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| Product | Description | |
|---|---|---|
| SCR7 pyrazine | SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14892-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107845. |  |
| SCR7 pyrazine | SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Alternative Names: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. Grades: ≥98% by HPLC. CAS No. 14892-97-8. Molecular formula: C18H12N4OS. Mole weight: 332.38. |  |
| SCR7 Pyrazine | SCR7 pyrazine also is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. It enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro upt to 19-fold. SCR7 pyrazine is a product of spontaneous cyclization of CRISPR enhancer SCR7 first reported by Srivastava, M., et al.DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.1 It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 μM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.1,2,3,4. Group: Biochemicals. Alternative Names: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine. Grades: Highly Purified. CAS No. 14892-97-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS, Molecular Weight: 332.38. US Biological Life Sciences. |  Worldwide |
| Scrambled 10Panx | Scrambled 10Panx. Group: Biochemicals. Grades: Purified. CAS No. 1315378-72-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Scrambled 10Panx | It is a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Alternative Names: scPanx; H-Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg-OH; L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-alpha-aspartyl-L-arginine. Grades: >98%. CAS No. 1315378-72-3. Molecular formula: C58H79N15O16. Mole weight: 1242.37. | |
| Scrambled ISP | Scrambled ISP. Alternative Names: Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Ile-Arg-Glu-Asp-Asp-Ser-Leu-Met-Leu-Tyr-Ala-Leu-Ala-Gln-Glu-Lys-Lys-Glu-Ser-Asn-Met-His-Glu-Ser-NH2. Molecular formula: C177H306N66O54S3. Mole weight: 4319.10. | |
| Scriptaid | Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Scriptide; GCK1026. CAS No. 287383-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15489. | |
| Scriptaid | A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-b/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2ug/ml (6-8uM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Group: Biochemicals. Alternative Names: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide. Grades: Highly Purified. CAS No. 287383-59-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SCS | SCS. Group: Biochemicals. Grades: Purified. CAS No. 3232-36-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Sculponeatin A | Sculponeatin A can be extracted from the herbs of Rabdosia amethystoides. Alternative Names: 10,13-Dideoxy-10α,21-epoxy-5β-hydroxyenmein. Grades: >98%. CAS No. 85287-60-1. Molecular formula: C20H24O6. Mole weight: 360.4. | |
| Sculponeatin N | Sculponeatin N can be isolated from the herbs of Rabdosia amethystoides. Alternative Names: Sculponeatin N; 1169805-98-4; [(1R,2S,4R,9R,10S,13R,14R)-2,14-dihydroxy-5,5,9-trimethyl-14-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]methyl 3-methylbut-2-enoate; HY-N1258; ZINC96023599. Grades: >98%. CAS No. 1169805-98-4. Molecular formula: C25H40O4. Mole weight: 404.6. | |
| Scutebarbatine A | Scutebarbatine A, a natural diterpenoid isolated from the herbs of Scutellaria barbata D. Don, exhibits the activity of anti-tumor via mitochondria-mediated apoptosis on A549 cancer. Uses: Anti-tumor. Alternative Names: (1R,2S,3R,4R,4aS,8aR)-3-Hydroxy-3,4,8,8a-tetramethyl-4-[(E)-2-(5- oxo-2,5-dihydro-3-furanyl)vinyl]-1,2,3,4,4a,5,6,8a-octahydronapht halene-1,2-diyl dinicotinate. Grades: >96%. CAS No. 176520-13-1. Molecular formula: C32H34N2O7. Mole weight: 558.6. | |
