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| Product | Description | |
|---|---|---|
| BP Fluor 488 cadaverine | BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Uses: Scientific research. Category: Signaling pathways. CAS No. 1178534-61-6. Pack Sizes: 1 mg. Product ID: HY-D2751. |  |
| BP Fluor 488 DBCO | BP Fluor 488 DBCO is a popular labeling dye used in copper-free Click Chemistry reactions. It will react with the azide group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences. Uses: Scientific research. Category: Signaling pathways. CAS No. 2423960-92-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W800680. | |
| BPH-1358 | BPH-1358 is a potent inhibitor of human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) with IC50s of 1.8 μM and 110 nM, respectively. It has activity against Staphylococcus aureus in vitro (MIC ~250 ng/mL). Synonyms: TS-07705; HY-118946. CAS No. 5352-53-4. Molecular formula: C32H30Cl2N6O2. Mole weight: 601.5. |  |
| BPH-1358 free base | BPH-1358 free base is a potent inhibitor of human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) with IC50s of 1.8 μM and 110 nM, respectively. It has activity against Staphylococcus aureus in vitro (MIC ~250 ng/mL). Synonyms: NSC 50460 free base; N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]biphenyl-4,4'-dicarboxamide; N,N'-Bis[3-(4,5-dihydro-1H-imidazole-2-yl)phenyl]-1,1'-biphenyl-4,4'-dicarboxamide; [1,1'-Biphenyl]-4,4'-dicarboxamide, N4,N4'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-; N,N'-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4,4'-biphenyldicarboxamide. Grade: ≥95%. CAS No. 801985-13-7. Molecular formula: C32H28N6O2. Mole weight: 528.60. | |
| BPH-1358 mesylate | BPH-1358 mesylate is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. BPH-1358 mesylate is active against S. aureus in vitro (MIC ~250 ng/mL). Synonyms: NSC50460 mesylate. Molecular formula: C34H36N6O8S2. Mole weight: 720.82. | |
| BPH-652 | BPH-652, also known as BMS-187745, has been found to be a SQS inhibitor that could probably be effective against S. aureus infections. Synonyms: BMS-187745; BPH-652; BMS 187745; BPH 652; BMS187745; BPH652; CHEMBL351151; BMS 188745 Potassium Salt; DNC009027; KB-75764; tripotassium; 4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate. Grade: 98%. CAS No. 157124-84-0. Molecular formula: C16H16K3O7PS. Mole weight: 500.63. | |
| BPH-652 | BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157124-84-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16115. | |
| BPH715 | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium; Bisphpshonate-715; [2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate; Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grade: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. | |
| BPHA | BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 193807-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114785. | |
| BPI-3016 | BPI-3016 is an analogue of human glucagon-like peptide 1 (hGLP-1) that has a long effect on type 2 diabetes mellitus. In vitro, BPI-3016 exhibited an affinity to GLP receptors and promotes cAMP production. In vivo, the half-life of BPI-3016 was 95h after single dosing in pharmacokinetic studies in diabetic cynomolgus monkey models. Uses: The treatment of type 2 diabetes. Synonyms: BPI-3016; BPI 3016; BPI3016. | |
| BPI-9016M | BPI-9016M, a potent, orally active and selective dual c-Met and AXL tyrosine kinase inhibitor, inhibits lung adenocarcinoma tumor cell growth, migration and invasion. Synonyms: N-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxamide; 3-Pyridinecarboxamide, N-[4-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-. Grade: ≥95%. CAS No. 1528546-94-2. Molecular formula: C25H18F2N4O3. Mole weight: 460.43. | |
