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| Product | Description | |
|---|---|---|
| Ropidoxuridine | Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPdR. CAS No. 93265-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13742. |  |
| Ropinirole | Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Synonyms: 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one. Grades: > 95%. CAS No. 91374-21-9. Molecular formula: C16H24N2O. Mole weight: 260.38. |  |
| Ropinirole Aminoacetic Acid | Ropinirole impurity. It was found that these compounds were all poor competitive inhibitors of GABA-AT, but some were substrates of the enzyme, suggesting their utility as scaffolds for potential GABA-AT mechanism-based inactivators. Group: Biochemicals. Alternative Names: 2-Amino-6-[2- (dipropylamino) ethyl]benzeneacetic Acid. Grades: Highly Purified. CAS No. 920755-10-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Ropinirole Cyclopentanylindone Impurity | An impurity of Ropinirole.Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Grades: > 95%. Molecular formula: C10H9NO. Mole weight: 159.19. | |
| Ropinirole-d4 Hydrochloride | Labelled Ropinirole, an antiparkinsonian agent. A selective dopamine D2-receptor agonist. Group: Biochemicals. Alternative Names: 4-[2-(Dipropylamino-d4)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride; 4-[2-(Di-n-propylamino-d4)ethyl]-2(3H)-indolone Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ropinirole EP Impurity D | Ropinirole EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-Despropyl Ropinirole; 4-(2-(propylamino)ethyl)indolin-2-one. CAS No. 106916-16-9. Molecular formula: C13H18N2O. Mole weight: 218.14. Catalog: APB106916169. |  |
| Ropinirole HCl | Ropinirole a selective D-2 agonist with Ki of 29 nM. Uses: Antiparkinson agents. Synonyms: SKF-101468A; SKF 101468A; SKF101468A; AS-041164; AS 041164; AS041164. Grades: >98%. CAS No. 91374-20-8. Molecular formula: C16H24N2O·HCl. Mole weight: 296.84. | |
| Ropinirole hydrochloride | powder, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Ropinirole hydrochloride (SKF-101468-A), SKF-101468-A, Ropinirole hydrochloride, Requip, SKF-98959, SKF 101468A, SKF 101468 hydrochloride, RRT = 1.4 [SB-410189], Ropark, SB-270341, Ralnea XL, RRT = 28.5 [SB-381331], Adartrel, Ropitar, Spiroco XL,2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1), SB 221243A (4-[2-(Dipropylamino)ethyl]-1-hydro-3-methenyl-2H-indol-2-on monohydrochloride), 2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, monohydrochloride (9CI), Parkirop, Repreve, Ronirol, SKF-96413. | |
| Ropinirole hydrochloride | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C16H25ClN2O. CAS No. 91374-20-8. Prepack ID 56483601-25mg. Molecular Weight 296.84. See USA prepack pricing. |  |
| Ropinirole hydrochloride | Ropinirole (SKF 101468) hydrochloride is an orally active, potent D 3 /D 2 receptor agonist with a K i of 29 nM for D 2 receptor. Ropinirole hydrochloride has pEC 50 s of 7.4, 8.4 and 6.8 for hD 2 , hD 3 and hD 4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D 1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 101468 hydrochloride. CAS No. 91374-20-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-B0623A. | |
| Ropinirole, Hydrochloride | An antiparkinsonian agent. A selective dopamine D2-receptor agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 91374-20-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. | Worldwide |
| Ropinirole Impurity 1 | An impurity of Ropinirole.Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Synonyms: 2-[2-(Dipropylamino)ethyl]-6-nitro-α-oxo-benzenepropanoic Acid Ethyl Ester. Grades: > 95%. CAS No. 91374-24-2. Molecular formula: C19H28N2O5. Mole weight: 364.45. | |
| Ropinirole Impurity 10 | Ropinirole Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(2-chloroethyl)indolin-2-one. CAS No. 168476-59-3. Molecular formula: C10H10ClNO. Mole weight: 195.65. Catalog: APB168476593. | |
| Ropinirole Impurity 4 | Ropinirole Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1027600-42-5. Molecular formula: C17H26N2O2. Mole weight: 290.41. Catalog: APB1027600425. | |
| Ropinirole Isohexyl Analog | An impurity of Ropinirole.Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Grades: > 95%. Molecular formula: C16H24N2O. Mole weight: 260.38. | |
| Ropinirole N-Oxide | An impurity of Ropinirole.Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, mAChRs, α1, and β-adrenoreceptors. Synonyms: 1,3-Dihydro-4-[2-(oxidodipropylamino)ethyl]-2H-indol-2-one. Grades: > 95%. CAS No. 1076199-41-1. Molecular formula: C16H24N2O2. Mole weight: 276.38. | |