| Scutebarbatine A | Formula: Group: Biochemicals. Grades: Plant Grade. CAS No. 176520-13-1. Pack Sizes: 10mg, 20mg. US Biological Life Sciences. | Worldwide |
| Scutebarbatine B | Scutebarbatine B, a natural diterpenoid isolated from the herbs of Scutellaria barbata D. Don, plays weak activities against HL60 cell lines. Alternative Names: Scutebarbatine B; 905929-95-5; [(1R,2S,3R,4R,4aS,8aR)-2-benzoyloxy-3-hydroxy-3,4,8,8a-tetramethyl-4-[(E)-2-(5-oxo-2H-furan-3-yl)ethenyl]-2,4a,5,6-tetrahydro-1H-naphthalen-1-yl] pyridine-3-carboxylate; CHEMBL3933122; HY-N1261. Grades: >98%. CAS No. 905929-95-5. Molecular formula: C33H35NO7. Mole weight: 557.6. | |
| Scutebarbatine X | Scutebarbatine X is a revolutionary biomedical compound, standing as an invaluable weapon for studying a myriad of ailments such as cancer, inflammation and neurodegenerative afflictions. Alternative Names: Scutebarbatine X. Grades: >97%. CAS No. 1312716-26-9. Molecular formula: C34H38N2O10. Mole weight: 634.7. | |
| Scutebata F | Scutebata F is from the herbs of Scutellaria barbata D.Don. Alternative Names: Barbatine C. Grades: >95%. CAS No. 1207181-62-1. Molecular formula: C30H37NO9. Mole weight: 555.6. | |
| scutelarin | From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via γ-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. Group: Enzymes. Synonyms: taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Enzyme Commission Number: EC 3.4.21.60. CAS No. 93389-45-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4151; scutelarin; EC 3.4.21.60; 93389-45-8; taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Cat No: EXWM-4151. |  |
| Scutellarein | Scutellarein is a natural flavonoid compound with anti-inflammatory effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone. CAS No. 529-53-3. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0752. | |
| Scutellarein | Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein , its glucuronide conjugated analogue. Group: Biochemicals. Alternative Names: 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,6,7-Tetrahydroxyflavone; 6-Hydroxyapigenin. Grades: Highly Purified. CAS No. 529-53-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Scutellarein | Scutellarin and Scutellarein could improve neuronal injury, and Scutellarein had better protective effect than scutellarin in rat cerebral ischemia. Uses: Enzyme inhibitor. Alternative Names: 6-Hydroxyapigenin; 5,6,7,4'-Tetrahydroxyflavone; 4',5,6,7-tetrahydroxyflavone; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one. Grades: 98%. CAS No. 529-53-3. Molecular formula: C15H10O6. Mole weight: 286.24. | |
| Scutellarein-d4 | Scutellarein-d4. Group: Biochemicals. Alternative Names: 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4; 4',5,6,7-Tetrahydroxyflavone; 6-Hydroxyapigenin-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C15H5D5O6, Molecular Weight: 291.27. US Biological Life Sciences. | Worldwide |
| Scutellarein tetramethyl ether | Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4',5,6,7-Tetramethoxyflavone. CAS No. 1168-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4314. | |
| Scutellaria Baicalensis P.E. 80% Baicalin HPLC | Scutellaria Baicalensis P.E. 80% Baicalin HPLC. |  CA, FL & NJ |