| bPiDDB | bPiDDB is a neuronal nicotinic acetylcholine receptor (AChR) antagonist with IC50s of 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1γδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors, respectively. Synonyms: Pyridinium, 1,1'-(1,12-dodecanediyl)bis[3-methyl-, bromide (1:2); Pyridinium, 1,1'-(1,12-dodecanediyl)bis[3-methyl-, dibromide; 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide; N,N'-Dodecylbis-Picolinium Bromide; N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide; 1,1'-(Dodecane-1,12-diyl)bis(3-methylpyridin-1-ium) bromide; BPiDDB. Grade: ≥95%. CAS No. 525596-66-1. Molecular formula: C24H38Br2N2. Mole weight: 514.38. | |
| bPiDDB | bPiDDB. Group: Biochemicals. Grades: Purified. CAS No. 525596-66-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BPIPP | BPIPP. Group: Biochemicals. Grades: Purified. CAS No. 325746-94-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BPIPP | BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It downregulates cAMP and cGMP synthesis, suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM), inhibits GC-stimulated Cl- transport in vitro, and suppresses toxin-induced intestinal fluid accumulation in vivo. BPIPP may be a useful treatment of diarrhea. Uses: Potential treatment of diarrhea. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione. Grade: ≥99% by HPLC. CAS No. 325746-94-9. Molecular formula: C22H16BrN3O3. Mole weight: 450.28. | |
| BPIQ-I | BPIQ-I is an extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 25 pM. It can inhibit the growth of SKOV3 and MDA-468 tumor cell lines with EC50 values of 6.5 and 30 μM, respectively. Uses: Protein kinase inhibitors. Synonyms: PD 159121. Grade: ≥95%. CAS No. 174709-30-9. Molecular formula: C16H12BrN5. Mole weight: 354.2. | |
| BPIQ-II hydrochloride | BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 8 pM. It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR. Synonyms: PD 158294. Grade: ≥98%. CAS No. 171179-37-6. Molecular formula: C15H10BrN5·HCl. Mole weight: 376.6. | |
| BPK-21 | BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2305052-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141549. | |
| BPK-25 | BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2305052-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141550. | |
| BPK-29 | BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. Synonyms: BPK 29; BPK29. Grade: 98% by HPLC. CAS No. 2143467-62-1. Molecular formula: C26H32ClN3O3. Mole weight: 470.0. | |
| BPKDi | BPKDi is an inhibitor of protein kinase D with IC50 of 1, 9, and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells. Synonyms: bipyridyl PKD inhibitor; 2'-(Cyclohexylamino)-6-(piperazin-1-yl)-2,4'-bipyridine-4-carboxamide. Grade: 99%. CAS No. 1201673-28-0. Molecular formula: C21H28N6O. Mole weight: 380.49. | |
| BPKDi | BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1201673-28-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118052. | |
| BpmI | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold overdigestion with enzyme about 95% of the dna fragments can be ligated and 95% may be recut. Group: Restriction Enzymes. Purity: 50U; 250U. CTGGAG(N)16↑ GACCTC(N)14&darr. Activity: 500-1000u.a./ml. Appearance: 10 X SE-buffer W, BSA. Storage: -20°C. Form: Liquid. Source: Bacillus pumilus. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1038RE. |  |
| BPMO | BPMO. Synonyms: PROPYLENE GLYCOL MONOOLEATE;EMALEX PGO;oleic acid, monoester with propane-1,2-diol;PROPYLENE GLYCOL OLEATE;9-Octadecenoic acid (9Z)-, monoester with 1,2-propanediol;9-OCTADECENOICACID,MONOESTERWITH1,2-PROPANEDIOL;9-Octadecenoic acid (Z)-, monoester with 1,2-propanediol 9-octadecenoic acid (z)-, monoester with1,2-propanediol 9-Octadecenoic acid(Z)-,monoester with 1,2-propanediol;Crill 25. CAS No. 1330-80-9. Product ID: CDF4-0103. Molecular formula: C21H40O3. Category: Food Emulsifiers. Product Keywords: Food Ingredients; Food Emulsifiers; BPMO; CDF4-0103; 1330-80-9; C21H40O3; 215-549-3; 1330-80-9. Purity: 0.99. EC Number: 215-549-3. Boiling Point: 176-183 °C(Press: 2 Torr). Density: 0.919[at 20°C]. |  |
