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Rivastigmine Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 105601-04-5. Molecular formula: C10H15NO. Mole weight: 165.24. Catalog: APB105601045.
Rivastigmine Impurity 11
Rivastigmine Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1049692-05-8. Molecular formula: C10H16ClNO. Mole weight: 201.69. Catalog: APB1049692058.
Rivastigmine Impurity 2
A impurity of Rivastigmine.Rivastigmine is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Grades: > 95%. Molecular formula: C14H22N2O4. Mole weight: 282.34.
Rivastigmine Impurity 22
Rivastigmine Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1230021-28-9. Molecular formula: C13H20N2O2. Mole weight: 236.32. Catalog: APB1230021289.
Rivastigmine Impurity E HCl
A impurity of Rivastigmine.Rivastigmine is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Grades: > 95%. Molecular formula: C13H20N2O2. HCl. Mole weight: 272.78.
Rivastigmine Impurity F
An impurity of Rivastigmine. Rivastigmine is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Synonyms: (αS)-3-Methoxy-N,N,α-trimethylbenzenemethanamine; (S)-1-(3-Methoxyphenyl)-N,N-dimethylethanamine; Rivastigmine EP Impurity F. Grades: ≥95%. CAS No. 889443-69-0. Molecular formula: C11H17NO. Mole weight: 179.26.
Rivastigmine metabolite
Rivastigmine metabolite (NAP 226-90) is an acetylcholinesterase ( AChE ) inhibitor which is produced in kidney. Rivastigmine metabolite is promising for research of Alzheimers Disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NAP 226-90. CAS No. 139306-10-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W020576.
Rivastigmine tartrate
Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC 50 s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENA 713; SDZ-ENA 713. CAS No. 129101-54-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-11017.
Rivastigmine tartrate
Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease. Synonyms: ENA 713; ENA713; ENA-713. Grades: >98%. CAS No. 129101-54-8. Molecular formula: C14H22N2O2.C4H6O6. Mole weight: 400.42.
Rivastigmine tartrate
Rivastigmine tartrate. CAS No. 129101-54-8. Product ID: 8-01841. Molecular formula: C14H22N2O2 C4H6O6. Mole weight: 400.43. Properties: White or slight-yellow crystalline powder LOD ≤0.5% Heavy Metals ≤20 ppm.
Rivastigmine tartrate
Rivastigmine tartrate. Group: Biochemicals. Grades: Purified. CAS No. 129101-54-8. Pack Sizes: 50mg. US Biological Life Sciences.
A brain selective acetylcholinesterase inhibitor. Group: Biochemicals. Alternative Names: Ethylmethyl-carbamic Acid 3-[ (1S) -1- (Dimethylamino) ethyl]phenyl Ester, Bitartrate. Grades: Highly Purified. CAS No. 129101-54-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Rivastigmine USP Related Compound F
An impurity of Rivastigmine, a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Synonyms: 3-Vinylphenyl ethyl(methyl)carbamate; 3-Ethenylphenyl ethyl(methyl)carbamate; N-Ethyl-N-methyl-3-vinylphenyl Carbamate. Grades: > 95%. CAS No. 1346602-84-3. Molecular formula: C12H15NO2. Mole weight: 205.26.
Rivenprost
Rivenprost is a potent and selective agonist for the EP4 receptor. It is selective for EP4 receptor over EP3, EP2, and EP1 receptors with Ki values of 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively. It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants. Synonyms: ONO-4819; Methyl 4- [2- [ (1R, 2R, 3R) -3-hydroxy-2- [ (E, 3S) -3-hydroxy-4- [3- (methoxymethyl) phenyl] but-1-enyl] -5-oxocyclopentyl] ethylsulfanyl] butanoate. Grades: ≥98%. CAS No. 256382-08-8. Molecular formula: C24H34O6S. Mole weight: 450.6.
Riviciclib, also known as P276-00, is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: P276-00 free base; 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-; (+)-trans-2-(2-chloro-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one; P-276-00; NSC-800813. Grades: ≥95%. CAS No. 920113-02-6. Molecular formula: C21H21Cl2NO5. Mole weight: 401.84.
Riviciclib HCl
Riviciclib, also known as P276-00, is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Synonyms: 2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride; P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl. CAS No. 920113-03-7. Molecular formula: C21H21Cl2NO5. Mole weight: 438.3.
Rivoglitazone
Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the research of type 2 diabetes mellitus. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-106056. CAS No. 185428-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-106181.
