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| Product | Description | |
|---|---|---|
| Ro 23-9358 | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Ro24-7429 | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 139339-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19149. |  |
| Ro 25-6981 | Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, is a selective and activity-dependent blocker of NMDA receptors containing the NR2B subunit. Synonyms: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid Ro 25-6981 (Maleate) Ro 25-6981 maleate 169274-78-6 1312991-76-6 SCHEMBL16669133 C22H29NO2.C4H4O4 4008AH 4-((1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methyl. Grades: >98 %. CAS No. 169274-78-6. Molecular formula: C22H29NO2.C4H4O4. Mole weight: 455.54. |  |
| Ro 25-6981 | Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169274-78-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13993. | |
| RO 25-6981 hydrochloride | RO 25-6981 hydrochloride is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. Synonyms: Ro 256981 HCl; Ro 25 6981 HCl; Ro 25-6981 HCl; 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol hydrochloride. Grades: 99%. CAS No. 919289-58-0. Molecular formula: C22H29NO2.HCl. Mole weight: 375.93. | |
| Ro 25-6981 hydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| Ro 25-6981 maleate | Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro. Group: Biochemicals. Alternative Names: (αR, βS)-α-(4-Hydroxyphenyl)- β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate. Grades: Highly Purified. CAS No. 1312991-76-6. Pack Sizes: 1mg, 10mg, 50mg. Molecular Formula: C22H29NO2.C4H4O4, Molecular Weight: 455.55. US Biological Life Sciences. |  Worldwide |
| Ro 25-6981 Maleate | Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312991-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13993A. | |
| Ro 25-6981 Maleate | The Maleate salt form of Ro 25-6981 which is a NMDA receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. IC50: 9 nM. Uses: The maleate salt form of ro 25-6981 which is a nmda receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. Synonyms: Ro 25-6981 Maleate; Ro25-6981 Maleate; Ro-25-6981 Maleate; αR-(4-hydroxyphenyl)-βS-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate. Grades: 98%. CAS No. 1312991-76-6. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Ro 25-6981 maleate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate. Group: Biochemicals. Grades: Purified. CAS No. 1217448-66-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. Synonyms: methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate; 2,2,2-trifluoroacetic acid; Ro26-4550; Ro-26-4550 trifluoroacetate; Ro 26-4550 trifluoroacetate; Ro264550 trifluoroacetate. CAS No. 1217448-66-2. Molecular formula: C26H30N4O3.CF3CO2H. Mole weight: 560.57. | |
| Ro 27-3225 | Ro 27-3225 is a potent and selective melanocortin 4 receptor (MC4R) agonist. CAS No. 274682-89-2. Molecular formula: C39H52N12O6. Mole weight: 784.90. | |
| RO 28-0450 | RO 28-0450 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO-28-1674; RO 28 1674; RO-28 1674; RO281674; 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide. Grades: 98%. CAS No. 300352-96-9. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO 28-1674 | RO 28-1674 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO 28 1674; RO-28-1674; RO-28 1674; RO281674; (S)-3-cyclopentyl-2-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)propanamide. Grades: 99%. CAS No. 599164-57-5. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| Ro 28-1675 | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO-3 | RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively). RO-3 is used in a combination of compounds to develop a substance used for alleviating pain and skin disorders. Synonyms: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine; RO-3; RO 3; RO3. Grades: ≥98% by HPLC. CAS No. 1026582-88-6. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
| RO-3 | RO-3. Group: Biochemicals. Grades: Purified. CAS No. 1026582-88-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. | |
| Ro 31-0432 | solid. Group: Fluorescence/luminescence spectroscopy. | |
| RO314724 | RO314724 is a MMP and HDAC inhibitor. Synonyms: RO 314724; RO-314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester. CAS No. 112105-54-1. Molecular formula: C19H35N3O6. Mole weight: 401.50. | |
| Ro-31-7549, Monohydrate - CAS 125313-65-7 | A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC?? = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Group: Fluorescence/luminescence spectroscopy. | |
