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| Product | Description | |
|---|---|---|
| Iguratimod Impurity 50 | Iguratimod Impurity 50. Uses: For analytical and research use. Molecular formula: C14H11NO6. Mole weight: 289.24. Catalog: APB11777. |  |
| Iguratimod Impurity 51 | Iguratimod Impurity 51. Uses: For analytical and research use. Molecular formula: C14H13NO4. Mole weight: 259.26. Catalog: APB11776. | |
| Iguratimod Impurity 53 | Iguratimod Impurity 53. Uses: For analytical and research use. Alternative Names: methyl 4-amino-3-bromo-2-hydroxybenzoate. Molecular formula: C8H8BrNO3. Mole weight: 246.06. Catalog: APB01617. | |
| Iguratimod Impurity 6 | Iguratimod Impurity 6. Uses: For analytical and research use. Molecular formula: C11H13ClN2O5S. Mole weight: 320.74. Catalog: APB11754. | |
| Iguratimod Impurity 7 | Iguratimod Impurity 7. Uses: For analytical and research use. Molecular formula: C19H18N2O8S. Mole weight: 434.42. Catalog: APB11757. | |
| Iguratimod Impurity 8 | Iguratimod Impurity 8. Uses: For analytical and research use. Molecular formula: C18H18N2O7S. Mole weight: 406.41. Catalog: APB11758. | |
| Iguratimod Impurity 8 | Iguratimod Impurity 8. Uses: For analytical and research use. Alternative Names: N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)acetamide. CAS No. 149456-97-3. Molecular formula: C18H20N2O6S. Mole weight: 392.43. Catalog: APB149456973. | |
| Iguratimod Impurity 9 | Iguratimod Impurity 9. Uses: For analytical and research use. CAS No. 544482-14-6. Molecular formula: C18H18N2O7S. Mole weight: 406.41. Catalog: APB544482146. | |
| Iguratimod Impurity 9 | Iguratimod Impurity 9. Uses: For analytical and research use. Alternative Names: N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)acetamide. CAS No. 149457-04-5. Molecular formula: C17H18N2O6S. Mole weight: 378.40. Catalog: APB149457045. | |
| Iguratimod Impurity D | Iguratimod Impurity D. Uses: For analytical and research use. Alternative Names: N-(6-chloro-7-(methylsulfonamido)-4-oxo-4H-chromen-3-yl)formamide. Molecular formula: C11H9ClN2O5S. Mole weight: 316.72. Catalog: APB01641. | |
| Iguratimod Impurity E | Iguratimod Impurity E. Uses: For analytical and research use. Alternative Names: N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)acetamide. CAS No. 123662-92-0. Molecular formula: C18H16N2O6S. Mole weight: 388.39. Catalog: APB123662920. | |
| Iguratimod Impurity F | Iguratimod Impurity F. Uses: For analytical and research use. Alternative Names: N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)pivalamide. Molecular formula: C21H22N2O6S. Mole weight: 430.47. Catalog: APB01640. | |
| Iguratimod Impurity G | Iguratimod Impurity G. Uses: For analytical and research use. Alternative Names: N-(3-formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)-N-(methylsulfonyl)formamide. Molecular formula: C18H14N2O7S. Mole weight: 402.38. Catalog: APB01639. | |
| Iguratimod Impurity H | Iguratimod Impurity H. Uses: For analytical and research use. Alternative Names: N-(7-(N-(methylsulfonyl)methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide. Molecular formula: C18H16N2O8S2. Mole weight: 452.46. Catalog: APB01638. | |
| Iguratimod Impurity I (Hydrochloride) | Iguratimod Impurity I (Hydrochloride). Uses: For analytical and research use. Alternative Names: N-(3-amino-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide hydrochloride. Molecular formula: C16H14N2O5S·HCl. Mole weight: 382.82. Catalog: APB01637. | |
| Iguratimod Impurity J | Iguratimod Impurity J. Uses: For analytical and research use. Alternative Names: N-(7-amino-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide. Molecular formula: C16H12N2O4. Mole weight: 296.28. Catalog: APB01636. | |
| IHCH-7086 | IHCH-7086 is a blood-brain barrier-permeable, partial β-arrestin-biased agonist of 5-HT2AR with a Ki of 12.59 nM. IHCH-7086 blocks D-lysergic acid diethylamide-induced head-twitch response in mice and alleviates depression-like behaviors in mice subjected to acute restraint stress or injected with Corticosterone (HY-B1618). IHCH-7086 is applicable to research related to depression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2957888-70-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169841. |  |
| iHCK-37 | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASN05260065. CAS No. 516478-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139147. | |
| iHCK-37 | iHCK-37 is a new specific pharmacological hematopoietic cell kinase (HCK) inhibitor. HCK is one of Src kinase family (SFK) member. Synonyms: ASN05260065. Grade: 98%. CAS No. 516478-09-4. Molecular formula: C30H32N4O2S2. Mole weight: 544.73. |  |
| IHMT-MST1-39 | IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42, 109, 286, 159 nM for MST1, MST2, MST3, MST4. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 can be used for the studies of type 1 diabetes (T1D) and type 2 diabetes (T2D)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414484-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164595. | |
| IHMT-MST1-58 | IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414484-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151257. | |
| IHMT-PI3Kδ-372 | IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research. Grade: 99%. CAS No. 2429889-62-1. Molecular formula: C26H23F2N7O2. Mole weight: 503.50. | |
| IHMT-PI3Kδ-372 | IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56~83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2429889-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131910. | |
| IHMT-PI3Kδ-372 S-isomer | An S isomer of IHMT-PI3Kδ-372, a potent and selective PI3Kδ inhibitor used for the treatment of chronic obstructive pulmonary disease. Synonyms: 2-[(1S)-1-[4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone. CAS No. 2429889-61-0. Molecular formula: C26H23F2N7O2. Mole weight: 503.5. | |