| BPN-15606 besylate | BPN-15606 besylate is a highly potent and orally active γ-secretase modulator (GSM) with acceptable PK/PD properties, including bioavailability, half-life and clearance. It attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50s of 7 and 17 nM, respectively. It decreases the level of Aβ42 and Aβ40 in the central nervous system of rats and mice. Synonyms: N-[(1S)-1-(4-Fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-4-methyl-3-pyridazinamine benzenesulfonate (1:1); 3-Pyridazinamine, N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-4-methyl-, benzenesulfonate (1:1). Molecular formula: C29H29FN6O4S. Mole weight: 576.64. | |
| BPO-27 racemate | BPO-27 racemate inhibited CFTR with IC50 ? 8 nM and had greatly improved in vitro metabolic stability and aqueous solubility compared to PPQ-102. Synonyms: BPO-27 (racemate); BPO 27 racemate; BPO27 racemate; BPO-27 racemate; CHEMBL1831075; CHEMBL 1831075; CHEMBL-1831075; BPO-27 racemat. CAS No. 1314873-02-3. Molecular formula: C26H18BrN3O6. Mole weight: 548.34. | |
| BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314873-02-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-19778A. | |
| BPR1J-097 | BPR1J-097 is a novel potent FLT3 inhibitor with an IC50 of 11?nM. Synonyms: BPR1J097; BPR1J-097; BPR1J 097; BPR1-J097; BPR1 J097; BPR1J097. Grade: >98%. CAS No. 1327167-19-0. Molecular formula: C27H28N6O3S. Mole weight: 516.62. | |
| BPR1J-097 hydrochloride | BPR1J-097 hydrochloride is a potent inhibitor of FLT3 (IC50 = 11 nM) with great anti-tumor activities in vivo. Synonyms: 4-(4-Methyl-1-piperazinyl)-N-(5-{3-[(phenylsulfonyl)amino]phenyl}-1H-pyrazol-3-yl)benzamide hydrochloride (1:1); Benzamide, 4-(4-methyl-1-piperazinyl)-N-[5-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-3-yl]-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C27H29ClN6O3S. Mole weight: 553.08. | |
| BPR1J-340 | BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD(+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Synonyms: BPR1J 340; BPR1J340. Grade: 98%. CAS No. 1395051-72-5. Molecular formula: C29H34N8O3. Mole weight: 542.63. | |
| BPR1K653 | SBPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent activity against the growth of xenograft tumors of the human cervical carcinoma KB and KB-derived MDR1-positive KB-VIN10 cells in nude mice. Finally, BPR1K653 also exhibited favorable pharmacokinetic properties in rats., BPR1K653 is a promising anti-cancer compound that has potential for the management of various malignancies, particularly for patients with MDR1-related drug resistance after prolonged chemotherapeutic treatments. Synonyms: BPR1K653; BPR1K 653; BPR1K-653. Grade: 98%. CAS No. 1192754-07-6. Molecular formula: C30H30Cl2N6O2. Mole weight: 541.04. | |
| BPR1K871 | BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DBPR114. CAS No. 2443767-35-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100865. | |
| BPR1M97 | BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist (Kis: 1.8 and 4.2 nM) with blood-brain barrier penetration. It produces potent antinociceptive effects. Synonyms: 3,4-Dichloro-N-[(1,2,3,4-tetrahydro-2-methyl-1-isoquinolinyl)methyl]benzamide. Grade: 98%. CAS No. 2059904-66-2. Molecular formula: C18H18Cl2N2O. Mole weight: 349.25. | |
| BPR1M97 | BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2059904-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128865. | |
| BPR1R024 | BPR1R024 is a selective and orally active colony stimulating factor-1 receptor (CSF1R) inhibitor with an IC50 of 0.53 nM. Synonyms: Urea, N-[4-[[7-(dimethylamino)-4-quinazolinyl]oxy]phenyl]-N'-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-. CAS No. 2503015-75-4. Molecular formula: C24H21F3N6O2. Mole weight: 482.46. | |