| Scutellaria Baicalensis Root Extract | Scutellaria baicalensis root extract is prepared from the herb of a member of the mint family from rich woods and moist soils in eastern North America. Scutellaria baicalensis root extract, also known as skullcap root extract, it was among seven ingredients in a combination oral herbal product known as PC-SPES that was used to treat prostate cancer. Scutellaria baicalensis extract also is used as an herbal remedy for inflammation and traumatic injury. Group: Others. Mole weight: 446.36. Scutellaria Baicalensis Root Extract; Scutellaria Baicalensis Georgi. Cat No: EXTC-030. | |
| Scutellaria Baicalensis Root Extract | Scutellaria Baicalensis Root Extract is a fully water-soluble plant cosmetic raw material obtained from the dried root of Scutellaria baicalensis Georgi. It mainly contains two flavonoid active ingredients, baicalin and baicalein, which has strong biological activity and is a multi-effect cosmetic additive. Grades: 95%. CAS No. 94279-99-9. Molecular formula: C20H26N2. Mole weight: 294.434. | |
| Scutellaria Baicalensis Root Extract | Scutellaria Baicalensis Root Extract is a type of herbal extract that is derived from the roots of the Chinese skullcap plant, scientifically known as Scutellaria baicalensis. This plant has been used in traditional Chinese medicine for hundreds of years to treat various ailments. Scutellaria Baicalensis Root Extract has anti-inflammatory, antioxidant, and antibacterial properties. It contains flavonoids, such as baicalin and wogonin, which are responsible for its medicinal properties. Scutellaria Baicalensis Root Extract may be used to alleviate inflammation, protect the skin against environmental stressors, and support the immune system. CAS No. 94279-99-9. Product ID: CI-HC-0238. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Scutellarin | Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 27740-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0751. | |
| Scutellarin | Scutellarin. Group: Biochemicals. Grades: Plant Grade. CAS No. 27740-01-8. Pack Sizes: 20mg. Molecular Formula: C21H18O12, Molecular Weight: 462.36. US Biological Life Sciences. | Worldwide |
| Scutellarin | Scutellarin has been shown to induce apoptosis of ovarian and breast tumor cells in vitro. Uses: Antioxidant. Alternative Names: 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-4-one-7-b-D-glucuronide. Grades: >98%. CAS No. 27740-01-8. Molecular formula: C21H18O12. Mole weight: 462.36. | |
| Scutellarin methyl ester | Scutellarin methyl ester. Group: Biochemicals. Grades: Plant Grade. CAS No. 119262-68-9. Pack Sizes: 10mg. Molecular Formula: C22H20O12, Molecular Weight: 476.39. US Biological Life Sciences. | Worldwide |
| SC-VC-PAB-DM1 | SC-VC-PAB-DM1 is a agent-linker conjugate for ADC with with potent antitumor activity by using DM1 (Mertansine, a tubulin inhibitor) , linked via the ADC linker SC-VC-PAB[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259318-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126693. | |
| SC-VC-PAB-MMAE | SC-VC-PAB-MMAE (NHS-VC-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NHS-VC-PAB-MMAE. CAS No. 2259318-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-126681. | |
| S-Cyanoethyl-L-cysteine | S-Cyanoethyl-L-cysteine. Group: Biochemicals. Alternative Names: 2-Amino-3-(2-cyano-ethylsulfanyl)-propionic acid. Grades: Highly Purified. CAS No. 3958-13-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C6H10N2O2S. US Biological Life Sciences. | Worldwide |