| Ropinirole N-Oxide | A metabolite of ropinirole. This compound has been found to decompose readily in DMSO and Chloroform. Group: Biochemicals. Alternative Names: 1, 3-Dihydro-4-[2- (oxidodipropylamino) ethyl]-2H-indol-2-one. Grades: Highly Purified. CAS No. 1076199-41-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ropivacaine | Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is used for the research of neuropathic pain management [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84057-95-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563. | |
| Ropivacaine-d7 Hydrochloride | Labeled Ropivacaine. Anesthetic (local). Group: Biochemicals. Grades: Highly Purified. CAS No. 1217667-10-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ropivacaine EP Impurity D HCl | Ropivacaine EP Impurity D HCl. Uses: For analytical and research use. Group: Impurity standards. CAS No. 112773-86-1. Molecular formula: C16H25ClN2O. Mole weight: 296.84. Catalog: APB112773861. | |
| Ropivacaine EP Impurity G HCl | Ropivacaine EP Impurity G HCl. Uses: For analytical and research use. Group: Impurity standards. CAS No. 112773-90-7. Molecular formula: C17H27ClN2O. Mole weight: 310.87. Catalog: APB112773907. | |
| Ropivacaine HCl.H2O | Ropivacaine hydrochloride is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. Uses: Anesthetics, local. Synonyms: LEA-103 HCl; LEA 103 HCl; LEA103 HCl. Grades: >98%. CAS No. 132112-35-7. Molecular formula: C17H26N2O.HCl. Mole weight: 310.86. | |
| Ropivacaine hydrochloride | 25g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H26N2O · HCl · H2O. CAS No. 98717-15-8. Prepack ID 90028387-25g. Molecular Weight 310.06. See USA prepack pricing. | |
| Ropivacaine hydrochloride | 5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H26N2O · HCl · H2O. CAS No. 98717-15-8. Prepack ID 90028387-5g. Molecular Weight 310.06. See USA prepack pricing. | |
| Ropivacaine hydrochloride | Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is widely used for neuropathic pain management in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 98717-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563B. | |
| Ropivacaine hydrochloride monohydrate | Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese [1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132112-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563A. | |
| Ropivacaine Hydrochloride Monohydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopychiral moleculeseuropean pharmacopoeia (ph. eur.)pharmacopoeial standards. Alternative Names: (-)-(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate,Ropivacaine hydrochloride monohydrate. | |
| Ropivacaine Hydrochloride Monohydrate (S-Ropivacaine HCl) | Ropivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Naropin. Ropivacaine was developed after bupivacaine was noted to be associated with cardiac arrest, particularly in pregnant women. Ropivacaine was found to have less cardiotoxicity than bupivacaine in animal models. Group: Biochemicals. Alternative Names: (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate; LEA-103. Grades: Highly Purified. CAS No. 132112-35-7. Pack Sizes: 100mg, 250mg, 500mg, 1g, 10g. Molecular Formula: C??H??ClN?O? , Molecular Weight: 328.88. US Biological Life Sciences. | Worldwide |
| Ropivacaine Impurity 20 | Ropivacaine Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133784-43-7. Molecular formula: C14H21ClN2O. Mole weight: 268.79. Catalog: APB133784437. | |
| Ropivacaine Impurity 5 | Ropivacaine Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1050482-18-2. Molecular formula: C17H26N2O. Mole weight: 274.41. Catalog: APB1050482182. | |
| Ropivacaine Impurity B | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C14H20N2O. Mole weight: 232.33. | |
| Ropivacaine Impurity C | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C15H22N2O. Mole weight: 246.36. | |
| Ropivacaine Impurity D | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C16H24N2O. Mole weight: 260.38. | |
| Ropivacaine Impurity E | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C17H26N2O. Mole weight: 274.41. | |
| Ropivacaine Impurity F | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C17H24N2O. Mole weight: 272.39. | |
| Ropivacaine Impurity G | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Uses: Anesthetics, local. Synonyms: ROPIVACAINE HYDROCHLORIDE MONOHYDRATE; Ropivacaine hydrochloride; Naropin; Ropivacaine hydrochloride hydrate; Ropivacaine (hydrochloride monohydrate); 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, hydrochloride, hydrate (1:1:1), (2S)-; ROPIVACAINE HCL MONOHYDRATE; MFCD00946578; V910P86109; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; hydrate; hydrochloride; Ropivacaine hydrochloride (USP); Ropivacaine hydrochloride [USP]; Anapaine; LEA-103 HCl; (S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate; Ropivacaine hydrochloride hydrate (JAN); LEA 103; LEA-103; (S)-(-)-1-propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide hydrochloride monohydrate. Grades: > 95%. Molecular formula: C17H26N2O. Mole weight: 274.41. | |
