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| Product | Description | |
|---|---|---|
| IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) | IL-17A-17F heterodimer protein is a heterodimer of the cytokines IL-17A and IL-17F, and its biological activity is between IL-17A and IL-17F. Both IL-17A and IL-17F can induce the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), composed of 265 amino acids (IL-17A (G24-A155) and IL-17F (R31-Q163)), is a biotinylated recombinant human IL-17A-17F heterodimer protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F. Grade: ≥95%. Mole weight: ~16 kDa. |  |
| IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) | IL-17A-17F heterodimer protein is a heterodimer of the cytokines IL-17A and IL-17F, and its biological activity is between IL-17A and IL-17F. Both IL-17A and IL-17F can induce the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi), composed of 266 amino acids (IL-17A (A26-A158) and IL-17F (R29-A161)), is a biotinylated recombinant mouse IL-17A-17F heterodimer protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F. Grade: ≥95%. Mole weight: 22-25&27-30 kDa. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 (Compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2205034-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-101913. |  |
| IL-17A antagonist 1 | IL-17A antagonist 1 is an antagonist of IL-17A, with a Kd of 0.66 μM and an IC50 of 1.14 μM. Synonyms: (S)-N-(1-((4-(2-(2-(1-(2-Amino-2-oxoethyl)cyclopentyl)-N,N-dimethylacetamido)ethyl)phenyl)amino)-3-(2-fluorophenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide; N-(4-{2-[({1-[2-(Dimethylamino)-2-oxoethyl]cyclopentyl}acetyl)amino]ethyl}phenyl)-2-fluoro-Nα-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-L-phenylalaninamide; 1,1-Cyclopentanediacetamide, N1-[2-[4-[[(2S)-3-(2-fluorophenyl)-2-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1-oxopropyl]amino]phenyl]ethyl]-N1,N1-dimethyl-. Grade: ≥95%. CAS No. 2205034-18-8. Molecular formula: C33H41FN6O4. Mole weight: 604.71. | |
| IL-17A antagonist 3 | IL-17A antagonist 3 is an antagonist of IL-17A. Synonyms: (4S,20R)-7-Chloro-N-methyl-4-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3,18-dioxo-2,19-diazatetracyclo[20.2.2.16,10.111,15]octacosa-1(24),6(28),7,9,11(27),12,14,22,25-nonaene-20-carboxamide; 2,19-Diazatetracyclo[20.2.2.16,10.111,15]octacosa-6,8,10(28),11,13,15(27),22,24,25-nonaene-20-carboxamide, 7-chloro-N-methyl-4-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-3,18-dioxo-, (4S,20R)-. Grade: ≥95%. CAS No. 2230780-65-9. Molecular formula: C33H33ClN6O4. Mole weight: 613.11. | |
| IL-17A inhibitor 1 | IL-17A inhibitor 1 is an inhibitor of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-; N-[(S)-(4,4-Difluorocyclohexyl)(7-{(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl}imidazo[1,2-b]pyridazin-2-yl)methyl]-4-methyl-1,2,5-oxadiazole-3-carboxamide. Grade: ≥95%. CAS No. 2452464-73-0. Molecular formula: C24H27F5N8O4. Mole weight: 586.51. | |
| IL-17A inhibitor 2 | IL-17A inhibitor 2, an IL-17A inhibitor, is used to treat psoriasis, rheumatoid arthritis and multiple sclerosis. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-(difluoromethyl)-; N-((S)-(4,4-difluorocyclohexyl)(7-((S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)methyl)-4-(difluoromethyl)-1,2,5-oxadiazole-3-carboxamide. CAS No. 2452464-77-4. Molecular formula: C24H25F7N8O4. Mole weight: 622.50. | |
| IL-17A modulator-1 | IL-17A modulator-1 is an IL-17A modulator that can be used to study diseases or disorders associated with the modulation of IL-17A activity, including diseases with immune component or autoimmune pathol, cancer and neurodegenerative disorders. It inhibits the biological effects of IL-17A with a pIC50 of 8.2. (Extracted from patent WO2021239743+A1, example 9). Synonyms: (S)-N-(1-((4-(3,5-dimethoxypyridin-4-yl)phenyl)amino)-1-oxo-3,3-diphenylpropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. CAS No. 2748749-29-1. Molecular formula: C33H31N5O4. Mole weight: 561.63. | |
