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| Product | Description | |
|---|---|---|
| IHR 1 | IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grade: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13. |  |
| IHR-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| IHR-1 | IHR-1 is a cell membrane impermeable Smo antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 548779-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110240. |  |
| IHR-Cy3 | IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt. Grade: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64. | |
| IHVR-17028 | IHVR-17028, a potent and broad-spectrum antiviral drug used in infectious disease research, has antiviral activity against BVDV, TCRV and DENV with EC50s of 0.4, 0.26 and 0.3 μM, respectively. It is a potent inhibitor of ER α-glucosidase I with an IC50 of 0.24 μM. Synonyms: Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-; N-Cyclohexyl-2,2-dimethyl-N-{6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl}propanamide. Grade: ≥98% (HPLC). CAS No. 1428247-78-2. Molecular formula: C23H44N2O5. Mole weight: 428.61. | |
| II-B08 | This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grade: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61. | |
| III-31-C | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| IIIM-290 | IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1, respectively. Synonyms: 2-[(E)-2-(2,6-Dichlorophenyl)vinyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 2-[(E)-2-(2,6-dichlorophenyl)ethenyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-. Grade: ≥95%. CAS No. 2213468-64-3. Molecular formula: C23H21Cl2NO5. Mole weight: 462.32. | |
| i-Inositol | i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: myo-Inositol; meso-Inositol. CAS No. 87-89-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B1411. | |
| IITZ-01 | IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| IK1 inhibitor PA-6 | IK1 inhibitor PA-6 is a pentamidine analogue. It is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 has the potential to treat atrial fibrillation and arrhythmia. Synonyms: PA-6; 1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane; N,N'-((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))dibenzimidamide. Grade: 98%. CAS No. 500715-03-7. Molecular formula: C31H32N4O2. Mole weight: 492.61. | |
| IK-930 | IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC 50 value of <0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153585. | |
| IκB kinase | The enzyme phosphorylates IκB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-κB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. Group: Enzymes. Synonyms: CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Enzyme Commission Number: EC 2.7.11.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3129; IκB kinase; EC 2.7.11.10; CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Cat No: EXWM-3129. |  |
| Ikarisoside F | Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grade: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61. | |
| Ikarugamycin | An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grade: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62. | |
| Ikarugamycin | Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Ikarugamycin | ?98% (HPLC), from Streptomyces sp. Group: Fluorescence/luminescence spectroscopy. | |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| iKIX1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. | |
| IKK 16 | IKK 16. Group: Biochemicals. Grades: Purified. CAS No. 1186195-62-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grade: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK 16 | IKK 16 is a selective I?B kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 873225-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687. | |
| IKK-16 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-?B pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687A. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is a potent and selective IκB kinase (IKK) inhibitor with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα, respectively. It inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Synonyms: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride; [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone hydrochloride; Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1). Grade: 98%. CAS No. 1186195-62-9. Molecular formula: C28H30ClN5OS. Mole weight: 520.09. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grade: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grade: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-β. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grade: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKK ? , active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| IKKβ-IN-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grade: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflammÂ… Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| IKKγ NBD Inhibitory Peptide | IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region and has been shown to block TNF-α-induced NF-kB activation. Synonyms: Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu; L-alpha-aspartyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-threonyl-L-alanyl-L-leucyl-L-alpha-aspartyl-L-tryptophyl-L-seryl-L-tryptophyl-L-leucyl-L-glutaminyl-L-threonyl-L-glutamic acid. Grade: >98%. CAS No. 372146-18-4. Molecular formula: C170H259N49O42S. Mole weight: 3693.23. | |