| S-Cyanoethyl-L-cysteine (2-Amino-3-(2-cyano-ethylsulfanyl)-propionic Acid) | S-Cyanoethyl-L-cysteine (2-Amino-3-(2-cyano-ethylsulfanyl)-propionic Acid). Group: Biochemicals. Alternative Names: 2-Amino-3-(2-cyano-ethylsulfanyl)-propionic Acid. Grades: Highly Purified. CAS No. 3958-13-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Scyliorhinin II | Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist. Alternative Names: L-Methioninamide, L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-seryl-L-lysyl-L-cysteinyl-L-prolyl-L-α-aspartylglycyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-valylglycyl-L-leucyl-, cyclic(7→13)-disulfide; Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2. Grades: ≥98%. CAS No. 112748-19-3. Molecular formula: C77H119N21O26S3. Mole weight: 1851.09. | |
| scyllo-Inosamine | scyllo-Inosamine is an intricately designed synthetic compound widely employed in studying grievous neurodegenerative afflictions such as Alzheimer's and Parkinson's disease. Its exalted status arises from its possession of remarkable neuroprotective attributes and its finesse in modifying enzyme activity. Alternative Names: 1-Amino-1-deoxy-scyllo-inositol. CAS No. 16051-25-5. Molecular formula: C6H13NO5. Mole weight: 179.17. | |
| scyllo-inosamine 4-kinase | Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol. Group: Enzymes. Synonyms: scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Enzyme Commission Number: EC 2.7.1.65. CAS No. 37278-08-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3096; scyllo-inosamine 4-kinase; EC 2.7.1.65; 37278-08-3; scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Cat No: EXWM-3096. | |
| scyllo-inosamine-4-phosphate amidinotransferase | 1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor. Group: Enzymes. Synonyms: L-arginine:inosamine-P-amidinotransferase; inosamine-P amidinotransferase; L-arginine:inosamine phosphate amidinotransferase; inosamine-phosphate amidinotransferase. Enzyme Commission Number: EC 2.1.4.2. CAS No. 52227-63-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2023; scyllo-inosamine-4-phosphate amidinotransferase; EC 2.1.4.2; 52227-63-1; L-arginine:inosamine-P-amidinotransferase; inosamine-P amidinotransferase; L-arginine:inosamine phosphate amidinotransferase; inosamine-phosphate amidinotransferase. Cat No: EXWM-2023. | |
| scyllo-Inosamine hydrochloride | scyllo-Inosamine hydrochloride is a multifaceted biomedical constituent evolved from inositol, having prospects in studying neurodegenerative ailments like Alzheimer's and Parkinson's. Alternative Names: 1-Amino-1-deoxy-scyllo-inositol HCl. CAS No. 4933-84-0. Molecular formula: C6H13NO4 HCl. Mole weight: 199.63. | |
| scyllo-Inositol | scyllo-Inositol is a renowned chemical compound, serving as a cornerstone in studying an array of neurological ailments, such as the dreaded Alzheimer's disease and the debilitating Parkinson's disease. Acknowledged for its antioxidative properties, this compound assists in studying the build-up of pernicious proteins within the cerebral domain. Alternative Names: inositol; myo-inositol; Scyllo-inositol; epi-Inositol; Muco-Inositol; Allo-inositol; i-Inositol;alloinositol; neoinositol; Hexahydroxycyclohexane; scyllo-Cyclohexanehexol; 1D-myo-Inositol; 1L-myo-Inositol; Inositol, cis-; Inositol, epi-; Inositol, neo-; epi-Cyclohexanehexol; (+)-Inositol; 1,2,3,4,5,6-Cyclohexanehexol; (-)-chiro-Inositol; ELND005; Rat antispectacled eye factor; Levoinositol1111. CAS No. 488-59-5. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| Scyllo-Inositol | Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488-59-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W010041. | |
