A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging (Ex/Em = 789/813 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 2143933-81-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-D1744.
ICG NHS ester
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICG-OSu. CAS No. 1622335-40-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D1041.
ICG Sulfo-NHS ester is an amine-reactive form of near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging. NIR fluorescence allows to observe the deep image from the surface of skin and being utilized in a wide range of research fields. The maxima of Ex/Em values are at 785/812 nm. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical property. Sulfo-NHS esters have higher water solubility than NHS esters, thus they do not need organic co-solvent and readily react with amine-modified oligonucleotides or amino groups of proteins, i.e. the ε-amino groups of lysine or the amine terminus of nucleotides to form a stable amide bond between dye and the biomolecule. We offer ICG Sulfo-NHS ester for labeling of antibodies, peptides, proteins, ligands, and amplification substrates optimized for cellular labeling and NIR imaging. Mole weight: 908.09.
ICG Thiol
ICG Thiol is an inactive form of near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging. The thiol is attached to ICG fluorophore trough a spacer. NIR fluorescence allows to observe the deep image from the surface of skin and being utilized in a wide range of research fields. The maxima of Ex/Em values are at 785/812 nm. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical property. ICG thiol can be labeled to biomolecules through a disulfide bond formation with thiol of cysteine residue or can be utilized as a reference standard for dye-conjugates. Mole weight: 790.3.
I-Cholestane
I-Cholestane. Alternative Names: i-Cholestane; 3,5-Cyclocholestane; (3aR,3bS,5aR,6R,8aS,8bS)-3a,5a-dimethyl-6-((R)-6-methylheptan-2-yl)hexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene; (3α,5α)-3,5-Cyclocholestane. CAS No. 465-56-5. Molecular formula: C27H46. Mole weight: 370.65.
Ichthammol is an antibacterial, fungicidal, antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 8029-68-3. Pack Sizes: 100g, 250g. Molecular Formula: N/A, Molecular Weight: US Biological Life Sciences.
Worldwide
Ichthammol USP
Ichthammol USP.
CA, FL & NJ
ICI-118551 HCl
A highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively). Alternative Names: ICI-118551; ICI118551; ICI 118551; ICI-118,551; ICI118,551; ICI 118,551. Grades: 98%. CAS No. 72795-19-8. Molecular formula: C17H28ClNO2. Mole weight: 313.866.
ICI 118551 Hydrochloride (Zenidolol)
Zenidolol (ICI-118551) Hydrochloride is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. Group: Inhibitors. Alternative Names: ICI-118,551. CAS No. 72795-01-8. Pack Sizes: 5mg. Product ID: S8114. Formula: C17H27NO2.HCl. Smiles: CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl. Storage Conditions: 2 years -80 in solvent.
United States; Europe
ICI 154,129
ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin. Uses: Narcotic antagonists. Alternative Names: N,N-Di(2-propenyl)-L-Tyr-N-[2-[[(S)-2-[[(S)-1-carboxy-3-methylbutyl]amino]-2-oxo-1-benzylethyl]thio]ethyl]-Gly-NH2; M-154129. Grades: >98%. CAS No. 83420-94-4. Molecular formula: C34H46N4O6S. Mole weight: 638.83.
ICI 174,864
ICI 174,864 is a potent and highly selective δ opioid antagonist. It shows partial agonist in vitro activity at δ receptors at high concentrations. Alternative Names: ICI 174,864; ICI174,864; ICI-174,864; N,N-Di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-L-leucine; NIH 10893; N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)-; N,N-Diallyl-Tyr-aib-Phe-Leu. Grades: >98%. CAS No. 89352-67-0. Molecular formula: C38H53N5O7. Mole weight: 691.87.
ICI 192,605
ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Alternative Names: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87.
ICI-199441 hydrochloride
ICI-199441 hydrochloride is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 hydrochloride can improve heart resistance to ischemia/reperfusion[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115199-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101205.
ICI 216140
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124001-41-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3112.