| RO31-8220 | Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycerols by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. Uses: Enzyme inhibitors. Synonyms: RO31-8220; RO 31-8220; RO-31-8220; RO318220. Grades: 0.98. CAS No. 125314-64-9. Molecular formula: C25H23N5O2S. Mole weight: 457.552. | |
| Ro-31-8220 - CAS 138489-18-6 | A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM). Group: Fluorescence/luminescence spectroscopy. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate. Group: Biochemicals. Grades: Purified. CAS No. 138489-18-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKC?, PKC?I, PKC?II, PKC?, PKC? and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3? (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate. CAS No. 138489-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13866. | |
| Ro 31-8220 Mesylate | Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-&epsilon. Synonyms: RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX.Bisindolylmaleimide IX Mesylate. Grades: >98%. CAS No. 138489-18-6. Molecular formula: C25H23N5O2S.CH4O3S. Mole weight: 553.65. | |
| Ro 31-8220 methanesulfonate salt | solid. Group: Fluorescence/luminescence spectroscopy. | |
| Ro-31-8425 - CAS 131848-97-0 | A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC?? = 15 nM for rat brain PKC). Group: Fluorescence/luminescence spectroscopy. | |
| RO3201195 | RO3201195 is an orally bioavailable and highly selective inhibitor of p38 MAPK which was selected for advancement into Phase I clinical trials. Synonyms: RO-3201195; RO 3201195; (5-Amino-1-(4-fluoro-phenyl)-1H-pyrazol-4-yl)-(3-(2,3-dihydroxy-propoxy)-phenyl)-methanone. CAS No. 249937-52-8. Molecular formula: C19H18FN3O4. Mole weight: 371.36. | |
| RO3201195 | RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC 50 value of 190 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 249937-52-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-118612. | |
| Ro-32-0432 - CAS 145333-02-4 | A selective cell-permeable protein kinase C inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| Ro 32-0432 hydrochloride | Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold greater selectivity for PKC-βI over PKC- &epsilon (IC50 = 108 nM). Synonyms: Ro 32-0432; Ro 320432; Ro-32-0432. 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; RO 32-0432 HCL; RO 32-0432 HYDROCHLORIDE; BISINDOLYLMALEIMIDE XI, HCL; BISINDOLYLMALEIMIDE XI HYDROCHLORIDE; BISINDOLYLMALEIMIDE XL, HCL; BISINDOYLMALEIMIDE XI HYDROCHLORIDE. Grades: ≥99% by HPLC. CAS No. 151342-35-7. Molecular formula: C28H28N4O2.HCl. Mole weight: 489.01. | |
| Ro 32-3555 | Ro 32-3555 is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). It inhibits both the cartilage and bone changes in this mouse model of OA, and thus shows great potential as a treatment of OA in humans. Synonyms: Ro-32-3555; Ro 32 3555; Ro323555; (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide; Cipemastat; Ro32-3555; 190648-49-8; GFUITADOEPNRML-SJORKVTESA-N; UNII-02HQ4TYQ60; Trocade. Grades: ≥97% by HPLC. CAS No. 190648-49-8. Molecular formula: C22H36N4O5. Mole weight: 436.55. | |
| RO3244794 | RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pK i of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 361457-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164580. | |
| Ro3280 | Ro3280 is a Polo-like kinase 1 (PLK1) inhibitor. Ro3280 shows strong antitumor activity in xenograft mouse models, has good selectivity against other kinases and has excellent in vitro cellular potency. Group: Biochemicals. Alternative Names: 4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide. Grades: Highly Purified. CAS No. 1062243-51-9. Pack Sizes: 5mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 543.61. US Biological Life Sciences. | Worldwide |
| RO3280 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Ro 3306 | Ro 3306. Group: Biochemicals. Grades: Purified. CAS No. 872573-93-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro-3306 | Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 872573-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12529. | |
| RO-3306 | RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis. Synonyms: RO-3306; RO 3306; RO3306. Grades: 0.98. CAS No. 872573-93-8. Molecular formula: C18H13N3OS2. Mole weight: 351.44. | |
| RO-3306 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| RO-3306 | Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. Group: Biochemicals. Alternative Names: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences. | Worldwide |