Rizatriptan 1,2-(4-dimethylamino)butane
Rizatriptan 1,2-(4-dimethylamino)butane. Group: Biochemicals. Alternative Names: 3-[2-(Dimethylamino)ethyl]-δ-[3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-2-yl]-N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-1-butanamine. Grades: Highly Purified. CAS No. 1135479-41-2. Pack Sizes: 10mg. Molecular Formula: C36H49N11, Molecular Weight: 635.85. US Biological Life Sciences.
Worldwide
Rizatriptan 2,2-dimer
Rizatriptan 2,2-dimer. Group: Biochemicals. Alternative Names: 3-[2-(Dimethylamino)ethyl]-δ-[3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-2-yl]-N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-butanamine. Grades: Highly Purified. CAS No. 1135479-44-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C36H49N11. US Biological Life Sciences.
Worldwide
Rizatriptan 2,2-dimer
Rizatriptan 2,2-dimer. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-[2-(Dimethylamino)ethyl]-δ-[3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-2-yl]-N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-butanamine. Product Category: Heterocyclic Organic Compound. CAS No. 1135479-44-5. Molecular formula: C36H49N11. Mole weight: 635.85. Product ID: ACM1135479445. Alfa Chemistry ISO 9001:2015 Certified.
Rizatriptan benzoate
Rizatriptan benzoate is the agonist for 5-HT 1B and 5-HT 1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 462. CAS No. 145202-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0206.
Rizatriptan benzoate
Rizatriptan benzoate. Group: Biochemicals. Grades: Purified. CAS No. 145202-66-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Synonyms: 3-[2-(Dimethylamino)ethyl]-δ-[3-[2-(dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-2-yl]-N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-2-butanamine. Grades: > 95%. CAS No. 1135479-44-5. Molecular formula: C36H49N11. Mole weight: 635.87.
Rizatriptan Dimer Impurity 1
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C28H35N7. Mole weight: 469.64.
Rizatriptan Dimer Impurity 2
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C28H32N9.Cl. Mole weight: 530.08.
Rizatriptan Dimer Impurity 3
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Synonyms: 2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine Benzoate; Rizatriptan Dimer Benzoate. Grades: > 95%. CAS No. 1016900-25-6. Molecular formula: C28H35N7.C7H6O2. Mole weight: 591.76.
Rizatriptan EP Impurity G
Rizatriptan EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((1H-1,2,4-triazol-1-yl)methyl)-3-(2-chloroethyl)-1H-indole. CAS No. 1000673-59-5. Molecular formula: C13H13ClN4. Mole weight: 260.08. Catalog: APB1000673595.
Rizatriptan impurity 1
Rizatriptan impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1030849-63-8. Molecular formula: C16H22N5+. Mole weight: 284.39. Catalog: APB1030849638.
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C9H11N5. 2 HCl. Mole weight: 425.68.
Rizatriptan impurity 16
Rizatriptan impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1257392-45-2. Molecular formula: C13H17BrN2. Mole weight: 281.2. Catalog: APB1257392452.
Rizatriptan impurity 4
Rizatriptan impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1135479-41-2. Molecular formula: C36H49N11. Mole weight: 635.87. Catalog: APB1135479412.
Rizatriptan Impurity A
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C16H21N5O C7H6O2. Mole weight: 421.5.
Rizatriptan Impurity B Oxalate
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C13H15N5. C2H2O4. Mole weight: 331.34.
Rizatriptan Impurity C
An impruity of Rizatriptan. Rizatriptan is a serotonin 5-HT1 receptor agonist. It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. CAS No. 208941-96-2. Molecular formula: C15H19N5. Mole weight: 269.35.
Rizatriptan Impurity D
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. Molecular formula: C19H28N5. Cl. Mole weight: 361.92.
Rizatriptan Impurity G
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Synonyms: 3-(2-Chloroethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole. Grades: > 95%. CAS No. 1000673-59-5. Molecular formula: C13H13ClN4. Mole weight: 260.73.
Rizatriptan N10-Oxide
Rizatriptan N10-Oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, N-oxide, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine N-oxide, Rizatriptan N-Oxide,Rizatriptan Benzoate Imp. H (EP). CAS No. 260435-42-5. IUPAC Name: N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine oxide. Molecular formula: C15H19N5O. Mole weight: 285.34. Catalog: APS260435425. SMILES: C[N+](C)([O-])CCc1c[nH]c2ccc(Cn3cncn3)cc12. Format: Neat.
