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| Product | Description | |
|---|---|---|
| PD 149163 | PD 149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine ethyl ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine ethyl ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C42H71N9O6. US Biological Life Sciences. |  Worldwide |
| PD-149163 | PD-149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 10mg. Molecular Formula: C42H71N9O6, Molecular Weight: 798.07. US Biological Life Sciences. | Worldwide |
| PD150606 | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 179528-45-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100529. |  |
| PD 150606 | PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12. |  |
| PD 150606 | PD 150606. Group: Biochemicals. Alternative Names: (2Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid; (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid. Grades: Highly Purified. CAS No. 179528-45-1. Pack Sizes: 10mg. Molecular Formula: C9H7IO2S, Molecular Weight: 306.12. US Biological Life Sciences. | Worldwide |
| PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid) | Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor. Group: Biochemicals. Alternative Names: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid. Grades: Highly Purified. CAS No. 426821-41-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD 151746 | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. Synonyms: PD-151746; PD 151746; PD151746. Grades: >98%. CAS No. 179461-52-0. Molecular formula: C11H8FNO2S. Mole weight: 237.25. | |
| PD153035 | PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271; AG1517; ZM 252868. CAS No. 153436-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14346. | |
| PD-153035 | PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211. | |
| PD153035 HCl | PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. Synonyms: SU5271; SU 5271; AG 1517; AG-1517; SU-5271 (AG1517) HCl; ZM 252868 HCl; ZM-252868 HCl; ZM252868 HCl; PD153035 HCl; PD 153035 HCl; PD-153035 HCl; AG 1517 hydrochloride; AG1517 hydrochloride; AG-1517 hydrochloride. Grades: >98%. CAS No. 183322-45-4. Molecular formula: C16H14BrN3O2.HCl. Mole weight: 396.67. | |
| PD153035 Hydrochloride | PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride. CAS No. 183322-45-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12013. | |
| PD-156707 | PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162412-70-6. Pack Sizes: 5 mg. Product ID: HY-123744. | |
| PD158780 | PD158780 is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity with IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4). Synonyms: PD-158780; PD 158780; PD158780. Grades: >98%. CAS No. 171179-06-9. Molecular formula: C14H12BrN5. Mole weight: 330.18. | |
| PD 158780 | PD 158780. Group: Biochemicals. Grades: Purified. CAS No. 171179-06-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD159206 | PD-159206 is a nucleocapsid inhibitor. It exhibits good antiviral activity against HIV. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD-159206; PD159206; PD 159206; CI 1013; CI-1013; CI1013; DIBA 4. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 171744-42-6. Molecular formula: C26H32N2O6S2. Mole weight: 532.67. Purity: >95%. IUPACName: N,N'-[Dithiobis(2,1-phenylenecarbonyl)]bis[isoleucine]. Canonical SMILES: O=C(N[C@@H]([C@@H](C)CC)C(O)=O)C1=CC=CC=C1SSC2=CC=CC=C2C(N[C@@H]([C@@H](C)CC)C(O)=O)=O. Product ID: ACM171744426. Alfa Chemistry ISO 9001:2015 Certified. Categories: DIBA-4 ENANTIOMER. |  |
| PD 160170 | PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM), which is selective over Y2 and Y5 receptors (Ki > 10 μM). Synonyms: PD 160170; PD160170; PD-160170; 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine. Grades: ≥98% by HPLC. CAS No. 181468-88-2. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| PD 160170 | PD 160170. Group: Biochemicals. Grades: Purified. CAS No. 181468-88-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD-160725 2-Hydroxyethanesulfonate | PD-160725 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-piperidinylmethyl)-2,3-quinoxalinedione; PD-160725 Isethionate Salt. Grades: Highly Purified. CAS No. 1262769-92-5. Pack Sizes: 10mg. Molecular Formula: C17H24N4O8S, Molecular Weight: 444.46. US Biological Life Sciences. | Worldwide |
| PD 161570 | PD 161570. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H35Cl2N7O. US Biological Life Sciences. | Worldwide |
| PD-161570 | PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. In addintion, PD-161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Synonyms: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD-161570; PD 161570; PD161570. CAS No. 192705-80-9. Molecular formula: C26H35Cl2N7O. Mole weight: 532.51. | |
| PD-161570 | A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-161989 2-Hydroxyethanesulfonate | PD-161989 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-pyrrolidinylmethyl)-2,3-quinoxalinedione. Grades: Highly Purified. CAS No. 1262770-05-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 166285 | PD 166285. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H29Cl4N5O2. US Biological Life Sciences. | Worldwide |
| PD-166285 | A broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-166285-d4 | A labeled broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy-d4]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PD 166285 dihydrochloride | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35. | |