| IKK-?, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| IKK-IN-1 | IKK-IN-1 is an IKK inhibitor. (Extracted from patent WO2002024679A1, compound example 18-13). Synonyms: 2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-(4-piperidinyl)-, hydrochloride (1:1); 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-5-(4-piperidinyl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride (1:1). Grade: ≥95%. CAS No. 406211-06-1. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| IKK-IN-3 | IKK-IN-3 is a potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ), with IC50s of 19 and 400 nM for IKKβ and IKKα, respectively. Synonyms: 1,2-Ethanediamine, N1-(8-methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-; N-(8-Methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-1,2-ethanediamine. CAS No. 615528-53-5. Molecular formula: C17H17N5S. Mole weight: 323.42. | |
| IKK-IN-4 | IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 (IKKβ or IKK2), with IC50s of 45 and 650 nM for IKKβ and IKKα, respectively. Synonyms: Imidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine, 2-[3-(2-aminoethyl)phenyl]-N,8-dimethyl-; 2-[3-(2-Aminoethyl)phenyl]-N,8-dimethylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine. CAS No. 615529-94-7. Molecular formula: C18H19N5S. Mole weight: 337.44. | |
| IL-10 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is a cytokine with potent and broad-spectrum anti-inflammatory properties. IL-10 inhibits the production of pro-inflammatory cytokines and the activation of Th1 and Th2 cells. IL-10 maintains the balance of the immune response, allowing for the clearance of infection while minimizing damage to the host. IL-10 can inhibit the pro-inflammatory response of innate and adaptive immune cells. Synonyms: Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451. Grade: ≥95%. Mole weight: 23-25 kDa. | |
| IL-11 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 from mouse | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 from rat | recombinant, expressed in baculovirus infected Sf9 cells, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 human | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12p40 human | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12p80 human | recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 Protein, Human (Biotinylated, HEK293, His) | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the Interleukin-12 family, which is unique in comprising only heterodimeric cytokines. IL-12 acts as a growth factor for activated T and NK cells, enhances the lysate activity of natural killer cells or lymphokine-activated killer cells, and stimulates IFN-γ production through resting PBMC. IL-12 also has anti-angiogenic activity. IL-12 Protein, Human (Biotinylated, HEK293, His) is a biotinylated protein, produced in HEK293 cells with His-tag. Synonyms: IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40. Grade: ≥95%. Mole weight: ~24&36.2 kDa. | |
| IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the Interleukin-12 family, which is unique in comprising only heterodimeric cytokines. IL-12 acts as a growth factor for activated T and NK cells, enhances the lysate activity of natural killer cells or lymphokine-activated killer cells, and stimulates IFN-γ production through resting PBMC. IL-12 also has anti-angiogenic activity. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated protein, produced in HEK293 cells with His-tag and Avi-tag. Synonyms: CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; Interleukin 12. Grade: ≥95%. Mole weight: ~40-45 kDa. | |
| IL-13 from rat | recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-13 Long Form from rat | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-13 Protein, Human (Biotinylated, HEK293, Avi-His) | Interleukin-13 (IL-13) is an immunoregulatory cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cells, mast cells, basophils, eosinophils, and nuocytes. IL-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis, and chitinase up-regulation. IL-13 recognizes IL-13/4R and IL-13Ra2 receptors, has anti-inflammatory effects on monocytes and macrophages, and inhibits the expression of inflammatory cytokines IL-1β, TNF-α, IL-6, and IL-8. IL-13 is a mediator of allergic inflammation and different diseases including asthma. Synonyms: Interleukin-13; IL-13. Grade: ≥95%. Mole weight: 22-35 kDa. | |