| IL-17A modulator-2 | IL-17A modulator-2 is an IL-17A modulator that can be used to study diseases or disorders associated with the modulation of IL-17A activity, including diseases with immune component or autoimmune pathol, cancer and neurodegenerative disorders. It inhibits the biological effects of IL-17A with a pIC50 of 8.3. (Extracted from patent WO2021239743+A1, example 27). Synonyms: (S)-N-(1-((4-(1-hydroxy-3,5-dimethoxypyridin-4(1H)-ylidene)cyclohexa-2,5-dien-1-ylidene)amino)-1-oxo-3,3-diphenylpropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2748749-47-3. Molecular formula: C33H31N5O5. Mole weight: 577.63. | |
| IL-17A Protein, Human (Biotinylated, 132a.a, HEK293, His-Avi) | Interleukin 17 (IL-17) family is a family of pro-inflammatory cystine node cytokines consisting of IL17A, IL17B, IL17C, IL17D, IL17E, and IL17F. IL-17A is a homodimer factor that plays a key role in host defense mechanisms against many bacterial and fungal pathogens, as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A Protein, Human (Biotinylated, 132a.a, HEK293, His-Avi), composed of 132 amino acids (G24-A155), is a biotinylated recombinant human IL-17A protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: CTLA-8; IL17; IL17A; IL-17CTLA-8; Interleukin 17A. Grade: ≥95%. Mole weight: 16-30 kDa. | |
| IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) | Interleukin 17 (IL-17) family is a family of pro-inflammatory cystine node cytokines consisting of IL17A, IL17B, IL17C, IL17D, IL17E, and IL17F. IL-17A is a homodimer factor that plays a key role in host defense mechanisms against many bacterial and fungal pathogens, as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi), composed of 133 amino acids (A26-A158), is a biotinylated recombinant mouse IL-17A protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: CTLA-8; IL17; IL17A; IL-17CTLA-8; Interleukin 17A. Grade: ≥95%. Mole weight: 20-28 kDa. | |
| IL-17C Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 17 (IL-17) family is a family of pro-inflammatory cystine node cytokines consisting of IL17A, IL17B, IL17C, IL17D, IL17E, and IL17F. IL-17C is predominantly expressed by epithelial cells and is produced by cells expressing Chromogranin A (enteroendocrine cells) and mucin (goblet cells). IL-17C is an early response cytokine in bacterial pathogen defense and upregulates the expression of a variety of antimicrobial peptides, including human beta-defensin 2 (hBD2), Lipocalin 2 (LCN2), and granzyme b. IL-17C stimulates the release of cytokines (IL-1β, TNF-α, and IL-6), and is implicated in autoimmune disorders and bacterial infections. IL-17C Protein, Human (Biotinylated, HEK293, His-Avi), composed of 179 amino acids (H19-V197), is a biotinylated recombinant human IL-17C protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: CX2; Cytokine CX2; IL17C; IL-17; CMGC126884; Interleukin 17C; Interleukin-17C. Grade: ≥90%. Mole weight: 24-26 kDa. | |
| IL-17F Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 17 (IL-17) family is a family of pro-inflammatory cystine node cytokines consisting of IL17A, IL17B, IL17C, IL17D, IL17E, and IL17F. IL-17F induces the expression of a variety of pro-inflammatory cytokines and chemokines. IL-17F signaling can lead to the production of antimicrobial peptides and matrix metalloproteinases. IL-17F signaling activates the MAP kinase pathway, leading to the activation of NF-κB, MAPK-AP-1, and C/EBP. IL-17F is a proinflammatory homodimer factor associated with many diseases, including psoriasis, ankylosing spondylitis, asthma and allergic airway inflammation, intestinal inflammation, and cancer. IL-17F Protein, Human (Biotinylated, HEK293, His-Avi), composed of 133 amino acids (R31-Q163), is a biotinylated recombinant human IL-17F protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1. Grade: ≥95%. Mole weight: 23-28 kDa. | |
| IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi) | Interleukin 17 (IL-17) family is a family of pro-inflammatory cystine node cytokines consisting of IL17A, IL17B, IL17C, IL17D, IL17E, and IL17F. IL-17F induces the expression of a variety of pro-inflammatory cytokines and chemokines. IL-17F signaling can lead to the production of antimicrobial peptides and matrix metalloproteinases. IL-17F signaling activates the MAP kinase pathway, leading to the activation of NF-κB, MAPK-AP-1, and C/EBP. IL-17F is a proinflammatory homodimer factor associated with many diseases, including psoriasis, ankylosing spondylitis, asthma and allergic airway inflammation, intestinal inflammation, and cancer. IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi), composed of 133 amino acids (R29-A161), is a biotinylated recombinant mouse IL-17F protein expressed in HEK293 cells with His tag and Avi tag. Synonyms: Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1. Grade: ≥95%. Mole weight: 30-35 kDa. | |
| IL-17 modulator 1 | IL-17 modulator 1 is an orally active and highly effective IL-17 modulator, which can be used in the study to prevent, treat or improve a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis. (Extracted from patent WO 2020127685). Synonyms: (S)-(4-(4-(3,3-dicyclopropyl-2-(1-isopropyl-1H-pyrazole-5-carboxamido)propanamido)phenyl)-3,5-dimethyl-1H-pyrazol-1-yl)methyl dihydrogen phosphate. CAS No. 2446803-85-4. Molecular formula: C28H37N6O6P. Mole weight: 584.60. | |
| IL-17 modulator 1 disodium | IL-17 modulator 1 disodium is an orally active and highly effective IL-17 modulator, which can be used in the study to prevent, treat or improve a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis. (Extracted from patent WO 2020127685). Synonyms: sodium (S)-(4-(4-(3,3-dicyclopropyl-2-(1-isopropyl-1H-pyrazole-5-carboxamido)propanamido)phenyl)-3,5-dimethyl-1H-pyrazol-1-yl)methyl phosphate. CAS No. 2446803-91-2. Molecular formula: C28H35N6Na2O6P. Mole weight: 628.57. | |
| IL-17 modulator 3 | IL-17 modulator 3 is an IL-17 modulator used in the study of inflammation, cancer and autoimmune diseases. (Extracted from patent US20200247785A1). Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-1-cycloheptyl-2-[[4-[(2R)-3-(4-methyl-1-piperazinyl)-3-oxo-2-[(1-oxopropyl)amino]propyl]phenyl]amino]-2-oxoethyl]-1-methyl-; N-((S)-1-cycloheptyl-2-((4-((R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-propionamidopropyl)phenyl)amino)-2-oxoethyl)-1-methyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2467731-88-8. Molecular formula: C31H45N7O4. Mole weight: 579.73. | |
| IL-17 modulator 4 | IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which is an orally active and highly effective IL-17 modulator. Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)-; (S)-N-(1,1-dicyclopropyl-3-((4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-3-oxopropan-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2446803-65-0. Molecular formula: C27H34N6O2. Mole weight: 474.60. | |
| IL-17 modulator 4 | IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2446803-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141692. | |
| IL-17 modulator 4 sulfate | IL-17 modulator 4 sulfate is a prodrug of IL-17 modulator 1, which is an orally active and highly effective IL-17 modulator. Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)-, compd. with sulfurate (3:2); (S)-N-(1,1-dicyclopropyl-3-((4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-3-oxopropan-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide sulfate (3:2). CAS No. 2446806-90-0. Molecular formula: C27H34N6O2.(2/3H2SO4). Mole weight: 539.99. | |
| IL-17 modulator 5 | IL-17 modulator 5 is an inhibitor of IL-17, with an IC50 of 1 nM. Synonyms: N-((S)-(5-((S)-1-(6-cyano-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-3,3,3-trifluoropropyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)(4,4-difluorocyclohexyl)methyl)-4-methyl-1,2,5-oxadiazole-3-carboxamide. CAS No. 2724206-27-1. Molecular formula: C28H23F6N9O2. Mole weight: 631.53. | |
| IL-1 alpha Protein, Human (Biotinylated, HEK293, Avi) | IL-1α is a pro-inflammatory cytokine of the interleukin 1 family that plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. IL-1α is a major agonist of IL-1 and mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44, and JNK pathways. IL-1α acts as an 'alarmin' and as a primum movens of tissue inflammation. IL-1 alpha protein, Human (Biotinylated, HEK293, Avi) is a biotinylated recombinant protein with Avi label that consists of 159 amino acids (S113-A271) and is produced by E. coli. Synonyms: Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1; IL-1a. Grade: ≥95%. Mole weight: ~19 kDa. | |