| Ropivacaine mesylate | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>[1] [2]. Ropivacaine is also an inhibitor of K 2P (two-pore domain potassium channel) TREK-1 with an IC 50 of 402.7 μM in COS-7 cell's membrane [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 854056-07-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0563C. | |
| Ropivacaine Monomethyl Impurity | A impurity of Ropivacaine.Ropivacaine is a local anaesthetic drug belonging to the amino amide group. Grades: > 95%. Molecular formula: C16H24N2O. Mole weight: 260.38. | |
| Ropivacaine Related Compound A | Ropivacaine Related Compound A. Group: Biochemicals. Grades: Highly Purified. CAS No. 21436-98-6. Pack Sizes: 1g, 5g, 10g, 25g, 50g. US Biological Life Sciences. | Worldwide |
| Ropivacaini Hydrochloridum Monohydricum | Ropivacaini Hydrochloridum Monohydricum. Uses: For analytical and research use. Group: Impurity standards. CAS No. 132112-35-7. Molecular formula: C17H29ClN2O2. Mole weight: 328.88. Catalog: APB132112357. | |
| Ropsacitinib | Ropsacitinib is a Janus kinase inhibitor. Synonyms: Tyk2-IN-8; PF-06826647; (1r,3r)-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile; trans-3-Cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]cyclobutaneacetonitrile. Grades: 98% by HPLC. CAS No. 2127109-84-4. Molecular formula: C20H17N9. Mole weight: 383.4. | |
| Roquefortine C | Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii , activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria [1]. Uses: Scientific research. Group: Natural products. CAS No. 58735-64-1. Pack Sizes: 500 μg; 1 mg. Product ID: HY-N6748. | |
| Roquefortine C | A potent tremorgenic mycotoxin originally isolated from penicillium roqueforti. It is a penicillium commercially used to ripen blue-veined cheese. Synonyms: Roquefortine; NSC 292134; (3E,5aS,10bR,11aS)-10b-(1,1-Dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione; (-)-Roquefortine C; Roquefortin. Grades: >99% by HPLC. CAS No. 58735-64-1. Molecular formula: C22H23N5O2. Mole weight: 389.45. | |
| Roquefortine C | ?98% (HPLC), from Penicillium roqueforti. Group: Fluorescence/luminescence spectroscopy. | |
| Roquefortine C (NSC292134) | Potent neurotoxin. Mycotoxin. Tremorgenic. Gram-positive bacteria growth inhibitor. Cytochrome p450 inhibitor. Lymphocyte proliferation inhibitor. Cytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 58735-64-1. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Roquefortine C (Roquefortine) | Roquefortine C is a potent neurotoxin produced by a diverse range of fungi, most notably Penicillium species. Group: Biochemicals. Alternative Names: Roquefortine. Grades: Highly Purified. CAS No. 58735-64-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Roquefortine E | Roquefortine E is an analogue of Roquefortine C which contains an additional isoprenyl unit on the imidazole similar to phenylhistin, a recently described antimitotic agent. Roquefortine E is a selective, albeit weakly active antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 871982-52-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Roquefortine E | An analogue of roquefortine C, containing an additional isoprenyl unit on the imidazole similar to phenylhistin. Roquefortine E is an antimitotic agent. It is a selective, albeit weakly active, antitumour agent. Grades: >95% by HPLC. CAS No. 871982-52-4. Molecular formula: C27H31N5O2. Mole weight: 457.57. | |
| Roquinimex | Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.IC50 value:Target: TNF alphaProphylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hy |  |
| Roquinimex | Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Linomide; FCF89; ABR212616. CAS No. 84088-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13743. | |
| Roquinimex | Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. Check for active clinical trials or closed clinical trials using this agent. Synonyms: FCF89; FCF-89; FCF 89; LS2616; LS-2616; LS 2616; Quinoline-3-carboxamide; CCRIS 7673; Linomide. Grades: >98%. CAS No. 84088-42-6. Molecular formula: C18H16N2O3. Mole weight: 308.33. | |
| ROR2 (427-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| ROR? Activator 1b | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ROR?/? Agonist, SR1078 | The ROR?/? Agonist, SR1078 controls the biological activity of ROR?/?. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| ROR-alpha/gamma Agonist | A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORalpha/gamma and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORa and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBa in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10mg/kg/i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ROR gama modulator 1 | ROR gama modulator 1, a tetrahydropyranylmethoxy benzenesulfonamide compound, is a retinoid-related orphan receptor gamma (RORy) modulator. Synonyms: GSK2981278; GSK-2981278; GSK 2981278. N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-(oxan-4-ylmethoxy)benzenesulfonamideROR gama modulator 1SCHEMBL15352875CS-5449; CS 5449; CS5449. CAS No. 1474110-21-8. Molecular formula: C25H35NO5S. Mole weight: 461.61. | |