| scyllo-Inositol-1-d | scyllo-Inositol-1-d. Group: Biochemicals. Alternative Names: Scyllitol-1-d; Cocositol-1-d; Quercinitol-1-d; 1,3,5/2,4,6-Hexahydroxycyclohexane-1-d; scyllo-Cyclohexanehexol. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| scyllo-inositol 2-dehydrogenase (NAD+) | The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA. Group: Enzymes. Synonyms: iolX (gene name). Enzyme Commission Number: EC 1.1.1.370. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0288; scyllo-inositol 2-dehydrogenase (NAD+); EC 1.1.1.370; iolX (gene name). Cat No: EXWM-0288. | |
| scyllo-inositol 2-dehydrogenase (NADP+) | The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)]. Group: Enzymes. Synonyms: iolW (gene name). Enzyme Commission Number: EC 1.1.1.371. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0289; scyllo-inositol 2-dehydrogenase (NADP+); EC 1.1.1.371; iolW (gene name). Cat No: EXWM-0289. | |
| scymnol sulfotransferase | The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5β-scymnol (the natural bile salt) and 5α-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5β-scymnol sulfate. Group: Enzymes. Enzyme Commission Number: EC 2.8.2.32. CAS No. 220581-70-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3392; scymnol sulfotransferase; EC 2.8.2.32; 220581-70-4. Cat No: EXWM-3392. | |
| Scyphostatin | It is a mammalian N-SMase inhibitor produced by the strain of Trichopeziza mollissima SANK 13892. It inhibits N-SMase with IC50 of 1.0 μmol/L. Alternative Names: (2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [(S)-1-hydroxymethyl-2-((1S,2S,6S)-2-hydroxy-3-oxo-7-oxa-bicyclo[4.1.0]hept-4-en-2-yl)-ethyl]-amide; (2'S,2''E,4S,4''E,5S,6S,6''E,8''R,10''S,12''E,14''R)-4,5-epoxy-6-hydroxy-6-[3'-hydroxy-2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-propyl]-2-cyclohexen-1-one; (+)-scyphostatin. CAS No. 169062-93-5. Molecular formula: C29H43NO5. Mole weight: 485.66. | |
| Scytalidin | It is a terpenoid antibiotic produced by the strain of Scytalidium sp. FSC-470. It has antifungal effect. The antibacterial activity is strongest when the pH value of liquid determination is 3.5, and the activity decreases when the pH value increases. Alternative Names: Scytalidic-acid; NSC-236264; 1H-Cyclonona(1,2-c:5,6-c')difuran-1,3,6,8(4H)-tetrone, 10-butyl-5,9,10,11-tetrahydro-10-hydroxy-4-pentyl-, (4S,10R)-; 1H-Cyclonona[1,2-c:5,6-c']difuran-1,3,6,8(4H)-tetrone, 10-butyl-5,9,10,11-tetrahydro-10-hydroxy-4-pentyl-, [4S-(4R*,10S*)]-. CAS No. 39012-16-3. Molecular formula: C22H28O7. Mole weight: 404.45. | |
| scytalidopepsin A | Isolated from the imperfect fungus Scytalidium lignicolum. Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane. A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has Mr = 406,000. Group: Enzymes. Synonyms: Scytalidium aspartic proteinase A; Scytalidium lignicolum aspartic proteinase; Scytalidium lignicolum aspartic proteinase A-2; Scytalidium lignicolum aspartic proteinase A-I; Scytalidium lignicolum aspartic proteinase C; Scytalidium lignicolum carboxyl proteinase; Scytalidium lignicolum acid proteinase. Enzyme Commission Number: EC 3.4.23.31. CAS No. 42613-34-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4269; scytalidopepsin A; EC 3.4.23.31; 42613-34-3; Scytalidium aspartic proteinase A; Scytalidium lignicolum aspartic proteinase; Scytalidium lignicolum aspartic proteinase A-2; Scytalidium lignicolum aspartic proteinase A-I; Scytalidium lignicolum aspartic proteinase C; Scytalidium lignicolum carboxyl proteinase; Scytalidium lignicolum acid proteinase. Cat No: EXWM-4269. | |