| BPR3P0128 | BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 μM and 0.14 μM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1345406-09-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161356. | |
| BPTES | BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity. Group: Inhibitors. CAS No. 314045-39-1. Pack Sizes: 10mg. Product ID: S7753. Formula: C24H24N6O2S3. Smiles: C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| BPTES | BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 314045-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12683. | |
| BPTES | BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. Grade: 98%. CAS No. 314045-39-1. Molecular formula: C24H24N6O2S3. Mole weight: 524.68. | |
| BPTF-IN-BZ1 | BPTF-IN-BZ1 is a BPTF inhibitor with high potency (Kd = 6.3 nM). Synonyms: 5-((4-(2-aminoethyl)phenyl)amino)-4-chloro-2-methylpyridazin-3(2H)-one. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
| BPTF-IN-BZ1 | BPTF-IN-BZ1, a BPTF inhibitor, possesses a high potency (Kd = 6.3 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 2766623-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132889. | |
| BPTU | BPTU is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM) that binds receptors outside of the helical bundle. BPTU blocks inhibition of spontaneous contraction of rat and mouse colon, which is induced by electrical field activation, nicotine and P2Y agonists. It exhibits antithrombotic activity and reduces platelet aggregation. Uses: Antithrombotic. Synonyms: BPTU; BMS-646786; BMS 646786; BMS646786; BMS compound 16; N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea. Grade: ≥98% by HPLC. CAS No. 870544-59-5. Molecular formula: C23H22F3N3O3. Mole weight: 445.43. | |
| BPTU | BPTU (BMS-646786) is a non-nucleotide P2Y1 receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-646786. CAS No. 870544-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13831. | |
| Bpu10I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme 80% of the dna fragments can be ligated. of these 90% can be recut. in the presence of 10% peg ligation is better. Group: Restriction Enzymes. Purity: 200U; 1000U. CC↑TNAGC GGANT↓CG. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer K. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries recombinant plasmids. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM NaCl; 0.1 mM EDTA; 1 mM DTT; 50% glycerol. Cat No: ET-1039RE. | |
| BPU-11 | BPU-11 is a HCN4 CLP ligand. It acts by modulating channel function and completely abolishing the cAMP-induced shift in V1/2. Synonyms: Biphenyl Urea 11. Grade: >98%. CAS No. 909664-41-1. Molecular formula: C32H31N5O. Mole weight: 501.62. | |
| Bpu14 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme about 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. TT↑CGAA AAGC↓TT. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer G. Storage: -20°C. Form: Liquid. Source: Bacillus pumilus 14. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 50% glycerol. Cat No: ET-1040RE. | |
| BpV(HOpic) | BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bisperoxovanadium. CAS No. 722494-26-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128693. | |
| bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. It is reported to function as an insulin mimetic and activate the insulin receptor kinase (IRK). BpV(HOpic) has been shown to activate the insulin receptor kinase of hepatoma cells and enhance PI3K/Akt signaling, which could prevent ischemia-reperfusion (I/R) injury to the myocardium. Synonyms: Bisperoxovanadium(HOpic). Grade: ≥95%. CAS No. 722494-26-0. Molecular formula: C6H4NO8V·2K. Mole weight: 347.2. | |