ICI 63197
ICI 63197. Group: Biochemicals. Grades: Purified. CAS No. 27277-00-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Icilin
Icilin. Group: Biochemicals. Grades: Purified. CAS No. 36945-98-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Icilin
Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Uses: Both heat sensitive (vr1) and cold-sensitive (cmr1 (rat); trpm8 (human)) receptors. Alternative Names: AG 3-5; AG3-5; AG-3-5; AG 3-5 cpd; 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one;3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone. Grades: ≥98%. CAS No. 36945-98-9. Molecular formula: C16H13N3O4. Mole weight: 311.29.
Icilin
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG-3-5. CAS No. 36945-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-11062.
Iclaprim
Iclaprim. Group: Biochemicals. Alternative Names: 5-[(2-Cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl)methyl]-2,4-pyrimidine-diamine. Grades: Highly Purified. CAS No. 192314-93-5. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C19H22N4O3. US Biological Life Sciences.
Worldwide
Iclaprim
Iclaprim is a diaminopyrimidine and acts as a dihydrofolate reductase (DHFR) inhibitor active against gram-positive organisms being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria. Alternative Names: AR-100; 5-[(2-cyclopropyl-7,8-dimethoxy-2h-chromen-5-yl)methyl]pyrimidine-2,4-diamine; RO-48-2622. CAS No. 192314-93-5. Molecular formula: C19H22N4O3. Mole weight: 354.41.
ICL-CCIC-0019
ICL-CCIC-0019 is an inhibitor of choline kinase α (CHKα). ICL-CCIC-0019 induces G1 block, endoplasmic reticulum stress apoptosis in cancer cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 936498-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115840.
ICM0201
It is originally isolated from Cunninghamella sp. F-1490. ICM0201 can inhibit the formation of osteoclasts in mouse bone marrow cells with IC50 of 0.78 μg/mL. Alternative Names: ICM 0201; ICM-0201. Molecular formula: C12H13NO6. Mole weight: 267.23.
ICMA
Dipole moment of indene-C60 monoadduct (ICMA) was estimated to be 2.34 debye. Film formation of ICMA under optimum conditions was studied.1 As a potential candidate for field effect transistors (FETs), ICMA exhibits unipolar n-channel characteristics and high electron mobility. Alternative Names: 1',4'-Dihydro-naphtho[2',3':1,2][5,6]fullerene-C60,C60 derivative, indene-C60 monoadduct. CAS No. 186682-36-0. Mole weight: 836.8.
ICMT-IN-1
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1313603-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156500.
ICMT Inhibitor (Cysmethynil)
An inhibitor of protein prenylation. Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt.A cell-permeable indole acetamide that acts as a substrate-competitive and AdoMet-noncompetitive Icmt.25uM) induces G1 cell cycle-arrest and autophagy-mediated, but not apoptotic, cell death in prostate cancer PC3 cells with concomitant PI 3-K/Akt and mTOR signaling blockage, consistent with inhibition of Icmt-mediated activation of Ras and Rheb GTPases. Murine PC3 xenograft studies reveal limited in vivo efficacy. Group: Biochemicals. Alternative Names: Cysmethynil; 2-(5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl)acetamide, 2-(1-Octyl-5-m-tolyl-1H-indol-3-yl) acetamide; Isoprenylcysteine Carboxyl Methyltransferase Inhibitor). Grades: Highly Purified. CAS No. 851636-83-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C25H32N2O, Molecular Weight: 376.5. US Biological Life Sciences.
Worldwide
Icomethasone
Icomethasone is a metabolite of Mometasone Furoate (M4425). Group: Biochemicals. Alternative Names: (11 β,16α)-9-Chloro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione; Icometasone. Grades: Highly Purified. CAS No. 4647-20-5. Pack Sizes: 10mg. Molecular Formula: C22H29ClO5, Molecular Weight: 408.92. US Biological Life Sciences.