Rizatriptan N10-Oxide
A metabolite of Rizatriptan. Group: Biochemicals. Alternative Names: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine N-Oxide. Grades: Highly Purified. CAS No. 260435-42-5. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Rizatriptan n10-oxide-d6
Rizatriptan n10-oxide-d6. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N,N-(Dimethyl-d6)-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine N-Oxide. Product Category: Heterocyclic Organic Compound. CAS No. 1261392-57-7. Molecular formula: C15H13D6N5O. Mole weight: 291.38. Purity: 0.96. IUPACName: 2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-N,N-bis(trideuteriomethyl)ethanamine oxide. Product ID: ACM1261392577. Alfa Chemistry ISO 9001:2015 Certified. Categories: Rizatriptan N-oxide.
Rizatriptan N,N,N-Trimethylethanammonium Chloride
Rizatriptan N,N,N-Trimethylethanammonium Chloride. Group: Biochemicals. Alternative Names: N,N,N-Trimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanaminium. Grades: Highly Purified. CAS No. 1030849-63-8. Pack Sizes: 10mg. Molecular Formula: C16H22ClN5, Molecular Weight: 319.83. US Biological Life Sciences.
Worldwide
Rizatriptan N-oxide
An impurity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Synonyms: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine N-Oxide. Grades: > 95%. CAS No. 260435-42-5. Molecular formula: C15H19N5O. Mole weight: 285.35.
Rizatriptan Trimethylammonium Chloride
A impruity of Rizatriptan.Rizatriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Synonyms: Rizatriptan N,N,N-Trimethylethanammonium Chloride. Grades: > 95%. CAS No. 1030849-63-8. Molecular formula: C16H22N5.Cl. Mole weight: 319.84.
RJR-2403
At concentrations up to 1 mM, RJR-2403 does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves for agonist-induced ileum contraction indicate that RJR-2403 is less than one-tenth as potent as nicotine with greatly reduced efficacy. RJR-2403 does not antagonize nicotine-stimulated muscle or ganglionic nAChR function (IC50 > 1 mM). Chronic exposure of M10 cells to RJR-2403 (10 microM) results in an up-regulation of high-affinity nAChRs phenomenologically similar to that seen with nicotine. RJR-2403 significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. By comparison, RJR-2403 was 15 to 30-fold less potent than nicotine in decreasing body temperature, respiration, Y-maze rears and crosses and acoustic startle response. Metanicotine was about 5-fold less potent than nicotine in the tail-flick test after s.c administration, but slightly more potent after central administration. Synonyms: Rivanicline; Metanicotine; RJR-2403; RJR 2403; RJR2403; Metanicotine; Rivanicline oxalate. Grades: >98%. CAS No. 15585-43-0. Molecular formula: C10H14N2. Mole weight: 162.23.
RJR 2403 oxalate
RJR 2403 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 220662-95-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RJR-2403 oxalate
A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo. Synonyms: (E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate; RJR2403 oxalate; RJR-2403 oxalate. Grades: >98%. CAS No. 220662-95-3. Molecular formula: C12H16N2O4. Mole weight: 252.27.
RJR 2429 dihydrochloride
RJR 2429, a heterocyclic substituted pyridine compound, is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 ± 17 nM;Emax = 110 ± 09% vs.nicotine). It induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Synonyms: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride; RJR-2429 2HCL; RJR-2429 dihydrochloride; RJR2429 dihydrochloride; RJR 2429 dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1021418-53-0. Molecular formula: C12H16N2.2HCl. Mole weight: 261.19.
RJR 2429 dihydrochloride
RJR 2429 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1021418-53-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RK-1009
RK-1009 is an antibiotic produced by Streptomyces sp. RK-1009. Synonyms: RK 1009; RK1009. Molecular formula: C45H64N2O10. Mole weight: 793.
RK-2
RK-2 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-negative bacteria. Synonyms: Lys-Pro-Tyr-Cys-Ser-Cys-Lys-Trp-Arg-Cys-Gly-Ile-Gly-Glu-Glu-Glu-Lys-Gly-Ile-Cys-His-Lys-Phe-Pro-Ile-Val-Thr-Tyr-Val-Cys-Cys-Arg-Arg-Pro.
RK-20448
RK-20448 is the cis-isomer of A-419259. RK-20448 acts as an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2 (IC50s = 0.24, 1.19, 10.74, and 5.85 μM, respectively). Synonyms: 7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 479501-40-1. Molecular formula: C29H34N6O. Mole weight: 482.62.