| scytalidopepsin B | A second endopeptidase from Scytalidium lignicolum (see scytalidopepsin A) that is insensitive to pepstatin and methyl 2-diazoacetamidohexanoate. 1,2-Epoxy-3-(p-nitrophenoxy)propane reacts with Glu53, which replaces one of the aspartic residues at the active centre. One of the smallest aspartic endopeptidases active as the monomer, with Mr 22,000. Similarly inhibitor-resistant endopeptidases are found in the basidiomycetes Lentinus edodes and Ganoderma lucidum, and in Polyporus tulipiferae, a second endopeptidase distinct from polyporopepsin, but these are of typical aspartic endopeptidase size, Mr about 36,000. Type example of peptidase family G1. Group: Enzymes. Synonyms: Scytalidium aspartic proteinase B; Ganoderma lucidum carboxyl proteinase; Ganoderma lucidum aspartic proteinase; Scytalidium lignicolum aspartic proteinase B; SLB. Enzyme Commission Number: EC 3.4.23.32. CAS No. 104781-89-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4270; scytalidopepsin B; EC 3.4.23.32; 104781-89-7; Scytalidium aspartic proteinase B; Ganoderma lucidum carboxyl proteinase; Ganoderma lucidum aspartic proteinase; Scytalidium lignicolum aspartic proteinase B; SLB. Cat No: EXWM-4270. | |
| Scytalol A | It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain. Alternative Names: 10H-Naphtho[2,3-c]pyran-10-one,1,3,4,4a,5,10a-hexahydro-3,5,9-trihydroxy-7-methoxy-3-methyl-, (3R,4aS,5S,10aR)-rel-(+)-. CAS No. 208183-19-1. Molecular formula: C15H18O6. Mole weight: 294.30. | |
| Scytalol B | It is produced by the strain of Scytalidium sp. 36-93. Alternative Names: 10H-Naphtho[2,3-c]pyran-10-one,1,3,4,4a,5,10a-hexahydro-5,9-dihydroxy-3,7-dimethoxy-3-methyl-, (3R,4aS,5S,10aR)-rel-(+)-. CAS No. 208183-20-4. Molecular formula: C16H20O6. Mole weight: 308.33. | |
| Scytalol C | It is produced by the strain of Scytalidium sp. 36-93. Alternative Names: Naphtho[1,2-b]furan-5(4H)-one,2,3,3a,9btetrahydro-6-hydroxy-2,8-dimethoxy-4-(methoxymethylene)-2-methyl-, (2R,3aR,4E,9bR)-rel-(-)-. CAS No. 208183-22-6. Molecular formula: C17H20O6. Mole weight: 320.34. | |
| Scytalol D | It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain. Alternative Names: 1(2H)-Naphthalenone, 3,4-dihydro-4,8-dihydroxy-6-methoxy-3-(2-oxopropyl)-, (3R,4R)-rel-(+)-. CAS No. 208183-24-8. Molecular formula: C14H16O5. Mole weight: 264.27. | |
| scytalone dehydratase | Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi. Group: Enzymes. Synonyms: scytalone 7,8-hydro-lyase. Enzyme Commission Number: EC 4.2.1.94. CAS No. 118901-79-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5078; scytalone dehydratase; EC 4.2.1.94; 118901-79-4; scytalone 7,8-hydro-lyase. Cat No: EXWM-5078. | |
| Scytonemin | Scytonemin is a biological pigment synthesized by many strains of cyanobacteria. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin (at 3 and 4 μM concentration) inhibited multiple myeloma cell growth associated with downregulation of the activity of Plk1 but no effect on the expression of Plk1. Scytonemin, representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity. Taken together, scytonemin is a promising novel agent for the treatment of multiple myeloma. Alternative Names: (3E,3'E)-3,3'-bis(4-hydroxybenzylidene)-[1,1'-bi(cyclopenta[b]indole)]-2,2'(3H,3'H)-dione; (1,1'-Bicyclopent(b)indole)-2,2'(3H,3'H)-dione, 3,3'-bis((4hydroxyphenyl)methylene)-3,3'-Bis((4-hydroxyphenyl)methylene)-(1,1'-bicyclopent(b)indole)-2,2'(3H,3'H)-dione. Grades: 98%. CAS No. 152075-98-4. Molecular formula: C36H20N2O4. Mole weight: 544.56. | |
| SD-06 | SD-06 is an inhibitor of p38α (IC50=170 nM). It is developed for the treatment of arthritis. Alternative Names: SD 0006; SD-0006; SD0006; SD-06; SD-06; SD-06. CAS No. 271576-80-8. Molecular formula: C20H20ClN5O2. Mole weight: 397.86. | |