| RO-3306, CDK 1 Inhibitor ((5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one) | Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Group: Biochemicals. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Ro 363 hydrochloride | Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 250580-70-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123268A. | |
| Ro 41-0960 | solid. Group: Fluorescence/luminescence spectroscopy. | |
| Ro 41-1049 hydrochloride | The hydrochloride salt form of Ro 41-1049 which is a MAO-A inhibitor and probably could be used in the study of Parkinson's disease. Uses: The hydrochloride salt form of ro 41-1049 which is a mao-a inhibitor and probably could be used in the study of parkinson's disease. Synonyms: RO-41-1049 hydrochloride; RO 41-1049 hydrochloride; RO-41-1049 HCl; UNII-19Z49HUF4G; N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide hydrochloride; Ro 41-1049 (hydrochloride); AC1NSKEH; R107_SIGMA. Grades: 98%. CAS No. 127917-66-2. Molecular formula: C12H13ClFN3OS. Mole weight: 301.77. | |
| Ro 41-?3290 | Ro 41-3290, a desethylated metabolite of Ro 41-3696, has shown to be also a partial agonist at the benzodiazepine receptor. Synonyms: 10-chloro-1-[(3S)-3-hydroxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydrobenzo[a]quinolizin-4-one; Ro 41-3290; Ro-41-3290. CAS No. 143943-72-0. Molecular formula: C24H21ClN2O3. Mole weight: 420.89. | |
| Ro 41-5253 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Ro 41-5253 | Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RAR?) antagonist. Ro 41-5253 can bind RAR? without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 144092-31-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116248. | |
| Ro4368554 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| RO4389620 | RO4389620 is a glucokinase activator. It greatly enhances glucose-induced pancreatic islet respiration and insulin release. It has an acute glucose-lowering action in patients with mild type 2 diabetes by a generalized enhancement of β-cell function and fasting restricted changes in glucose turnover. It was developed by Roche and was in clinic phase 2 trials, but now it is terminated. Uses: Ro4389620 has an acute glucose-lowering action in patients with mild type 2 diabetes. Synonyms: RO-4389620; RO 4389620; Piragliatin; (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide. Grades: 98%. CAS No. 625114-41-2. Molecular formula: C19H20ClN3O4S. Mole weight: 421.89. | |
| RO462005 | RO462005 is an endothelin receptor selective agonist. Uses: Endothelin receptor antagonists. Synonyms: RO462005; RO-462005; RO 462005; Ro-46-2005; Ro 46-2005; Ro46-2005. Grades: 98%. CAS No. 150725-87-4. Molecular formula: C23H27N3O6S. Mole weight: 473.54. | |
| RO-46-8443 | RO-46-8443, a benzenesulfonamide derivative, has been found to be a non-peptide endothelin ETB receptor antagonist and could probably be useful in some biological studies of ETB receptors in pathology. Synonyms: RO 46-8443; RO46-8443; RO-46-8443; RO 468443; RO-468443; RO468443; RO 46,8443; RO-46,8443; RO46,8443. 4-tert-butyl-N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl]benzenesulfonamide; AC1NSM3O; SCHEMBL795046; GTPL1011; Ro 46-8443. Grades: 98%. CAS No. 175556-12-4. Molecular formula: C31H35N3O8S. Mole weight: 609.69. | |
| Ro 48-8071 | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro-48-8071. Grades: >98%. CAS No. 161582-11-2. Molecular formula: C23H27BrFNO2. Mole weight: 448.37. | |
| Ro 48-8071 fumarate | Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC 50 of appr 6.5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 189197-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18630A. | |
| Ro 48-8071 fumarate | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro 48-8071; Ro48-8071; Ro-48-8071; Ro 488071; Ro488071; Ro-488071. Grades: >98%. CAS No. 189197-69-1. Molecular formula: C27H31BrFNO6. Mole weight: 564.44. | |
| Ro 48-8071 fumarate | Ro 48-8071 fumarate. Group: Biochemicals. Grades: Purified. CAS No. 189197-69-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RO4927350 | RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback increase in MEK phosphorylation, which has been observed with other MEK inhibitors. Synonyms: RO 4927350; RO-4927350. CAS No. 876755-27-0. Molecular formula: C27H28N4O6S. Mole weight: 536.60. | |