| bpV(phen) | Potent protein phosphotyrosine phosphatase inhibitor Insulin receptor kinase (IRK) inducer. Insulin mimetic in vitro and in vivo. Apoptosis inducer. ERK inducer. Mitogen-activated protein kinase phosphatase-1 (MKP-1) inducer. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 171202-16-7. Pack Sizes: 5mg, 25mg. Molecular Formula: K[VO(O2)2C12H8N2]. 3H2O. US Biological Life Sciences. | Worldwide |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grade: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| bpV(pic) potassium hydrate | BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium. It is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 31 nM. It is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells and stimulating lipogenesis in adipocytes. BpV(pic) has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells and is also an inhibitor of G6Pase. Synonyms: Bisperoxovanadium(pic). Grade: ≥96%. CAS No. 148556-27-8. Molecular formula: C6H4NO7V·2K·2H2O. Mole weight: 367.3. | |
| BPy-TP2 | Electron transport or hole blocking material in OLEDs. Alternative Names: 2,7-Bis(2,2'-bipyridin-5-yl)triphenylene,2,7-Di(2,2'-bipyridin-5-yl)triphenylene,-(7-[2,2'-Bipyridin]-5-yl-2-triphenylenyl)-2,2'-bipyridine. CAS No. 1394813-58-1. Mole weight: 536.62. |  |
| BQ-123 | BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. Uses: Endothelin receptor antagonists. Synonyms: BQ123; BQ-123; BQ 123. Cyclo(D-trp-D-asp-pro-D-val-leu). Grade: 98%. CAS No. 136553-81-6. Molecular formula: C31H42N6O7. Mole weight: 610.70. | |
| BQ-123 | BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136553-81-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12378. | |
| BQ-123 | BQ-123. Group: Biochemicals. Grades: Purified. CAS No. 136553-81-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| BQ-123 Sodium Salt | Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Source:Synthetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 136553-81-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C31H42N6O7 Na. US Biological Life Sciences. | Worldwide |
| BQ-3020 | BQ-3020. Group: Biochemicals. Grades: Purified. CAS No. 143113-45-5. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| BQ-3020 | BQ-3020 is a potent and selective ETB endothelin receptor agonist (Ki = 0.18 and 970 nM at human ETB and ETA receptors, respectively). Synonyms: endothelin receptor antagonist; Acetyl-(Ala11·15)-Endothelin-1 (6-21). CAS No. 143113-45-5. Molecular formula: C96H140N20O25S. Mole weight: 2006.3. | |
| BQ-788 | BQ-788 is a potent and selective ETB receptor antagonist with an IC50 of 1.2 nM. Synonyms: BQ-788 free acid; D-Norleucine, N-((cis-2,6-dimethyl-1-piperidinyl)carbonyl)-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-; N-cis-2,6-Dimethylpiperidinocarbonyl-β-tBu-Ala-D-Trp(1-methoxycarbonyl)-D-Nle-OH. Grade: 95%. CAS No. 173326-37-9. Molecular formula: C34H51N5O7. Mole weight: 641.80. | |
| BQ-788 | BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 173326-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15894A. | |
| BQ 788 sodium salt | BQ 788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM) without significant activity on ETA receptor (IC50= 1300 nM). Uses: Antihypertensive agents. Synonyms: cis-N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine Monosodium Salt; N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; (R)-2-((R)-2-((S)-2-((2S,6R)-2,6-Dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoic Acid Sodium Salt. Grade: 95%. CAS No. 156161-89-6. Molecular formula: C34H50N5NaO7. Mole weight: 663.78. | |
| BQ-788 sodium salt | BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156161-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15894. | |