| RORγt agonist 3 | RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 3 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136326A1, compound 23) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2664106-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-142938. | |
| ROR gamma-t-IN-1 | ROR gamma-t-IN-1, an orally bioavailable and CNS penetrant RORγt inhibitors. In vivo: it demonstrated EAE efficacy dose dependently via oral administration RORγ FRET assay: pIC50=8.4; Th17 assay: pIC50> 8.2. Synonyms: GSK805; GSK805; GSK805; ROR gamma-t-IN-1; RORγt Inverse Agonist II; N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamideROR gamma-t-IN-1SCHEMBL14746799CS-5079; HY-12776; CS 5079; HY 12776; CS5079; HY12776. CAS No. 1426802-50-7. Molecular formula: C23H18Cl2F3NO4S. Mole weight: 532.36. | |
| RORg Inverse Agonist, SR2211 (1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211) | A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor g (RORg) and acts as a highly selective and inverse agonist (Ki =105nM; IC50 ~320nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.CAS Number:1359164-11-6. Group: Biochemicals. Grades: Highly Purified. CAS No. 1359164-11-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Roridin A | It has antifungal effect, and it can inhibit 50% of mast cell tumor P815 cells at 0.001 μg/mL in vitro. Synonyms: Roridine A; Roridan A; NSC 200737; Antibiotic 379X; Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-. Grades: ≥98%. CAS No. 14729-29-4. Molecular formula: C29H40O9. Mole weight: 532.62. | |
| Roridin C | Roridin C is a fungal sesquiterpene derived from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: Trichodermol; BRN 1287601; 12,13-Epoxytrichothec-9-en-4-beta-ol; (2S,2'R,4'R,5'S,5a'R,9a'R)-5',5a',8'-trimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-4'-ol. Grades: >98%. CAS No. 2198-93-8. Molecular formula: C15H22O3. Mole weight: 250.33. | |
| Roridin D | Roridin D is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: Roridin-D; 7'-Deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)verrucarin A; Verrucarin A, 7'-deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)-; NSC-374338. CAS No. 14682-29-2. Molecular formula: C29H38O9. Mole weight: 530.61. | |
| Roridin E | Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It exhibits anticancer activity against various cancer cell lines. Synonyms: Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-((1R)-1-hydroxyethyl)-, (2'E,7'R)-. Grades: ≥95% by HPLC. CAS No. 16891-85-3. Molecular formula: C29H38O8. Mole weight: 514.61. | |
| Roridine H | Roridin E is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: CL-72-VB-s; CL-72-VB-2; NSC 274540; Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7',5'-(ethylideneoxy)-. CAS No. 29953-50-2. Molecular formula: C29H36O8. Mole weight: 512.59. | |
| Roridin J | Roridin J is originally isolated from Myrothecium roridum S-1135 (NRRL 3005) and it has anti-leukemia effect in mice. Synonyms: NSC-319082. CAS No. 74072-83-6. Molecular formula: C29H36O9. Mole weight: 528.59. | |
| Roridin L2 | Roridin L2 is originally isolated from M. roridum var. and it has antibacterial and antitumor effects. Synonyms: (2S,2'R,4'R,5'S,5a'R,9a'R)-5a'-(hydroxymethyl)-5',8'-dimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-4'-yl (2Z,4E)-7-hydroxy-6-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethoxy)octa-2,4-dienoate. Grades: >70%. CAS No. 85124-22-7. Molecular formula: C29H38O9. Mole weight: 530.61. | |
| ROS1 (1883-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| ROS 234 dioxalate | ROS 234 dioxalate. Group: Biochemicals. Grades: Purified. CAS No. 184576-87-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ROS 234 dioxalate | ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Synonyms: ROS 234 dioxalate; ROS234 dioxalate; ROS-234 dioxalate; N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate. Grades: ≥99% by HPLC. CAS No. 184576-87-2. Molecular formula: C13H15N5.2C2H2O4. Mole weight: 421.37. | |
| Rosabulin | Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is a potential new therapy for cancer including chemoresistant tumors. Synonyms: STA-5312; STA 5312; STA5312. Grades: 98%. CAS No. 501948-05-6. Molecular formula: C22H16N4O2S. Mole weight: 400.45. | |
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