Worldwide
Icomethasone 21-Acetate
Icomethasone 21-Acetate. Group: Biochemicals. Alternative Names: Icometasone-21-acetate; 9-Chloro-11 β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione; (11 β,16α)-21-(Acetyloxy)-9-chloro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione. Grades: Highly Purified. CAS No. 24916-91-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Icomethasone 21-Mesylate
Icomethasone 21-Mesylate is a derivative of Icomethasone, used in the preparation of Mometasone. Group: Biochemicals. Alternative Names: (11 β , 16α ) -9-Chloro-11, 17-dihydroxy-16-methyl-21-[ (methylsulfonyl) oxy]pregna-1, 4-diene-3, 20-dione. Grades: Highly Purified. CAS No. 352315-75-4. Pack Sizes: 10mg. Molecular Formula: C23H31ClO7S, Molecular Weight: 487.01. US Biological Life Sciences.
Worldwide
Icomidocholic acid
Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aramchol; C20-FABAC. CAS No. 246529-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19796.
Icosanal. Alternative Names: Icosanal;Eicosanal;2400-66-0;FWBUWJHWAKTPHI-UHFFFAOYSA-N;EINECS219-275-5;AI3-24217. Grades: 95%. CAS No. 2400-66-0. Molecular formula: C20H40O. Mole weight: 296.53.
Icosanamide
Icosanamide, a derivative of fatty acid, displays promise as a therapeutic agent for diverse inflammatory ailments. With its impressive anti-inflammatory attributes, the compound has garnered attention for handling autoimmune diseases and treating conditions such as rheumatoid arthritis. Its efficacy is well-documented in several clinical studies. Alternative Names: Eicosanamide; Arachamide. CAS No. 51360-63-5. Molecular formula: C20H41NO. Mole weight: 311.554.
The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids. Group: Enzymes. Synonyms: acyl-CoA Δ5-desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0972; icosanoyl-CoA 5-desaturase; EC 1.14.19.10; acyl-CoA Δ5-desaturase (ambiguous). Cat No: EXWM-0972.
Icotinib Hydrochloride (BPI-2009H), or Icotinib, is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Alternative Names: BPI-2009H. Grades: >98%. CAS No. 610798-31-7. Molecular formula: C22H21N3O4. Mole weight: 391.42.
Icotinib
Icotinib (BPI-2009) is a potent, CNS-penetrant and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M and EGFRL861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BPI-2009. CAS No. 610798-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15164A.
Icotinib hydrochloride
Icotinib Hydrochloride is a quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), which is upregulated in a variety of cancer cell types. Icotinib supresses the cancer cell proliferation via EGFR tyrosine kinase inhibition. Alternative Names: Icotinib HCl; BPI-2009; BPI 2009; BPI2009. Grades: >98%. CAS No. 1204313-51-8. Molecular formula: C22H22ClN3O4. Mole weight: 427.88.
Icotinib Impurity 1
Icotinib Impurity 1. Uses: For analytical and research use. CAS No. 1058651-74-3. Molecular formula: C22H21N3O5. Mole weight: 407.43. Catalog: APB1058651743.
Icotinib Impurity 10
Icotinib Impurity 10. Uses: For analytical and research use. CAS No. 2376901-56-1. Molecular formula: C20H21N3O5. Mole weight: 383.4. Catalog: APB2376901561.
Icotinib Impurity 11
Icotinib Impurity 11. Uses: For analytical and research use. CAS No. 2305154-39-4. Molecular formula: C17H12N4O2. Mole weight: 304.31. Catalog: APB2305154394.
Icotinib Impurity 12
Icotinib Impurity 12. Uses: For analytical and research use. CAS No. 610798-26-0. Molecular formula: C20H20ClN3O4. Mole weight: 401.85. Catalog: APB610798260.
Icotinib Impurity 13
Icotinib Impurity 13. Uses: For analytical and research use. CAS No. 610798-18-0. Molecular formula: C20H20BrN3O4. Mole weight: 446.3. Catalog: APB610798180.
Icotinib Impurity 14
Icotinib Impurity 14. Uses: For analytical and research use. CAS No. 1887066-23-0. Molecular formula: C22H25N3O5. Mole weight: 411.46. Catalog: APB1887066230.
Icotinib Impurity 15
Icotinib Impurity 15. Uses: For analytical and research use. CAS No. 1887066-21-8. Molecular formula: C20H21N3O4. Mole weight: 367.41. Catalog: APB1887066218.