| IHR 1 | IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grade: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13. | |
| IHR-Cy3 | IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt. Grade: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64. | |
| IHVR-17028 | IHVR-17028, a potent and broad-spectrum antiviral drug used in infectious disease research, has antiviral activity against BVDV, TCRV and DENV with EC50s of 0.4, 0.26 and 0.3 μM, respectively. It is a potent inhibitor of ER α-glucosidase I with an IC50 of 0.24 μM. Synonyms: Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-; N-Cyclohexyl-2,2-dimethyl-N-{6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl}propanamide. Grade: ≥98% (HPLC). CAS No. 1428247-78-2. Molecular formula: C23H44N2O5. Mole weight: 428.61. | |
| II-B08 | This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grade: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61. | |
| IID432 | IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC50 of 8 ?nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3094992-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175741. | |
| IIIM-290 | IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1, respectively. Synonyms: 2-[(E)-2-(2,6-Dichlorophenyl)vinyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 2-[(E)-2-(2,6-dichlorophenyl)ethenyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-. Grade: ≥95%. CAS No. 2213468-64-3. Molecular formula: C23H21Cl2NO5. Mole weight: 462.32. | |
| i-Inositol | i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol; meso-Inositol. CAS No. 87-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-B1411. | |
| i-Inositol-d6 | i-Inositol-d6 is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol-d6; meso-Inositol-d6. CAS No. 68922-44-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1411S. | |
| i-Inositol (Standard) | i-Inositol (Standard) is the analytical standard of i-Inositol. This product is intended for research and analytical applications. i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol (Standard); meso-Inositol (Standard). CAS No. 87-89-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B1411R. | |
| IITZ-01 | IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| IK1 inhibitor PA-6 | IK1 inhibitor PA-6 is a pentamidine analogue. It is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 has the potential to treat atrial fibrillation and arrhythmia. Synonyms: PA-6; 1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane; N,N'-((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))dibenzimidamide. Grade: 98%. CAS No. 500715-03-7. Molecular formula: C31H32N4O2. Mole weight: 492.61. | |
| IK-595 | IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3018909-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181067. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-153585. | |
| IK-930 | IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44. | |
| IκBα Antibody [L13L21] | IKB alpha,IkB-alpha,IκBα,NFKBIA,NFKBIA/IkB alpha. Group: Antibodies. Alternative Names: NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA; MAD3; NFKBI. Pack Sizes: 20uL. Product ID: F3539. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| IκB kinase | The enzyme phosphorylates IκB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-κB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. Group: Enzymes. Synonyms: CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Enzyme Commission Number: EC 2.7.11.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3129; IκB kinase; EC 2.7.11.10; CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Cat No: EXWM-3129. |  |
| Ikarisoside F | Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grade: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61. | |
| Ikarugamycin | Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| Ikarugamycin | An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grade: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62. | |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. | |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grade: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK 16 | IKK 16. Group: Biochemicals. Grades: Purified. CAS No. 1186195-62-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| IKK 16 | IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873225-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-13687. | |
| IKK-16 | IKK-16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM. Group: Inhibitors. Alternative Names: IKK Inhibitor VII. CAS No. 873225-46-8. Pack Sizes: 10mg. Product ID: S2882. Formula: C28H29N5OS. Smiles: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13687A. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is a potent and selective IκB kinase (IKK) inhibitor with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα, respectively. It inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Synonyms: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride; [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone hydrochloride; Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1). Grade: 98%. CAS No. 1186195-62-9. Molecular formula: C28H30ClN5OS. Mole weight: 520.09. | |
| IKK2-IN-4 | IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 354811-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112456. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grade: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grade: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-β. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grade: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grade: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflamm Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| IKKγ NBD Inhibitory Peptide | IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region and has been shown to block TNF-α-induced NF-kB activation. Synonyms: Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu; L-alpha-aspartyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-threonyl-L-alanyl-L-leucyl-L-alpha-aspartyl-L-tryptophyl-L-seryl-L-tryptophyl-L-leucyl-L-glutaminyl-L-threonyl-L-glutamic acid. Grade: >98%. CAS No. 372146-18-4. Molecular formula: C170H259N49O42S. Mole weight: 3693.23. | |
