl (3R)-2-hydroxy-3-(propanamido)-3,4-dihydro-2H-1,2-benzoxaborinine-8-carboxylate; VNRX-7145; 2H-1,2-Benzoxaborin-8-carboxylic acid, 3,4-dihydro-2-hydroxy-3-((1-oxopropyl)amino)-, (2-ethyl-1-oxobutoxy)methyl ester, (3R)-; [(2-Ethylbutanoyl)oxy]methyl (3R)-2-hydroxy-3-(propionylamino)-3,4-dihydro-2H-1,2-benzoxaborinine-8-carboxylate. CAS No. 1842399-68-1. Molecular formula: C19H26BNO7. Mole weight: 391.22.
Ledipasvir
Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A , with EC 50 s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.62 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-5885. CAS No. 1256388-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15602.
Ledipasvir
Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead. Group: Fluorinated apis. Alternative Names: GS5885. CAS No. 1256388-51-8. Molecular formula: C49H54F2N8O6. Mole weight: 889. Appearance: Solid powder. Purity: >98%. IUPACName: methyl N-[(2S)-1-[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate. Catalog: OFC1256388518.
Ledipasvir
Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection. Uses: Antiviral agents. Synonyms: GS5885; GS-5885; GS 5885; Ledipasvir; trade name: Harvoni. Grades: >98%. CAS No. 1256388-51-8. Molecular formula: C49H54F2N8O6. Mole weight: 889.0.
Ledipasvir acetone
Ledipasvir is an inhibitor of hepatitis C virus NS5A. Synonyms: GS 5885 acetone; GS5885 acetone; GS-5885 acetone; methyl ((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate compound with propan-2-one (1:1). Grades: >98%. CAS No. 1441674-54-9. Molecular formula: C52H60F2N8O7. Mole weight: 947.08.
Ledipasvir diacetone
Against JFH1/3a-NS5A, DCV was more potent (EC(50) = 0.52 nM) than GS-5885 (EC(50) = 141 nM). DCV sensitivity was increased against JFH1/3a-NS5A-M28V (EC50 = 0.006 nM), A30V (EC(50) = 0.012 nM), and E92A (EC(50) = 0.004 nM) while the NS5A-A30K and -Y93H variants exhibited reduced sensitivity to DCV (EC50 values of 23 nM and 1120 nM, respectively) and to GS-5885 (EC50 values of 1770 nM and 4300 nM, respectively). GS-5885 was well tolerated and resulted in median maximal reductions in HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30 mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the predominant sites of mutation following GS-5885 dosing. Plasma pharmacokinetics was consistent with QD dosing. Synonyms: GS-5885 diacetone; GS 5885 diacetone; GS5885 diacetone. Grades: >98%. CAS No. 1502655-48-2. Molecular formula: C55H66F2N8O8. Mole weight: 1005.16.
Ledipasvir D-tartrate
Against JFH1/3a-NS5A, DCV was more potent (EC(50) = 0.52 nM) than GS-5885 (EC(50) = 141 nM). DCV sensitivity was increased against JFH1/3a-NS5A-M28V (EC50 = 0.006 nM), A30V (EC(50) = 0.012 nM), and E92A (EC(50) = 0.004 nM) while the NS5A-A30K and -Y93H variants exhibited reduced sensitivity to DCV (EC50 values of 23 nM and 1120 nM, respectively) and to GS-5885 (EC50 values of 1770 nM and 4300 nM, respectively). GS-5885 was well tolerated and resulted in median maximal reductions in HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30 mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the predominant sites of mutation following GS-5885 dosing. Plasma pharmacokinetics was consistent with QD dosing. Synonyms: GS-5885 D-tartrate; GS 5885 D-tartrate; GS5885 D-tartrate. Grades: >98%. CAS No. 1502654-87-6. Molecular formula: C53H60F2N8O12. Mole weight: 1039.09.
Ledipasvir D-tartrate
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A , with EC 50 values of 34 pM against GT1a and 4 pM against GT1b replicon. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-5885 D-tartrate. CAS No. 1502654-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15602B.
Ledipasvir Impurity 1
Ledipasvir Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1502654-87-6. Molecular Formula: C53H60F2N8O12. Mole Weight: 1039.1. Catalog: APB1502654876.
Ledipasvir Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1441670-89-8. Molecular Formula: C27H26BrF2N3O2. Mole Weight: 542.42. Catalog: APB1441670898.
Ledol
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Ledol. CAS No. 577-27-5. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-121388.