RK-24466
RK-24466 is a cell-permeable and ATP-competitive inhibitor of lymphocyte-speci?c protein tyrosine kinase (Lck). It was shown to suppress cell receptor-stimulated IL-2 production in mice. Synonyms: Lck Inhibitor?; 4-Amino-5-(4-Phenoxyphenyl)-7H-Pyrrolo[2,3-D]pyrimidin-7-yl-Cyclopentane; 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine. Grades: ≥95%. CAS No. 213743-31-8. Molecular formula: C23H22N4O. Mole weight: 370.5.
RK-286C
RK-286C is a protein kinase C (PKC) inhibitor produced by Streptomyces sp. RK-286. It inhibits PKC activity with IC50 of 3.0 μmol/L, as well as suppresses platelet aggregation induced by collagen and ADP. Synonyms: RK 286C; RK286C. CAS No. 126572-73-4. Molecular formula: C27H23N3O4. Mole weight: 453.5.
RK-33
RK-33 is a first-in-class inhibitor of DDX3. It causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells, which has therapeutic use in cancers. Synonyms: RK 33; RK33. CAS No. 1070773-09-9. Molecular formula: C23H20N6O3. Mole weight: 428.44.
RK-33
RK-33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1070773-09-9. Molecular formula: C23H20N6O3. Mole weight: 428.45. Catalog: APB1070773099.
RK-33
RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1070773-09-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100455.
RK-397
RK-397 is a macrolide antibiotic produced by Streptomyces sp. 87-397. It is cytotoxic against human leukemia HL-60 and K-562 cells at a concentration of 50 μg/mL. It induces bleb-formation on K-562 cells at the concentrations over 0.05 μg/mL. Synonyms: RK 397; RK397; 14-demethyl-mycoticin; 14-demethylmycoticina. CAS No. 154396-73-3. Molecular formula: C35H56O10. Mole weight: 636.8.
Rk-682
Rk-682. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RK-682;RK-682, STREPTOMYCES SPECIES;3-HEXADECANOYL-5-HYDROXYMETHYL-TETRONIC ACID;ANTIBIOTIC RK-682;ANTIBIOTIC TAN 1364B. Product Category: Heterocyclic Organic Compound. Appearance: Pale yellow solid. CAS No. 154639-24-4. Molecular formula: C21H36O5. Mole weight: 368.51. Purity: ≥98%. IUPACName: RK-682. Product ID: ACM154639244. Alfa Chemistry ISO 9001:2015 Certified. Categories: RK 62.
RK-682 is the inhibitor for protein tyrosine phosphatase ( PTPase ), heparanase , phospholipase A2 and HIV-1 protease. RK-682 inhibits the dephosphorylation of CD45 ( IC 50 is 54 μM) and VHR ( IC 50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC 50 s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150627-37-5. Pack Sizes: 200 μg. Product ID: HY-135564A.
RK-682 calcium salt
It is a dimeric calcium complex of the major analogue of tetronic acid complex isolated from streptomyces. It inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. Synonyms: TAN 1364B; CI 010; Calcium bis[(R)-2-oxo-3-hexadecanoyl-5-(hydroxymethyl)-2,5-dihydrofuran-4-olate]; (5R)-4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone, calcium salt (2:1); RK-682 calcium salt (2:1). Grades: >95% by HPLC. CAS No. 332131-32-5. Molecular formula: C42H70CaO10. Mole weight: 775.09.
RKI-1313 is a negative control of RKI-1447, which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activity. Synonyms: RKI-1313; RKI 1313; RKI1313. 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. CAS No. 1342276-76-9. Molecular formula: C17H16N4O2S. Mole weight: 340.401.
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC 50 values of 14.5 nM and 6.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342278-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15755.
RKI-1447
RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition. Synonyms: RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. Grades: >98%. CAS No. 1342278-01-6. Molecular formula: C16H14N4O2S. Mole weight: 326.374.
RKI 1447 dihydrochloride
RKI 1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 values of 14.5 nM and 6.2 nM, respectively. It suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM). Synonyms: RKI 1447 dihydrochloride; RKI1447 dihydrochloride; RKI-1447 dihydrochloride; N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride; RKI 1447 2Hcl. Grades: ≥99% by HPLC. Molecular formula: C16H14N4O2S.2HCl. Mole weight: 399.29.