Icotinib Impurity 16
Icotinib Impurity 16. Uses: For analytical and research use. CAS No. 1708935-17-4. Molecular formula: C19H15N3O3. Mole weight: 333.35. Catalog: APB1708935174.
Icotinib Impurity 17
Icotinib Impurity 17. Uses: For analytical and research use. CAS No. 2376901-55-0. Molecular formula: C20H21N3O5. Mole weight: 383.4. Catalog: APB2376901550.
Icotinib Impurity 18
Icotinib Impurity 18. Uses: For analytical and research use. CAS No. 1318600-04-2. Molecular formula: C22H23N3O6. Mole weight: 425.44. Catalog: APB1318600042.
Icotinib Impurity 19
Icotinib Impurity 19. Uses: For analytical and research use. CAS No. 1318600-10-0. Molecular formula: C22H25N3O6. Mole weight: 427.46. Catalog: APB1318600100.
Icotinib Impurity 2
Icotinib Impurity 2. Uses: For analytical and research use. CAS No. 1643673-64-6. Molecular formula: C22H20ClN3O4. Mole weight: 425.87. Catalog: APB1643673646.
Icotinib Impurity 20
Icotinib Impurity 20. Uses: For analytical and research use. CAS No. 1318600-06-4. Molecular formula: C22H23N3O6. Mole weight: 425.44. Catalog: APB1318600064.
Icotinib Impurity 21
Icotinib Impurity 21. Uses: For analytical and research use. CAS No. 1708935-20-9. Molecular formula: C21H19N3O4. Mole weight: 377.4. Catalog: APB1708935209.
Icotinib Impurity 3
Icotinib Impurity 3. Uses: For analytical and research use. CAS No. 1643673-51-1. Molecular formula: C22H20FN3O4. Mole weight: 409.42. Catalog: APB1643673511.
Icotinib Impurity 4
Icotinib Impurity 4. Uses: For analytical and research use. CAS No. 1058651-82-3. Molecular formula: C28H29N3O11. Mole weight: 583.55. Catalog: APB1058651823.
Icotinib Impurity 5
Icotinib Impurity 5. Uses: For analytical and research use. CAS No. 2249867-59-0. Molecular formula: C18H13N3O2. Mole weight: 303.32. Catalog: APB2249867590.
Icotinib Impurity 6
Icotinib Impurity 6. Uses: For analytical and research use. CAS No. 1869913-77-8. Molecular formula: C20H21N3O5. Mole weight: 383.4. Catalog: APB1869913778.
Icotinib Impurity 7
Icotinib Impurity 7. Uses: For analytical and research use. CAS No. 2249867-60-3. Molecular formula: C19H15N3O2. Mole weight: 317.35. Catalog: APB2249867603.
Icotinib Impurity 8
Icotinib Impurity 8. Uses: For analytical and research use. CAS No. 153437-34-4. Molecular formula: C17H15N3O2. Mole weight: 293.33. Catalog: APB153437344.
Icotinib Impurity 9
Icotinib Impurity 9. Uses: For analytical and research use. CAS No. 412930-46-2. Molecular formula: C18H17N3O2. Mole weight: 307.35. Catalog: APB412930462.
Icotrokinra
Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-77242113; JNJ-2113; PN-235. CAS No. 2763602-16-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10587.
Icovamenib
Icovamenib (BMF-219) is a selective, orally active, irreversible Menin inhibitor. Icovamenib forms a stable and irreversible covalent bond with Menin. Icovamenib promotes selective and controlled proliferation of beta cells and improvement of beta cell function in ex vivo human islet cultures. Icovamenib enhances glycemic control in animal diabetic models. Icovamenib induces a dose-dependent enhancement in insulin secretion potentiated by the GLP-1 RA. Icovamenib can be used for the study of multiple hematologic malignancies, solid tumors, and diabetes mellitus, such as diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM) and chronic lymphocytic leukemia and type 2 diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMF-219; Menin-MLL inhibitor 21. CAS No. 2448172-22-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150105.
ICRF-193
ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21416-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118590.
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. Uses: Scientific research. Category: Signaling pathways. CAS No. 677331-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16665.
iCRT 14
iCRT 14. Group: Biochemicals. Grades: Purified. CAS No. 677331-12-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.