| IKK-IN-1 | IKK-IN-1 is an IKK inhibitor. (Extracted from patent WO2002024679A1, compound example 18-13). Synonyms: 2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-(4-piperidinyl)-, hydrochloride (1:1); 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-5-(4-piperidinyl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride (1:1). Grade: ≥95%. CAS No. 406211-06-1. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| IKK-IN-3 | IKK-IN-3 is a potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ), with IC50s of 19 and 400 nM for IKKβ and IKKα, respectively. Synonyms: 1,2-Ethanediamine, N1-(8-methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-; N-(8-Methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-1,2-ethanediamine. CAS No. 615528-53-5. Molecular formula: C17H17N5S. Mole weight: 323.42. | |
| IKK-IN-4 | IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 (IKKβ or IKK2), with IC50s of 45 and 650 nM for IKKβ and IKKα, respectively. Synonyms: Imidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine, 2-[3-(2-aminoethyl)phenyl]-N,8-dimethyl-; 2-[3-(2-Aminoethyl)phenyl]-N,8-dimethylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine. CAS No. 615529-94-7. Molecular formula: C18H19N5S. Mole weight: 337.44. | |
| Ikshusterol | Ikshusterol is a sterol that can be extracted from Hibiscus moscheutos L[1]. Uses: Scientific research. Category: Natural products. CAS No. 34427-61-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4017. | |
| IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is a cytokine with potent and broad-spectrum anti-inflammatory properties. IL-10 inhibits the production of pro-inflammatory cytokines and the activation of Th1 and Th2 cells. IL-10 maintains the balance of the immune response, allowing for the clearance of infection while minimizing damage to the host. IL-10 can inhibit the pro-inflammatory response of innate and adaptive immune cells. Synonyms: Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451. Grade: ≥95%. Mole weight: 23-25 kDa. | |
| IL-12 Protein, Human (Biotinylated, HEK293, His) | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the Interleukin-12 family, which is unique in comprising only heterodimeric cytokines. IL-12 acts as a growth factor for activated T and NK cells, enhances the lysate activity of natural killer cells or lymphokine-activated killer cells, and stimulates IFN-γ production through resting PBMC. IL-12 also has anti-angiogenic activity. IL-12 Protein, Human (Biotinylated, HEK293, His) is a biotinylated protein, produced in HEK293 cells with His-tag. Synonyms: IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40. Grade: ≥95%. Mole weight: ~24&36.2 kDa. | |
| IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) | Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the Interleukin-12 family, which is unique in comprising only heterodimeric cytokines. IL-12 acts as a growth factor for activated T and NK cells, enhances the lysate activity of natural killer cells or lymphokine-activated killer cells, and stimulates IFN-γ production through resting PBMC. IL-12 also has anti-angiogenic activity. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated protein, produced in HEK293 cells with His-tag and Avi-tag. Synonyms: CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; Interleukin 12. Grade: ≥95%. Mole weight: ~40-45 kDa. | |
| IL-13 Protein, Human (Biotinylated, HEK293, Avi-His) | Interleukin-13 (IL-13) is an immunoregulatory cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cells, mast cells, basophils, eosinophils, and nuocytes. IL-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis, and chitinase up-regulation. IL-13 recognizes IL-13/4R and IL-13Ra2 receptors, has anti-inflammatory effects on monocytes and macrophages, and inhibits the expression of inflammatory cytokines IL-1β, TNF-α, IL-6, and IL-8. IL-13 is a mediator of allergic inflammation and different diseases including asthma. Synonyms: Interleukin-13; IL-13. Grade: ≥95%. Mole weight: 22-35 kDa. | |
| IL-15-IN-1 | IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor that inhibits the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. Synonyms: Ethyl 3-[8-({4-methyl-5-[(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)octanamido]benzoate; Benzoic acid, 3-[[8-[[5-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methyl]-4-methyl-4H-1,2,4-triazol-3-yl]thio]-1-oxooctyl]amino]-, ethyl ester. Grade: ≥95%. CAS No. 1831830-20-6. Molecular formula: C30H36N6O4S. Mole weight: 576.71. | |
| IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His) | Interleukin-15 (IL-15) is an inflammatory cytokine that stimulates the expression of tumor necrosis factor α (TNF-α), IL-1β, and inflammatory chemokines. IL-15 is secreted primarily by monocytes and macrophages, which are activated by the products of viral or bacterial infections. IL-15 binds and signals through a trimetric receptor consisting of a common gamma chain, IL-2Rβ, and IL-15Rα. Similar to IL-2, IL-15 triggers the proliferation of normal B lymphocytes and the production of immunoglobulins. IL-15Rα/IL-15 complex can activate the anti-tumor function of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His), produced in HEK293 cells, is a recombinant biotinylated human IL-15Rα (I31-S108) and IL-15 (N49-S162) fusion protein with His-tag. Synonyms: IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15. Grade: ≥95%. Mole weight: 25-28 kDa. | |
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