| BQ-788 Sodium Salt | Highly selective ETB-receptor antagonist (IC50=1.2nM). BQ 788 is an endothelin type B (ETB) receptor antagonist and is a potential antidote for the cardiovascular toxicity with hypotension and bradycardia. Group: Biochemicals. Alternative Names: cis-N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine Monosodium Salt; N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; (R) -2- ( (R) -2- ( (S) -2- ( (2S, 6R) -2, 6-Dimethylpiperidine-1-carboxamido) -4, 4-dimethylpentanamido) -3- (1- (methoxycarbonyl) -1H-indol-3-yl) propanamido) hexanoic Acid Sodium Salt; N-cis-2, 6-Di methyl piperidinocarbonyl-BETA-tBu-Ala-D-Trp (1-methoxycarbonyl) -D-Nle; BQ 788. Grades: Highly Purified. CAS No. 156161-89-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BQCA | BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1 receptor. Uses: A highly selective positive allosteric modulator of the m1 muscarinic acetylcholine receptor (machr). Synonyms: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic Acid. Grade: ≥98%. CAS No. 338747-41-4. Molecular formula: C18H15NO4. Mole weight: 309.32. | |
| BQR695 | BQR695 is a potent and selective PI4K inhibitor exhibiting potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC50?values of 90?nM and 71 nM, respectively). Uses: Antimalarial. Synonyms: NVP-BQR695; NVP-BQR-695; NVP-BQR 695; BQR695; BQR-695; BQR 695. NVP-BQR695; CS-8070; HY-18748; CS 8070; HY 18748; CS8070; HY18748; 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide. Grade: 99%. CAS No. 1513879-21-4. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Synonyms: BQU57; BQU 57; BQU-57. Grade: >98%. CAS No. 1637739-82-2. Molecular formula: C16H13F3N4O. Mole weight: 334.1. | |
| BQU57 | BQU57 is a selective inhibitor of RalA/RalB small GTPases, with a binding potency (Kb) of 7.7 μM for RalB-GDP. BQU57 can block its interaction with effector proteins (such as SEC5 and EXO84), inhibiting tumor cell migration, invasion and non-adherent growth. BQU57 downregulates the NF-κB signaling pathway, reduces the expression of IL-6, IL-8 and MMP-13, and inhibits apoptosis by regulating the Bcl-2/Bax balance. BQU57 also protects the extracellular matrix by inhibiting the Ral/NF-κB pathway and can be used for the study of degenerative diseases. BQU57 exhibits significant antitumor activity in triple-negative breast cancer (TNBC) models, inhibiting orthotopic tumor growth and lung metastasis and enhancing paclitaxel chemotherapy sensitivity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637739-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12875. | |
| BR | Bromine is a dark reddish-brown fuming liquid with a pungent odor. Denser than water and soluble in water. Hence sinks in water. Toxic by inhalation. Accelerates the burning of combustible material. It is very corrosive to tissue and to metals.;GasVapor; Liquid;FUMING RED-TO-BROWN LIQUID WITH PUNGENT ODOUR.;Dark reddish-brown, fuming liquid with suffocating, irritating fumes.;Dark reddish-brown, fuming liquid with suffocating, irritating fumes. Molecular formula: Br2;Br2. Mole weight: 159.81g/mol. IUPAC Name: molecular bromine. SMILES: BrBr. InChI: InChI=1S/Br2/c1-2. | |
| BR-103354 | BR-103354 is a fibroblast activation protein (FAP) inhibitor with IC50 of 14 nM. BR-103354 functions as an anti-diabetic and anti-NASH agent. Synonyms: BR 103354; BR103354. Grade: >98%. CAS No. 2505339-87-5. Molecular formula: C19H15F2N5O2S. Mole weight: 415.42. | |
| brachyurin | From hepatopancreas of the fiddler crab, Uca pugilator. In peptidase family S1 (trypsin family). Other serine endopeptidases that degrade collagen, but are not listed separately here, include a second endopeptidase from Uca pugilator, digestive enzymes from other decapod crustacea, and an enzyme from the fungus Entomophthora coronata. Group: Enzymes. Synonyms: Uca pugilator collagenolytic proteinase; crab protease I; crab protease II. Enzyme Commission Number: EC 3.4.21.32. CAS No. 848900-32-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4127; brachyurin; EC 3.4.21.32; 848900-32-3; Uca pugilator collagenolytic proteinase; crab protease I; crab protease II. Cat No: EXWM-4127. | |
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