| IL-13 Variant human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-15 from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-15 from rat | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-15 human | Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-15-IN-1 | IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor that inhibits the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. Synonyms: Ethyl 3-[8-({4-methyl-5-[(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)octanamido]benzoate; Benzoic acid, 3-[[8-[[5-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methyl]-4-methyl-4H-1,2,4-triazol-3-yl]thio]-1-oxooctyl]amino]-, ethyl ester. Grade: ≥95%. CAS No. 1831830-20-6. Molecular formula: C30H36N6O4S. Mole weight: 576.71. | |
| IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His) | Interleukin-15 (IL-15) is an inflammatory cytokine that stimulates the expression of tumor necrosis factor α (TNF-α), IL-1β, and inflammatory chemokines. IL-15 is secreted primarily by monocytes and macrophages, which are activated by the products of viral or bacterial infections. IL-15 binds and signals through a trimetric receptor consisting of a common gamma chain, IL-2Rβ, and IL-15Rα. Similar to IL-2, IL-15 triggers the proliferation of normal B lymphocytes and the production of immunoglobulins. IL-15Rα/IL-15 complex can activate the anti-tumor function of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His), produced in HEK293 cells, is a recombinant biotinylated human IL-15Rα (I31-S108) and IL-15 (N49-S162) fusion protein with His-tag. Synonyms: IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15. Grade: ≥95%. Mole weight: 25-28 kDa. | |
| IL-16 (121aa) human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-16 from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-16 human | Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) | IL-17A-17F heterodimer protein is a heterodimer of the cytokines IL-17A and IL-17F, and its biological activity is between IL-17A and IL-17F. Both IL-17A and IL-17F can induce the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), composed of 265 amino acids (IL-17A (G24-A155) and IL-17F (R31-Q163)), is a biotinylated recombinant human IL-17A-17F heterodimer protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F. Grade: ≥95%. Mole weight: ~16 kDa. | |
| IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) | IL-17A-17F heterodimer protein is a heterodimer of the cytokines IL-17A and IL-17F, and its biological activity is between IL-17A and IL-17F. Both IL-17A and IL-17F can induce the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi), composed of 266 amino acids (IL-17A (A26-A158) and IL-17F (R29-A161)), is a biotinylated recombinant mouse IL-17A-17F heterodimer protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F. Grade: ≥95%. Mole weight: 22-25&27-30 kDa. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 ?M and an IC50 of 1.14 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2205034-18-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101913. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 is an antagonist of IL-17A, with a Kd of 0.66 μM and an IC50 of 1.14 μM. Synonyms: (S)-N-(1-((4-(2-(2-(1-(2-Amino-2-oxoethyl)cyclopentyl)-N,N-dimethylacetamido)ethyl)phenyl)amino)-3-(2-fluorophenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide; N-(4-{2-[({1-[2-(Dimethylamino)-2-oxoethyl]cyclopentyl}acetyl)amino]ethyl}phenyl)-2-fluoro-Nα-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-L-phenylalaninamide; 1,1-Cyclopentanediacetamide, N1-[2-[4-[[(2S)-3-(2-fluorophenyl)-2-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1-oxopropyl]amino]phenyl]ethyl]-N1,N1-dimethyl-. Grade: ≥95%. CAS No. 2205034-18-8. Molecular formula: C33H41FN6O4. Mole weight: 604.71. | |
| IL-17A antagonist 3 | IL-17A antagonist 3 is an antagonist of IL-17A. Synonyms: (4S,20R)-7-Chloro-N-methyl-4-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3,18-dioxo-2,19-diazatetracyclo[20.2.2.16,10.111,15]octacosa-1(24),6(28),7,9,11(27),12,14,22,25-nonaene-20-carboxamide; 2,19-Diazatetracyclo[20.2.2.16,10.111,15]octacosa-6,8,10(28),11,13,15(27),22,24,25-nonaene-20-carboxamide, 7-chloro-N-methyl-4-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-3,18-dioxo-, (4S,20R)-. Grade: ≥95%. CAS No. 2230780-65-9. Molecular formula: C33H33ClN6O4. Mole weight: 613.11. | |
| IL-17A from rat | recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-17A inhibitor 1 | IL-17A inhibitor 1 is an inhibitor of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-; N-[(S)-(4,4-Difluorocyclohexyl)(7-{(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl}imidazo[1,2-b]pyridazin-2-yl)methyl]-4-methyl-1,2,5-oxadiazole-3-carboxamide. Grade: ≥95%. CAS No. 2452464-73-0. Molecular formula: C24H27F5N8O4. Mole weight: 586.51. | |
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