| RO4929097 | RO4929097, a small-molecule inhibitor of γ secretase (IC50 = 4 nM, EC50=5 nM), inhibits cellular processing of Aβ40 (EC50 = 14 nM) and Notch (EC50 = 5 nM). It was shown to decrease the levels of Notch transcriptional target HES1 in human primary melanoma cell lines. Uses: Enzyme inhibitors. Synonyms: RO-4929097; 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide. Grades: >98%. CAS No. 847925-91-1. Molecular formula: C22H20F5N3O3. Mole weight: 469.4. | |
| RO4929097 | RO4929097 (RG-4733) is an orally active ? secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of A?40 and Notch with EC50 of 14 nM and 5 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG-4733. CAS No. 847925-91-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11102. | |
| RO4987655 | RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: RO4987655; RO-4987655; RO 4987655; CH4987655; CH-4987655; CH 4987655. CAS No. 874101-00-5. Molecular formula: C20H19F3IN3O5. Mole weight: 565.288. | |
| RO-5028442 | RO-5028442 is a potent and brain-penetrant hV1a antagonist. RO-5028442 is undergoing clinical trials for autistic disorder therapy. Synonyms: RO-5028442; RO 5028442; RO5028442. [6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone. CAS No. 920022-47-5. Molecular formula: C25H28ClN3O2. Mole weight: 437.968. | |
| RO5045337 | RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Synonyms: R7112, RG7112, RG 7112; RG-7112; RO5045337; RO 5045337; RO-5045337. CAS No. 939981-39-2. Molecular formula: C38H48Cl2N4O4S. Mole weight: 727.786. | |
| RO5068760 | RO5068760 is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation. Synonyms: RO5068760; RO 5068760; RO-5068760. CAS No. 947182-25-4. Molecular formula: C28H27FIN3O6. Mole weight: 647.44. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3 (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively), without significant activity on other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Synonyms: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol; Ro51; Ro-51; CHEMBL494161; 1050670-85-3; SCHEMBL4970553. Grades: ≥98% by HPLC. CAS No. 1050670-85-3. Molecular formula: C17H23IN4O4. Mole weight: 474.29. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3. P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Group: Biochemicals. Alternative Names: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2-pyrimidinyl]amino]-1,3-propanediol; RO-51. Grades: Highly Purified. CAS No. 1050670-85-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RO5126766 | RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis. Synonyms: RO5126766; RO 5126766; RO-5126766; CH5126766; CH-5126766; CH 5126766. Grades: >98%. CAS No. 946128-88-7. Molecular formula: C21H18FN5O5S. Mole weight: 471.463. | |
| RO5166017 | RO5166017 is a highly potent, selective, and orally active agonist for the trace amine-associated receptor 1(TAAR1) with no significant activity at other targets. It is weak and rapidly metabolized (endogenous ligands). It has strong pharmacological activity at other targets. Uses: Ro5166017 has strong pharmacological activity. Synonyms: RO5166017; RO 5166017; RO-5166017; (4S)-4-[(N-ethylanilino)methyl]-4,5-dihydro-1,3-oxazol-2-amine;RO-5166017;(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine. Grades: >98 %. CAS No. 1048346-74-2. Molecular formula: C12H17N3O. Mole weight: 219.29. | |
| Ro5203280 | Ro5203280 is a small-molecular PLK1 inhibitor. Ro5203280 shows a high efficacy for suppressing nasopharyngeal carcinoma growth with low toxicity in mouse studies. It suppresses nasopharyngeal carcinoma growth by inducing G2-M arrest and mitotic arrest and finally induces apoptosis through inhibiting PLK1 phosphorylation. Ro5203280 may be a potential chemotherapeutic agent for nasopharyngeal carcinoma treatment. Synonyms: RO3280; RO-3280; RO 3280; Ro5203280; Ro-5203280; Ro 5203280. Grades: 0.98. CAS No. 1062243-51-9. Molecular formula: C27H35F2N7O3. Mole weight: 543.62. | |
| RO-5203648 | RO-5203648 is a novel selective full agonist of the trace amine-associated receptor 1 (TAAR1). It showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. It increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. It displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Uses: Ro-5203648 displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Synonyms: RO-5203648; RO 5203648; RO5203648; (4S)-4-(3,4-dichlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine;RO5203648;(S)-4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-amine. Grades: >99 %. CAS No. 1043491-54-8. Molecular formula: C9H8Cl2N2O. Mole weight: 231.07. | |
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