Ledoxantrone
Heterocyclic Organic Compound. Alternative Names: Ledoxantrone;CI 958. CAS No. 113457-05-9. Molecular formula: C21H27N5OS. Mole weight: 397.544. Catalog: ACM113457059.
Ledoxantrone
Ledoxantrone, also known as sedoxantrone or CI-958, is an anthrapyrazole antineoplastic antibiotic molecule with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Synonyms: Ledoxantrone; sedoxantrone; CI-958; CI 958; CI958. CAS No. 113457-05-9. Molecular formula: C21H27N5OS. Mole weight: 397.54.
LED Quantum Dots (Zinc Selenide /Zinc Sulphide Quantum Dots)
LED Quantum Dots (Zinc Selenide /Zinc Sulphide Quantum Dots). Group: other quantum dots.
LEE011 hydrochloride
CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.Treatment with LEE011 significantly reduced proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis at nanomolar concentrations (mean IC50=307 ± 68 nmol/L in sensitive lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. Responsiveness of neuroblastoma xenografts to LEE011 translated to the in vivo setting in that there was a direct correlation of in vitro IC50 values with degree of subcutaneous xenograft growth delay. Synonyms: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride; Ribociclib hydrochloride; LEE011; LEE-011 LEE 011. Grades: >98%. CAS No. 1211443-80-9. Molecular formula: C23H31ClN8O. Mole weight: 471.0.
LEE011 succinate
LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. Synonyms: Ribociclib succinate; LEE 011 succinate; LEE-011 succinate. Grades: >98%. CAS No. 1374639-75-4. Molecular formula: C27H36N8O5. Mole weight: 552.63.
LEE011 succinate hydrate
LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Synonyms: Ribociclib succinate hydrate; LEE 011 succinate hydrate; LEE-011 succinate hydrate. Grades: >98%. CAS No. 1374639-79-8. Molecular formula: C27H38N8O6X. Mole weight: 570.64.
Leelamine is an orally active pyruvate dehydrogenase kinase ( PDK ) inhibitor with an IC 50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1446-61-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W005629.
Leelamine
Leelamine, a diterpene molecule, has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Leelamine is also a PDK(pyruvate dehydrogenase kinase inhibitor). Synonyms: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine; dehydroabietylamine; DEHYDROABIETYLAMINE; (+)-Dehydroabietylamine; Dehydroabiethylamine; 16496-99-4 Leelamine (hydrochloride). Grades: ≥90%. CAS No. 1446-61-3. Molecular formula: C20H31N. Mole weight: 285.5.
Leelamine hydrochloride
Leelamine is a diterpene amine exhibiting low affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It also acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Leelamine inhibits intracellular cholesterol transport and suppresses cancer cell growth. Synonyms: Lylamine hydrochloride; Dehydroabiethylamine hydrochloride; [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine hydrochloride. Grades: ≥98%. CAS No. 16496-99-4. Molecular formula: C20H31N·HCl. Mole weight: 321.9.
Leelamine hydrochloride
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees [1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor , which is known to regulate fatty acid synthesis [2,3]. Uses: Scientific research. Group: Natural products. CAS No. 16496-99-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110028.
Lefamulin
Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BC-3781. CAS No. 1061337-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16908.
Lefamulin acetate
Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BC-3781 acetate. CAS No. 1350636-82-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16908A.
Leflunomide
Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent. Uses: Scientific research. Group: Natural products. Alternative Names: HWA486; RS-34821; SU101. CAS No. 75706-12-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0083.
Leflunomide
100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C12H9F3N2O2. CAS No. 75706-12-6. Prepack ID 77117657-100mg. Molecular Weight 270.21. See USA prepack pricing.
Leflunomide
Leflunomide. Group: Biochemicals. Grades: Purified. CAS No. 75706-12-6. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Leflunomide 3-isomer
Leflunomide 3-isomer. Group: Biochemicals. Alternative Names: 5-Methyl-N-[3- (trifluoromethyl) phenyl]-4-isoxazolecarboxamide; Leflunomide imp. E (EP). Grades: Highly Purified. CAS No. 61643-23-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C12H9F3N2O2. US Biological Life Sciences.
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Group: Biochemicals. Alternative Names: 5- methyl isoxazole-4- [4-trifluoro methyl carboxanilide] -d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Leflunomide-d4(phenyl-d4)
Heterocyclic Organic Compound. CAS No. 1189987-23-2. Molecular formula: 274.23. Purity: 98 atom % D. Catalog: ACM1189987232.
Leflunomide EP impurity A
Leflunomide EP impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 455-14-1. Molecular Formula: C7H6F3N. Mole Weight: 161.13. Catalog: APB455141.