| IL-1β Antibody [H12N7] | IL-1 beta,IL-1 beta (Pro-form),IL-1 beta/IL1B,IL-1 beta/IL-1F2,IL-1β. Group: Antibodies. Alternative Names: Interleukin-1 beta; IL-1 beta; Catabolin; IL1B; IL1F2. Pack Sizes: 20uL. Product ID: F3067. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| IL-1 beta Protein, Human (Biotinylated, His-Avi) | IL-1β is a potent proinflammatory cytokine of the interleukin 1 family that is produced by activated macrophages, monocytes, and a subset of dendritic cells known as slanDC. IL-1β is an important mediator of the inflammatory response and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1 beta Protein, Human (Biotinylated, His-Avi), a Biotinylated IL-1 beta protein consisting of 153 amino acids (A117-S269), is produced in E. coli with His-tag and Avi-tag. Synonyms: Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1BETA; IL1F2; IL-1β; IL-1 beta; IL-1B; Interleukin-1β. Grade: ≥95%. Mole weight: ~20.1 kDa. | |
| IL-1R Antagonist | IL-1R antagonist is an interleukin-1 receptor homology and a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88), modulating the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mice with deep partial-thickness scald wound, IL-1R antagonist decreases the expression of inflammation related factors IL-1β and TNF-α and fibrosis related factors TGF-β1, MMP-1, CTGF, and type 1 collagen, promoting wound healing and ruducing fibrosis degree. Synonyms: Hydrocinnamoyl-L-valyl Pyrrolidine; N-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide. Grade: ≥98%. CAS No. 566914-00-9. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| IL2 | Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5. | |
| IL-21 Protein, Mouse (Biotinylated, His-Avi) | Interleukin-21 (IL-21) is a pleiotropic cytokine that acts on a wide range of lymphocytes, myeloid cells, and epithelial cells. These effects include effects on cell proliferation, survival, differentiation, and function. IL-21 is produced by activated CD4+ T cells, and acts on natural killer cells, CD4+ cells, and B cells to induce and sustain antibody production and mediate antibody class switching. IL-21 promotes a range of autoimmune diseases, including systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and psoriasis. Synonyms: Interleukin-21; IL-21; Za11; CVID11. Grade: ≥95%. Mole weight: ~17.9 kDa. | |
| IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) | Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 binds to a heterodimer receptor composed of IL-12RB1 and IL-23R, activating the Jak-Stat signaling cascade and preferentially acting on memory CD4(+) T cells. Synonyms: IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF. Grade: ≥90%. Mole weight: ~55.8 kDa. | |
| IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 binds to a heterodimer receptor composed of IL-12RB1 and IL-23R, activating the Jak-Stat signaling cascade and preferentially acting on memory CD4(+) T cells. Synonyms: IL23 alpha; IL12 beta; IL23 alpha&IL12 beta; IL12 β; IL23 alpha&IL12 β; IL-23A&IL-12B; IL23A&IL12B. Grade: ≥95%. Mole weight: ~24 kDa (IL-23 alpha) & 40-50 kDa (IL-12 beta). | |
| IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) | Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 is a member of the IL-12 cytokine family that has a pro-inflammatory effect and promotes angiogenesis. IL-23 stabilizes RORγt, thereby enabling Th17 cells to release their effector cytokines, such as IL-17, IL-21, IL-22, and GM-CSF, which mediate protection against extracellular fungi and bacteria and participate in barrier immunity. IL-23 also induces the proliferation of CD4 memory T cells (but not naive T cells). Synonyms: Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; IL23p19; IL23A; P19; SGRF. Grade: ≥95%. Mole weight: 23-28 kDa. | |
| IL-23R inhibitor peptide-1 | IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC50 of 0.0069 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2894052-23-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10723. | |
| IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin-25 (IL-25), also known as IL-17E, induces the expression of IL-4, IL-5, IL-13, TGF-β, and G-CSF. In non-immune cells, IL-25 can stimulate cell proliferation, inhibit cell apoptosis, produce inflammatory cytokines and chemokines, and regulate cell-cell adhesion and cell movement. IL-25 activates the NF-κB, MAPKs, and JAK/STAT signaling pathways. IL-25 is an important molecule that controls intestinal immunity and is involved in chronic inflammation associated with the gastrointestinal tract. IL-25 has potent anti-tumor activity in vivo against several human cancers, including melanoma, breast, lung, colon, and pancreatic cancers. Synonyms: IL-25; IL-17E; IL17E; Interleukin-17E; Interleukin-25. Grade: ≥95%. Mole weight: 25-35 kDa. | |
| IL-2 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 2 (IL-2) is a member of the IL-2 related family that functions to stimulate T-cell growth through the IL-2 receptor. IL-2 is a cytokine signaling molecule in the immune system that regulates the activity of white blood cells (white blood cells, usually lymphocytes) responsible for immunity. IL-2 mediates its action by binding to IL-2 receptors, which are expressed by lymphocytes. IL-2 has been used to treat renal cell carcinoma and metastatic melanoma. Synonyms: Interleukin-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2. Grade: ≥95%. Mole weight: 16-18 kDa. | |
| IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) | Interleukin 2 (IL-2) is a member of the IL-2 related family that functions to stimulate T-cell growth through the IL-2 receptor. IL-2 is a cytokine signaling molecule in the immune system that regulates the activity of white blood cells (white blood cells, usually lymphocytes) responsible for immunity. IL-2 mediates its action by binding to IL-2 receptors, which are expressed by lymphocytes. IL-2 has been used to treat renal cell carcinoma and metastatic melanoma. Synonyms: IL2; T-cell growth factor; TCGF; Aldesleukin. Grade: ≥95%. Mole weight: 27-30 kDa. | |
| IL4I1-IN-1 | IL4I1-IN-1 (Compound Ex 232 pg 200) is a selective interleukin 4-induced protein 1 (IL4I1) inhibitor with an EC50 of 2 nM. IL4I1-IN-1 inhibits IL4I1-mediated oxidative deamination of phenylalanine, reducing the production of phenylpyruvate, H2O2 and NH3. IL4I1-IN-1 is promising for research of cancers with high IL4I1 expression, such as endometrial carcinoma, ovarian cancer, and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3082703-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-174262. | |
| IL-4-inhibitor-1 | IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1332184-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139092. | |
| IL-4-inhibitor-1 | IL-4-inhibitor-1 is an IL-4 inhibitor with an EC50 of 1.81 μM. It is selective for IL-4 over IL-13 (EC50 = 18.2 μM). It inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50 = 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. Synonyms: 2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile; 3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-; 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-3-pyridinecarbonitrile. Grade: ≥95%. CAS No. 1332184-63-0. Molecular formula: C18H12FN3O2. Mole weight: 321.31. | |
| IL-4 Protein, Human (Biotinylated) | Interleukin-4 (IL-4) is a receptor for IL-4 RA that induces the differentiation of naive helper T cells (Th0 cells) into Th2 cells. IL-4 is mainly produced by mast cells, Th2 cells, eosinophils, and basophils. IL-4 is a pluripotent cytokine involved in humoral immunity and adaptive immune regulation. IL-4 stimulates the proliferation of activated B cells and T cells, and the differentiation of B cells into plasma cells. IL-4 reduces the production of Th1 cells, macrophages, IFNγ, and dendritic cells IL-12. Synonyms: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1. Grade: ≥90%. Mole weight: ~17.8 kDa. | |
| IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin-4 (IL-4) is a receptor for IL-4 RA that induces the differentiation of naive helper T cells (Th0 cells) into Th2 cells. IL-4 is mainly produced by mast cells, Th2 cells, eosinophils, and basophils. IL-4 is a pluripotent cytokine involved in humoral immunity and adaptive immune regulation. IL-4 stimulates the proliferation of activated B cells and T cells, and the differentiation of B cells into plasma cells. IL-4 reduces the production of Th1 cells, macrophages, IFNγ, and dendritic cells IL-12. Synonyms: IL4; IL-4; Interleukin 4; MGC79402; Pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; Binetrakin; BSF1; BSF-1; BSF-1. Grade: ≥95%. Mole weight: 23-25 kDa. | |
| IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin-5 (IL-5), an interleukin produced by type 2 T helper cells and mast cells, upregulates IL-2Rα on B cells, enhances IgA production, and stimulates the growth and differentiation of B cells and CTLs. By binding to the interleukin-5 receptor, IL-5 stimulates B cell growth and increases immunoglobulin (mainly IgA) secretion. IL-5 is a member of the helical bundle cytokine family, along with IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-5 is a homodimer factor that acts primarily on the eosinophilic arm of the Th2 response, promoting the survival, differentiation, and chemotaxis of these cells. Synonyms: Interleukin-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF; IL5. Grade: ≥95%. Mole weight: 18-24 kDa. | |
| IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) | Interleukin-5 (IL-5), an interleukin produced by type 2 T helper cells and mast cells, upregulates IL-2Rα on B cells, enhances IgA production, and stimulates the growth and differentiation of B cells and CTLs. By binding to the interleukin-5 receptor, IL-5 stimulates B cell growth and increases immunoglobulin (mainly IgA) secretion. IL-5 is a member of the helical bundle cytokine family, along with IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-5 is a homodimer factor that acts primarily on the eosinophilic arm of the Th2 response, promoting the survival, differentiation, and chemotaxis of these cells. Synonyms: Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF. Grade: ≥95%. Mole weight: 16-35 kDa. | |
| IL-6 (88-121) (human) | IL-6 (88-121) competitively inhibits the binding of human IL-6 to its receptor by interacting with the IL-6 receptor to a significant degree. Synonyms: H-ILE-ILE-THR-GLY-LEU-LEU-GLU-PHE-GLU-VAL-TYR-LEU-GLU-TYR-LEU-GLN-ASN-ARG-PHE-GLU-SER-SER-GLU-GLU-GLN-ALA-ARG-ALA-VAL-GLN-MET-SER-THR-LYS-OH; interleukin-6 fragment 88-121. Grade: 95%. CAS No. 145990-81-4. Molecular formula: C179H281N45O58S. Mole weight: 4023.47. | |
| IL-6 Antibody [E21C4] | IL-6 Antibody [E21C4]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2097. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| IL-6 Antibody [F4K18] | IL-6. Group: Antibodies. Alternative Names: Interleukin-6; IL-6; B-cell stimulatory factor 2 (BSF-2); CTL differentiation factor (CDF); Hybridoma growth factor; Interferon beta-2 (IFN-beta-2); IL6; IFNB2. Pack Sizes: 20uL. Product ID: F3023. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Iladatuzumab | Iladatuzumab (MCDS0593A) is a humanized IgG1 anti-human CD79B monoclonal antibody. Iladatuzumab can be used to synthesize antibody-drug conjugates (ADC) Iladatuzumab vedotin (DCDS0780A; HY-P99657), which has the potential for B-cell non-Hodgkin lymphoma (B-NHL) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MCDS0593A. CAS No. 1906205-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99656. | |
| Ilamycin A | Ilamycin A is produced by the strain of Str. islandicus A-165-Z1. It is resistant to mycobacteria, including human mycobacterium tuberculosis, and also to streptomycin resistant bacteria. Grade: >97%. CAS No. 11006-41-0. Molecular formula: C54H75N9O12. Mole weight: 1042.22. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IY-81149. CAS No. 172152-36-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101664. | |
| Ilaprazole | Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It significantly prevented the development of reflux oesophagitis. Synonyms: 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3H-benzoimidazole; IY 81149; 1H-BenziMidazole,2-[[(4-Methoxy-3-Methyl-2-pyridinyl)Methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-. Grade: > 95%. CAS No. 172152-36-2. Molecular formula: C19H18N4O2S. Mole weight: 366.44. | |