| PD166326 | PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases , with IC 50 s of 6 nM and 8 nM for Src and Abl , respectively. PD166326 exhibits antileukemic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 185039-91-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118144. | |
| PD166326 | PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T. Synonyms: PD-166326; PD 166326; 6-(2,6-Dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 185039-91-2. Molecular formula: C21H16Cl2N4O2. Mole weight: 427.28. | |
| PD 166793 | PD 166793. Group: Biochemicals. Alternative Names: PD 166793-0000; N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-Valine. Grades: Highly Purified. CAS No. 199850-67-4. Pack Sizes: 10mg. Molecular Formula: C17H18BrNO4S, Molecular Weight: 412.3. US Biological Life Sciences. | Worldwide |
| PD 166793 | PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3. | |
| PD166866 | PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. PD166866 has clear antiproliferative effects. Uses: Protein kinase inhibitors. Synonyms: PD166866; PD-166866; PD 166866. Grades: 98%. CAS No. 192705-79-6. Molecular formula: C20H24N6O3. Mole weight: 396.45. | |
| PD 166866 | PD 166866. Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C20H24N6O3. US Biological Life Sciences. | Worldwide |
| PD-166866 | A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF). Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-166866 | PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC 50 of 52.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 192705-79-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101296. | |
| PD 168077 maleate | PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. It is suitable for central and peripheral delivery, and used in studies of penile erection, learning and memory. Synonyms: PD 168077 maleate; PD168077 maleate; PD-168077 maleate; N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate. Grades: ≥99% by HPLC. CAS No. 630117-19-0. Molecular formula: C20H22N4O.C4H4O4. Mole weight: 450.49. | |
| PD 168077 maleate | PD 168077 maleate. Group: Biochemicals. Grades: Purified. CAS No. 630117-19-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD-168077 maleate | PD-168077 maleate is a selective dopamine D 4 receptor agonist, with a K i of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 630117-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-21098A. | |
| PD 168077 Maleate (D4 Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077) | A selective D4 dopamine receptor agonist (Ki = 8.7nM, EC50 = 8.3nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 630117-19-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 168368 | PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors. It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide. Grades: ≥95%. CAS No. 204066-82-0. Molecular formula: C31H34N6O4. Mole weight: 554.6. | |
| PD 168393 | PD 168393. Group: Biochemicals. Alternative Names: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide. Grades: Highly Purified. CAS No. 194423-15-9. Pack Sizes: 1mg. Molecular Formula: C17H13BrN4O, Molecular Weight: 369.22. US Biological Life Sciences. | Worldwide |
| PD-168393 | PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice. Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393; PD 168393; PD-168393. CAS No. 194423-15-9. Molecular formula: C17H13BrN4O. Mole weight: 369.222. | |
| PD 168568 dihydrochloride | PD 168568 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 210688-56-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD 168568 dihydrochloride | PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki= 8.8 and 1842 nM at D4 and D2 receptors respectively). Synonyms: PD 168568 dihydrochloride; PD168568 dihydrochloride; PD-168568 dihydrochloride; 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride. Grades: ≥98% by HPLC. CAS No. 210688-56-5. Molecular formula: C22H27N3O.2HCl. Mole weight: 422.39. | |
| PD 169316 | PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. Synonyms: PD-169316; PD 169316; PD169316. Grades: 98.0%. CAS No. 152121-53-4. Molecular formula: C20H13FN4O2. Mole weight: 360.348. | |
| PD173074 | PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. Uses: Differentiation, self-renewal. Synonyms: PD173074; PD 173074; PD-173074. Grades: 0.98. CAS No. 219580-11-7. Molecular formula: C28H41N7O3. Mole weight: 523.682. | |
| PD-173074 | PD 173074. Group: Biochemicals. Alternative Names: N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; PD 173074. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-173074-d9 | Labeled PD 173074. Group: Biochemicals. Alternative Names: N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl-d9) urea. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PD 173074 (N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N- (1, 1-dimethylethyl) urea | A potent and selective FGFR1 tyrosine kinase inhibitor (IC50 = 21.5nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential. Group: Biochemicals. Alternative Names: PD173074, N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N- (1, 1-dimethylethyl) urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor) | PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor). Group: Biochemicals. Alternative Names: 1-tert-butyl-3-[2-[4- (diethylamino) butylamino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 25mg. Molecular Formula: C28 H41 N7O3 , Molecular Weight: 523.7. US Biological Life Sciences. | Worldwide |