| Sd1 | Sd1 is an antibacterial peptide isolated from Saccharum officinarum (Sugarcane). It has activity against fungi. Alternative Names: Arg-Tyr-Cys-Leu-Ser-Gln-Ser-His-Arg-Phe-Lys-Gly-Leu-Cys-Met-Ser-Ser-Ser-Asn-Cys-Ala-Asn-Val-Cys-Gln-Thr-Glu-Asn-Phe-Pro-Gly-Gly-Glu-Cys-Lys-Ala-Asp-Gly-Ala-Thr-Arg-Lys-Cys-Phe-Cys-Lys-Lys-Ile-Cys. | |
| SD 1008 | SD 1008. Group: Biochemicals. Grades: Purified. CAS No. 960201-81-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SD2 | Sd2 is an antibacterial peptide isolated from Helianthus annuus (Common sunflower). It has activity against fungi. Alternative Names: Asn-Glu-Met-Gly-Gly-Pro-Leu-Val-Val-Glu-Ala-Arg-Thr-Cys-Glu-Ser-Gln-Ser-His-Lys-Phe-Lys-Gly-Thr-Cys-Leu-Ser-Asp-Thr-Asn-Cys-Ala-Asn-Val-Cys-His-Ser-Glu-Arg-Phe-Ser-Gly-Gly-Lys-Cys-Arg-Gly-Phe-Arg-Arg-Arg-Cys-Phe-Cys-Thr-Thr-His-Cys. | |
| SD 208 | SD 208. Group: Biochemicals. Grades: Purified. CAS No. 627536-09-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SD-208 | SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. Alternative Names: SD-208; SD 208; SD208; TGF-β RI Kinase Inhibitor V. Grades: >98%. CAS No. 627536-09-8. Molecular formula: C17H10ClFN6. Mole weight: 352.75. | |
| SD-208 | SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII. Uses: Scientific research. Category: Signaling pathways. CAS No. 627536-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13227. | |
| SD-282 | SD-282 is an ATP-competitive inhibitor of p38 kinase. SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. SD-282 may have potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes. Alternative Names: SD282; SD 282; SCIO-282; SCIO 282; SCIO282; rac-Talmapimod. CAS No. 309915-13-7. Molecular formula: C27H30ClFN4O3. Mole weight: 513.00. | |
| Sd3 | Sd3 is an antibacterial peptide isolated from Saccharum officinarum (Sugarcane). It has activity against fungi. Alternative Names: Arg-His-Arg-His-Cys-Phe-Ser-Gln-Ser-His-Lys-Phe-Val-Gly-Ala-Cys-Leu-Arg-Glu-Ser-Asn-Cys-Glu-Asn-Val-Cys-Lys-Thr-Glu-Gly-Phe-Pro-Ser-Gly-Glu-Cys-Lys-Trp-His-Gly-Ile-Val-Ser-Lys-Cys-His-Cys-Lys-Arg-Ile-Cys. | |
| SD-36 | SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase[1]. SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2429877-44-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-129602. | |
| SD-36 | SD-36 is a potent, selective, and efficacious PROTAC degrader of STAT3 protein. SD-36 exhibits nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. Alternative Names: Phosphonic acid, P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]-; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; P-[[2-[[[(5S,8S,10aR)-8-[[[(1S)-4-Amino-1-[[(diphenylmethyl)amino]carbonyl]-4-oxobutyl]amino]carbonyl]-3-[8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-1-oxo-7-octyn-1-yl]decahydro-6-oxopyrrolo[1,2-a][1,5]diazocin-5-yl]amino]carbonyl]-1H-indol-5-yl]difluoromethyl]phosphonic acid; SD 36; SD36. Grades: ≥95%. CAS No. 2429877-44-9. Molecular formula: C59H62F2N9O12P. Mole weight: 1158.17. | |
| SD-436 | SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2497585-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169360. | |
| SD-436 | SD-436. CAS No. 2497585-50-7. | |
| SD-70 | SD-70 is an inhibitor for histone demethylase JMJD2C and exhibits antitumor efficacy. SD-70 inhibits viability of cancer cells CWR22Rv1 (9% cell survival at 10 μM), PC3 (14% cell survival at 2 μM) and DU145 (26% cell survival at 2 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 332173-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121522. | |
| SD-91 | SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STAT3 degrader-2. CAS No. 2497583-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150251. | |
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