| Ilaprazole | Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Group: Biochemicals. Grades: Highly Purified. CAS No. 172152-36-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H18N4O2S, Molecular Weight: 366.44. US Biological Life Sciences. |  Worldwide |
| Ilaprazole-d3 | Ilaprazole-d3 is labelled Ilaprazole (I266400) which is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Group: Biochemicals. Grades: Highly Purified. CAS No. 10370969-17-3. Pack Sizes: 1mg. Molecular Formula: C19H15D3N4O2S, Molecular Weight: 369.46. US Biological Life Sciences. | Worldwide |
| Ilaprazole-[d3] | Ilaprazole-[d3] is the labelled analogue of Ilaprazole. Ilaprazole is a medication of the proton pump inhibitor (PPI) class used for the treatment of dyspepsia, gastroesophageal reflux disease (GORD/GERD), peptic ulcer disease (PUD) and duodenal ulcer. Synonyms: 2-(((4-(Methoxy-d3)-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole; Ilaprazole-d3; 2-[[[4-(Methoxy-d3)-3-methyl-2-pyridinyl]methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole; Ilaprazole D3. Grade: >95%. CAS No. 1070969-17-3. Molecular formula: C19H15D3N4O2S. Mole weight: 369.46. | |
| Ilaprazole Impurity 1 | Ilaprazole Impurity 1. Uses: For analytical and research use. Molecular formula: C27H27N5O3S. Mole weight: 501.61. Catalog: APB10580. |  |
| Ilaprazole Impurity 1 | Ilaprazole Impurity 1. Grade: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
| Ilaprazole Impurity 10 | Ilaprazole Impurity 10. Grade: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
| Ilaprazole Impurity 10 | Ilaprazole Impurity 10. Uses: For analytical and research use. CAS No. 172152-35-1. Molecular formula: C19H18N4OS. Mole weight: 350.44. Catalog: APB172152351. | |
| Ilaprazole Impurity 100 | Ilaprazole Impurity 100. Uses: For analytical and research use. Molecular formula: C20H20N4O2S. Mole weight: 380.47. Catalog: APB08181. | |
| Ilaprazole Impurity 101 | Ilaprazole Impurity 101. Uses: For analytical and research use. Molecular formula: C19H15N3O3. Mole weight: 333.35. Catalog: APB08182. | |
| Ilaprazole Impurity 102 | Ilaprazole Impurity 102. Uses: For analytical and research use. Molecular formula: C18H16N4O2S. Mole weight: 352.41. Catalog: APB08188. | |
| Ilaprazole Impurity 103 | Ilaprazole Impurity 103. Uses: For analytical and research use. Molecular formula: C20H18N5OS+. Mole weight: 376.46. Catalog: APB08183. | |
| Ilaprazole Impurity 104 | Ilaprazole Impurity 104. Uses: For analytical and research use. Molecular formula: C40H40N8O2S22+. Mole weight: 728.93. Catalog: APB08186. | |
| Ilaprazole Impurity 105 | Ilaprazole Impurity 105. Uses: For analytical and research use. Molecular formula: C40H40N8O2S32+. Mole weight: 760.99. Catalog: APB08184. | |
| Ilaprazole Impurity 106 | Ilaprazole Impurity 106. Uses: For analytical and research use. Molecular formula: C19H15N4OS+. Mole weight: 347.42. Catalog: APB08185. | |
| Ilaprazole Impurity 11 | Ilaprazole Impurity 11. Grade: > 95%. Molecular formula: C19H18N4O4S. Mole weight: 398.44. | |
| Ilaprazole Impurity 11 | Ilaprazole Impurity 11. Uses: For analytical and research use. Molecular formula: C19H19N4OS+. Mole weight: 351.45. Catalog: APB10614. | |
| Ilaprazole Impurity 12 | Ilaprazole Impurity 12. Uses: For analytical and research use. CAS No. 228351-50-8. Molecular formula: C19H19N4O+. Mole weight: 319.39. Catalog: APB228351508. | |
| Ilaprazole Impurity 12 | Ilaprazole Impurity 12. Grade: > 95%. Molecular formula: C19H17ClN4O2S. Mole weight: 400.89. | |
| Ilaprazole Impurity 13 | Ilaprazole Impurity 13. Grade: > 95%. Molecular formula: C19H17ClN4O2S. Mole weight: 400.89. | |
| Ilaprazole Impurity 14 | Ilaprazole Impurity 14. Grade: > 95%. Molecular formula: C20H20N4OS. Mole weight: 364.47. | |
| Ilaprazole Impurity 14 | Ilaprazole Impurity 14. Uses: For analytical and research use. CAS No. 1018229-53-2. Molecular formula: C11H9N3O. Mole weight: 199.21. Catalog: APB1018229532. | |
| Ilaprazole Impurity 15 | Ilaprazole Impurity 15. Grade: > 95%. Molecular formula: C16H20N2O4. Mole weight: 304.35. | |
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