| PD 173212 | PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM), with selectivity over K+, Na+ and L-type Ca2+ channels. Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. Synonyms: PD-173212; PD 173212; PD173212; N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide. Grades: ≥98% by HPLC. CAS No. 217171-01-2. Molecular formula: C38H53N3O3. Mole weight: 599.85. | |
| PD 173212 | PD 173212. Group: Biochemicals. Grades: Purified. CAS No. 217171-01-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 173952 | PD 173952. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C24H21Cl2N5O2. US Biological Life Sciences. | Worldwide |
| PD-173952 | A Bcr-Abl tyrosine kinase inhibitor used in treatment research for chronic myelegenous leukemia (CML). Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD-173955 | PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Synonyms: PD173955; PD 173955; PD-173955. Grades: 0.98. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. | |
| PD-173955 | PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD173955; PD 173955; PD173955. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. Purity: >98%. IUPACName: 6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one. Canonical SMILES: O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C. Product ID: ACM260415632. Alfa Chemistry ISO 9001:2015 Certified. | |
| Pd 174265 | Pd 174265. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD 174265;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE. Product Category: Heterocyclic Organic Compound. Appearance: Yellow solid. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.23. Purity: ≥97%. Product ID: ACM216163530. Alfa Chemistry ISO 9001:2015 Certified. | |
| PD 174265 | PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC 50 of 450 pM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216163-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112411. | |
| PD 174265 | PD 174265 is a cell-permeable, reversible inhibitor of EGFR tyrosine kinase activity with IC50 value of 0.45 nM. Synonyms: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline; N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide. Grades: ≥98%. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.2. | |
| PD 176252 | PD 176252. CAS No: 204067-01-6 |  Sarchem Laboratories New Jersey NJ |
| PD 176252 | PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67. | |
| PD 176252 | PD 176252. Group: Biochemicals. Grades: Purified. CAS No. 204067-01-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD180970 | PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia. Synonyms: PD 180970; PD-180970; PF-1515965; PF 1515965; PF1515965; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-. Grades: ≥95%. CAS No. 287204-45-9. Molecular formula: C21H15Cl2FN4O. Mole weight: 429.27. | |
| PD184161 | PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term. Synonyms: PD 184161; PD-184161; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide. CAS No. 212631-67-9. Molecular formula: C17H13BrClF2IN2O2. Mole weight: 557.56. | |
| PD 184161 | PD 184161. Group: Biochemicals. Alternative Names: 5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide. Grades: Highly Purified. CAS No. 212631-67-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H13BrClF2IN2O2. US Biological Life Sciences. | Worldwide |
| PD 184352 | PD 184352. Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 3, 4-Difluoro-2- (2-chloro-4-iodophenylamino) -N-cyclopropyl methoxybenzamide; CI 1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H14ClF2IN2O2. US Biological Life Sciences. | Worldwide |
| PD-184352 | An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 3, 4-Difluoro-2- (2-chloro-4-iodophenylamino) -N-cyclopropyl methoxybenzamide; CI 1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 184,352 (2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040) | MEK (MAPKK) inhibitor. Potent and selective MAPK (ERK kinase 1; MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo). Suppresses activation of MAPK but does not block its activity. Antiproliferative. Causes cell-cycle arrest in G1 phase. Tumor suppressor. Apoptosis inducer. Group: Biochemicals. Alternative Names: 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H14ClF2IN2O2, Molecular Weight: 478.7. US Biological Life Sciences. | Worldwide |
| PD184352 (Cl-1040, 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide) | PD184352 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD 198306 | PD 198306. Group: Biochemicals. Grades: Purified. CAS No. 212631-61-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 198306 | PD 198306, an amino-benzamide compound, is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50=8 nM). It inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30-100 nM. It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). Synonyms: PD-198306; PD 198306; PD198306; N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide. Grades: ≥98% by HPLC. CAS No. 212631-61-3. Molecular formula: C18H16F3IN2O2. Mole weight: 476.23. | |
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